Real-world effectiveness of post-trastuzumab emtansine treatment for human epidermal growth factor receptor 2-positive metastatic breast cancer: a multicenter, matched cohort analy... by C. Courtinard, V. Barbet, R. Schiappa, F. Pilleul, S. Michiels, S. Dabakuyo, S. Gourgou, A. Jaffre, B. Asselain, L. Bosquet, K. Dunton, M. Rosenlund, Z. Liang, J. Cathcart, S. Delaloge

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Therapeutic effect of dihydroartemisinin on Alzheimer’s disease model mice with senile macular degeneration by Gao Han, Gong Xuewu, Zhang Meng, Wang Yuejing, Wang Yuchun, Zhang Keshuang, Yao Hongbo

“…The AD mouse model was established and treated with donepezil and DHA, respectively. Morris water maze was used to detect the spatial learning and memory ability of AD mice. …”
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Effect of Faricimab versus Aflibercept on Hyperreflective Foci in Patients with Diabetic Macular Edema from the YOSEMITE/RHINE Trials by Usha Chakravarthy, FRCOphth, PhD, Varun Chaudhary, MD, FRCS(C), Srinivas R. Sadda, MD, Colin S. Tan, FRCOphth, FRCSEd (Ophth), Stela Vujosevic, MD, PhD, Sascha Fauser, MD, Kara Gibson, PhD, Carl Glittenberg, MD, Nancy Holekamp, MD, FASRS, Ben Lanza, PhD, Andreas Maunz, PhD, Jeffrey R. Willis, MD, PhD, Rishi P. Singh, MD

“…Participants: Adults with vision loss due to center-involving DME. Methods: A deep learning–based algorithm was used to automatically quantify HRF in spectral-domain OCT volume scans from YOSEMITE/RHINE. …”
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Randomised waitlist-controlled trial of a 10-week community programme using a plant-based diet in a predominantly Māori population in Tairāwhiti (Gisborne) by Morgen Smith, Nicholas Wright, Patrick McHugh, Bruce Duncan, Christina Chwyl

“…Of the participants, 59% identified as Māori and 5% as Pasifika.Intervention A 10-week programme consisting of 2 hours, two times per week sessions (40 hours total), involving skills-based learning and health education.Primary and secondary outcome measures Primary measures were changes in weight, BMI and HbA1c. …”
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Repurposing of Some Nucleoside Analogs Targeting Some Key Proteins of the Avian H5N1 Clade 2.3.4.4b to Combat the Circulating HPAI in Birds: An In Silico Approach by Mohd Yasir Khan, Abid Ullah Shah, Nithyadevi Duraisamy, Mohammed Cherkaoui, Maged Gomaa Hemida

“…Unfortunately, there are no specific vaccines or antiviral drugs that could help prevent and treat the infection caused by this virus in birds. …”
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Potential therapeutic effects of Ferula gummosa Boiss. Extract on Autistic-like behaviors in maternally separated mice: Role of NMDA receptor gene by Forozan Yaghoubi, Hossein Amini-Khoei, Kamal Solati, Antoni Sureda, Zahra Lorigooini

“…NMDA receptors are crucial in the functioning of the brain, especially in memory and learning, and have been implicated in the development of ASD. …”
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A novel peptide inhibitor of TRPM2 channels improves recovery of memory function following traumatic brain injury by James E. Orfila, Robert M. Dietz, Christian Schroeder, Olivia P. Patsos, Amelia Burch, Kiara E. Bahamonde, Kelley A. Coakley, Danelle J. Carter, Amy C. Clevenger, Tara B. Hendry-Hofer, Tuan D. Le, Joseph K. Maddry, Joseph K. Maddry, Joseph K. Maddry, Steven G. Schauer, Steven G. Schauer, Steven G. Schauer, Vikhyat S. Bebarta, Paco S. Herson

“…Mice administered tat-M2NX 2 h after TBI exhibited a significant reduction of freezing behavior compared to control tat-scrambled (tat-SCR)-treated mice, suggesting improvement in memory function after TBI. …”
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Radio-pathomic estimates of cellular growth kinetics predict survival in recurrent glioblastoma by Sonoko Oshima, Jingwen Yao, Samuel Bobholz, Raksha Nagaraj, Catalina Raymond, Ashley Teraishi, Anna-Marie Guenther, Asher Kim, Francesco Sanvito, Nicholas S Cho, Blaine S. C. Eldred, Jennifer M Connelly, Phioanh L Nghiemphu, Albert Lai, Noriko Salamon, Timothy F Cloughesy, Peter S LaViolette, Benjamin M Ellingson

“…Aim: A radio-pathomic machine learning (ML) model has been developed to estimate tumor cell density, cytoplasm density (Cyt) and extracellular fluid density (ECF) from multimodal MR images and autopsy pathology. …”
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Real-time morphological and dosimetric adaptation in nasopharyngeal carcinoma radiotherapy: insights from autosegmented fractional fan-beam CT by Xiao-li Yu, Jiang Hu, Yu-xian Yang, Guang-yu Wang, Xin Yang, Wen-chao Diao, Lu Liu, Xiao-bo Jiang, Chen-di Xu, Liu-wen Lin, Le-cheng Jia, Hua Li, Yan-fei Liu, Ying Sun, Guan-qun Zhou

“…Methods This retrospective study analyzed 23 NPC patients (681 FBCT scans) treated at Sun Yat-sen Cancer Center from August 2022 to May 2024. …”
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Therapy response prediction of focal cortex stimulation based on clinical parameters: a multicentre, non-interventional study protocol by Andreas Schulze-Bonhage, Ann Mertens, Felix von Podewils, Martin Hirsch, Yaroslav Winter, Susanne Knake, Ekaterina Pataraia, Thomas Mayer, Yvonne G Weber, Rainer Surges, Jan Wagner, Hajo M Hamer, Tim Wehner, Christoph Baumgartner, Lukas Imbach, Bernhard J Steinhoff, Sotirios Kalousios, Jürgen Hesser, Matthias Dümpelmann, Elisabeth Kaufmann, Josua Kegele, Georg Leonhardt, Carlos M Quesada, Berthold R Voges

“…Clinical data of up to 100 patients treated with FCS are collected across 20 collaborating epilepsy centres in four European countries. …”
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Microbial vitamin biosynthesis links gut microbiota dynamics to chemotherapy toxicity by Lars E. Hillege, Kai R. Trepka, Benjamin G. H. Guthrie, Xueyan Fu, Romy Aarnoutse, Maia R. Paymar, Christine Olson, Chen Zhang, Edwin Ortega, Lorenzo Ramirez, Judith de Vos-Geelen, Liselot Valkenburg-van Iersel, Irene E. G. van Hellemond, Arnold Baars, Johanna H. M. J. Vestjens, John Penders, Adam Deutschbauer, Chloe E. Atreya, Wesley A. Kidder, Marjolein L. Smidt, Janine Ziemons, Peter J. Turnbaugh

“…We profiled gut microbes in colorectal cancer patients treated with capecitabine and carefully monitored side effects. …”
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Impact of COVID-19 on recorded blood pressure screening and hypertension management in England: an analysis of monthly changes in the quality and outcomes framework indicators in O... by Richard J McManus, Ben Goldacre, David Evans, Alex J Walker, Christopher Wood, Jessica Morley, Brian MacKenna, Christopher T Rentsch, Seb Bacon, Chris Bates, Helen J Curtis, Amir Mehrkar, Peter Inglesby, Jonathan Cockburn, Laurie Tomlinson, John Parry, Frank Hester, Amelia Green, Miriam Samuel, Rose Higgins, Andrew D Brown, Viyaasan Mahalingasivam, Caroline Morton, Rebecca M Smith, Louis Fisher, Lisa Hopcroft, Jon Massey, Iain Dillingham, Steven Maude, Milan Wiedemann, Colm Andrews, Christine Cunningham, Victoria Speed, Caroline Walters

“…The percentage of patients with a record of hypertension treated to target in the preceding 12 months reduced from a maximum of 71% (March 2020) to a minimum of 47% (February 2021) in patients aged ≤79 years and from 85% (March 2020) to a minimum of 58% (February 2021) in patients aged ≥80 years before recovery. …”
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Host Plasma Microenvironment in Immunometabolically Impaired HIV Infection Leads to Dysregulated Monocyte Function and Synaptic Transmission Ex Vivo by Flora Mikaeloff, Marco Gelpi, Alejandra Escós, Tianqi Wang, Soham Gupta, Anna Olofsson, Sara Svensson Akusjärvi, Sabrina Schuster, Prajakta Naval, Vikas Sood, Negin Nikouyan, Andreas D. Knudsen, Beate Vestad, Julie Høgh, Johannes R. Hov, Thomas Benfield, Marius Trøseid, Vinay Pawar, Marijana Rucevic, Rui Benfeitas, Ákos Végvári, Liam O'Mahony, Rajkumar Savai, Niklas K. Björkström, Magda Lourda, João Pedro deMagalhães, Siegfried Weiss, Adil Mardinoglu, Mukesh Kumar Varshney, Annika C. Karlsson, Yasir Ahmed Syed, Susanne D. Nielsen, Ujjwal Neogi

“…Abstract Risk stratification using multi‐omics data deepens understanding of immunometabolism in successfully treated people with HIV (PWH) is inadequately explained. …”
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Multi-omics analysis and experiments uncover the link between cancer intrinsic drivers, stemness, and immunotherapy in ovarian cancer with validation in a pan-cancer census by Yilin Li, Cen Chen, Xiaoyu Ji, Ningxiao Jiang, Fei Wang, Xiangqian Gao, Weiwei Chen, Qiang Tang, Yan Li, Shinan Zhang, Gaofeng Qin, Yingjiang Xu, Yanlin Wang, Lingwen Kong, Lei Han, Jie Mei

“…We then developed the CSCI to predict the prognosis and response to immunotherapy in ovarian cancer patients using advanced machine learning algorithms. When applied to PD1/PD-L1 ICI transcriptomic cohorts, CSCI consistently and accurately predicts tumor progression and immunotherapy benefits, with a mean AUC greater than 0.8. …”
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Digital education and exercise therapy versus minimal intervention for young people at high risk of early onset knee osteoarthritis after ACL reconstruction: a study protocol for t... by Jackie L. Whittaker, Amanda Cammalleri, Candice Archibald, Alexandra Brooks-Hill, Patrick Chin, Sarah Clark, Jennifer C. Davis, Alison M. Hoens, Michael A. Hunt, Karin Kausky, Angelina Ko, Lise Leveille, Linda C. Li, Parth Lodhia, Justin M. Losciale, Maxi Miciak, Amber D. Mosewich, Adnan Sheikh, Trish Silvester-Lee, Linda K. Truong, Dominic Wade, David R. Wilson, Hui Xie, Xian He Yan, Ewa M. Roos

“…Participants randomized to the experimental intervention will receive a digital (remote videoconferencing) 6-month program of group-based learning, individualized weekly home-based exercise therapy and physical activity program with tracking, and 1:1 physiotherapist-guided counseling. …”
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Radiomic analysis of patient and interorgan heterogeneity in response to immunotherapies and BRAF-targeted therapy in metastatic melanoma by Riyue Bao, Yana G Najjar, Diwakar Davar, John M Kirkwood, Jason John Luke, Sarah Newman, Hassane M Zarour, Afsaneh Amouzegar, Rivka R Colen, Murat Ak, Priyadarshini Mamindla, Serafettin Zenkin, Vishal Peddagangireddy, Sarah Behr, Alexandra G Tompkins, Zane N Gray, Rebekah E Dadey, Nasim Batavani, Nursima Ak, Taha Yasin Pak, Mohammadreza Amjadzadeh, Amy Goodman, Darcy L Ploucha, Curtis Tatsuoka

“…We queried the UPMC Hillman Cancer Center registry for patients with metastatic melanoma (MEL) treated with immune checkpoint inhibitors (ICI) (anti-programmed cell death protein-1 (PD-1)/cytotoxic T-lymphocyte associated protein 4 (CTLA-4) (ipilimumab+nivolumab; I+N) or anti-PD-1 monotherapy) or BRAF-targeted therapy. …”
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Remdesivir associated with reduced mortality in hospitalized COVID-19 patients: treatment effectiveness using real-world data and natural language processing by José Ramón Arribas López, María Pilar Ruiz Seco, Francisco Fanjul, Beatriz Díaz Pollán, Patricia González Ruano Pérez, Adrián Ferre Beltrán, Rosa De Miguel Buckley, Laura Portillo Horcajada, Cristina De Álvaro Pérez, Paulo Jorge Barroso Santos Carvalho, Savana Research Group, Melchor Riera Jaume

“…We aimed to use natural language processing (NLP) and machine learning (ML) to assess the impact of RDV on COVID19-associated outcomes including time to discharge and in-hospital mortality. …”
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PRAWO RZYMSKIE W INTERNECIE by Zuzanna Służewska

“…In the modern world, where history knowledge is often treated as an useless ballast, especially the researchers of antiquity should make use of technical innovations in the field of dissemination of information because it enables their knowledge to survive. …”
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Perfil socioeconômico e cultural do estudante ingressante no curso de graduação em enfermagem [Social, economic, and cultural profile of incoming undergraduate students at the scho... by Norma Valéria Dantas de Oliveira Souza, Lucia Helena Garcia Penna, Luana dos Santos Cunha, Amanda de Almeida Sant’anna Baptista, Iraneide Ferreira Mafra, Débora Cristina de Almeida Mariano

“…That is regarded as a pro in the teaching-learning process. However, factors such as low family income and poor sanitation come up as concerning issues requiring transforming action.   …”
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Combining Artificial Intelligence and Human Support in Mental Health: Digital Intervention With Comparable Effectiveness to Human-Delivered Care by Clare E Palmer, Emily Marshall, Edward Millgate, Graham Warren, Michael Ewbank, Elisa Cooper, Samantha Lawes, Alastair Smith, Chris Hutchins-Joss, Jessica Young, Malika Bouazzaoui, Morad Margoum, Sandra Healey, Louise Marshall, Shaun Mehew, Ronan Cummins, Valentin Tablan, Ana Catarino, Andrew E Welchman, Andrew D Blackwell

“…The program used an artificial intelligence (AI)–driven conversational agent to deliver clinician-written content via machine learning, with clinician oversight and user support. …”
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