Cell‐to‐cell and type‐to‐type heterogeneity of signaling networks: insights from the crowd by Attila Gabor, Marco Tognetti, Alice Driessen, Jovan Tanevski, Baosen Guo, Wencai Cao, He Shen, Thomas Yu, Verena Chung, Single Cell Signaling in Breast Cancer DREAM Consortium members, Bernd Bodenmiller, Julio Saez‐Rodriguez, Augustinas Prusokas, Alidivinas Prusokas, Renata Retkute, Anand Rajasekar, Karthik Raman, Malvika Sudhakar, Raghunathan Rengaswamy, Edward S.C. Shih, Min‐jeong Kim, Changje Cho, Dohyang Kim, Hyeju Oh, Jinseub Hwang, Kim Jongtae, Yeongeun Nam, Sanghoo Yoon, Taeyong Kwon, Kyeongjun Lee, Sarika Chaudhary, Nehal Sharma, Shreya Bande, Gao Gao fan zhu Cankut Cubuk, Pelin Gundogdu, Joaquin Dopazo, Kinza Rian, Carlos Loucera, Matias M Falco, Martin Garrido‐Rodriguez, Maria Peña‐Chilet, Huiyuan Chen, Gabor Turu, Laszlo Hunyadi, Adam Misak, Baosen Guo, Wencai Cao, He Shen, Lisheng Zhou, Xiaoqing Jiang, Pieta Zhang, Aakansha Rai, Rintu Kutum, Sadhna Rana, Rajgopal Srinivasan, Swatantra Pradhan, James Li, Vladimir Bajic, Christophe Van Neste, Didier Barradas‐bautista, Somayah Abdullah Albarade, Igor Nikolskiy, Musalula Sinkala, Duc Tran, Hung Nguyen, Tin Nguyen, Alexander Wu, Benjamin DeMeo, Brian Hie, Rohit Singh, Jiwei Liu, Xueer Chen, Leonor Saiz, Jose M. G Vilar, Peng Qiu, Akash Gosain, Anjali Dhall, Dinesh Bajaj, Harpreet Kaur, Krishna Bagaria, Mayank Chauhan, Neelam Sharma, Gajendra Raghava, Sumeet Patiyal, Jianye Hao, Jiajie Peng, Shangyi Ning, Yi Ma, Zhongyu Wei, Atte Aalto, Jorge Goncalves, Laurent Mombaerts, Xinnan Dai, Jie Zheng, Piyushkumar Mundra, Fan Xu, Jie Wang, Krishna Kant Singh, Mingyu Lee

“…The challenge results show that despite the stochastic nature of signal transduction in single cells, the signaling events are tightly controlled and machine learning methods can accurately predict new experimental data.…”
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Polystyrene nanoplastics exposure induces cognitive impairment in mice via induction of oxidative stress and ERK/MAPK-mediated neuronal cuproptosis by Yinuo Chen, Yiyang Nan, Lang Xu, Anqi Dai, Rosa Maria Martinez Orteg, Mantong Ma, Yan Zeng, Jinquan Li

“…Methods Seven-week-old male C57BL/6 mice were exposed to PS-NPs at dose of 12.5 mg/kg, and were co-treated with the antioxidant N-acetylcysteine (NAC). …”
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Effects of parenting classes and economic strengthening for caregivers on the cognition of HIV-exposed infants: a pragmatic cluster randomised controlled trial in rural Zimbabwe by Frances M Cowan, Lorraine Sherr, Victoria Simms, Helen Mebrahtu, Zivai Mupambireyi, Andrea M Rehman, Rudo Chingono, Edward Matsikire, Rickie Malaba, Patience Ndlovu

“…Primary outcomes measured 12 months after baseline (4.5 months postintervention completion) included: i) global child development measured using the Mullen early learning composite score; ii) retention in HIV care. …”
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Unlocking the Potential of Wear Time of a Wearable Device to Enhance Postpartum Depression Screening and Detection: Cross-Sectional Study by Eric Hurwitz, Samantha Meltzer-Brody, Zachary Butzin-Dozier, Rena C Patel, Noémie Elhadad, Melissa A Haendel

“…If not diagnosed and treated, PPD is associated with long-term developmental challenges in the child and maternal morbidity. …”
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Spatial distribution of paediatric tuberculosis and factors associated with adverse treatment outcomes in Ashanti Region, Ghana: a retrospective analysis by Maxwell Afranie Appiah, Mawuli Gohoho, Ebenezer Enam Adzaklo, Geoffrey Delali Komla Gone, Joshua Kwabena Aniaku, Perfect Edinam Asamoah, John Owusu Gyapong, Emmanuel Kyeremateng, Emmanuel Tinkorang

“…Thus, it is recommended that the National Tuberculosis Control Programme (NTP) establish a learning platform where districts with high paediatric TB notification rates share their best practices to encourage others to learn to increase the detection of paediatric TB. …”
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Anti-NMDA Encephalitis Associated with a Mature Ovarian Teratoma: A Compelling Case Report by Antonio Medina Luna, Octavio César Augusto Caamal Torres, Ramón Adrián Magaña Dávalos, Carlos Esteban Vidal Valderrama

“…Initially diagnosed with anxiety and major depressive disorder with psychotic symptoms at Methodist Hospital in Houston, she was treated with multiple medications but showed no significant improvement. …”
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Gluteoplastia de aumento: a importância do ensino na formação atual do residente frente à demanda crescente Buttocks increase: the importance of teaching in current resident facing... by Diogo Almeida Lima, Daniel Akira Minakami, Lucas Chagas Pereira, Maieve Corralo Grando, Ricardo Souza Cruz, André Ramalho Braga, Enéas Cardoso de Almeida Neto, Rodrigo Araújo Guimarães, Ronaldo Carrara de Almeida, Acrysio Peixoto de Souza Neto, Cristiam Machado Haesbaert, Márcio Grave, Ricardo Morgental Zambenedetti, Marcelo Moreira Cardoso, José Humberto Cardoso Resende

“…METHODS: Seeing in the residency teaching sites suitable for such a practice, we make a study of 20 cases treated by resident physicians in training under supervision in order to observe the applicability and feasibility of the method and its results. …”
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Improving Systematic Review Updates With Natural Language Processing Through Abstract Component Classification and Selection: Algorithm Development and Validation by Tatsuki Hasegawa, Hayato Kizaki, Keisho Ikegami, Shungo Imai, Yuki Yanagisawa, Shuntaro Yada, Eiji Aramaki, Satoko Hori

“…While these approaches show promise, traditional models typically treat abstracts as uniform text. We hypothesize that selective training on specific abstract components could enhance model performance for systematic review screening. …”
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Screening and Risk Analysis of Atrial Fibrillation After Radiotherapy for Breast Cancer: Protocol for the Cross-Sectional Cohort Study “Watch Your Heart (WATCH)” by Laura Saint-Lary, Baptiste Pinel, Loic Panh, Gaelle Jimenez, Julien Geffrelot, Youlia Kirova, Jeremy Camilleri, David Broggio, Marie-Odile Bernier, Corinne Mandin, Christelle Levy, Serge Boveda, Juliette Thariat, Sophie Jacob

“…MethodsWATCH is a cohort study that will include 200 patients over 65 years old, treated with RT for BC 5 years before inclusion and without a history of AF. …”
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PLXDC1+ Tumor‐Associated Pancreatic Stellate Cells Promote Desmoplastic and Immunosuppressive Niche in Pancreatic Ductal Adenocarcinoma by Yanhua Du, Yizhou Zhao, Judong Li, Jiaxin Wang, Shenglan You, Yao Zhang, Li Zhang, Jihong Yang, Hamid Alinejad‐Rokny, Shujie Cheng, Chenghao Shao, Duowu Zou, Youqiong Ye

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Bromelain prevents Alzheimer's disease progression by suppressing oxidative stress and upregulating apolipoprotein A1 in 5x familial Alzheimer's disease transgenic mice by Julia Chu-Ning Hsu, Po-An Hu, Chia-Hui Chen, Chia-Ju Lee, Hsuan-Yun Hu, Man-Chen Hsu, Wen-Hua Chen, Hsueh-Te Lee, Tzong-Shyuan Lee

“…Bromelain treatment significantly improved motor function, spatial learning, and memory in 5xFAD mice. Analysis of brain tissues revealed reduced levels of Aβ precursor protein and Aβ protein in the hippocampus and cerebral cortex of bromelain-treated mice, potentially mediated through downregulation of ATP-binding cassette subfamily A member 5 and ATP-binding cassette subfamily B member 9 transporters and upregulation of apolipoprotein A1. …”
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Quo vadis autoimmune hepatitis? - Summary of the 5th international autoimmune hepatitis group research workshop 2024Keypoints by Bastian Engel, David N. Assis, Mamatha Bhat, Jan Clusmann, Joost PH. Drenth, Alessio Gerussi, María-Carlota Londoño, Ye Htun Oo, Ida Schregel, Marcial Sebode, Richard Taubert

“…Chronic autoimmune responses against the liver can cause hepatic and extrahepatic symptoms, decreased quality of life and reduced liver transplant-free survival if inadequately treated. Although standard treatment with corticosteroids and thiopurines improves the life expectancy of patients with AIH, remission rates and tolerability are generally overestimated and the development of alternative first-line and salvage therapies has been disappointingly slow compared to in rheumatological diseases or inflammatory bowel disease. …”
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Effect of Repetitive Transcranial Magnetic Stimulation on Patients with Post-Stroke Cognitive Impairment by Zheyi YU, Weiming ZHANG

“…On the basis of routine treatment, the observation group was treated with rTMS once a day, five times a week for eight weeks. …”
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Evaluating a train-the-trainer approach for implementing obstetric life support in diverse healthcare contexts throughout Arizona: a mixed methods protocol by Shayna D. Cunningham, Rogie Royce Carandang, Laurie S. Wood, Marcia Barry, Peggy Baker, Makayla Murphy, Cheryl K. Roth, Les R. Becker, Brook Thomson, Vincent Mosesso, Jacqueline Vidosh, John Phelps, Benjamin Sutton, James J. Grady, Kristen Annis-Brayne, Andrea Shields

“…Abstract Background Most medical responders are not adequately trained to recognize and treat maternal medical emergencies, including maternal cardiac arrest, and national credentialing standards do not exist. …”
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Combined inhibition of dopamine D1/D2 receptors induces cognitive and emotional dysfunction through oxidative stress and dopaminergic neuron damage by Xue Li, Yao Zhuang, Ya Ru Zhang, Ke Ke Fan, Xin Xin Chen, Xin Xing Chen, Xuan Yi Liu, Jing Sun, Li Liu

“…In this study, we aimed to investigate the dose-dependent effects of co-DR1/2I (combined administration of dopamine receptor 1 inhibitor SCH39166 and dopamine receptor 2 inhibitor raclopride) on oxidative stress, learning, memory, emotion, and motor function in the substantia nigra, striatum, and hippocampus of mice.MethodsAfter administering varying doses of co-DR1/2I through gastric tubes to male C57BL/6 mice, we used enzyme-linked immunosorbent assay to measure monoamine oxidase B (MAO-B), reactive oxygen species (ROS), and superoxide dismutase (SOD) activity. …”
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Characterization and Evaluation of Department of Veterans Affairs Commission on Accreditation of Rehabilitation Facilities–Accredited Interdisciplinary Pain Rehabilitation Programs... by Jolie N Haun, Christopher A Fowler, Dustin D French, Megan C McHugh, Jacquelyn N Heuer, Lisa M Ballistrea, Rachel C Benzinger, S Angel Klanchar, Friedhelm Sandbrink, Jennifer L Murphy

“…This protocol informs the use of a mixed methods approach to evaluate a multimodal intervention (ie, IPRP), made up of multiple evidence-based practices to treat a complex comorbid condition. Future work may include data management infrastructure development and cost evaluations to inform clinical and operational decision-making. …”
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Integrative radiomics of intra- and peri-tumoral features for enhanced risk prediction in thymic tumors: a multimodal analysis of tumor microenvironment contributions by Liang zhu, Jiamin Li, Xuefeng Wang, Yan He, Siyuan Li, Shuyan He, Biao Deng

“…The data were sourced from patients treated at the Affiliated Hospital of Guangdong Medical University between 2015 and 2023, with all imaging obtained through preoperative CT scans. …”
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A Domain-Specific Pretrained Model for Detecting Malignant and Premalignant Ocular Surface Tumors: A Multicenter Model Development and Evaluation Study by Zhongwen Li, Yangyang Wang, Wei Qiang, Xuefang Wu, Yanyan Zhang, Yiyuan Gu, Kuan Chen, Donghua Qi, Liheng Xiu, Yunduan Sun, Daoyuan Li, Yahui Xi, Shiqi Yin, Feng Wen, Mingmin Zhu, Yi Shao, Jiewei Jiang, Wei Chen, Guohai Wu

“…Malignant and premalignant ocular surface tumors (OSTs) can be sight-threatening or even life-threatening if not diagnosed and treated promptly. Artificial intelligence holds great promise for the early detection of these diseases. …”
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Choline alleviates cognitive impairment in sleep-deprived young mice via reducing neuroinflammation and altering phospholipidomic profile by Si-Yu Huang, Zhi-Jun Yang, Jin Cheng, Hang-Yu Li, Si Chen, Zi-Hui Huang, Jie-Dong Chen, Ruo-Gu Xiong, Meng-Tao Yang, Chen Wang, Meng-Chu Li, Shuang Song, Wen-Ge Huang, Dong-Liang Wang, Hua-Bin Li, Qiu-Ye Lan

“…This study suggests that choline could develop into functional food or medicine ingredient to prevent and treat cognitive impairment by sleep disturbances, particularly children and adolescents.…”
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Electronic patient-reported outcomes, fever management, and symptom prediction among patients with BRAF V600 mutant stage III–IV melanoma: The Kaiku Health platform by Peter Mohr, Paolo Ascierto, Alfredo Addeo, Maria Grazia Vitale, Paola Queirolo, Christian Blank, Jussi Ekström, Joonas Vainio, Vesa Kataja, Sibel Gunes, Mia Engström-Risku, Henriette Thole, Ailis Fagan, Frederico Calado, Ruben Marques, Judith Lijnsvelt

“…Additionally, we evaluated prediction of symptom onset or continuation using a machine learning (ML) model. Methods: Patients ≥18 years old with high-risk stage III (adjuvant) or unresectable/metastatic stage IV BRAF V600E/K–mutant melanoma treated with BRAF/MEK inhibitor combination were included in a descriptive cohort study. …”
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