Bioinformatics and experimental validation identify biomarkers for diagnosing Alzheimer’s disease by Hui Liu, Hui Liu, Chenye Li, Congchen Zhai, Congchen Zhai, Mei Li, Lan Ma

“…Serum samples were collected from 41 AD patients treated at the Second Affiliated Hospital of Harbin Medical University between October 2023 and November 2024, along with 41 control subjects. …”
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25-gauge vitrectomy with gas tamponade for uncomplicated rhegmatogenous retinal detachment: experienced vs. inexperienced surgeons by Martin Pencak, Zbynek Stranak, Jakub Dite, Jana Vranova, Pavel Studeny, Miroslav Veith

“…With good technique and the use of modern vitrectomy machines and instruments, some inexperienced surgeons can achieve a high single-surgery success rate, suggesting a short learning curve. The complication rate is comparable between experienced and inexperienced surgeons.…”
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Methotrexate Toxic Effects on the Cerebellum and Vitamin C Protective Function by Hala Mohamed AlKhalidi, Shatha Shayan Almutairi, Ali Hassan A. Ali

“…However, recent research has shown that it also plays a role in a variety of cognitive processes, such as learning, attention, and even emotion regulation. This study aimed to evaluate how vitamin C might lessen the negative effects of methotrexate on the cerebellum of male albino rats. …”
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Quantitatively defined stromal B cell aggregates are associated with response to checkpoint inhibitors in unresectable melanoma by James W. Smithy, Xiyu Peng, Fiona D. Ehrich, Andrea P. Moy, Mohammad Yosofvand, Colleen Maher, Nathaniel Aleynick, Rami Vanguri, Mingqiang Zhuang, Jasme Lee, MaryLena Bleile, Yanyun Li, Michael A. Postow, Katherine S. Panageas, Travis J. Hollmann, Margaret K. Callahan, Ronglai Shen

“…In pre-treatment melanoma samples from 50 patients treated with immune checkpoint inhibitors (ICIs), a higher stromal B cell percentage is associated with the clinical benefit of ICI therapy. …”
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Pitolisant alleviates brain network dysfunction and cognitive deficits in a mouse model of Alzheimer’s disease by Yang Zou, Linhan Yang, Jiahui Zhu, Jihua Fan, Hanrun Zheng, Xiang Liao, Zhiqi Yang, Kuan Zhang, Hongbo Jia, Arthur Konnerth, Yan-jiang Wang, Chunqing Zhang, Yun Zhang, Sunny C. Li, Xiaowei Chen

“…Pitolisant is a clinically approved H3R antagonist/inverse agonist that treats narcolepsy. Here, we find that pitolisant reverses AD-like pathophysiology and cognitive impairments in an AD mouse model. …”
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Multi-omics profiling of cross-resistance between ceftazidime-avibactam and meropenem identifies common and strain-specific mechanisms in Pseudomonas aeruginosa clinical isolates by Bartosz J. Bartmanski, Anja Bösch, Steven Schmitt, Niranjan R. Ireddy, Qun Ren, Jacqueline Findlay, Adrian Egli, Maria Zimmermann-Kogadeeva, Baharak Babouee Flury

“…Whole-genome sequencing revealed strain heterogeneity and different evolutionary paths, with three genes mutated in three or more strains: dacB in CZA-treated strains and oprD and ftsI in MEM-treated strains. …”
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Versatility of biodegradable temporizing matrix in acute burn management: Invasive procedures through a synthetic dermal substitute by Joanneke Maitz, Therese Pham, Daniel Isacson, Rodney Martin, James Laycock, Matthew Rickard, Peter Maitz

“…This case highlights the versatility of BTM, suggesting that once partially or fully integrated, the neo-dermis can be treated like native skin for invasive procedures or surgical interventions. …”
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Neuroprotective and Antiamnesic Effects of Mitragyna inermis Willd (Rubiaceae) on Scopolamine-Induced Memory Impairment in Mice by David Bougolla Pahaye, Elisabeth Ngo Bum, Germain Sotoing Taïwé, Gwladys Temkou Ngoupaye, Neteydji Sidiki, Fleur Clarisse Okomolo Moto, Nadège Kouemou, Stephanie Jacqueline Kameni Njapdounke, Gisele Nkantchoua, Antoine Kandeda, Jean Pierre Omam Omam, Veronique Mairaira, Josiane Lucie Ojong

“…The times spent in target quadrant in MWM increased while the transfer latency decreased in mice treated by M. inermis at the dose of 196.5 mg/kg. …”
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Artificial intelligence-based digital pathology using H&E-stained whole slide images in immuno-oncology: from immune biomarker detection to immunotherapy response prediction by Yeseul Kim, Eugene Kim, Young Kwang Chae, Jaeyoun Choi, Chan Mi Jung, Christmann Low, Ju Young Lee, Jonghanne Park, Sukjoo Cho, Lee Cooper, Jessica Zhang, Horyun Choi, Allen Cho, Emma J Yu, Jeffrey H Chuang

“…Immuno-oncology and the advent of immunotherapies, in particular immune checkpoint inhibitors (ICIs), have fundamentally altered the way we treat cancer. Yet only a small subset of patients actually responds to ICIs, and many face significant adverse effects, making the accurate selection of patients for ICIs essential to the work of immuno-oncology. …”
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SAFETY AND EFFICACY OF THORACOSCOPIC LOBECTOMY IN PATIENTS WITH STAGE I NON-SMALL CELL LUNG CANCER by A. B. Ryabov, O. V. Pikin, V. A. Bagrov, K. I. Kolbanov, V. A. Glushko, D. A. Vursol, A. M. Amiraliev, V. V. Barmin, O. A. Aleksandrov

“…A total of 479 NSCLC patients with clinical stage I NSCLC were treated at the Department of Thoracic Surgery of Hertzen Research Cancer Center from 2010 to 2019.Results. …”
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Oral administration of butylated hydroxytoluene induces neuroprotection in a streptozotocin-induced rat Alzheimer’s disease model via inhibition of neuronal ferroptosis by Parisa Faraji, Elham Parandavar, Hartmut Kuhn, Mehran Habibi-Rezaei, Astrid Borchert, Elham Zahedi, Shahin Ahmadian

“…Three weeks after surgery, we assessed the learning capabilities and the short-term memory of three experimental groups using the conventional y-maze test: (i) streptozotocin-treated rats (BHT pre-treatment), (ii) streptozotocin-treated rats (no BHT pre-treatment), (iii) sham-operated rats (BHT pre-treatment but no streptozotocin administration). …”
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Improving opioid guideline adherence: evaluation of a multifaceted, theory-informed pilot intervention for family physicians by Andrea D Furlan, Michael Hamilton, Meldon Kahan, Pamela Leece, Navindra Persaud, Yalnee Shantharam, Samah Hassam, Daniel Z Buchman, Sheryl Spithoff, Anita Srivastava, Beth A Sproule, Leslie Carlin

“…This study aimed to assess changes in Canadian family physicians’ knowledge and practices after completing the OSA package.Design We conducted a mixed-method evaluation using a pre-test and post-test design that involved the collection of both qualitative and quantitative data.Setting This research was conducted in the primary care setting in Ontario, Canada.Participants We recruited a purposive sample of nine family physicians in Ontario who use long-term opioid therapy to treat patients with chronic pain.Interventions The OSA package included four components: an online knowledge test, an online learning programme, a safe medication practice self-assessment questionnaire and chart audit with feedback.Outcome measures Our measures included changes in knowledge, opioid safety practices and physicians’ perspectives on the OSA package.Results We found statistically significant improvements between pre-test and post-test knowledge scores at both baseline and 6-month follow-up. …”
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Spatio-Temporal Data Augmentation Method for Network Traffic Prediction by Sung Oh, Myeong-Jun Oh, Jong-Kyung Im, Ji-Yeon Park, Joung-Sik Kim, Na-Rae Yi, Myung-Ho Kim, Sung-Ho Bae

“…Enhancing the generalization performance of CNN-based deep learning models for network traffic prediction requires a substantial amount of data. …”
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Astaxanthin Mitigates ADHD Symptoms in Spontaneously Hypertensive Rats via Dopaminergic Modulation and Brain–Gut Axis Regulation by Yueyang Leng, Ning Wu, Jing Wang, Lihua Geng, Yang Yue, Quanbin Zhang

“…Attention Deficit Hyperactivity Disorder (ADHD) is a prevalent neurodevelopmental disorder that significantly impacts learning, daily functioning, and personal development. …”
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Electron-beam FLASH whole brain irradiation induced a unique changes of intestinal flora by Feifei Gao, Wei Cheng, Yanxi Ma, Boyi Yu, Xinle Lang, Xiaodong Jin, Jianxin Wang, Xianhong Liu, Cuixia Di, Hui Wang, Fei Ye, Ting Zhao, Weiqiang Chen, Qiang Li

“…Abstract Background Whole-brain radiotherapy (WBRT) is an important way to treat multiple metastases. Ultra-high dose rate (FLASH) can avoid neurotoxicity caused by conventional irradiation, it has attracted much attention. …”
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DIDADTIC TOOLS FOR THE STUDENTS’ ALGORITHMIC THINKING DEVELOPMENT by T. P. Pushkaryeva, T. A. Stepanova, V. V. Kalitina

“…Using of kinesthetic training simulators in educational process provide the effective development of algorithmic style of thinking and increase the level of understanding and learning of educational material on algorithms and programming.Scientific novelty. …”
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Employing Quantum Entanglement for Real-Time Coordination of Distributed Electric Vehicle Charging Stations: Advancing Grid Efficiency and Stability by Dawei Wang, Hanqi Dai, Yuan Jin, Zhuoqun Li, Shanna Luo, Xuebin Li

“…Real-time electricity prices are treated as dynamic decision variables influenced by station utilization, elasticity response curves, and the marginal cost of renewable and grid electricity. …”
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Single-cell and bulk transcriptome analyses reveal elevated amino acid metabolism promoting tumor-directed immune evasion in colorectal cancer by Tianyue Sun, Yan Chen, Ying-Xuan Chen

“…Furthermore, CD8+ T cells showed increased Granzyme B levels when co-cultured with CRC cells in which Psat1 or Shmt2 was knocked down. Finally, a machine learning-derived risk score based on six genes was established to translate single-cell findings to bulk transcriptomes. …”
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Keterlibatan Stakeholder Pada Strategi TI; Studi Pemetaan Sistematis by Hidayatul Aini Puteri, Apol Pribadi Subriadi

“…Learning stakeholder strategies has been carried out in various fields. …”
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Cognitive recovery of post critical care patients with and without COVID-19: differences and similarities, an observational study by Anna Gorsler, Christiana Franke, Anneke Quitschau, Nadine Külzow

“…Abstract Background Coronavirus disease (COVID-19) patients treated in an intensive care unit (ICU) are at high risk of developing cognitive impairments of a “post-intensive care syndrome” (PICS). …”
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