549 Mental health care for patients with potential decision-making capacity compromise: Challenging Ontario’s mental healthcare legislation by Leslie Shai, Gilbert Sharpe, Edyta Marcon

“…We will identify best practices/learning across locales. Patients who have been involuntarily treated/confined will be welcomed to voice what the law should contain. …”
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Neuroprotective Effects of ZiBuPiYin Recipe on db/db Mice via PI3K-Akt Signaling Pathway by Activating Grb2 by Wei-ming Ren, Ze-bin Weng, Xin Li, Li-bin Zhan

“…In this study, 6-8 weeks aged db/db mice were treated with excipients or ZBPYR for 6 weeks. Body weight and RBG were recorded weekly. …”
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Recent advancements in hematopoietic stem cell transplantation in Taiwan by Chi-Cheng Li, Xavier Cheng-Hong Tsai, Wei-Han Huang, Tso-Fu Wang

“…Third, although the incidence of idiopathic pneumonia syndrome was low (1.1%), its mortality rate was high (58.1%). Fourth, difficult-to-treat mantle cell and T-cell lymphomas treated with autologous HSCT during earlier remission had higher survival rates. …”
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Child and Parent Perspectives on Daily Functioning after Perinatal Brain Injury by Lisanne M. Baak, MD, Corline E.J. Parmentier, MD, PhD, Nienke Wagenaar, MD, PhD, Fleur-Sophie N. Buijsen, BSc, Anne A.M. van Wendel de Joode, Jan Willem Gorter, MD, PhD, Manon J.N.L. Benders, MD, PhD, Floris Groenendaal, MD, PhD, Linda S. de Vries, MD, PhD, Cora H. Nijboer, PhD, Thomas Alderliesten, MD, PhD, Corine Koopman-Esseboom, MD, PhD, Cornelia H. Verhage, Rian M.J.C. Eijsermans, Niek E. van der Aa, MD, PhD, Marjolijn Ketelaar, PhD

“…Study design: Cross-sectional questionnaire study of participants ≥8 years of age born with hypoxic-ischemic encephalopathy treated with therapeutic hypothermia, or with perinatal arterial ischemic stroke, and their parents. …”
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A rapid, affordable, and reliable method for profiling microbiome biomarkers from fecal images by Donghyeok Lee, Annemiek Maaskant, Huy Ngo, Roy C. Montijn, Jaco Bakker, Jan A.M. Langermans, Evgeni Levin

“…Summary: Human and veterinary healthcare professionals are interested in utilizing the gut-microbiome as a target to diagnose, treat, and prevent (gastrointestinal) diseases. However, the current microbiome analysis techniques are expensive and time-consuming, and data interpretation requires the expertise of specialists. …”
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Gut microbiota and SCFAs improve the treatment efficacy of chemotherapy and immunotherapy in NSCLC by Yanping Yang, Maosong Ye, Yijun Song, Wenyu Xing, Xing Zhao, Yufan Li, Jiacheng Shen, Jian Zhou, Kinji Arikawa, Shengdi Wu, Yuanlin Song, Nuo Xu

“…We analyzed gut microbiota in non-small cell lung cancer (NSCLC) patients treated with chemo-immunotherapy, comparing responders and non-responders using 16S rRNA sequencing. …”
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Speech Analysis as a Tool for Detection and Monitoring of Medical Conditions: A review by Magdalena IGRAS-CYBULSKA, Daria HEMMERLING, Mariusz ZIÓŁKO, Wojciech DATKA, Ewa STOGOWSKA, Michał KUCHARSKI, Rafał RZEPKA, Bartosz ZIÓŁKO

“…For that reason it should be treated as a medical screening test and should be an indication of the need for classic medical tests.…”
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Effects of Adenotonsillectomy on Neurocognitive Function in Pediatric Obstructive Sleep Apnea Syndrome by Fumie Horiuchi, Yasunori Oka, Kenjiro Komori, Yasumasa Tokui, Teruhisa Matsumoto, Kentaro Kawabe, Shu-ichi Ueno

“…Obstructive sleep apnea syndrome (OSAS) in children does not only present with symptoms of sleep disturbances but also with associated symptoms such as growth failure, enuresis, academic learning difficulties, and behavioral problems, including attention deficit/hyperactivity disorder- (ADHD-) like symptoms. …”
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Quantitative ultrasound classification of healthy and chemically degraded ex-vivo cartilage by Angela Sorriento, Lorena Guachi-Guachi, Claudia Turini, Enrico Lenzi, Paolo Dolzani, Gina Lisignoli, Sajedeh Kerdegari, Gaetano Valenza, Claudio Canale, Leonardo Ricotti, Andrea Cafarelli

“…We propose for the first time a combination of these ultrasound parameters through machine learning models aimed at automatically identifying healthy and degraded cartilage samples. …”
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Characteristics of five-phase acupoints from data mining of randomized controlled clinical trials followed by multidimensional scaling by Seoyoung Lee, Yeonhee Ryu, Hi-Joon Park, In-Seon Lee, Younbyoung Chae

“…In this study, we used machine-learning methods to examine clinical trial data for diseases treated using prescribed five-phase acupoint patterns. …”
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Oral trehalose improves histological and behavior symptoms of mucopolysaccharidosis type II in iduronate 2-sulfatase deficient mice by Hyesook Lee, Jung-Hwa Han, Roo Gam Jeong, Yun Jeong Kang, Byung Hyun Choi, Seo Rin Kim, Chong Kun Cheon, Jin Hur, Soo Yong Lee

“…In the present study, to investigate the efficacy of oral trehalose in Ids-knock-out (KO) mice, Ids-KO and wild type (WT) mice were treated with 2% trehalose dissolved in distilled water ad libitum for 24 weeks. …”
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Adult-Onset Fluoxetine Treatment Does Not Improve Behavioral Impairments and May Have Adverse Effects on the Ts65Dn Mouse Model of Down Syndrome by Markus Heinen, Moritz M. Hettich, Devon P. Ryan, Susanne Schnell, Katharina Paesler, Dan Ehninger

“…On the contrary, we observed seizures and mortality in fluoxetine-treated Ts65Dn mice, raising the possibility of a drug × genotype interaction with respect to these adverse treatment outcomes. …”
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Effects of Extremely Low-Frequency Electromagnetic Fields on Neurogenesis and Cognitive Behavior in an Experimental Model of Hippocampal Injury by Mohammad Hassan Sakhaie, Mansoureh Soleimani, Bagher Pourheydar, Zahra Majd, Pezhman Atefimanesh, Sara Soleimani Asl, Mehdi Mehdizadeh

“…Based on the findings, exposure to ELF-EMF enhanced spatial learning and memory in the MWM test. ELF-EMF exposure significantly enhanced the number of BrdU+ and NeuN+ cells in the dentate gyrus of adult mice (P<0.001 and P<0.05, resp.). …”
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Real-world clinical multi-omics analyses reveal bifurcation of ER-independent and ER-dependent drug resistance to CDK4/6 inhibitors by Zhengyan Kan, Ji Wen, Vinicius Bonato, Jennifer Webster, Wenjing Yang, Vladimir Ivanov, Kimberly Hyunjung Kim, Whijae Roh, Chaoting Liu, Xinmeng Jasmine Mu, Jennifer Lapira-Miller, Jon Oyer, Todd VanArsdale, Paul A. Rejto, Jadwiga Bienkowska

“…Abstract To better understand drug resistance mechanisms to CDK4/6 inhibitors and inform precision medicine, we analyze real-world multi-omics data from 400 HR+/HER2- metastatic breast cancer patients treated with CDK4/6 inhibitors plus endocrine therapies, including 200 pre-treatment and 227 post-progression samples. …”
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Graph attention network-based multi-source data fusion for atmospheric CO2 concentrations estimation by De Bao, Zheng Ma, Liheng Zhong, Jining Yan, Yi Li, Leigang Sun

“…Existing interpolation and machine learning methods have been used to estimate missing CO2 concentrations, but these approaches result in coarse resolutions and fail to account for spatial correlations. …”
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Fulminant necrotizing amoebic colitis presenting as acute appendicitis: a case report and comprehensive literature review by Nur Rahadiani, Muhammad Habiburrahman, Agi Satria Putranto, Diah Rini Handjari, Marini Stephanie, Ening Krisnuhoni

“…After the surgery, the patient was transferred to the high care unit and treated with metronidazole after histopathologic findings confirmed the etiology. …”
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Reproductive-Age Women’s Knowledge and Care Seeking for Malaria Prevention and Control in Ghana: Analysis of the 2016 Malaria Indicator Survey by Martin Amogre Ayanore, John Tetteh, Asiwome Ameko, Wisdom Kudzo Axame, Robert Kaba Alhassan, Augustine Adoliba Ayanore, Victor Mogre, Seth Owusu-Agyei

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Administration of Polyphenol-Rich Sugarcane Extract Alleviates Deficits Induced by Amyloid-Beta_1–42 (Aβ_1–42) in Transgenic <i>C. elegans</i> by Deniz Heydarian, Matthew Flavel, Mihiri Munasinghe, Markandeya Jois, Jency Thomas

“…This study utilized transgenic <i>C. elegans</i> expressing Aβ_1–42 to investigate PRSE’s impact on lifespan, sensory behavior, learning, memory, and amyloid fibril accumulation. …”
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Clinical characteristics of adrenal crisis in 371 adult patients with glucocorticoid-induced adrenal insufficiency by Ying Qiu, Ying Qiu, Ying Luo, Xinqian Geng, Yujian Li, Yujian Li, Yunhua Feng, Ying Yang

“…This study aims to analyze the clinical characteristics of GIAI patients with AC and explore the related risk factors.MethodsClinical data of adult GIAI patients treated at our hospital between January 1, 2014, and December 31, 2023 were included. …”
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Enhancing Postural Monitoring in Wheelchair Users Through Context Classification by Nerea Perez, Aitziber Mancisidor, Itziar Cabanes, Patrick Vermander

“…These models have been developed using machine learning techniques, such as K-Nearest Neighbors (KNN), Artificial Neural Networks (ANN) and Support Vector Machines (SVM). …”
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