Insights and interventions for improving cultural humility towards Asian American, Native Hawaiian and Pacific Islander populations in medical curricula: a qualitative case study by Sandra Kong, Nathan Irvin, Connie Cai, Carolyn Im, Ethan Mondell, Thomas K Le, Shari M Lawson

“…Medical student focus groups identified three interventions to improve cultural humility-based training for treating AANHPI patients: reflection spaces, community engagement and clinical training on documenting cultural needs. …”
Get full text

Optimizing transcranial focused ultrasound parameters: A methodological advancement in non-invasive brain stimulation for next-gen clinical applications by Sachin Gupta, Mustafa Mudhafar, Yogini Dilip Borole, V. Mahalakshmi, Janjhyam Venkata Naga Ramesh, Muhammad Attique Khan

“…Background: Transcranial-focused ultrasound (FUS), a non-invasive neuromodulation method, is gaining popularity for treating neurological and psychiatric disorders. However, changing stimulation settings for precise brain targeting remains challenging.Methods: Existing techniques have spatial resolution, skull acoustic transmission, and parameter selection issues that reduce clinical efficacy. …”
Get full text

Recent advances in metal oxide-biochar composites for water and soil remediation: A review by Hermann Tamaguelon Dzoujo, Victor Odhiambo Shikuku, Sylvain Tome, Aurelle Clandy Ntinkam Simo, Emily C. Ng'eno, Zachary M. Getenga, Marie Annie Etoh, David Daniel Joh Dina

“…Nevertheless, the use of biochar in improving soil fertility, immobilizing contaminants and treating wastewater has presented many limitations. …”
Get full text

A randomised controlled feasibility trial comparing culturally adapted psychoeducation and treatment as usual for persons with bipolar disorders in Nigeria by Dung Ezekiel Jidong, M. Ishrat Husain, Tarela Juliet Ike, Ameer Khoso, Maigari Yusufu Taru, Charles Nnaemeka Nwoga, Christopher Francis, Shadrack B. Mwankon, John Ezekiel Jidong, Juliet Y. Pwajok, Suleman Shakoor, Atta Muhammad Asif, Siqi Xue, Nusrat Husain

Get full text

Unravelling the target landscape of tranylcypromines for new drug discovery by Yihui Song, Junbiao Chang, Bin Yu

“…This review aims to explore the target landscape of TCPs, highlight key structure–activity relationships (SARs), and emphasize the therapeutic potential of TCPs for treating various diseases. Finally, the lessons learned from our medicinal chemistry practice, challenges and future directions of TCP-based drug discovery are briefly discussed.…”
Get full text

Activated TBK1 promotes ACSL1-mediated microglia lipid droplet accumulation and neuroinflammation in Parkinson’s disease by Chunlei Han, Huizhi Wang, Moxuan Zhang, Liuliu Wu, Anni Wang, Pengda Yang, Yuan Gao, Chaonan Zhang, Jianing Gao, Tao Xue, Tingting Du, Yucheng Ji, Lin Shi, Chunkui Zhang, Renpeng Li, Yilei Xiao, Jianguo Zhang, Fangang Meng

“…Our findings suggest that manipulating lipid droplet biogenesis by modulating ACSL1 may be a potential strategy for treating neuroinflammation in PD patients.…”
Get full text

Artificial Intelligence and Ethical Dimensions of Automated Traffic Enforcement: Implications for Public Health, Healthcare Equity, and Social Justice by Patricia Haley

“…Additionally, the study examines three core social justice principles: substantive equality (addressing systemic disadvantages rather than treating all violations identically), participatory parity (ensuring affected communities can participate meaningfully in policy decisions), and non-domination (preventing the arbitrary exercise of state power through automated systems). …”
Get full text

Is transphyseal intramedullary fixation of the distal radius in pediatric fractures a safe procedure? An MRI study by Marco Giordano, Michela Florio, Silvia Careri, Marco Cirillo, Angelo Gabriele Aulisa, Angelo Gabriele Aulisa, Fabio Massimo Pezzoli, Francesco Falciglia

“…Despite the use of pinning through the growth plate, which was proposed in the past and is still being used to treat these fractures, an instrumental validation to define this procedure as safe has not yet been done. …”
Get full text

Postoperative loss of perineuronal nets in the hippocampal CA1 region results in memory consolidation deficits by Zun-sai Feng, Jiang-nan Wu, Gui-cheng Wang, Zi-qing Xu, Yan-jing Guo, Shi-yu Hao, Gong-ming Wang, Meng-yuan Zhang

“…This study provides new theoretical insights and potential targets for preventing and treating postoperative memory consolidation deficits.…”
Get full text

La prevención como un recurso de intervención psicosocial en el paciente con VIH by Solvey del Río Marichal, Yunior Hernández Cardet, Antonio Delgado Chamberlain, Luis Enrique Cortés Pérez, Yury Montalvo Velásquez

“…The research also was  also  aimed at contributing to the rise in the quality of life, lifelong learning and human development of individuals living with HIV.     …”
Get full text

Identification and validation of biomarkers, construction of diagnostic models, and investigation of immunological infiltration characteristics for idiopathic frozen shoulder by Han-tao Jiang, Li-ping Shen, Meng-Qi Pang, Min-jiao Wu, Jiang Li, Wei-jie Gong, Gang Jin, Rang-teng Zhu

“…At the outset, we conducted differential expression analysis, weighted gene co-expression network analysis (WGCNA), and utilized the cytoHubba plugin, complemented by two machine learning algorithms, receiver operating characteristic (ROC) analysis, and expression level evaluation to identify biomarkers for FS. …”
Get full text

Ligand supplementation restores the cancer therapy efficacy of the antirheumatic drug auranofin from serum inactivation by Yuan Wang, Bei Cao, Qianqian Wang, Sinan Zhong, Xin Fang, Junjian Wang, Albert S. C. Chan, Xiaolin Xiong, Taotao Zou

“…Abstract Auranofin, an FDA-approved antirheumatic gold drug, has gained ongoing interest in clinical studies for treating advanced or recurrent tumors. However, gold ion’s dynamic thiol exchange nature strongly attenuates its bioactivity due to the fast formation of covalent albumin-gold adducts. …”
Get full text

Deciphering the role of CAPZA2 in neurodevelopmental disorders: insights from mouse models by Mei Guo, Liming Liu, Xiao Mao, Manyu Xiao, Xiaobin He, Xing Pan, Yuewen Chen, Wanying Yi, Qibin Li, Xianglan Piao, Hua Wang, Yang Du, Yong Cheng

“…These insights highlight the gene’s essential role in brain development and function, with potential implications for understanding and treating neurodevelopmental disorders.…”
Get full text

ER stress genes (COL1A1, LOXL2, VWF) predicts IKK-16 as a Candidate therapeutic target for colitis-related inflammation and fibrosis suppression by Ke Zhang, Jiao Yang, Qing-Qing Yang, Jun-An Guo, Qian-Hui Huang, Chan Cui, Yue-Mei Wang, Qiao-Feng Wu, Qiao-Feng Wu, Jun-Meng Wang

“…This study aims to identify ERS-related genes involved in UC fibrosis and explore potential therapeutic targets.MethodsDifferentially expressed ERS-related genes (DE-ERGs) were identified through comprehensive analysis of public datasets. Machine learning methods screened VWF, MZB1, COL1A1, and LOXL2 as key regulators. …”
Get full text

Gut microbiome alterations and hepatic encephalopathy post-TIPS in liver cirrhosis patients by Shengpeng Li, Zhengguo Xu, Hua Diao, An Zhou, Dianji Tu, Sumin Wang, Yunxuan Feng, Xiaojie Feng, Yi Lai, Shiming Yang, Bo Tang

“…Abstract Background The transjugular intrahepatic portosystemic shunt (TIPS), a crucial tool for treating complications related to portal hypertension in patients with liver cirrhosis, is often associated with an increased risk of postoperative complications such as hepatic encephalopathy. …”
Get full text

Adsorptive removal of organics and nutrients from septic tank effluent using oak wood chip biochar: Kinetic analysis and numerical modeling by Chimdi Muoghalu, Herbert Cirrus Kaboggoza, Swaib Semiyaga, Musa Manga

“…Cost-effective polishing techniques like biochar, a carbon-rich sorbent, can effectively treat septic effluent, protecting the environment and public health. …”
Get full text

A Comparison of the Results of Two Different Double-Row Repair Techniques in Arthroscopic Repair of Rotator Cuff Tears by Gökhan Ünlü, Mehmet Faruk Çatma, Ahmet Burak Satılmış, Tolgahan Cengiz, Serhan Ünlü, Mustafa Erdem, Önder Ersan

“…Arthroscopic rotator cuff repair has become the gold standard for treating symptomatic, full-thickness rotator cuff tears. …”
Get full text

Microglia-targeting nanosystems that cooperatively deliver Chinese herbal ingredients alleviate behavioral and cognitive deficits in Alzheimer’s disease model mice by Peng Zhou, Quan Chao, Chen Li, Ningjing Wang, Siqi Guo, Pingping Wang, Pingyuan Ge, Caihong Li, Rui Guo, Nianyun Yang, Zhangdi Lu, Zhishu Tang, Qichun Zhang, Tingming Fu, Qingqing Xiao, Huaxu Zhu

“…Therefore, overcoming the BBB and targeted delivery of anti-inflammatory agents to microglia seem to be effective practical strategies for treating AD. A large proportion of natural active extracts possess exceptional immunomodulating capabilities. …”
Get full text

Refining management strategies for Lennox–Gastaut syndrome: Updated algorithms and practical approaches by Stéphane Auvin, Alexis Arzimanoglou, Mercè Falip, Pasquale Striano, J. Helen Cross

“…Most people with LGS have learning difficulties and need a lot of support, often in residential care. …”
Get full text

A Correlational Study on the Teaching Methodologies and the Competencies of Graduates in a Private University in the Philippines by Kingie Micabalo, Winnie Marie Poliquit, Estela Ibanez, Robert Pabillaran, Quennie Marie Edicto, Jesszon Cano

“…Frequency and simple percentage, weighted mean, Chi-Square Test of Independence, and One-way ANOVA were used to treat and interpret the data. The findings revealed that, in a pervasive way, the teaching and learning methodologies among faculties embodied in the flipped classroom, project-based learning, cooperative learning, problem-based learning, and competency-based learning in the Department were perceived by the graduates. …”
Get full text