Localised Therapies Using 3D‐Printed Collagen‐Based Micro‐Implant for Ocular Indications by Hamid Heidari Kashkooli, Arian Farokh, Sajad Mohammadi, Martina Marcotulli, Silvia Franco, Roberta Angelini, Giancarlo Ruocco, Hanieh Khalili, Gianluca Cidonio

“…Abstract Current limitations in treating retinal diseases like age‐related macular degeneration (AMD) and diabetic retinopathy (DR) are due to the short ocular residence time of biologics and the difficulty of precise drug delivery. …”
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Long-Term Evaluation of Patients Undergoing Genitoplasty due to Disorders of Sex Development: Results from a 14-Year Follow-Up by Heng Zhang, Jinhong Pan, Huixiang Ji, Yongquan Wang, Wenhao Shen, Limei Liu, Gensheng Lu, Zhansong Zhou

“…To summarize the experience in treating patients with genitoplasty due to disorders of sex development in China. …”
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Understanding the prescribing practices of mental health providers during pregnancy: The role of uncertainty in the patient-provider relationship by Rachel Eakley, Susan Kools, Allison Deutch, Audrey Lyndon

“…Despite these risks, patients report difficulty accessing or maintaining mental health treatment during pregnancy. …”
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Comparative analysis of closed reduction with external fixation versus closed reduction with percutaneous pinning for distal radius fractures by Roozbeh Nazari, Shahnam Mousavi, Mohammad Fakoor, Arash Hassanpour Dargah, Behnam Hamiat Mayan, Homa Taheri, Seyedeh Maryam Mousavinezhad, Nahid Senobari, Mehrdad Gooshvar, Pouya Ebrahimi

“…Percutaneous pinning proved to be a more effective method for treating distal radius type I and III fractures. Compared to those treated with external fixation, patients experienced fewer post-treatment complications, lower pain levels, and less difficulty in daily activities.…”
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Case Report: Iatrogenic intraperitoneal hematoma compresses the ureters leading to urogenic sepsis by Zhengyi Zhang, Peng Ding, Meijie Yang, Xiujuan Zhou, Kunlan Long

“…It is characterized by complex etiology, atypical clinical symptoms, rapid disease progression, and difficulty in treatment, making it a focal point and challenge in clinical diagnosis and therapy. …”
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Emerging Trends in the Application of Nanosuspension-Based Biomaterials for Anticancer Drug Delivery by Aldeeb MME, Wilar G, Suhandi C, Mohammed AFA, Mahmoud SA, Elamin KM, Wathoni N

“…Furthermore, the targeted applications of these nanosuspensions in treating of cancers such as glioma is discussed to emphasize their potential clinical relevance. …”
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Abstract 188: Rescue Left Middle Cerebral Artery Stenting With Xience Skypoint Everolimus‐Eluting Stent: Technical Report by Raman Singh, Hakeem Shakir, Shyian Jen, Uttam Verma

“…Conclusion Xience Skypoint EES can be successful in treating symptomatic MCA stenosis refractory to maximal medical therapy with good long term results.…”
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Microneedle delivery platform integrated with Staphylococcus epidermidis-derived extracellular vesicles-based nanoantibiotics for efficient bacterial infection atopic dermatitis tr... by Hong Zhou, Shuting Zhang, Xinxin Liu, Aiping Feng, Siyuan Chen, Wei Liu

“…Due to the difficulty of overcoming the abnormal epidermal barriers and addressing S. aureus infections without disrupting indigenous skin microbiota, effective treatment of bacterial infection atopic dermatitis (AD) remains a significant clinical challenge. …”
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Treatment of a femoral neck fracture in a patient with dwarfism: a case report by Junyan Zhao, Liuliu Chen, Kun He, Muyao Li, Zhenwen Li, Hui Lin, Songjun Li

“…Compared with the widespread use of three cannulated screws, the femoral neck system (FNS), a type of internal fixation device for treating femoral neck fractures, was chosen for internal fixation within the medullary cavity due to stenosis. …”
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Case Report: The window that closed too soon: lessons from a late CLN2 diagnosis and death of a 9-year-old boy by Anna Bryzik, Dawid Larysz, Patrycja Larysz, Julia Izabela Karpierz, Justyna Paprocka

“…Even with repeated medical contact and neurological evaluations, this case highlights the difficulty of diagnosing NCLs and the significant chance of missing the limited therapeutic window. …”
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Efficacy of acupuncture for functional constipation in elderly: a systematic review and meta-analysis by ShiWei Song, WenFeng Hao, HongFang Fu

“…However, there was a significant difference in the Bristol Stool Scale scores. The Defecation Difficulty Score and Patient Assessment of Constipation Quality of Life (PAC-QOL) showed p-values that indicated no significant effect. …”
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Physicians’ clinical experience and perspectives following a pilot, blended learning, point of care ultrasound course in Ghana- a mixed methods analysis by Anna Pathak, Felix Limbani, Yaw Asante Awuku, Angela Booth, Elizabeth Joekes

“…They considered the pilot curriculum adequate for general practice and the majority of applications of low difficulty (71%). For cases sent for second opinion, they are self-reported that their findings were confirmed in 60–78% of cases. …”
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Severe pneumonia in HIV/COVID-19 co-infection (case study) by Z. G. Tagirova, Zh. B. Ponezheva, V. V. Makashova, S. V. Shabalina, S. A. Magomedova, Z. M. Danialbekova, I. T. Shakhbanov

“…This article presents a clinical case of severe pneumonia in HIV/COVID-19 co-infection that demonstrates the difficulty in treating such patients. An HIV-infected patient of stage 4B who has refused ART, as well as vaccination against a new coronavirus infection, becomes ill with COVID-19. …”
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Complicated Urinary Tract Tuberculosis in a 13-Year-Old Adolescent with Chronic Kidney Disease and Antituberculous Drug-Induced Hepatotoxicity by Heda Melinda Nataprawira, Adhitya Agung Pratama, Ahmedz Widiasta, Jupiter Sibarani, Dany Hilmanto, Nanan Sekarwana, Dedi Rachmadi

“…A 13-year-old adolescent girl presented with pain, difficulty in micturition, and gross hematuria for almost two years before admission, and she had left flank pain since one year ago and significant loss of body weight during the illness. …”
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Characteristics of gastric fluid microbiota in patients with refractory Helicobacter pylori infection by Huiting Zhu, Shijie Sun, Shijie Sun, Yujing Wang, Yujing Wang, Wensi Zhang, Shiyu Du, Yanli Zhang

“…The close interaction between characteristic microbiota and H. pylori subspecies may be a key factor contributing to the difficulty in treating RHPI.…”
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Phytomedicine nanoformulations for Parkinson's disease by Chinthu V. Saji, K P Mohanakumar, Rajesh A Shenoi

“…When integrated with nanotechnology, phytomedicines can overcome key limitations of herbal molecules, such as poor solubility, low bioavailability, and difficulty in crossing the blood brain barrier (BBB). …”
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Hydrogel‐Transformable Probiotic Powder for Targeted Eradication of Helicobacter pylori with Enhanced Gastric Mucosal Repair and Microbiota Preservation by Yongkang Lai, Hanchun Shen, Shige Wang, Yongliang Ouyang, Xinyuan Zhang, Bin Hu, Xiaoyi Zhang, Guisheng Li, Lizhi Xu, Jiulong Zhao

“…This strategy combines targeted eradication, mucosal healing, and microbiome restoration, offering a new approach to treating gastric infections.…”
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Wnt3a Enhances Mesenchymal Stem Cell Engraftment and Differentiation in a Chronic Obstructive Pulmonary Disease Rat Model by Wu H, Zhong Y, Li Y, Zhou X, Zhao T, Wan D, Zhu Y, Zhang Z, Li X, Gan X

“…Huala Wu,1,* Yulan Zhong,2,* Yangjingsi Li,3 Xiangxiang Zhou,2 Tiantian Zhao,1 Daomou Wan,1 Yuanzhe Zhu,1 Zhiyan Zhang,1 Xiaolei Li,1,4 Xin Gan1,4 1Department of Respiratory and Critical Care Medicine, Jiangxi Provincial Key Laboratory of Respiratory Diseases, Jiangxi Institute of Respiratory Diseases, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, People’s Republic of China; 2Department of Respiratory and Critical Care Medicine, Chest Hospital of Jiangxi Province, Nanchang, Jiangxi, 330006, People’s Republic of China; 3Department of Respiratory and Critical Care Medicine, Jiangxi Provincial People’s Hospital, Nanchang, Jiangxi, 330006, People’s Republic of China; 4China-Japan Friendship Jiangxi Hospital, National Regional Center for Respiratory Medicine, Nanchang, Jiangxi, 330200, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xin Gan; Xiaolei Li, Email ganxin1207@126.com; xiaoleili1225@163.comBackground: Bone marrow mesenchymal stem cell (BMSC) therapy is a novel approach for treating COPD. However, the difficulty in engraftment and easy clearance of BMSCs in vivo has hindered their clinical application. …”
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Operative Technique: Proximal Femur Allograft Reconstruction and Subtalar Fusion after Total Calcanectomy for a Large Giant Cell Tumor of the Calcaneus by Israel C Manuel, Ilian Dominiq D Eusebio, Emilleo A Dacanay, Bernardino B Alpuerto II

“…Presentation of Case: We present a 21-year-old male with a large mass in the right heel with pain and difficulty ambulating. The mass involves clinically the whole of calcaneus and is hard, non-tender, non-erythematous, and non-movable. …”
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Assessing the clinical support capabilities of ChatGPT 4o and ChatGPT 4o mini in managing lumbar disc herniation by Suning Wang, Ying Wang, Linlin Jiang, Yong Chang, Shiji zhang, Kun Zhao, Lu Chen, Chunzheng Gao

“…Abstract Purpose This study evaluated and compared the clinical support capabilities of ChatGPT 4o and ChatGPT 4o mini in diagnosing and treating lumbar disc herniation (LDH) with radiculopathy. …”
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