SBRT for bridging and downstaging HCC before transplant by Zhihao Li, Michael Yan, Marco P.A.W. Claasen, Luckshi Rajendran, Christian T.J. Magyar, Saheli Saha, Cameron Lee, Nazia Selzner, Elmar Jaeckel, Anand Ghanekar, Mark Cattral, Blayne A. Sayed, Markus Selzner, Ian McGilvray, Chaya Shwaartz, Trevor Reichman, Grainne M. O’Kane, Arndt Vogel, Robert C. Grant, Tae Kyoung Kim, Catherine Soo-Yee Naidoo, Ali Hosni, Rebecca Wong, Aruz Mesci, Jelena Lukovic, Aisling Barry, John Kim, Laura A. Dawson, Gonzalo Sapisochin

“…Most patients had compensated liver function pre-SBRT and were treated with a median SBRT dose of 36 Gy in six fractions. …”
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The efficacy, safety and clinical feasibility of a percutaneous atrial septal shunt device for pulmonary arterial hypertension: a single-center cohort study by Mingfei Li, Dandan Chen, Jianing Fan, Dan Tian, Lei Zhang, Xiaochun Zhang, Shasha Chen, Yuan Zhang, Wenzhi Pan, Lihua Guan, Daxin Zhou, Junbo Ge

“…The primary endpoints of the study included the rate of major cardiovascular and cerebrovascular adverse events (MACCEs), serious adverse events (SAEs), and serious device-related adverse events (SADEs) within 12 months of shunt implantation. Data analysis was conducted using SAS 9.3. Results A total of 12 patients were enrolled in the study and successfully completed the operation. 10 subjects had completed 12 months’ follow-up after operation, while two subjects had died. …”
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Safety and efficacy of rotigotine in patients with frontotemporal dementia: a phase 2, double-blind, randomized, placebo-controlled, multicenter trialResearch in context by Giacomo Koch, Martina Assogna, Yasmine Gadola, Antonella Alberici, Francesco Di Lorenzo, Sonia Bonnì, Ilaria Borghi, Emanuele Cerulli Irelli, Lucia Mencarelli, Michele Maiella, Romina Esposito, Elias Paolo Casula, Valentina Pezzopane, Alessia D'Acunto, Francesca Candeo, Matteo Ferraresi, Gisella Guerrera, Luca Battistini, Enrico Premi, Valeria Bracca, Silvia Lucchini, Francesco Bertagna, Pasquale Romano, Andrea Ludovici, Antonio Daniele, Caterina Motta, Clarissa Ferrari, Alessandro Martorana, Barbara Borroni

“…The current findings provide data in a large sample of bvFTD that might be useful for the design of future clinical trials. …”
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Response‐adapted zanubrutinib and tislelizumab as a potential strategy to enhance CD19 CAR T‐cell therapy in relapsed/refractory large B‐cell lymphoma: A retrospective observationa... by Rong Shen, Wei‐Guo Cao, Li Wang, Ling‐Shuang Sheng, Yi‐Lun Zhang, Wen Wu, Peng‐Peng Xu, Shu Cheng, Meng‐Ke Liu, Yan Dong, Yue Wang, Xiang‐Qin Weng, Xu‐Feng Jiang, Qi Song, Hong‐Mei Yi, Lei Li, Sheng Chen, Zi‐Xun Yan, Wei‐Li Zhao

“…Genomic and transcriptomic data indicated that this regimen was effective across genetic subtypes and abrogated T‐cell exhaustion within the TME. …”
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Inhibitory effect of chlorogenic acid extract from peach blossoms on growth of Monilinia fructicola by WANG Haijing, ZHANG Man, LI Haiping, WU Meilan, LIU Chunsheng, SU Kai, ZHANG Chenguang, MENG Dong, YANG Qing, SUPRUN Ivan Ivanovich, WU Junkai

“…M. fructicola was cultured on potato dextrose agar (PDA) medium, and mycelium plugs (7 mm diameter) were treated with varying concentrations of CGA extracts (0.2, 0.3 or 0.4 mg·mL-1) or chlorogenic acid standard. …”
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Jing-Yin-Gu-Biao formula protects mice from postinfluenza Staphylococcus aureus infection by ameliorating acute lung injury and improving hypercoagulable state via inhibiting NETos... by Biao Lei, Biao Lei, Jingwen Mu, Jingwen Mu, Guihua Xu, Xiaodong Yang, Xiaodong Yang, Wenbo Huang, Liang Hu, Dan Liu, Dan Liu, Ting Cheng, Ting Cheng, Yuhe Ma, Yuhe Ma, Lirong Xu, Lirong Xu, Qiankun Liang, Qiankun Liang, Yuan Lin, Linqiong Zhou, Linqiong Zhou, Linqiong Zhou, Chunxian Zhou, Chunxian Zhou, Wei Zhang, Wei Zhang, Wei Zhang, Yuejuan Zheng, Yuejuan Zheng

“…Single cell RNA-sequencing (scRNA-seq) data indicated that neutrophils had the highest cytokine score in lungs and JYGBF inhibited neutrophil chemotaxis, reactive oxygen species (ROS) biosynthesis and ERK1/2 cascades in neutrophils. …”
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Implementing a nurse-enabled, integrated, shared-care model involving specialists and general practitioners in early breast cancer post-treatment follow-up (EMINENT): a single-cent... by Raymond J. Chan, Fiona Crawford-Williams, Chad Yixian Han, Lee Jones, Alexandre Chan, Daniel McKavanagh, Marissa Ryan, Christine Carrington, Rebecca L. Packer, Megan Crichton, Nicolas H. Hart, Emma McKinnell, Melissa Gosper, Juanita Ryan, Bethany Crowe, Ria Joseph, Carolyn Ee, Jane Lee, Steven M. McPhail, Katharine Cuff, Laisa Teleni, Jon Emery

“…Feasibility and effectiveness outcome measures, including health-related quality of life (primary outcome), physical activity and nutrition, patient experience, and financial toxicity were collected at baseline, and at 3-, 6-, and 12-months, with health service utilisation data at 24-months. Bivariate and multivariable, intention-to-treat analyses were conducted. …”
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Ruxolitinib as a treatment strategy for SARS-CoV-2 pneumonia: clinical experience in a real-world setting by Roberto Ovilla-Martinez, Xochitl Cota-Rangel, Jose De La Peña-Celaya, Mariana Alejandra Alvarado-Zepeda, Alejandro Jiménez Sastré, Humberto Azuara Forcelledo, Bernardino Ordoñez Rodriguez, Juan Pulido Broca, Aaron Molina Jaimes, Alejandro Muñiz-Carvajal, Maria Magdalena Bahena García, Eduardo Cervera Ceballos, Nidia Paulina Zapata Canto, Jorge Oscar García Mendez, Omar Noel García Jímenez, Jesus Alberto Salas Heredia, Javier Solis Soto, Ruben Alberto Villalobos Mendez, Gregorio Ignacio Ibarra, Cindy Ledesma de la Cruz, Nora Araujo Martinez, Jessi Juárez Lara, Cecilio Omar Ceballos Zuñiga, Felipe Vicente Villaseñor Pérez, Jose Carlos Herrera Garcia, Patricia Nuche Salazar, Alfredo Dominguez Paregrina, Bertha Arizpe Bravo, Gabriela Enciso Figueroa, Teresita Trujillo, Adriana Miguel Álvarez, Diego de Jesús García Gallegos, Alejandro Ortiz Arroyo, Claudia Ivette Solorzano Soto, Hiram Javier Jaramillo Ramírez, Ibis De la Cruz Hernández, Sergio De Gante Martínez, Guadalupe Esmeralda Montesinos Gómez, Silvia Martínez Velasco, Roberto García Graullera, Miguel Angel Vázquez López, Victor Itaí Urbalejo Ceniceros, Yolanda Lugo García, Ana Itamar González Ávila, Jorge Duque Rodriguez, Rodolfo Ruiz Luján, Violeta I. Rodríguez Rivera, Lucio Soberanes Ramírez, Pamela Elena Baez-Islas

“…Methodology: We analysed the data obtained by an observational cohort of patients with SARS-CoV-2 pneumonia treated with ruxolitinib in 22 hospitals of Mexico. …”
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Potential active ingredients and mechanisms of Shufeitie ointment in the treatment of chronic obstructive pulmonary disease by integrating transdermal chemistry and network pharmac... by Jianing Sun, Jianing Sun, Di Zhang, Panpan Wang, Panpan Wang, Panpan Wang, Panpan Wang, Junhan Shi, Junhan Shi, Junhan Shi, Junhan Shi, Tan Xue, Tan Xue, Panpan Zhang, Panpan Zhang, Qi Wang, Qi Wang, Xinjing Gui, Xinjing Gui, Xinjing Gui, Xinjing Gui, Suyun Li, Suyun Li, Jiansheng Li, Jiansheng Li, Xuelin Li, Xuelin Li, Xuelin Li, Xuelin Li, Ruixin Liu, Ruixin Liu, Ruixin Liu, Ruixin Liu, Ruixin Liu, Ruixin Liu

“…To predict the potential mechanisms by which SFTOT may treat COPD, network pharmacology was used to construct a component-target-collaterals network. …”
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RO5126766 attenuates osteoarthritis by inhibiting osteoclastogenesis and protecting chondrocytes through mediating the ERK pathway by Han Wang, Xiwen Yuan, Jie Han, Zuoxing Wu, Zheru Ma, Fan Shi, Zhengqiong Luo, Zihan Chen, Chenyang Guo, Guixin Yuan, Xuemei He, Zemin Ling, Lin Meng, Rong Shen, Jianming Huang, Ren Xu

“…Background: Osteoarthritis (OA) is a degenerative joint disease that remains challenging to treat due to lack of complete understanding of its pathogenesis. …”
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The spiritual needs and care of children and young people with life-threatening or life-shortening conditions, and parents (SPARK): a mixed-method investigation by Bryony Beresford, Natalie Richardson, Suzanne Mukherjee, Rebecca Nye, Jan Aldridge, Karl Atkin, Mark Clayton, Faith Gibson, Julia Hackett, Richard Hain, Mohammed Arshad, Paul Nash, Bob Phillips

“…Design and research participants A mixed-method, multicomponent design was used with the quantitative and qualitative data collected. There were four work packages. Work package 1: survey of chaplaincy services in the National Health Service acute trusts in England (n = 98/136). …”
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Pre-existing oncohematological disease in kidney transplant recipients: impact on graft survival, acute rejection, and long-term clinical outcomes by Alberto Mella, Alberto Mella, Roberta Clari, Roberta Clari, Valeria Deiana, Valeria Deiana, Roberta Giraudi, Roberta Giraudi, Gloria Giovinazzo, Gloria Giovinazzo, Ester Gallo, Ester Gallo, Caterina Dolla, Caterina Dolla, Antonio Lavacca, Antonio Lavacca, Ana Maria Manzione, Ana Maria Manzione, Fabrizio Fop, Fabrizio Fop, Anna Allesina, Anna Allesina, Federica Cavallo, Sara Bringhen, Dario Ferrero, Roberto Mina, Corrado Tarella, Corrado Tarella, Benedetto Bruno, Filippo Mariano, Filippo Mariano, Luigi Biancone, Luigi Biancone

“…IntroductionOncohematological disorders are heterogeneous conditions that present significant challenges in management prior to transplantation. Data about rejection risk, disease recurrence, eligibility criteria, and requested remission time before kidney transplant (KT) are still lacking.MethodsAll KTRs between January 1, 2000, and March 31, 2023 (n = 2871) were analyzed. …”
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Increase in colonic propionate as a method of preventing weight gain in adults aged 20–40 years: iPREVENT, a multicentre, double-blind, randomised, parallel-group trial by Gary Frost, Joana C Vasconcelos, Jennifer E Pugh, Aisha Anjum, Katerina Petropoulou, George Thom, Louise McCombie, Martina Tashkova, Sumayya Alshehhi, Daphne Babalis, Leah Holroyd, Christina Prechtl, Tom Preston, Mike J Lean, Waljit Dhillo, A Toby Prevost, and Douglas Morrison

“…Due to the COVID-19 lockdowns and pivot to collection of self-reported weight data, the ‘Principal weight’ measurement for the primary outcome consists of 38% self-reported weight data. …”
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Luspatercept for the treatment of lower-risk myelodysplastic syndrome with SF3B1 mutation: a real-world single-center research in China by Weiru Liang, Rui Kang, Yufei Zhao, Lingxiao Xing, Baohang Zhang, Yimeng Shi, Yuan Li, Guangxin Peng, Xin Zhao, Xu Liu, Jing Hu, Xiangrong Hu, Kang Zhou, Yang Yang, Youzhen Xiong, Jianping Li, Huihui Fan, Wenrui Yang, Lei Ye, Liping Jing, Li Zhang, Fengkui Zhang

“…Background Luspatercept, approved by the FDA and EMA for patients with transfusion-dependent lower-risk myelodysplastic syndrome (LR-MDS) unresponsive to erythropoiesis-stimulating agents (ESAs), lacks extensive real-world data, particularly in China.Methods We retrospectively analyzed 14 LR-MDS-SF3B1 patients treated with luspatercept for ≥12 weeks.Results Median age was 60 years (range 47-72); 42.9% were male. …”
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Exploration of fecal microbiota in newly diagnosed patients with inflammatory bowel disease using shotgun metagenomics by Macarena Orejudo, Manuel J. Gómez, Sabino Riestra, Montserrat Rivero, Ana Gutiérrez, Iago Rodríguez-Lago, Luis Fernández-Salazar, Daniel Ceballos, José Manuel Benítez, Mariam Aguas, Iria Bastón-Rey, Fernando Bermejo, María José Casanova, Rufo H. Lorente-Poyatos, Yolanda Ber, Daniel Ginard, María Esteve, Ruth de Francisco, María José García, Rubén Francés, Rubén Francés, Ainhoa Rodríguez, Noelia Alcaide Suárez, Elena Guerra del Río, Pilar Soto, Pilar Nos, Manuel Barreiro-de Acosta, Iván Guerra, Daniel Hervías Cruz, Manuel Domínguez Cajal, Vanesa Royo, Montserrat Aceituno, Laila Aldars-García, Ana Garre, Cristina Ramírez, Irene Soleto, Ina Schuppe-Koistinen, Lars Engstrand, Montse Baldán-Martín, Fátima Sánchez-Cabo, Javier P. Gisbert, María Chaparro

“…Previous microbiota studies in IBD generally have involved patients treated with immunosuppressive agents, which can affect the results. …”
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Local elections 2000: analyzing the results of the elections by Alvidas Lukošaitis

“…Not a few statistical data is presented in the work. Author postulates that the elections have elucidated the processes ongoing in the party system and the leaders of the political powers. …”
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The transcription factor PbeNAC83 positively regulates the Valsa canker resistance in apple and pear by DOU Zhiqi, CAI Minrui, DU Chenglong, HU Huanhuan, ZUO Cunwu

“…[Methods] Based on transcriptome data, we screened PbeNAC83(Chr9.g47397) and performed bioinformatics analysis on it. …”
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Screening of reference genes in Callosobruchus maculatus (Coleoptera: Bruchidae) fourth-instar larvae under high-temperature and antibiotic treatments(高温及抗生素处理下四纹豆象四龄幼虫内参基因的筛选)... by 耿加美(GENG Jiamei), 何云川(HE Yunchuan), 陈秋霖(CHEN Qiulin), 高扬(GAO Yang), 周瀛(ZHOU Ying), 祝增荣(ZHU Zengrong)

“…HSP70 expression levels showed significant differences (P＜0.05) between the high-temperature-treated group and the control group after normalization to RpL39_1 or RpL39_2. …”
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Predictors of Recurrence After Curative Surgery for Stage I Colon Cancer: Retrospective Cohort Analysis of the Italian Society of Surgical Oncology Colorectal Cancer Network Collab... by Giulia Turri, MD, Luigi Martinelli, MD, Daniela Rega, MD, Nicolò Tamini, MD, Lucia Paiano, MD, Simona Deidda, MD, QuocRiccardo Bao, MD, Laura Lorenzon, MD, PhD, Raffaele De Luca, MD, Caterina Foppa, MD, PhD, Valentina Mari, MD, Giovanni Taffurelli, MD, Arcangelo Picciariello, MD, PhD, Patrizia Marsanic, MD, Leandro Siragusa, MD, Francesco Bagolini, MD, Riccardo Nascimbeni, MD, Gianluca Rizzo, MD, PhD, Sara Vertaldi, MD, Michele Zuolo, MD, Giorgio Bianchi, MD, Lisa Marie Rorato, MD, Rossella Reddavid, MD, PhD, Gaetano Gallo, MD, PhD, Lorenzo Crepaz, MD, Alberto Di Leo, MD, Mario Trompetto, MD, Enrico Potenza, MD, Mauro Santarelli, MD, Nicola de’Angelis, MD, PhD, Francesco Ciarleglio, MD, Marco Milone, MD, PhD, Claudio Coco, MD, Guido Alberto Tiberio, MD, Gabriele Anania, MD, Giuseppe S. Sica, MD, PhD, Andrea Muratore, MD, Donato Francesco Altomare, MD, Isacco Montroni, MD, PhD, Maurizio De Luca, MD, Antonino Spinelli, MD, PhD, Michele Simone, MD, Roberto Persiani, MD, Gaya Spolverato, MD, Angelo Restivo, MD, Nicolò de Manzini, MD, Marco Braga, MD, Paolo Delrio, MD, Giuseppe Verlato, MD, PhD, Corrado Pedrazzani, MD, Adriana Gioia, Cristina Vacca, Dario Parini, Giovanni Tomasicchio, Marcello Calabrò, Bruno Sensi, Filomena Misuriello, Carlo Alberto Schena, Silvia Picotto

“…Given the low risk of recurrence of stage I CC, some international guidelines do not recommend intensive follow-up after surgery. However, data on the actual incidence, risk factors, and site of recurrences are scarce. …”
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Long-term outcome in Wiskott-Aldrich syndrome and X-linked thrombocytopenia patients: an observational -prospective multi-center study of the Italian Primary Immune Deficiency Netw... by Annarosa Soresina, Roberto Rondelli, Lucia Dora Notarangelo, Franco Locatelli, Alessandro Aiuti, Alessandra Biffi, Marco Rabusin, Claudio Pignata, Giuseppe Menna, Arcangelo Prete, Maura Faraci, Attilio Rovelli, Francesca Conti, Patrizia Bertolini, Chiara Azzari, Caterina Cancrini, Marco Zecca, Francesca Ferrua, Maria Pia Cicalese, Francesco Cecere, Laura Dotta, Baldassarre Martire, Silvia Giliani, Daniele Moratto, Cinzia Mazza, Alessandro Plebani, Luigi D. Notarangelo, Andrea Pession, Raffaele Badolato, Fulvio Fulvio

“…Considering the cut-off date year 2000, it improved to >80%. Patients with WAS treated by haploidentical HSCT with αβTCRT-/CD19 B-cell depletion or gene therapy showed 100% survival at 5 years. …”
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