ANEMIA EM GESTANTES ATENDIDAS EM MATERNIDADES, EM SÃO LUÍS (MA) by Fernanda Figueiredo dos Santos, Sueli Ismael Oliveira da Conceição, Silvio Gomes Monteiro

“…ANEMIA IN PREGNANT WOMEN TREATED IN MATERNITY UNITS IN SÃO LUIS (MA) Abstract: To evaluate the prevalence of nutritional anemia and the factors associated in pregnant women treated in two maternity hospitals in São Luis, Maranhão. …”
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One-Year Evaluation of Paliperidone Palmitate 6-Monthly: Satisfaction and Perceived Effectiveness Among Patients, Relatives, and Clinicians by Manchado Perero S, Rodríguez Lorente A, García-Pérez A, Isidro García G, Forcen-Muñoz LA, Ovejero S, Sáez Povedano R, González-Galdámez AL, Iturralde LM, Bonilla MR, Fuentes-Pérez P, Ovejas-Catalán C, Suárez-Pinilla P, Fernandez Abascal Puente B, Omaña Colmenares M, Campos-Navarro MP, Baca-García E, Fernández AL, Benavente-López S, Platero AR, Navalón MB, Sánchez-Alonso S, Vázquez-Bourgon J, Pappa S, García-Carmona JA

“…Nonetheless, there was no data available with patients treated with paliperidone 6-month (PP6M). …”
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Autophagy-induced NR2F1 activation promotes the apoptosis of lens epithelial cells and facilitates cataract-associated fibrosis through targeting STAT3 by Hangjia Zuo, Xianyang Liu, Bingjing Lv, Ning Gao, Miaomiao Du, Xiang Gao, Yongguo Xiang, Rongxi Huang, Meiting Lin, Yakun Wang, Yonglin Chen, Hong Cheng, Tong Zhang, Shijie Zheng, Wenjuan Wan, Ke Hu

“…In the present study, we analyzed the single-cell data and found that the mRNA expression of nuclear receptor subfamily 2 group F member 1 (NR2F1/COUP-TFI) was notably decreased in fibrocytes compared with epithelium. …”
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Cynaroside ameliorates TNBS-induced colitis by inhibiting intestinal epithelial cell apoptosis via the PI3K/AKT signalling pathway by Ju Huang, Ju Huang, Jing Li, Jing Li, Zhijun Geng, Zhijun Geng, Lixia Yin, Lixia Yin, Minzhu Niu, Qingqing Li, Qingqing Li, Xinyue Liu, Xinke Cheng, Xiaofeng Zhang, Xue Song, Xue Song, Yueyue Wang, Yueyue Wang, Lian Wang, Lugen Zuo, Jianguo Hu, Jianguo Hu

“…Combining network pharmacology prediction analysis with our validation data from animal models and colonic organoids, we demonstrated that Cyn significantly inhibits IEC apoptosis, as indicated by a decrease in the proportion of TUNEL-positive cells and changes in apoptosis-related protein levels. …”
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Impact of antiparasitic therapy on cardiovascular outcomes in chronic Chagas disease. A systematic review and meta-analysisResearch in context by Anis Rassi, Jr, Alyssa Grimshaw, Ashwin Sarwal, Ranjit Sah, Sangam Shah, Nelson I. Agudelo Higuita, Fabio Mahamed Rassi, Michaele Francesco Corbisiero, Hannah M. Kyllo, Jordan Stellern, Samantha Kaplan, Luis A. Marcos, Edgar A. Ramírez-García, Martin Casapia, Peter Hotez, Maria Elena Bottazzi, Shital Patel, Carlos Franco-Paredes, José Antonio Marin-Neto, Andrés F. Henao-Martínez

“…We included aggregated data from randomized controlled studies and observational reports (full articles and abstracts) featuring antiparasitic interventions with benznidazole or nifurtimox compared to a control group. …”
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A protocol for pre-treatment testing for antibodies to galactose-alpha-1,3-galactose to mitigate the risk of cetuximab hypersensitivity reactions – a retrospective cohort review by Nicholas Della Marta, Alexander Yuile, Claire Mok, Joe Wei, Meredith Oatley, Tracey Skinner, Samuel Miller, Amanda L. Hudson, Sheryl van Nunen, Stephen J. Clarke, Connie I. Diakos, Madhawa De Silva, David L. Chan, Gavin M. Marx, Nick Pavlakis

“…Patients and Methods: Records were reviewed across three medical oncology centres that have adopted alpha-gal antibody screening measures. Data for patients with metastatic colorectal cancer treated with cetuximab were retrieved. …”
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KMBARC registry: protocol for a multicentre observational cohort study on non-cystic fibrosis bronchiectasis in Korea by Yun Su Sim, Hyun Lee, Hayoung Choi, Shinhee Park, Woo Jin Kim, Kwang Ha Yoo, Seung Jun Lee, Tae-Hyung Kim, Bumhee Yang, Ina Jeong, Soo-Jung Um, Deog Kyeom Kim, Ji-Hyun Lee, Byoung Soo Kwon, Young-Jae Cho, Hye Yun Park, Chin Kook Rhee, Sang Haak Lee, Ju Ock Na, An-Soo Jang, Ji Ye Jung, Seung Won Ra, Ji-Ho Lee, Sang-Ha Kim, Changhwan Kim, Youlim Kim, Chang Youl Lee, Hyun Kuk Kim, Jae Seung Lee, Sei Won Lee, Yeon-Mok Oh

“…The exclusion criteria are as follows: (1) bronchiectasis due to cystic fibrosis; (2) traction bronchiectasis associated with interstitial lung disease; (3) patients actively being treated for pneumonia, pulmonary tuberculosis or non-tuberculous mycobacterial infection; (4) patients who are unable or unwilling to provide informed consent; and (5) pregnant patients. …”
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Safety and efficacy of glofitamab for relapsed/refractory large B-cell lymphoma in a multinational real-world study by Evgenii Shumilov, Rebecca Wurm-Kuczera, Andrea Kerkhoff, Meng Wang, Thomas Melchardt, Udo Holtick, Ulrike Bacher, Philipp Staber, Paolo Mazzeo, Corinna Leng, David Böckle, Alexander Hölscher, Joseph Kauer, Natalia Rotter, Vladan Vucinic, Jakob Rudzki, David Nachbaur, Veit Bücklein, Ulf Schnetzke, Isabelle Krämer, Kai Wille, Alexander Hasse, Bastian von Tresckow, Mathias Hänel, Christian Koenecke, Giuliano Filippini Velazquez, Andreas Viardot, Christoph Schmid, Lorenz Thurner, Dominik Wolf, Marion Subklewe, Martin Dreyling, Peter Dreger, Sascha Dietrich, Ulrich Keller, Ulrich Jäger, Richard Greil, Thomas Pabst, Georg Lenz, Björn Chapuy

“…Abstract: Glofitamab, a bispecific antibody targeting CD20 and CD3, is approved for relapsed/refractory diffuse large B-cell lymphoma (r/r DLBCL) after at least 2 prior treatment lines, but real-world data are scarce. In this retrospective, multicenter, multinational study, we evaluated the outcomes of 70 patients with r/r DLBCL treated with glofitamab as part of the compassionate use patient program in Germany, Austria, and Switzerland. …”
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Hepatocyte necroptosis is associated with liver damage in dairy cows with ketosis by Menglin Liu, Jingmin Gu, Chenchen Zhao, Jinxia Li, Fanrong Kong, Xinyu Du, Dandan Qi, Enzhu Li, Jie Gao, Xiliang Du, Yuxiang Song, Guowen Liu, Wenwen Gao, Xinwei Li, Lin Lei

“…Importantly, treatment with 100 µM Necrostatin 1 or 3 µM GSK-872 notably attenuated TNF-α-induced necroptosis signaling, inflammatory cytokine expression, and the activity of ALT, AST, GGT, and GLDH. In conclusion, these data suggest that necroptosis is associated with hepatic damage, and may be a potential therapeutic target to ameliorate liver dysfunction in dairy cows with ketosis.…”
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LUMOS - Low and Intermediate Grade Glioma Umbrella Study of Molecular Guided TherapieS at relapse: Protocol for a pilot study by Zarnie Lwin, Eng-Siew Koh, Mustafa Khasraw, Elizabeth H Barnes, Hui K Gan, Anna K Nowak, Cleo Robinson, Benhur Amanuel, Michael E Buckland, Sonia Yip, Benjamin Y Kong, Hao-Wen Sim, Bryan W Day, Roel Verhaak, Terrance Johns, Marc A Thomas, Tindaro Giardina, Andrew M Scott, Jonathon Parkinson, Rosalind Jeffree, Richard de Abreu Lourenco, Elizabeth J Hovey, Lawrence M Cher, Ganessan Kichendasse, Merryn Hall, Emily Tu

“…Library preparation and targeted capture will be performed using the TruSight Tumor 170 (TST170) kit and samples sequenced on NextSeq 550 (Illumina) using NextSeq V.2.5 hi output reagents, according to the manufacturer’s instructions. Data analysis will be performed using the Illumina BaseSpace TST170 app v1.02 and a custom tertiary pipeline, implemented within the Clinical Genomics Workspace software platform from PierianDx (also refer to section 3.2). …”
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Pre-earthquake kidney function is a predictor of outcomes in earthquake-related crush syndrome by Ramazan Daniş, Savaş Öztürk, İsmail Koçyiğit, Jehat Kılıç, Merve Civan, Tuncay Şahutoğlu, Dilek Torun, Engin Onan, Ahmet Alper Kıykım, Simal Köksal Cevher, Gürsel Yıldız, Zeynep Ebru Eser, Fatma Betül Güzel, Süleyman Karaköse, Tolga Yıldırım, Mehmet Polat, Ebru Gök Oğuz, Ali Gürel, Yasemin Coşkun Yavuz, Hasan Kayabaşı, Zehra Eren, Mehmet Rıza Altıparmak, Nurhan Seyahi, Mehmet Küçüksu, Sibel Gökçay Bek, Esra Akçalı, İrem Pembegül, Zeki Aydın, Elif Arı Bakır, Saliha Yıldırım, Sabahat Ecder, Mehmet Horoz, Funda Sarı, Yavuz Ayar, Murat Tuğcu, Ayça İnci, Numan Görgülü, Nedim Yılmaz Selçuk, Gülizar Şahin, Cuma Bülent Gül, Hamat Dheir, Özdem Kavraz, Abdülkadir Ünsal, Sedat Üstündağ, Ali Rıza Odabaş, Serhan Tuğlular

“…Methods A multi-center retrospective analysis was performed using data from 469 patients treated at 46 nephrology clinics. …”
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Area-level socioeconomic inequalities in hypertension care cascade in China: a nationwide population-based study based on the ChinaHEART projectResearch in context by Wenyao Peng, Siqi Lin, Xuan Liu, Bowang Chen, Xueke Bai, Chaoqun Wu, Xiaoyan Zhang, Yang Yang, Jianlan Cui, Wei Xu, Lijuan Song, Hao Yang, Wenyan He, Yan Zhang, Xi Li, Jiapeng Lu

“…The composite value of area-level SES was generated from national census data and categorized into tertiles. Multivariable mixed models with random effects to account for county-level administrative area were fitted to compute odds ratios (OR) and 95% confidence intervals (CIs) for the independent and interactive associations of both area- and individual-level SES with hypertension management (awareness, treatment, combination therapy and control) and their disparities across different population subgroups. …”
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Sex and outcomes of patients with microsatellite instability-high and BRAF V600E mutated metastatic colorectal cancer receiving immune checkpoint inhibitors by Michael Hoffmeister, Hermann Brenner, Chiara Cremolini, Sara Lonardi, Filippo Pietrantonio, Julien Taieb, David Tougeron, Robyn L Ward, Marco Vitellaro, Thierry André, Pierre Laurent-Puig, Jitendra Jonnagaddala, Francesca Bergamo, Raghav Sundar, Claire Gallois, Michael J Overman, Jakob Nikolas Kather, Lisa Salvatore, Romain Cohen, Rossana Intini, Priya Jayachandran, Miriam Koopman, Javier Ros, Marwan Fakih, Vincenzo Nasca, Giacomo Mazzoli, Jeanine M L Roodhart, Filippo Ghelardi, Elena Elez, Durgesh Wankhede, Marta Ligero, Joseph Zhao, Koen Zwart, Jeroen Derksen, Nicholas Hawkins, Javier Carmona

“…Growing evidence supports the role of sex in determining susceptibility to anticancer therapies, but data is lacking for patients with MSI-H CRC.Methods In this real-world cohort comprising 624 patients with MSI-H mCRC receiving ICIs, we investigated the impact of sex on patients’ outcomes, overall and according to RAS-BRAF mutational status or type of treatment (anti-PD-(L)1 with or without anti-CTLA-4 agents). …”
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Effectiveness of fixed-dose combination of rosuvastatin and ezetimibe in heterozygous familial hypercholesterolemia from the RENAISSANCE registry by I. A. Alekseeva, U. V. Chubykina, M. V. Ezhov, A. V. Tyurina, T. E. Kolmakova, N. A. Tmoyan, A. A. Sokolov, T. A. Rozhkova, N. S. Kurochkina, I. V. Sergienko, I. V. Avdeeva, V. E. Oleynikov, A. S. Alieva, N. G. Androsyuk, M. A. Kiselevа, Yu. G. Grigorieva, A. S. Asekritova, E. S. Kylbanova, A. V. Pavlova, A. I. Ershova, A. N. Meshkov, V. I. Mikhailina, A. V. Blokhina, A. S. Limonova, O. V. Kopylova, A. S. Vorobyev, I. D. Astrakhantseva, Yu. A. Vorobyeva, Yu. A. Ermakova, D. I. Sadykova, E. S. Slastnikova, L. F. Galimovа, I. I. Shaposhnik, V. V. Genkel, A. V. Egorova, N. V. Mukha, P. V. Vasilenko, D. N. Zaitsev, Z. F. Kim, V. K. Zafiraki, M. V. Zykov, V. A. Korneva, T. Yu. Kuznetsova, Yu. A. Malyshenko, T. I. Petelina, E. V. Mikova, A. M. Namitokov, E. D. Kosmacheva, I. I. Pshenichnikova, V. O. Konstantinov, S. E. Bednova, M. I. Voevoda, O. V. Timoshenko, Yu. I. Ragino, A. E. Filippov, A. M. Tuktarov, V. S. Gurevich, M. V. Muzalevskaya, S. A. Urazgildeevа, R. A. Khokhlov, S. V. Yarkovaya, E. A. Shutemova, E. V. Kudelkina, N. N. Bizyaeva

“…The clinical and demographic data of 3151 patients with HeFH at high or very high cardiovascular risk from the RENAISSANCE registry were retrospectively analysed. …”
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The age-adjusted international prognostic index 2 (A-FLIPI2) for elderly patients with follicular lymphoma by Jiesong Wang, Junlei Jia, Jingwei Yu, Jing Liu, Meng Gao, Hengqi Liu, Lanfang Li, Lihua Qiu, Shiyong Zhou, Bin Meng, Wenchen Gong, Zhengzi Qian, Xianhuo Wang, Huilai Zhang

“…Therefore, we retrospectively analysed clinical data of 128 elderly patients (aged 60 years or older) with FL treated at Tianjin Medical University Cancer Institute & Hospital from 2002 to 2020. …”
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NTRK1-rearranged histiocytosis: clinicopathologic and molecular features by Rivers Fragneau, Sylvie Fraitag, Paul G. Kemps, Zofia Hélias-Rodzewicz, Somak Roy, Benjamin Bonsang, Allison L. Bartlett, Subhra Dhar, Martin Jankofsky, Jozef Zlocha, Karel Svojgr, Lenka Krsková, Andrica C. H. de Vries, Robert M. Verdijk, Jan A. M. van Laar, Roos J. Leguit, Philippe Drabent, Eric D. Carlsen, Jonhan Ho, Arivarasan D. Karunamurthy, Mariarita Santi, Marie-Laure Jullié, Florian Babor, Robert Lorsbach, Astrid G. S. van Halteren, Sébastien Héritier, Eli L. Diamond, Benjamin H. Durham, Ashish R. Kumar, Arunaloke Bhattacharya, Julien Haroche, Jean Donadieu, Arndt Borkhardt, Jennifer L. Picarsic, Jean-François Emile

“…Slides were centrally reviewed; clinical and molecular data were collected. The 50 cases comprised 30 children and 20 adults with a median age of 11.5 years (range, 0-73 years) and a male predominance (64%). …”
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HLA-A∗03:01 as predictive genetic biomarker for glatiramer acetate treatment response in multiple sclerosis: a retrospective cohort analysisResearch in context by Brian C. Zhang, Tilman Schneider-Hohendorf, Rebecca Elyanow, Beatrice Pignolet, Simon Falk, Christian Wünsch, Marie Deffner, Erik Yusko, Damon May, Daniel Mattox, Eva Dawin, Lisa Ann Gerdes, Florence Bucciarelli, Lisa Revie, Gisela Antony, Sven Jarius, Christiane Seidel, Makbule Senel, Stefan Bittner, Felix Luessi, Joachim Havla, Matthias Knop, Manuel A. Friese, Susanne Rothacher, Anke Salmen, Fumie Hayashi, Roland Henry, Stacy Caillier, Adam Santaniello, Maria Seipelt, Christoph Heesen, Sandra Nischwitz, Antonios Bayas, Hayrettin Tumani, Florian Then Bergh, Gerd Meyer zu Hörste, Tania Kümpfel, Catharina C. Gross, Brigitte Wildemann, Martin Kerschensteiner, Ralf Gold, Sven G. Meuth, Frauke Zipp, Bruce A.C. Cree, Jorge Oksenberg, Michael R. Wilson, Stephen L. Hauser, Scott S. Zamvil, Luisa Klotz, Roland Liblau, Harlan Robins, Joseph J. Sabatino, Jr., Heinz Wiendl, Nicholas Schwab, Jessa Alexander, Riley Bove, Sergio Baranzini, Bruce A.C. Cree, Eduardo Caverzasi, Richard Cuneo, Stacy J. Caillier, Tiffany Cooper, Ari J. Green, Chu-Yueh Guo, Jeffrey M. Gelfand, Refujia Gomez, Sasha Gupta, Jill Hollenbach, Meagan Harms, Roland G. Henry, Stephen L. Hauser, Myra Mendoza, Jorge R. Oksenberg, Nico Papinutto, Sam Pleasure, Adam Santaniello, Joseph J. Sabatino, Jr., William A. Stern, Michael R. Wilson, Scott Zamvil, Orhan Aktas, Antje Giede-Jeppe, Barbara Gisevius, Markus Kowarik, Friedemann Paul, Veit Rothhammer, Corinna Trebst, Uwe Zettl

“…Clinical data from 1987 patients with MS treated with GA or IFN and available HLA information from the NationMS, ACP, EPIC, BIONAT, and CombiRx trial cohorts were used for a subsequent analysis. …”
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Effects of melatonin and palmitic acid on the wax content of mango leaf epidermis by WU Jingbo, HUANG Yuyu, WU Xiao, WANG Peng, GU Chao, YIN Hao, QI Kaijie, ZHAN Rulin, ZHANG Shaoling

“…The wax content and chemical composition of mango leaf epidermis were analyzed and determined by gas chromatography-mass spectrometry (GC-MS), and statistical data were analyzed to investigate the influence of exogenous reagents on the wax of leaf epidermis. …”
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The effects of computerised decision support systems on nursing and allied health professional performance and patient outcomes: a systematic review and user contextualisation by Carl Thompson, Teumzghi Mebrahtu, Sarah Skyrme, Karen Bloor, Deidre Andre, Anne Maree Keenan, Alison Ledward, Huiqin Yang, Rebecca Randell

“…Evidence limitations Allied health professionals (AHPs) were underrepresented compared to nurses; systems, studies and outcomes were heterogeneous, preventing statistical aggregation; very wide confidence intervals around effects meant clinical significance was questionable; decision and implementation theory that would have helped interpret effects – including null effects – was largely absent; economic data were scant and diverse, preventing estimation of overall cost-effectiveness. …”
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Effects of cinnamic acid treatment on aroma of Kyoho grape during low temperature storage by HU Yulong, TIAN Shufen, WANG Chaoxia, WANG Rong, MA Chuang, JIANG Jianfu

“…At 10 days before the expected harvest date, cinnamic acid solutions with concentrations of 0, 1, 5, and 10 mmol·L-1 were evenly and meticulously sprayed on the surface of the grape clusters. The group treated with 0 mmol·L-1 was set as the control group (CK). …”
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