Effects of a lifestyle intervention programme after 1 year of follow-up among South Asians at high risk of type 2 diabetes: a cluster randomised controlled trial by Sajjad Ahmad, Gary S Frost, Jonathan Valabhji, Marjo-Riitta Järvelin, Anuradhani Kasturiratne, Mirthe Muilwijk, Prasad Katulanda, Khurram Shahzad, Sara Mahmood, Jaspal S Kooner, John C Chambers, Saranya Palaniswamy, Irene GM van Valkengoed, Rajitha Wickremasinghe, Samreen Siddiqui, Sujeet Jha, Swati Waghdhare, Marie Loh, Heather M Gage, Lathika K Athauda, Ranil Jayawardena, Tayyaba Batool, Saira Burney, Matthew Glover, Vodathi Bamunuarachchi, Manju Panda, Madawa Madawanarachchi, Baldeesh Rai, Iqra Sattar, Wnurinham Silva, Ravindra Prasan Rannan-Eliya, Nilmini Wijemunige, Khadija I Khawaja

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Multivariate predictive model of the therapeutic effects of metoprolol in paediatric vasovagal syncope: a multi-centre studyResearch in context by Yaxi Cui, Jing Zhang, Yuwen Wang, Ying Liao, Keyu Liu, Wenrui Xu, Shu Wu, Chufan Sun, Chunyu Zhang, Qingyou Zhang, Ping Liu, Yuli Wang, Yanjun Deng, Chen Shen, Yao Lin, Hong Cai, Juan Zhang, Runmei Zou, Ping Liu, Shuo Wang, Hongfang Jin, Lin Shi, Cheng Wang, Junbao Du

“…Fourteen patients (2.9%) were excluded for lacking follow-up data. Patients were classified as responders or non-responders based on symptom improvement after 1–3 months of metoprolol therapy. …”
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Golden hour management in the patient with intraparenchymal cerebral hemorrhage: an Italian intersociety document by Gianluigi Morello, Daniela Alampi, Raffaele Aspide, Alessandra Beretta, Rita Bertuetti, Federico Bilotta, Etrusca Brogi, Giovanni Buscema, Anselmo Caricato, Davide Caruzzo, Carlo Alberto Castioni, Arturo Chieregato, Andrea Cortegiani, Alessandro De Cassai, Andrea Fabbri, Domenico Gelormini, Paolo Gritti, Lucrezia Guadrini, Alberto Librizzi, Nicola Latronico, Nicola Limbucci, Marina Munari, Edoardo Picetti, Giuseppina Pipitone, Gianluca Pucciarelli, Chiara Robba, Danilo Toni, Salvatore Sardo, Simone Maria Zerbi, Nicola Zugni, Frank Rasulo

“…While only a few topics are supported by robust evidence, experts strongly recommend early brain angio CT, risk stratification using scoring systems, clear communication of patient data, and intubation for impaired consciousness. …”
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Interpersonal counselling for adolescent depression delivered by youth mental health workers without core professional training: the ICALM feasibility RCT by Jon Wilson, Viktoria Cestaro, Eirini Charami-Roupa, Timothy Clarke, Aoife Dunne, Brioney Gee, Sharon Jarrett, Thando Katangwe-Chigamba, Andrew Laphan, Susie McIvor, Richard Meiser-Stedman, Jamie Murdoch, Thomas Rhodes, Carys Seeley, Lee Shepstone, David Turner, Paul Wilkinson

“…Mixed-methods process data were collected to understand how the intervention was implemented across settings, explore acceptability and monitor contamination. …”
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Therapeutic Targeting of Decr1 Ameliorates Cardiomyopathy by Suppressing Mitochondrial Fatty Acid Oxidation in Diabetic Mice by Qing‐Bo Lu, He‐Ting Sun, Kuo Zhou, Jia‐Bao Su, Xin‐Yu Meng, Guo Chen, Ao‐Yuan Zhang, An‐Jing Xu, Chen‐Yang Zhao, Yuan Zhang, Yao Wang, Hong‐Bo Qiu, Zhuo‐Lin Lv, Zheng‐Yang Bao, Jian Zhu, Feng Xiao, Xue‐Xue Zhu, Hai‐Jian Sun

“…Neonatal rat cardiomyocytes were treated with high glucose (HG) and palmitic acid (HP) to simulate diabetic cardiac injury. …”
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Prognostic value of quickSOFA as a predictor of 28-day mortality among febrile adult patients presenting to emergency departments in Dar es Salaam, Tanzania. by Noémie Boillat-Blanco, Zainab Mbarack, Josephine Samaka, Tarsis Mlaganile, Aline Mamin, Blaise Genton, Laurent Kaiser, Thierry Calandra, Valérie D'Acremont

“…Medical history, clinical examination, laboratory and microbiological data were collected to document the cause of fever. …”
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Malaria in Turkey: A comprehensive analysis of diagnosis, treatment, and the impact of COVID-19, ten years after malaria elimination (2012–2023) by Özgün Ekin Şahin, Zeynepgül Kalay, Nagehan Didem Sarı, Ayşe Batırel, Gülden Ersöz, Günay Tuncer Ertem, Tuba Turunç, Ramazan Gözüküçük, Funda Şimşek Çelener, Arzu Kantürk, Kaya Süer, Şafak Özer Balın, Ayşe Sağmak Tartar, Güven Çelebi, Hülya Kuşoğlu, Selma Ateş, Sevil Alkan, Duru Mıstanoğlu Özatağ, Hande Berk, Cengiz Uzun, Çağla Karakoç, İlknur Erdem, Necati Mumcu, Fatma Çölkesen, Arzu Altunçekiç, Ayşe İnci, Fatma Yılmaz Karadağ, Emine Türkoğlu Yılmaz, Mustafa Arslan, Ahmet Şahin, Haluk Erdoğan, Orçun Zorbozan, Hatice Ertabaklar, Oğuz Ertan, Lal Sude Gücer, Önder Ergönül

“…Methods: We collected the patient data from 30 centers by using Qualtrics Survey Software. …”
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Clinical and molecular spectrum of TK2-deficiency: a large Brazilian cohort by Cristiane Araujo Martins Moreno, Mariana Cunha Artilheiro, Alulin Tacio Quadros Santos Monteiro Fonseca, André Macedo Serafim da Silva, Tatiana Ribeiro Fernandes, Clara Gontijo Camelo, Michelle Abdo Paiva, Filipe Tupinamba di Pace, Andre Luiz Santos Pessoa, Vitor Lucas Lopes Braga, Tamiris Carneiro Mariano, Eduardo de Paula Estephan, Maria da Penha Morita, Anna Paula Paranhos Miranda Covaleski, Vanessa Van der Linden, Pedro José Tomaselli, Giuliano Roberto Scarpellini, Juliana Gurgel-Giannetti, Lívia Maria Ferreira Sobrinho, Thais Martins de Oliveira, Rodrigo Holanda Mendonça, Elizabeth Lemos Silveira Lucas, Marcelo Maroco Cruzeiro, Carlos Wagner Pereira Junior, Wilson Marques Júnior, Claudia Ferreira da Rosa Sobreira, Acary Sousa Bulle Oliveira, Fernando Kok, Michio Hirano, Andres Nascimento-Osorio, David Schlesinger, Edmar Zanoteli

“…Motor and respiratory assessments were systematically performed in 13 patients, three of them were receiving the nucleosides replacement therapy. Natural history data was gathered from the follow up of five adult patients. …”
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Elevating larval source management as a key strategy for controlling malaria and other vector-borne diseases in Africa by Fredros Okumu, Sarah J. Moore, Prashanth Selvaraj, Arnon Houri Yafin, Elijah O. Juma, GloriaSalome G. Shirima, Silas Majambere, Andy Hardy, Bart G. J. Knols, Betwel J. Msugupakulya, Marceline Finda, Najat Kahamba, Edward Thomsen, Ayman Ahmed, Sarah Zohdy, Prosper Chaki, Peter DeChant, Kimberly Fornace, Nicodem Govella, Steven Gowelo, Emmanuel Hakizimana, Busiku Hamainza, Jasper N. Ijumba, William Jany, Hmooda Toto Kafy, Emmanuel W. Kaindoa, Lenson Kariuki, Samson Kiware, Eliningaya J. Kweka, Neil F. Lobo, Dulcisária Marrenjo, Damaris Matoke-Muhia, Charles Mbogo, Robert S. McCann, April Monroe, Bryson Alberto Ndenga, Halfan S. Ngowo, Eric Ochomo, Mercy Opiyo, Richard Reithinger, Chadwick Haadezu Sikaala, Allison Tatarsky, David Takudzwa, Fedra Trujillano, Ellie Sherrard-Smith

“…The World Health Organization (WHO) guidelines on malaria prevention recommend the use of LSM as a supplementary intervention to the core vector control methods (insecticide-treated nets and indoor residual spraying), arguing that its feasibility in many settings can be limited by larval habitats being numerous, transient, and difficult to find or treat. …”
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DHCR7 inhibition ameliorates MetALD and HCC in mice and human 3D liver spheroids by Gen Yamamoto, Raquel Carvalho-Gontijo Weber, Wonseok Lee, Vivian Zhang, Haeum Jang, Sadatsugu Sakane, Xiao Liu, Hyun Young Kim, David A. Brenner, Na Li, Tatiana Kisseleva

“…In turn, dsiRNA-based knockdown of DHCR7 reduced HepG2 proliferation (↓ PCNA, p <0.05; CCNE, p <0.05) and expression of MetALD-HCC markers (↓ AFP, p <0.05; GPC3, p <0.05; YAP, p <0.01). Conclusions: Our data demonstrate that targeting DHCR7 can become a strategy for the treatment of MetALD and HCC. …”
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Safety and effectiveness of the early-onset sepsis calculator to reduce antibiotic exposure in at-risk newborns: a cluster-randomised controlled trialResearch in context by Bo M. van der Weijden, Sanne W.C.M. Janssen, Marijke C. van der Weide, Renske J.P.M. Cornelisse-van Vugt, Gavin W. ten Tusscher, Claire A.M. Lutterman, Arvid W.A. Kamps, Carmen M. Lorente Flores, Jeroen Hol, Henriëtte van Laerhoven, Maarten Rijpert, Nadia A. Oeij, Irene A.M. Schiering, Sylvia A. Obermann-Borst, Douwe H. Visser, Lisanne M. van Leeuwen, René F. Kornelisse, Annemarie M.C. van Rossum, Merijn W. Bijlsma, Frans B. Plötz, Niek B. Achten

“…Interpretation: These trial data support safety and effectiveness of the EOS calculator for harm criteria and for the proportion of participants that started antibiotic therapy. …”
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VPA Enhances Pulp Regeneration by Regulating LPS-Induced Human Dental Pulp Stem Cells Odontogenic Differentiation by Zhihua Wang, Minghao Wang, Zhirong Luo, Yi Fu, Xiaomiao Zhu, Dongyu Li, Wenkai Jiang, Xiaogang Cheng, Chengxiong Cai, Xiaoru Zhu, Paul R. Cooper, Shengchao Wang, Wenxi He

“…Clinical Relevance: These data demonstrate that VPA is a highly effective pharmacological candidate for dental pulp maintenance and regeneration, highlighting its clinical significance in restorative dentistry.…”
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A group psychological intervention for postnatal depression in British mothers of South Asian origin – the ROSHNI-2 RCT by Nusrat Husain, Karina Lovell, Carolyn A Chew-Graham, Farah Lunat, Penny Bee, Matthias Pierce, Najia Atif, Saadia Aseem, Kamaldeep Bhui, Peter Bower, Traolach Brugha, Nasim Chaudhry, Akbar Ullah, Linda Davies, Nadeem Gire, Deepali Sharma, Jahanara Miah, Waqas Ahmed, Joe Kai, Ilyas Mirza, Jillian Morrison, Naeem Mohmed, Atif Rahman, Shanaya Rathod, Najma Siddiqi, Waquas Waheed, Christopher Williams, Nosheen Zaidi, Richard Emsley, Richard Morriss

“…Analysis of the primary outcome and the long-term follow-up (at 12 months) used a logistic random-effects model to estimate the odds ratio of caseness between treatments, adjusting for centre, severity of depression and education at baseline. Cost data were collected using an Economic Patient Questionnaire. …”
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Assessment of the relationship between diabetes treatment intensification and quality measure performance using electronic medical records. by Renée J G Arnold, Shuo Yang, Edward J Gold, Sepehr Farahbakhshian, John J Sheehan

“…<h4>Materials and methods</h4>Electronic medical records and diabetes registry data from a large, accountable care organization (ACO) were used to isolate a sample of adult patients with type 2 diabetes who received at least one oral antidiabetes agent and had at least one HbA1C level measurement ≥8.0% (64 mmol/mol; i.e., uncontrolled diabetes) between 7/1/2011 and 6/30/2015. …”
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Peptidylglycine alpha-amidating monooxygenase is important in mice for beta-cell cilia formation and insulin secretion but promotes diabetes risk through beta-cell independent mech... by Yi-Chun Chen, Nils E. Bäck, Jenicia Zhen, Lena Xiong, Mitsuhiro Komba, Anna L. Gloyn, Patrick E. MacDonald, Richard E. Mains, Betty A. Eipper, C. Bruce Verchere

“…Interestingly, non-amidated hIAPP was less fibrillogenic in vitro, and high glucose-treated hIAPPw/w βPamKO islets had reduced amyloid burden. …”
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Impact of select actionable genomic alterations on efficacy of neoadjuvant immunotherapy in resectable non-small cell lung cancer by Charles Lu, Mehmet Altan, Apar Pataer, Tina Cascone, Annikka Weissferdt, Jianjun Zhang, Boris Sepesi, Ara A Vaporciyan, Marcelo V Negrao, Hai T Tran, Stephen G Swisher, John V Heymach, Don L Gibbons, Brett W Carter, Jack A Roth, Ferdinandos Skoulidis, Yasir Y Elamin, Xiuning Le, Wayne L Hofstetter, J Jack Lee, Bonnie S Glisson, Myrna C B Godoy, Garrett L Walsh, Jia Wu, Humam Kadara, George R Blumenschein, Heather Y Lin, Nicolas Zhou, William N William, Cheuk H Leung, Frank V Fossella, Anne S Tsao, Jonathan M Kurie, Lauren A Byers, Reza J Mehran, David C Rice, Luisa M Solis Soto

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Selective inhibition of canonical STAT3 signaling suppresses K-ras mutant lung tumorigenesis and reinvigorates anti-tumor immunity by Michael J. Clowers, Michael J. Clowers, Zahraa Rahal, Sung-Nam Cho, Avantika Krishna, Avantika Krishna, Bo Yuan, Leticia G. Hamana Zorrilla, T. Kris Eckols, Moses M. Kasembeli, Samuel Liu, Stephen Peng, Marco Ramos-Castaneda, Annamarie L. Thompson, Carlos Ignacio Rodriguez Reyna, Katherine E. Larsen, Maria T. Grimaldo, Maria T. Grimaldo, Shanshan Deng, Nastaran Karimi, Cody Chou, Walter V. Velasco, Melody Zarghooni, Sayan Alekseev, Luisa M. Solis Soto, Edwin J. Ostrin, Edwin J. Ostrin, Humam Kadara, Humam Kadara, Suhendan Ekmekcioglu, Suhendan Ekmekcioglu, David J. Tweardy, David J. Tweardy, Seyed Javad Moghaddam, Seyed Javad Moghaddam

“…IntroductionK-ras mutant lung adenocarcinoma (KM-LUAD) is a difficult-to-treat cancer subtype in which chronic inflammation pervades the tumor immune microenvironment (TIME). …”
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Prostate radiotherapy in patients with metastatic hormone-sensitive prostate cancer: A systematic review and meta-analysis of randomised controlled trials by Navid Roessler, Marcin Miszczyk, Alessandro Dematteis, Fabio Zattoni, Tamás Fazekas, Filippo Carletti, Giuseppe Reitano, Akihiro Matsukawa, Ahmed R. Alfarhan, Angelo Cormio, Abdulrahman S. Alqahtani, Timo F.W. Soeterik, Giulia Marvaso, Giorgio Gandaglia, Péter Nyirády, Paweł Rajwa, Łukasz Nyk, Peter Soo Palencia, Michael S. Leapman, Barbara A. Jereczek-Fossa, Shahrokh F. Shariat

“…Local radiotherapy (RT) was shown to improve survival in patients with mHSPC; however, new data require a re-assessment of the indication and value of local RT in mHSPC. …”
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Association between clinician team segregation, receipt of cardiovascular care and outcomes in valvular heart diseases by Ikeoluwapo Kendra Bolakale‐Rufai, Shannon M. Knapp, Janina Quintero Bisono, Adedoyin Johnson, Wanda Moore, Ekow Yankah, Ryan Yee, Dalancee Trabue, Brahmajee Nallamothu, John M. Hollingsworth, Stephen Watty, Francesca Williamson, Natalie Pool, Megan Hebdon, Nneamaka Ezema, Quinn Capers, Courtland Blount, Nia Kimbrough, Denee Johnson, Jalynn Evans, Brandi Foree, Anastacia Holman, Karen Lightbourne, David Brown, Brownsyne Tucker Edmonds, Khadijah Breathett

“…Methods and results Using Optum's Clinformatics® Data Mart Database (CDM, US commercial and Medicare beneficiaries) from 2010 to 2018, we identified patients with a primary diagnosis of VHD. …”
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Effect of exogenous Brassinolide on improving fruit quality and reducing fruit cracking in Junzao jujube by YANG Cheng, WANG Zhenlei, ZHANG Chuanjiang, LIU Wei, WU Cuiyun, LIN Minjuan

“…Excel 2016 was used for data collection and analysis, SPSS 27.0 was used for significance analysis, Origin 2021 was used for mapping, and correlation analysis and principal component analysis were carried out for each index at whiteripe stage. …”
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