Clinical role of intraperitoneal chemotherapy in patients with pancreatic ductal adenocarcinoma concomitant with occult peritoneal dissemination: A multicenter retrospective study by Tomohisa Yamamoto, Toshio Shimokawa, Masamichi Hayashi, Masamichi Mizuma, Katsuhisa Hirano, Atsushi Oba, Toshimichi Asano, Hideyo Miyato, Makoto Yoshida, Ippei Matsumoto, Yasunari Kawabata, Katsunori Sakamoto, Fuyuhiko Motoi, Shigeto Ishii, Yuki Homma, Hiromitsu Maehira, Yutaro Matsunaga, Tetsuya Ikemoto, Masafumi Nakamura, Yuko Mataki, Tsuyoshi Notake, Keiichi Akahoshi, Hideki Takami, So Yamaki, Daisuke Hashimoto, Yasutoshi Kimura, Satoshi Hirano, Yosuke Inoue, Tsutomu Fujii, Michiaki Unno, Yasuhiro Kodera, Joji Kitayama, Sohei Satoi, the Study Group of Pancreatic Ductal Adenocarcinoma with Peritoneal Dissemination

“…Methods Data of patients with peritoneal dissemination was retrospectively collected and analyzed (i.p.…”
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Long-term prognostic impact of the left anterior descending coronary artery as the STEMI-related culprit vessel: subanalysis of the EXAMINATION-EXTEND trial by Pablo Vidal-Calés, Kamil Bujak, Riccardo Rinaldi, Anthony Salazar-Rodríguez, Luis Ortega-Paz, Josep Gómez-Lara, Víctor Jiménez-Díaz, Marcelo Jiménez, Pilar Jiménez-Quevedo, Roberto Diletti, Pascual Bordes, Gianluca Campo, Antonio Silvestro, Jaume Maristany, Xacobe Flores, Antonio De Miguel-Castro, Andrés Íñiguez, Alfonso Ielasi, Maurizio Tespili, Mattie Lenzen, Nieves Gonzalo, Matteo Tebaldi, Simone Biscaglia, Rafael Romaguera, Joan Antoni Gómez-Hospital, Patrick W. Serruys, Manel Sabaté, Salvatore Brugaletta

“…ABSTRACT Introduction and objectives: There is limited data on the impact of the culprit vessel on very long-term outcomes after ST-elevation myocardial infarction (STEMI). …”
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How to Apply the Sequential Correction Technique to Treatment of Congenital Cervicothoracic Scoliosis: A Technical Note and Case Series by Saihu Mao, Kai Sun, Song Li, Jie Zhou, Hongda Bao, Benlong Shi, Xu Sun, Zhen Liu, Yong Qiu, Zezhang Zhu

“…ABSTRACT Objective Hemivertebrae in the cervicothoracic junction in the pediatric population are treated conventionally with a two‐rod instrumentation pattern. …”
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Characterization of FosA13, a novel fosfomycin glutathione transferase identified in a Morganella morganii isolate from poultry by Runzhi Zhang, Runzhi Zhang, Yan Yu, Yan Yu, Lulu Huang, Susu Chen, Ruxi Hu, Xiuxiu Wang, Dawei Huang, Chunhan Song, Junwan Lu, Qiyu Bao, Qiyu Bao, Qiyu Bao, Qiyu Bao, Yunliang Hu, Pengfei Jiang, Wei Pan

“…Compared with the control strain (pUCP19/DH5α), the recombinant strain carrying fosA13 (pUCP19-fosA13/DH5α) presented a fourfold increase in the MIC value for fosfomycin. The enzyme kinetics data of FosA13 revealed effective inactivation of fosfomycin, with a kcat/Km of (1.50 ± 0.02)×104 M-1·s-1. …”
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Stressful life events in childhood and adulthood and risk of physical, psychological and cognitive multimorbidities: a multicohort studyResearch in context by Yaguan Zhou, Mika Kivimäki, Julianne Holt-Lunstad, Lijing L. Yan, Yue Zhang, Hui Wang, Sunyi Wang, Xiaolin Xu

“…Methods: We harmonised and pooled longitudinal data from three nationally representative cohort studies from the Program on Global Ageing, Health and Policy: the US Health and Retirement Study (HRS), the English Longitudinal Study on Ageing (ELSA), and the China Health and Retirement Longitudinal Study (CHARLS), encompassing the years 2011–2020. …”
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Clinical outcome analysis of surgical treatment for primary retroperitoneal leiomyosarcoma by Li Yang, Qiu Hui, Wu Jianhui, Li Chengpeng, Liu Bonan, Liu Qiao, Hao Chunyi, Lv Ang

“…[Objective] To analyze the clinical outcomes of surgical treatment for primary retroperitoneal leiomyosarcoma (RLMS). [Methods] Clinical data of 41 RLMS patients treated at the Soft Tissue and Retroperitoneal Tumor Center of Peking University Cancer Hospital from 2011 to 2020 were retrospectively analyzed. …”
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Sexual dimorphism in lung transcriptomic adaptations in fetal alcohol spectrum disorders by Vishal D. Naik, Dylan J. Millikin, Daniel Moussa, Hong Jiang, Alexander L. Carabulea, Joseph D. Janeski, Jiahui Ding, Kang Chen, Marta Rodriguez-Garcia, Sunil Jaiman, Stephen A. Krawetz, Gil Mor, Jayanth Ramadoss

“…Pregnant rats were orogastrically treated once daily with alcohol (4.5 g/kg, gestational day [GD] 4 to 10, peak BAC, 216 mg/dl; 6.0 g/kg, GD 11 to 20, peak BAC, 289 mg/dl) or 50% maltose dextrin (isocalorically matched pair-fed controls) to control for calories derived from ethanol. …”
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The comparison of efficacy and safety between cadonilimab (PD-1/CTLA-4) and anti-PD-1 inhibitors in patients with recurrent or metastatic cervical cancer: a retrospective real-worl... by Baoyue Pan, He Huang, Ting Wan, Qidan Huang, Shanyang He, Shijie Xu, Siyu Chen, Jiaxin Yin, Jundong Li, Min Zheng

“…The second cohort comprised 201 patients who were treated with anti-PD-1 inhibitors (alone or in combination) but did not receive cadonilimab, between August 1, 2018, and March 31, 2024. …”
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AI-Based Quantification of Enhancing Tumor Volume on Contrast-Enhanced MRI to Predict Pathologic Response and Prognosis in HCC After HAIC Plus Targeted Therapy and Immunotherapy by Zhou Y, Li J, Li Q, Liu L, Huang P, Mao Y, Yang Y, Lv F, Liu Z

“…We aimed to use artificial intelligence (AI) to predict treatment effectiveness earlier using routine MRI scans, helping clinicians decide optimal timing for surgery.What did we do? We analyzed data from 35 liver cancer patients treated with this combination therapy. …”
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Understanding limb necrotizing infections: A comprehensive approach by A. Garrido-Hidalgo, J. García-Coiradas, M. Echevarría-Marín, S. Llanos, J.A. Valle-Cruz, F. Marco

“…Methods: A retrospective observational study was conducted, including all surgically treated NSTI patients at our center from January 2016 to December 2022, examining epidemiological and clinical data. …”
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Сombat wounds microflora in modern warfare by V. P. Kovalchuk, N. S. Fomina, V. M. Kondratiuk, О. О. Fomin, Y. V. Lazarenko, K. V. Gumenyuk

“…Results from bacteriological studies of 151 wounded individuals treated in the same hospitals during the period from 2017 to 2020 were used for comparative analysis. …”
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油莎豆的制油工艺研究Oil extraction process of tiger nut by 刘佳杰1,2,3，万楚筠2,3,郑畅2,3，沈汪洋1,4，杨国燕1,4 LIU Jiajie1,2,3，WAN Chuyun2,3，ZHENG Chang2,3， SHEN Wangyang1,4，YANG Guoyan1,4

“…综上，未脱皮油莎豆在85 ℃真空烘箱处理180 min后在80~90 ℃进行螺旋压榨，再进行超临界CO2萃取是一种既能高效提取油莎豆油又能保证粕品质的方法。 In order to provide data reference for efficient extraction of tiger nut oil and deep processing and utilization of its meal, the tiger nut oil was extracted by screw pressing-leaching process. …”
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Impact of 18 F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Scan on Initial Evaluation of Head and Neck Squamous Cell Carcinoma: Our Experience at a Tertiary... by Satish Nair, Sharad Mohan, Ajith Nilakantan, Atul Gupta, Akshat Malik, Abhishek Gupta

“…Descriptive analysis of demographic data and analytical analysis of the sensitivity and specificity of WB 18 F-FDG PET-CT scan and also the change in staging and treatment plan after WB 18 F-FDG PET-CT scan was analyzed using SPSS version 18. …”
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Surgical treatment of isolated soft tissue gunshot shrapnel injuries by combining primary delayed sutures with platelet-rich autoplasma injections into mine-explosive wounds by S. M. Zavhorodnii, O. I. Kotenko, M. B. Danyliuk, M. A. Kubrak

“…Results. 60 (100.0 %) patients were urgently hospitalized to the third stage of medical evacuation and treated according to standard treatment protocols for this pathology at the third stage of evacuation. …”
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Pharmaceutical Providing for Prevention and Treatment of Influenza in Children by Olіynyk O., Kіrda І., Voitsekhivska I.

“…Only three groups have the means to prevent and treat of influenza with amount of 9 trade names, and the only three trade names of medicines are produced in Ukraine. …”
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Caplacizumab use in immune-mediated thrombotic thrombocytopenic purpura: an international multicentre retrospective Cohort study (The Capla 1000+ project)Research in context by Paul Coppo, Michael Bubenheim, Ygal Benhamou, Linus Völker, Paul Brinkkötter, Lucas Kühne, Paul Knöbl, Maria Eva Mingot-Castellano, Cristina Pascual-Izquierdo, Javier de la Rubia, Julio del Rio Garma, Shruti Chaturvedi, Camila Masias, Marshall Mazepa, X. Long Zheng, György Sinkovits, Marienn Réti, Christopher J. Patriquin, Katerina Pavenski, Tiago Boechat, João Farias, Eduardo Flavio Oliveira Ribeiro, Michaela Larissa Lobo de Andrade, Agnès Veyradier, Bérangère Joly, Raïda Bouzid, Kazuya Sakai, Masanori Matsumoto, Pasquale Agosti, Ilaria Mancini, Flora Peyvandi, Eleni Gavriilaki, Matthew Stubbs, Amjad Hmaid, Spero Cataland, Bernhard Lämmle, Marie Scully

“…One thousand and fifteen patients were treated with daily TPE, immunosuppression with corticosteroids ± rituximab, and caplacizumab (caplacizumab group), which was compared to historic controls treated with TPE and corticosteroids ± rituximab (control group, N = 510). …”
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Sexuality and bleeding in von Willebrand disease by Calvin B. van Kwawegen, Hester Pastoor, Jeroen Eikenboom, Karin Fijnvandraat, Paula Ypma, Floor C.J.I. Heubel-Moenen, Karin P.M. van Galen, Evelien P. Mauser-Bunschoten, Karina Meijer, Saskia E.M. Schols, Marjon H. Cnossen, Johanna G. van der Bom, Joke de Meris, Ferdows Atiq, Marieke J.H.A. Kruip, Frank W.G. Leebeek, K. Fijnvandraat, M. Coppens, J. de Meris, K. Meijer, R.Y.J. Tamminga, P.F. Ypma, H.C.J. Eikenboom, J.G. van der Bom, F.J.W. Smiers, F.C.J.I. Heubel-Moenen, A. van der Veer, S.E.M. Schols, F.W.G. Leebeek, M.H. Cnossen, F. Atiq, C.B. van Kwawegen, E.P. Mauser-Bunschoten, K.P.M. van Galen

“…This highlights the need for health care providers to address sexual health during consultations and treat HMB to improve overall care for VWD patients.…”
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Management and early outcomes of children with appendicitis in the UK and Ireland during the COVID-19 pandemic: a survey of surgeons and observational study by Nigel J Hall, David Williams, Vivek Gupta, Anna-may Long, Nuha Yassin, Alan Askari, David Colvin, Stewart Cleeve, Arun Kelay, Chris Driver, Clare Rees, Eleri Cusick, Hetal Patel, Ingo Jester, Khalid Elmalik, Sean Marven, Tim Bradnock, Oliver Brown, Andrew Jackson, Richard Egan, Laura Phillips, Marianne Hollyman, Bankole Oyewole, Fenella Welsh, Dale Vimalachandran, Melissa Gabriel, Kate Cross, Iain Yardley, Mark Peter, Andrew Beamish, Sophie Lewis, Milan Gopal, Joshua McIntyre, Merrill McHoney, Ionica Stoica, Hany Gabra, Tristan Boam, Angeliki Kosti, Katie cross, Andrew Mitchell, Michael Terry, George S Bethell, Clare M Rees, Jonathan R Sutcliffe, Florin Djendov, Victor Emordi, Sarah Staight, Christina Major, Oscar Croysdale, Mike Nelson, Hannah Rhodes, Juliette King, Gillian Winter, Selena Curkovic, Raef Jackson, Bhushanrao Jadhav, Thomas Raymond, Vijay Gangalam, Deepak Selvakumar, Reda Habak, Muslim Abdullah, Mohamed Ahmed Osama, Khlud Asanai, Noman Zafar, Sophia Lewis, Florence Kashora, Dixa Thakrar, Dean Rex, Annita Budzanowski, Jennifer Binnington, Simon Timbrell, Megan Ridgeway, Shirley Chan, Amani Asour, Adetayo Aderombi, Donald Menzies, Ali Murtada, Corina Dragu, Vincent Quan, Krashna Patel, Sesi Hotonu, Ashley Meikle, Ajay Belgaumkar, Prabhat Narayan, Thomas Badenoch, Frances Goulder, Katie Siggens, Kizzie Peters, Fiona Kirkham, Paul Froggatt, Karen Lai, Cristina Navarro, Dorinda Chandrabose, Simon Toh, Elizabeth Gemmill, Keira Lily, Mark Dilworth, Dimitrios Stamatiou, Alasdair Macmillan, Danielle Clyde, Majid Rashid, Gandrapu Srinivas, Katherine Buckley, Darren Smith, Henry Dowson, Gautam Singh, Seshu Kumar Bylapudi, Louise Phillips, Kimberley Hallam, Marisa Clemente, Karol Pal, George Ninkovic-Hall, Emila Paul, Theo Pelly, Joe Vance-Daniel, Venkatesh Kanakala, Edward J Nevins, James Dixon, Michael John, Jude Prince, Georgios Karagiannidis, Suzette Samlalsingh, Chrsitine Ozone, Amina Bouhelal, Siddhartha Handa, Sathasivam Rajeev, Ellen Ross, Ali Wadah, John Hallett, Shirish Tewari, Vinay Shah, Nick Reay-Jones, Salman Bodla, Harriet Corbett, Sumita Chhabra, Athanasios Tyraskis, Benjamin Allin, Angus Fitchie, Michael Stanton, Mark Vipond, Harry Dean, Matthew Boal, Jonathan Goring, Mahmoud Marei, Christian Verhoef, Jonathan Ducey, Chipo Mushonga, Dan Frith, Ashok Ram, Ferzine Mohamed, Rick MacMahon, Mohammed Fakhrul-Aldeen, Iain Bain, Graham Branagan, Rachel Carten, Chee Wan Lai, Anindya Niyogi, Claudia Koh, Christian Fox, Stavros Loukogeorgakis, Joe Curry, Jayaram Sivaraj, Milda Jancauskaite, Helen Please, Wayne Fradley, Maki Jitsumara, Sinead Hassett, Ancuta Muntean, Sarah Yassin, Suzanne Lawther, Ciaran Durand, Mohamed Eltom, Kirsty Brennan, Clara Chong, Hasan Mukhtar, Hany Khalil, Stephanie Clark, Ashish Desai, Amulya Saxena, Joshua Cave, Alistair Sharples, Lukas O’Brien, George Kerans, Ashwini Ghorpade, Felicity Arthur, Muhammad Tobbal, Rachael Robertson, Ben Martin, Ben Woodward, Kieran McGovern, Duncan Rutherford

“…This study aims to report management and outcomes, to date, of children with appendicitis in the UK and Ireland during the COVID-19 pandemic.Design Survey of consultant surgeons who treat children with appendicitis that informed a prospective multicentre observational cohort study.Setting Data were collected from centres in the UK and Ireland for cases admitted between 1 April and 31 May 2020 (first 2 months of the COVID-19 pandemic) at both general surgical and specialist paediatric surgical centres.Participants The study cohort includes 838 children with a clinical and/or radiological diagnosis of acute appendicitis of which 527 (63%) were male.Main outcomes measured Primary outcome was treatment strategy used for acute appendicitis. …”
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EFFECT OF THE THERAPEUTIC-PREVENTIVE COMPLEX ON THE PARAMETERS OF GLUTATHIONE SYSTEM AND GLUTATHIONE-DEPENDENT ENZYMES OF THE ORAL FLUID IN CHILDREN WITH CHRONIC CATARRHAL GINGIVIT... by L.F. Kaskova, V.A. Honcharenko

“…A number of methods to treat chronic catarrhal gingivitis in children including the treatment of the background of diabetes mellitus was proposed the scientists. …”
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Tumour-intrinsic PDL1 signals regulate the Chk2 DNA damage response in cancer cells and mediate resistance to Chk1 inhibitors by Clare E. Murray, Anand V. R. Kornepati, Carlos Ontiveros, Yiji Liao, Bárbara de la Peña Avalos, Cody M. Rogers, Zexuan Liu, Yilun Deng, Haiyan Bai, Suresh Kari, Alvaro S. Padron, Jacob T. Boyd, Ryan Reyes, Curtis A. Clark, Robert S. Svatek, Rong Li, Yanfen Hu, Meiling Wang, José R. Conejo-Garcia, Lauren A. Byers, Kavya Ramkumar, Anil K. Sood, Jung-Min Lee, Christin E. Burd, Ratna K. Vadlamudi, Harshita B. Gupta, Weixing Zhao, Eloïse Dray, Patrick Sung, Tyler J. Curiel

“…Pharmacologic tumour PDL1 depletion with cefepime or ceftazidime replicated genetic tumour PDL1 depletion by reducing tumour Chk2, inducing Chk1i synthetic lethality in a tumour PDL1-dependent manner, and reducing in vivo tumour growth when combined with Chk1i. Conclusions Our data challenge the prevailing surface PDL1 paradigm, elucidate important and previously unappreciated roles for tumour-intrinsic PDL1 in regulating the ATM/Chk2 DNA damage response axis and E3 ligase-mediated protein degradation, suggest tumour PDL1 as a biomarker for Chk1i efficacy, and support the rapid clinical potential of pharmacologic tumour PDL1 depletion to treat selected cancers.…”
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