Reconstruction of a lncRNA-Associated ceRNA Network in Endothelial Cells under Circumferential Stress by Zhuhui Huang, William Adiwignya Winata, Kui Zhang, Yang Zhao, Yang Li, Ning Zhou, Shaoyou Zhou, Wei Fu, Bokang Qiao, Guoqi Li, Yihui Shao, Jubing Zheng, Ran Dong

“…Our data demonstrated that NEAT1 may be a core factor among the mechanical stress factors and that cyclic stress can significantly reduce expression of NEAT1, give rise to inflammation in the early stage of endothelial dysfunction, and promote EC apoptosis, which may play an essential role in vein graft failure.…”
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Mitochondrial stress disassembles nuclear architecture through proteolytic activation of PKCδ and Lamin B1 phosphorylation in neuronal cells: implications for pathogenesis of age-r... by Adhithiya Charli, Yuan-Teng Chang, Jie Luo, Bharathi Palanisamy, Emir Malovic, Zainab Riaz, Cameron Miller, Manikandan Samidurai, Gary Zenitsky, Huajun Jin, Vellareddy Anantharam, Arthi Kanthasamy, Anumantha G. Kanthasamy, Anumantha G. Kanthasamy

“…Electron microscopy also visualized nuclear membrane damage in Tebu-treated N27 cells. In silico analyses identified threonine site on Lamin B1 (T575) as a phosphorylation site of PKCδ. …”
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ACC1 is a dual metabolic-epigenetic regulator of Treg stability and immune tolerance by Philipp Stüve, Gloria J. Godoy, Fernando N. Ferreyra, Florencia Hellriegel, Fatima Boukhallouk, Yu-San Kao, Tushar H. More, Anne-Marie Matthies, Tatiana Akimova, Wolf-Rainer Abraham, Volkhard Kaever, Ingo Schmitz, Karsten Hiller, Matthias Lochner, Benoît L. Salomon, Ulf H. Beier, Michael Rehli, Tim Sparwasser, Luciana Berod

“…Conclusions: We identified ACC1 as a metabolic checkpoint in Treg biology. Our data demonstrate that ACC1 inhibition promotes Treg differentiation and long-term stability in vitro and in vivo. …”
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ANP32E expression in pancreatic cancer is associated with impaired gemcitabine efficacy and poor patient prognosis by Xiaohong Liu, Yelin Zhao, Li Zhang, Junting Wang, Liaoxin Luo, Shihui Zhang, Qin Zhu, Yuchen Shi, Chenyu Yuan, Qifeng Xiao, Mengran Xiong, Yuanyuan Duan, Hebing Chen, Hongjuan Yao, Lin Cai, Jianwei Zhang, Guangxi Li, Liang Li

“…Methods: We collected clinical characteristics and treatment information from a total of 75 PDAC patients to assess the association of ANP32E expression via immunohistochemical (IHC) staining with overall survival (OS) in patients who were or were not treated with gemcitabine-based chemotherapy, followed by a clinical replication study with transcriptomic data from the TCGA database and functional validation experiments involving the knockdown of ANP32E in the Hup-T3 and SU86.86 human pancreatic cancer cell lines. …”
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A Randomized, Double-Blind, Multicenter Clinical Study Comparing the Efficacy and Safety of a Drug Combination of Lopinavir/Ritonavir-Azithromycin, Lopinavir/Ritonavir-Doxycycline,... by Purwati, Budiono, Brian Eka Rachman, Yulistiani, Andang Miatmoko, Nasronudin, Soroy Lardo, Yongki Iswandi Purnama, Mafidhatul Laely, Ike Rochmad, Taufik Ismail, Sri Wulandari, Dwi Setyawan, Alfian Nur Rosyid, Herley Windo Setiawan, Prastuti Asta Wulaningrum, Tri Pudy Asmarawati, Erika Marfiani, Shinta Karina Yuniati, Muhammad Rabiul Fuadi, Pepy Dwi Endraswari, Purwaningsih, Eryk Hendrianto, Deya Karsari, Aristika Dinaryanti, Nora Ertanti, Igo Syaiful Ihsan, Disca Sandyakala Purnama, Yuni Indrayani

“…Further studies should involve observation of older patients with severe clinical symptoms in order to collate significant amounts of demographic data.…”
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Relation between Genomic DNA Breakpoints in MLL Gene and Treatment Outcome in Infants with Acute Leukemia by GA Tsaur, C Meyer, TO Riger, AM Kustanovich, EV Fleischman, YuV Ol’shanskaya, AM Popov, OI Sokova, EA Matveeva, OV Nikulina, AE Drui, OR Arakaev, OV Streneva, SA Rumyantsev, EV Shorikov, AG Solodovnikov, LI Savel’ev, R Marschalek, LG Fechina

“…The latter was the only independent covariate in multivariate analysis. Our data provide additional information of molecular genetic features of MLL-rearranged infant AL.…”
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Neoadjuvant apatinib addition to sintilimab and carboplatin-taxane based chemotherapy in patients with early triple-negative breast cancer: the phase 2 NeoSAC trial by Guoshuang Shen, Zhilin Liu, Miaozhou Wang, Yi Zhao, Xinlan Liu, Yujin Hou, Wenbiao Ma, Jingqi Han, Xiaofeng Zhou, Dengfeng Ren, Fuxing Zhao, Zitao Li, Shifen Huang, Yongzhi Chen, Yingjian He, Yan Liu, Zijun Zhu, Yongxin Li, Jinming Li, Mengting Da, Hongnan Mo, Feng Du, Liang Cui, Jing Bai, Zhen Liu, Fei Ma, Jiuda Zhao

“…Comparison of pre-neoadjuvant and post-surgery data revealed that the pCR group treated with this novel regimen exhibited an upregulation of distinct immune cell subsets, thereby activating the tumor microenvironment. …”
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Korean Registry on the Current Management of Helicobacter pylori (K-Hp-Reg): Interim Analysis of Adherence to the Revised Evidence-Based Guidelines for First-Line Treatment by Hyo-Joon Yang, Joon Sung Kim, Ji Yong Ahn, Ok-Jae Lee, Gwang Ha Kim, Chang Seok Bang, Moo In Park, Jae Yong Park, Sun Moon Kim, Su Jin Hong, Joon Hyun Cho, Shin Hee Kim, Hyun Joo Song, Jin Woong Cho, Sam Ryong Jee, Hyun Lim, Yong Hwan Kwon, Ju Yup Lee, Seong Woo Jeon, Seon-Young Park, Younghee Choe, Moon Kyung Joo, Dae-Hyun Kim, Jae Myung Park, Beom Jin Kim, Jong Yeul Lee, Tae Hoon Oh, Jae Gyu Kim, Korean College of Helicobacter and Upper Gastrointestinal Research

“…The modified intention-to-treat eradication rate for first-line treatment was 81.0%, with 80.4% of the prescriptions adhering to the revised guidelines. …”
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Use of non-specific immunoglobulins in Catalonia in three third-level hospitals: a descriptive analysis of a hospital-prescribed medication registry by J. Riera-Arnau, J. Riera-Arnau, E. Ballarín, R. Llop, R. Llop, E. Montané, E. Montané, P. Hereu, P. Hereu, G. Vancells, N. Padullés-Zamora, N. Padullés-Zamora, A. M. Barriocanal, G. Cardona-Peitx, C. Casasnovas, C. Casasnovas, J. B. Montoro, M. Nuñez, E. Santacana Juncosa, E. Santacana Juncosa, A. Selva-O’Callaghan, X. Solanich, X. Solanich, X. Solanich, M. Sabaté Gallego, M. Sabaté Gallego

“…Almost all pediatric patients (56; 81.2%) were treated under A-level indications, as for 217 (65.6%) adults. …”
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Preliminary safety and effectiveness of psilocybin-assisted therapy in adults with fibromyalgia: an open-label pilot clinical trial by Jacob S. Aday, Jacob S. Aday, Jenna McAfee, Deirdre A. Conroy, Avinash Hosanagar, Avinash Hosanagar, Vijay Tarnal, Vijay Tarnal, Cody Weston, Katherine Scott, Dana Horowitz, Jamarie Geller, Jamarie Geller, Steven E. Harte, Steven E. Harte, Steven E. Harte, Niloufar Pouyan, Niloufar Pouyan, Niloufar Pouyan, Nicolas G. Glynos, Nicolas G. Glynos, Anne K. Baker, Anne K. Baker, Jeffrey Guss, Alan K. Davis, Alan K. Davis, Alan K. Davis, Helen J. Burgess, George A. Mashour, George A. Mashour, George A. Mashour, Daniel J. Clauw, Kevin F. Boehnke, Kevin F. Boehnke

“…Currently, there are limited treatment options available that effectively treat FM symptoms. Psilocybin-assisted therapy (PAT) is an emerging combined drug-therapy intervention, but no studies to-date have investigated PAT for FM.MethodsHere, we report findings from an open-label, pilot clinical trial of PAT for FM (N = 5). …”
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Definitive chemoradiotherapy combined with anti-PD-1 immunotherapy for inoperable esophageal squamous cell carcinoma: a multicenter real-world study by Xiongtao Yang, Xiaomin Wang, Qin Xiao, Xiaolin Ge, Nuo Yu, Jiao Li, Guojie Feng, Ziyu Zheng, Yingying Jiang, Lin Lu, Xiaojie Xia, Lei Deng, Tao Zhang, Wenqing Wang, Wenyang Liu, Jianyang Wang, Zefen Xiao, Zongmei Zhou, Nan Bi, Hui Wang, Cheng Chen, Xin Wang

“…A historical control group treated with dCRT alone was used for comparison. Stabilized inverse probability of treatment weights (sIPTW) analyses were conducted to compare survival. …”
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Post-registration experience of nivolumab in advanced hepatocellular carcinoma: an international study by Dominik Bettinger, Bo Yu, David Szafron, Yinghong Wang, Mahvish Muzaffar, Thomas Marron, Uqba Khan, Yi-Hsiang Huang, David J Pinato, Ahmed Kaseb, Anwaar Saeed, Tomi Jun, Sirish Dharmapuri, Musharraf Navaid, ChiehJu Lee, Anushi Bulumulle, Sonal Paul, Petros Fessas, Neil Nimkar, Hannah Hildebrand, Tiziana Pressiani, Yehia I Abugabal, Nicola Personeni, Lorenza Rimassa, Celina Ang, Abdul Rafeh Naqash, Francesca Benevento

“…Background Nivolumab is Food and Drug Administration approved in sorafenib-experienced, advanced hepatocellular carcinoma (HCC). Post-registration data of treatment in a real-world setting is lacking.Patients and methods We performed an international, multicenter observational study to confirm safety and efficacy of nivolumab in 233 patients treated outside clinical trials from eight centers in North America, Europe and Asia.Results Patients received nivolumab for Barcelona Clinic Liver Cancer stage C (n=191, 92.0%) and Child-Pugh (CP) A (n=158, 67.8%) or B (n=75, 32.2%) HCC as first (n=85, 36.5%) or second to fourth systemic therapy line (n=148, 63.5%). …”
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Safety of a co-designed cognitive behavioural therapy intervention for people with type 1 diabetes and eating disorders (STEADY): a feasibility randomised controlled trialResearch... by Marietta Stadler, Natalie Zaremba, Amy Harrison, Jennie Brown, Divina Pillay, Jacqueline Allan, Rachael Tan, Salma Ayis, Emmanouela Konstantara, Janet Treasure, David Hopkins, Khalida Ismail

“…Baseline mental health data (Structured Clinical Interview for DSM-5, SCID-5RV), and secondary biomedical outcomes (HbA1c; glucose time in range; TIR) and person-reported outcome measures (PROM: Diabetes Eating Problems Survey-Revised, DEPS-R; Eating Disorder Examination Questionnaire Short, EDE-QS; Type 1 Diabetes Distress Scale, T1DDS; Generalised Anxiety Disorder Assessment, GAD-7; Patient Health Questionnaire, PHQ-9; Impact of Diabetes Profile, DIDP) were collected. …”
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Astaxanthin ameliorates benzalkonium chloride–induced dry eye disease through suppressing inflammation and oxidative stress via Keap1‐Nrf2/HO‐1 signaling pathways by Ziyu Liu, Yaqiong Li, Jiayu Bao, Siyuan Li, Ya Wen, Peng Zhang, Jun Feng, Yinghui Wang, Lei Tian, Ying Jie

“…Methods Therapeutic targets for AST were identified using data from the GeneCards, PharmMapper, and Swiss Target Prediction databases, and STITCH datasets. …”
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Study the effect of Lactobacillus plantarum ATCC 14917 for caries prevention and anti-obesity by Wei Yang, Wei Yang, Mingxin Jiang, Bairu Chen, Bairu Chen, Kongzhao Jiang, Nan Ma, Nan Ma, Yimin Li, Yimin Li, Meng Wang, Meng Wang, Meihua Bao, Meihua Bao, Chengyue Wang, Chengyue Wang, Xiaopeng Yang, Xiaopeng Yang

“…They were split into three groups: the control group (Control), the caries and obesity group (CA _OB) and the caries and obesity treated with L. plantarum ATCC14917 group (LP). L. plantarum ATCC 14917 was applied during the experiment, and the associated indices were then thoroughly assessed. …”
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Cell-intrinsic PD-L1 signaling drives immunosuppression by myeloid-derived suppressor cells through IL-6/Jak/Stat3 in PD-L1-high lung cancer by Bhumsuk Keam, Se-Hoon Lee, Yingying Li, Yoon Kyung Jeon, Hye Young Kim, Sehui Kim, Hyein Jeong, Soo Hyun Lee, Jaemoon Koh, Jeemin Yim, Seung Geun Song, Hanbyeol Kim, Yeon Kyu Chung, Hongsoon Kim, Chul-Hwan Lee, Doo Hyun Chung

“…To address the mechanism of ICI resistance in PD-L1-positive NSCLC, we investigated the role of tumor-cell-intrinsic function of PD-L1 in interleukin (IL)-6-mediated immunosuppression.Methods Cohorts of NSCLC patients treated with ICI and public datasets were analyzed. …”
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Does coenzyme Q10 improve semen quality and circulating testosterone level? a systematic review and meta-analysis of randomized controlled trials by Tunmise M. Akhigbe, Tunmise M. Akhigbe, Fabrael B. Fidelis, Fabrael B. Fidelis, Adebayo O. Adekunle, Adebayo O. Adekunle, Victory J. Ashonibare, Victory J. Ashonibare, Bolaji A. Akorede, Bolaji A. Akorede, Mansur S. Shuaibu, Mansur S. Shuaibu, Suliat A. Hassan, Cecilia A. Adegbola, Cecilia A. Adegbola, Precious J. Ashonibare, Precious J. Ashonibare, Opeyemi M. Oladapo, Opeyemi M. Oladapo, Adetomiwa E. Adeogun, Adetomiwa E. Adeogun, Adetomiwa E. Adeogun, Seun G. Bamidele, Seun G. Bamidele, Precious A. Oyedokun, Precious A. Oyedokun, Mungala Mukolokota, Mungala Mukolokota, Omotolani S. Kukoyi, Omotolani S. Kukoyi, Ayoola A. Oladipo, Ayoola A. Oladipo, Olayinka E. Adelowo, Olayinka E. Adelowo, Marvelous D. Akangbe, Marvelous D. Akangbe, Jennifer R. Hughes, Albert M. Ricken, Martine Culty, Maria C. W. Avellar, Roland E. Akhigbe, Roland E. Akhigbe

“…The studies included a total of 877 male subjects; 462 CoQ10-treated and 415 untreated/placebo-treated. We found significantly higher total sperm counts (SMD -13.38 [95% CI: −16.33, −10.43] P< 0.0001), total (SMD -7.26 [95% CI: −10.15, −4.36] P< 0.00001) and progressive motility (SMD -6.386 [95% CI: −10.04, −2.73] P= 0.0006), and normally formed sperm (SMD -1.96 [95% CI: −3.29, −0.62] P= 0.004) in CoQ10-treated male subjects compared with untreated/placebo-treated male subjects. …”
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T2‐low severe asthma clinical spectrum and impact: The Greek PHOLLOW cross‐sectional study by Konstantinos Porpodis, Nikolaos Zias, Konstantinos Kostikas, Argyris Tzouvelekis, Michael Makris, George N. Konstantinou, Eleftherios Zervas, Stelios Loukides, Paschalis Steiropoulos, Konstantinos Katsoulis, Anastasios Palamidas, Aikaterini Syrigou, Maria Gangadi, Antonios Christopoulos, Dimosthenis Papapetrou, Fotios Psarros, Konstantinos Gourgoulianis, Eleni Tzortzaki, Stylianos K. Vittorakis, Ioannis Paraskevopoulos, Ilias Papanikolaou, Georgios Krommidas, Dimitrios Latsios, Nikolaos Tzanakis, Miltiadis Markatos, Angeliki Damianaki, Argyrios Manikas, Alexia Chatzipetrou, Dimitrios Vourdas, Ioanna Tsiouprou, Christina Papista, Marina Bartsakoulia, Nikolas Mathioudakis, Petros Galanakis, Petros Bakakos

“…Abstract Background Data on type 2 (T2)‐low severe asthma (SA) frequency is scarce, resulting in an undefined unmet therapeutic need in this patient population. …”
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Therapeutic gene targets and epigenetic modifications in rheumatoid arthritis: Insights from MTX, JAK inhibitors, and LLDT-8 by Jianan Zhao, Yunshen Li, Runrun Zhang, Yu Shan, Chenyang Song, Yaxin Cheng, Yiming Shi, Yixin Zheng, Fuyu Zhao, Junyu Fan, Cen Chang, Yuejuan Zheng, Dongyi He

“…Methods: Primary FLS were isolated from synovial tissues of RA and osteoarthritis (OA) patients and treated with MTX, JAK inhibitors, and LLDT-8. RNA sequencing identified differentially expressed genes (DEGs) under each treatment. …”
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Sodium valproate, a potential repurposed treatment for the neurodegeneration in Wolfram syndrome (TREATWOLFRAM): trial protocol for a pivotal multicentre, randomised double-blind c... by Una Martin, Timothy Barrett, Susan Mollan, Karen E Morrison, Ruth Evans, Isabelle Meunier, Rajat Gupta, Andrew Peet, Martin Wilson, Sulev Koks, Wojciech Młynarski, Patrick Yu-Wai-Man, Agathe Roubertie, Darren Barton, Dewi Astuti, Renuka P Dias, Lucinda Billingham, Kun Hu, Malgorzata Zatyka, Archana Kulkarni, Benjamin Wright, Kristian Brock, Victoria Homer, Rebecca Malpass, Heather Rose, Christophe Orssaud, Zsuzsanna Nagy, Tracy Lynch, Sabrina Cronier, Amandip Malhi, Pooja Takhar, Amy Lamb, Gema Esteban-Bueno

“…Using hierarchical repeated measures analyses with a 5% significance level, 80% power and accounting for an estimated 15% missing data rate, a sample size of 70 was set. The primary outcome measure, visual acuity, will be centrally reviewed and analysed on an intention-to-treat population.Ethics and dissemination The protocol was approved by the National Research Ethics Service (West of Scotland; 18/WS/0020) and by the Medicines and Healthcare products Regulatory Agency. …”
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