Long-term functioning status of COVID-19 survivors: a prospective observational evaluation of a cohort of patients surviving hospitalisation by Linamara Rizzo Battistella, Felipe Fregni, Marta Imamura, Vinicius Delgado Ramos, Lucas Ramos De Pretto, Simon K H A A Van Cauwenbergh, Sabrina Saemy Tome Uchiyama, Denise Matheus, Flavia Kuhn, Ana Alice Amaral de Oliveira, Gabriella Souza Naves, Aline Rossetti Mirisola, Fernando de Quadros Ribeiro, Andre Tadeu Sugawara, Mauricio Cantarino, Rafael Andrade Santos Antunes Cavalca, Vanessa Pagano, Melina Valentim Marques, Elizabeth Mendes da Silva, Alessandra Pereira Gomes

“…Most (92.85%, 727 of 783) participants reported unrestricted oral intake. Data indicated no generalised fatigue (mean score: 39.18, SD: 9.77; 95% CI: 38.50 to 39.86). …”
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A holistic approach to promoting early child development: a cluster randomised trial of a group-based, multicomponent intervention in rural Bangladesh by Stephen P Luby, Mahbubur Rahman, Fahmida Tofail, Lia CH Fernald, Esther O Chung, Helen O Pitchik, Fahmida Akter, Jesmin Sultana, Abul Kasham Shoab, Tarique Md. Nurul Huda, Tania Jahir, Md Ruhul Amin, Md Khobair Hossain, Jyoti Bhushan Das, Kendra A Byrd, Farzana Yeasmin, Laura H Kwong, Jenna E Forsyth, Malay K Mridha, Peter J Winch

“…Analyses were intention to treat. Data collectors were independent from implementers.Results In July–August 2017, 621 pregnant women and primary caregivers of children<15 months were enrolled (group n=160, combined n=160, control n=301). …”
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Association of Dipeptidyl Peptidase-4 Inhibitors with Glaucoma Risk in Patients with Type 2 Diabetes: A Nationwide Cohort Study by Yi-An Lu, MD, Peng-Tai Tien, MD, PhD, Yih-Dih Cheng, PhD, Yow-Wen Hsieh, PhD, Der-Yang Cho, MD, Shang-Feng Tsai, MD, PhD, Chien-Hsiang Weng, MD, MPH, Heng-Jun Lin, Hui-Ju Lin, MD, PhD, I-Jong Wang, MD, PhD, Chien-Chih Chou, MD, PhD

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Preoperative Briganti Nomogram Score and Risk of Prostate Cancer Progression After Robotic Surgery Beyond EAU Risk Categories by Antonio Benito Porcaro, Rossella Orlando, Andrea Panunzio, Alessandro Tafuri, Alberto Baielli, Francesco Artoni, Claudio Brancelli, Luca Roggero, Sonia Costantino, Andrea Franceschini, Michele Boldini, Lorenzo Pierangelo Treccani, Francesca Montanaro, Sebastian Gallina, Alberto Bianchi, Emanuele Serafin, Giovanni Mazzucato, Francesco Ditonno, Mariana Finocchiaro, Alessandro Veccia, Riccardo Rizzetto, Matteo Brunelli, Vincenzo De Marco, Salvatore Siracusano, Maria Angela Cerruto, Riccardo Bertolo, Alessandro Antonelli

“…<i>Materials and Methods</i>: From January 2013 to December 2021, data on PCa patients treated with robot-assisted radical prostatectomy at a single tertiary referral center were extracted. …”
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A nomogram integrating the clinical and CT imaging characteristics for assessing spread through air spaces in clinical stage IA lung adenocarcinoma by Yantao Yang, Li Li, Huilian Hu, Chen Zhou, Qiubo Huang, Jie Zhao, Yaowu Duan, Wangcai Li, Jia Luo, Jiezhi Jiang, Zhenghong Yang, Guangqiang Zhao, Yunchao Huang, Lianhua Ye

“…Data from clinical assessments and CT imaging were gathered from all participants. …”
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Integrated multi-omics profiling reveals the role of the DNA methylation landscape in shaping biological heterogeneity and clinical behaviour of metastatic melanoma by Andrea Anichini, Francesca P. Caruso, Vincenzo Lagano, Teresa M. R. Noviello, Rossella Tufano, Gabriella Nicolini, Alessandra Molla, Ilaria Bersani, Francesco Sgambelluri, Alessia Covre, Maria F. Lofiego, Sandra Coral, Anna Maria Di Giacomo, Elena Simonetti, Barbara Valeri, Mara Cossa, Filippo Ugolini, Sara Simi, Daniela Massi, Massimo Milione, Andrea Maurichi, Roberto Patuzzo, Mario Santinami, Michele Maio, Michele Ceccarelli, Roberta Mortarini, On behalf of the EPigenetic Immune-oncology Consortium Airc (EPICA) investigators

“…Pre-therapy lesions (n = 28) from a cohort of MM patients treated with adjuvant immune checkpoint blockade were characterized for the DNA methylation profile. …”
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Therapeutic role of miR-26a on cardiorenal injury in a mice model of angiotensin-II induced chronic kidney disease through inhibition of LIMS1/ILK pathway by Weijie Ni, Yajie Zhao, Jinxin Shen, Qing Yin, Yao Wang, Zuolin Li, Taotao Tang, Yi Wen, Yilin Zhang, Wei Jiang, Liangyunzi Jiang, Jinxuan Wei, Weihua Gan, Aiqing Zhang, Xiaoyu Zhou, Bin Wang, Bi-Cheng Liu, Yuanyuan Ji

“…Dunnett’s multiple comparison and t-test were used to analyze the data. Results:. Compared with the control mice, miR-26a expression was significantly downregulated in both the kidney and the heart after Ang-II infusion. …”
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Medicare part D prescribing for direct oral anticoagulants in the United States: Cost, use and the "rubber effect". by Panayiotis D Ziakas, Irene S Kourbeti, Loukia S Poulou, Georgios S Vlachogeorgos, Eleftherios Mylonakis

“…We summarized prescription data for claims and drug payment, stratified by drug class, specialty and calendar year. …”
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Child outcomes after prenatal exposure to platinum and taxane-based chemotherapy: an unplanned interim analysis of the international network on cancer, infertility, and pregnancy s... by Indra A. Van Assche, Kristel Van Calsteren, Evangeline A. Huis in ’t Veld, Mathilde van Gerwen, Laura Heylen, Charlotte L. LeJeune, Elyce Cardonick, Michael J. Halaska, Robert Fruscio, Monica Fumagalli, Elisabeth M. van Dijk-Lokkart, Jurgen Lemiere, Martine van Grotel, Lieven Lagae, Marry M. van den Heuvel-Eibrink, Frédéric Amant

“…Summary: Background: Platina and taxanes are frequently used chemotherapeutic agents to treat cancer, also when diagnosed during pregnancy. …”
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Multi-omics characterization of oncosis in spinal cord injury by Zhipeng Jiang, Youwei Guo, Zihan Wang, Jinhao Ouyang, Hailong Huang, Haoxuan Huang, Tianqian Shen, Lei Wang, Wen Yin, Xingjun Jiang, Caiping Ren

“…We conducted an analysis of bulk RNA-seq data to identify differentially expressed ORGs at five distinct time points post-injury. …”
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Mediation analysis of antidepressant use, depressive symptoms, and recurrent falls in community-dwelling older fallers: An exploratory study by Adson da Silva Passos, PhD, Adriana Sanudo, PhD, Érika Yukie Ishigaki, MSc, Maria Aquimara Zambone Magalhães, MSc, Silvana Barbosa Pena, PhD, Andreia Cristina Feitosa do Carmo, MSc, Sérgio Márcio Pacheco Paschoal, PhD, Monica Rodrigues Perracini, PhD, Luiz Eugênio Garcez Leme, PhD

“…Design: Cross-sectional study using secondary data from a randomized clinical trial. Setting and participants: Community-dwelling older adults (n = 609, aged 73.4 ± 7.4 years) who had experienced at least one fall in the past 12 months. …”
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Metabolome and transcriptome analysis reveal the effect of methyl jasmonate on phytosterol biosynthesis in Brassica napus by Xueyan Wang, Min Liu, Ruinan Yang, Xiaobo Cui, Jie Liu, Yu Zhang, Yizhou He, Li Yu, Fei Ma, Xiong Zhang, Yuanyuan Zhang, Shengyi Liu, Peiwu Li, Liangxiao Zhang

“…Based on the multiomics data, a gene‐phytosterol regulatory network was constructed. …”
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Diffuse gliomas: insights into clinical and histopathological features and survival rates from two centers in a middle-income country by Edgar G. Ordóñez-Rubiano, Edgar G. Ordóñez-Rubiano, Edgar G. Ordóñez-Rubiano, Cristian Siabato, Nicolás Rincón-Arias, Nicolás Rincón-Arias, Paula A. Pulido, Paula A. Pulido, Hebert D. Pimienta-Redondo, Hebert D. Pimienta-Redondo, Sebastián Espinosa-Gaona, Sebastián Espinosa-Gaona, Santiago Useche-Diosa, Santiago Useche-Diosa, María Andrea Moreno, María Andrea Moreno, Hernando A. Cifuentes-Lobelo, Oscar F. Zorro-Guio, Javier G. Patiño-Gómez, Javier G. Patiño-Gómez, Alba Lucía Cómbita, César Payán-Gómez, Luz D. Gutierrez-Castañeda, Luz D. Gutierrez-Castañeda, Alexandra Ramos-Márquez, Alexandra Ramos-Márquez, Diego F. Gómez, Oscar Mendoza, Matias Baldoncini, Matias Baldoncini, Rafael Parra-Medina, Rafael Parra-Medina

“…This study aims to describe the clinical, histopathological, and demographic features of glioma patients treated in two reference centers in Colombia.MethodsThis descriptive cross-sectional study included all patients with a histologically confirmed glioma treated at two institutions in Bogotá, Colombia, between January 2015 and December 2023. 272 patients with diffuse gliomas were included, and data were collected on sociodemographic characteristics, clinical presentation, histopathologic diagnosis, immunohistochemical markers, extent of resection, functionality, complications, and survival.ResultsAmongst all cases, 36.00% were glioblastomas, 14.70% oligodendrogliomas, and 12.10% astrocytomas. 49.10% of patients were females, average age was 48.8 ± 21.0 years. …”
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Glycaemic control in labour with diabetes: GILD, a scoping study by Nia Wyn Jones, Eleanor J Mitchell, Kate F Walker, Susan Ayers, Lucy Bradshaw, Georgina Constantinou, Tasso Gazis, Shalini Ojha, Phoebe Pallotti, Stavros Petrou, Rachel Plachcinski, Michael Rimmer, Liz Schroeder, Jim G Thornton, Natalie Wakefield

“…Work package 3 Based on data from previous work packages, a randomised trial using an umbrella design and master protocol has been designed, with an aim to include women with all types of diabetes. …”
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The influence of H. pylori infection in HER2-positive gastric cancer cell lines: insights from Wnt/β-catenin pathway by Valli De Re, Mariateresa Casarotto, Giulia Brisotto, Stefania Zanussi, Mariangela De Zorzi, Ombretta Repetto, Elena Muraro, Paola Spessotto, Paolo Baldo, Vito Racanelli, Marco Vincenzo Lenti, Marco Vincenzo Lenti, Marino Venerito, Matteo Fassan, Matteo Fassan, Agostino Steffan, Stefano Realdon, Renato Cannizzaro, Renato Cannizzaro

“…Both N87R and N87p cells were infected with HV-HP and LV-HP strains and then treated with epidermal growth factor (EGF), TRAS or a combination of both. …”
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Introducing differentiated service delivery models for tuberculosis treatment: a pilot project to inform national policy in Uganda by Odile Ferroussier‐Davis, Deus Lukoye, Susan Alwedo, Mary N. Mudiope, Joanitah Nalunjogi, James Bruce Kirenga, Joseph N. Kabanda, Julius N. Kalamya, Benson Nasasira, Estella Birabwa, Seyoum Dejene, Miriam Murungi, Immaculate Ddumba, Brittany Moore, Aldomoro Burua, Henry Luzze, Ebony Quinto, Moorine Sekadde, Raymond Byaruhanga, Patrick Ajuna, Ivan Arinaitwe, Cordelia Katureebe, Proscovia Namuwenge, Michelle R. Adler, Stavia Turyahabwe

“…Overall, 1582/1864 (84.9%) clients were successfully treated, compared to 858/1177 (72.9%) in 2018–2019 (p < 0.001). …”
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Real-world effectiveness and safety of prolonged bedaquiline course in the treatment of drug-resistant tuberculosis—a multi-center retrospective cohort study in a country with a hi... by Yuanyuan Yu, Jie Cao, Hongqiu Pan, Hui Zhong, Xiaocui Wu, Jinghui Yang, Liping Cheng, Qingrong Qu, Lei Wang, Fuhui Lu, Hongyu Chen, Jie Wang, Wei Sha, Qin Sun

“…To date, the effectiveness and safety data regarding prolonged BDQ treatment are still lacking, and the additional benefits of prolonged BDQ use remain unclear. …”
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The Association of Socioeconomic Status (SES) with Procedural Management and Mortality After Percutaneous Coronary Intervention (PCI): An Observational Study from the Pan-London PC... by Krishnaraj S. Rathod, Pitt Lim, Sam Firoozi, Richard Bogle, Ajay K. Jain, Philip A. MacCarthy, Miles C. Dalby, Iqbal S. Malik, Anthony Mathur, James Spratt, Ranil De Silva, Roby Rakhit, Jonathan Hill, Sundeep Singh Kalra, Simon Redwood, Richard Andrew Archbold, Andrew Wragg, Daniel A. Jones

“…Methods: We conducted an observational cohort study of 123,780 consecutive PCI procedures from the Pan-London (United Kingdom) PCI registry. This data set is collected prospectively and includes all patients treated between January 2005 and December 2015. …”
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Home Blood Pressure Control and Drug Prescription Patterns among Thai Hypertensives: A 1-Year Analysis of Telehealth Assisted Instrument in Home Blood Pressure Monitoring Nationwid... by Anut Sakulsupsiri, Pairoj Chattranukulchai, Sarawut Siwamogsatham, Patchaya Boonchayaanant, Witthawat Naeowong, Aekarach Ariyachaipanich, Vorarit Lertsuwunseri, Voravut Rungpradubvong, Sudarat Satitthummanid, Sarinya Puwanant, Suphot Srimahachota, Wacin Buddhari, Smonporn Boonyaratavej, Surapun Sitthisook, Prapimporn Shantavasinkul, Peera Buranakitjaroen, Apichard Sukonthasarn, Somkiat Sangwatanaroj

“…Controlled HBP is defined as having HBP data at one year of follow-up within the defined target range (<135/85 mmHg). …”
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Prognostic significance of serum MUC5AC in resected pancreatic ductal adenocarcinoma: initial insights by Ashish Manne, Yonghua Bao, Ankur Sheel, Amir Sara, Upender Manne, Kannan Thanikachalam, Ashwini Esnakula, Timothy M. Pawlik, Jordan M. Cloyd, Susan Tsai, Anup Kasi, Ravi Kumar Paluri, Deepak Sherpally, Sravan Jeepalyam, Lianbo Yu, Wancai Yang

“…Among patients with pre-treatment data (n = 11), sMUC5AC levels were significantly higher among patients with poorly differentiated tumors.ConclusionThis study provides compelling evidence for the clinical utility of sMUC5AC as a prognostic biomarker among patients with resected PDA. …”
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