Syphilis in pregnant women and congenital syphilis from 2012 to 2021 in Switzerland: a multicentre, retrospective study by Chloé Alberto, Noémie Wagner, Yves Fougère, Patrick M. Meyer Sauteur, Gioia Scherler, Karoline Aebbi-Popp, Marc Baumann, Nina Schöbi, Gaud Catho, Stéphane Emonet, Christian Polli, Lisa Kottanattu, Christian Kahlert, David Baud, Alix Coste, Begoña Martinez De Tejada, Klara M. Posfay Barbe, Laurence Toutous Trellu

“…A history of treated syphilis was known for 44% (65/147) of the mothers corresponding to a serological scar and the remaining 56% (82/147) were newly identified syphilis cases. …”
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Matrix metalloproteinases and heat shock proteins on extracellular vesicles in colorectal cancer patients: association with metabolic status by N. V. Yunusova, D. A. Svarovsky, E. E. Dandarova, D. N. Kostromitsky, A. A. Dimcha, O. V. Cheremisina, S. G. Afanasiev, A. I. Konovalov, Z. A. Startseva, I. V. Kondakova, M. R. Patysheva, A. E. Grigor'eva, L. V. Spirina

“…However, taking into account the lack of data in the literature on the level of MMPs and HSPs expression in the composition of the total pool of EVs and in the composition of FABP4-positive EVs in patients with PTC and CRC patients, the aim of the work was formulated.Aim. …”
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Comparative Effects of Two Acupuncture Protocols in the Management of Chronic Insomnia: A Randomized Controlled Trial by Li L, Xia M, Chen X, Wang F, Li J, Zhao N, Liu Z, Chen Y

“…The treatment group received acupuncture at HT7, BL15, LR3 and BL18, while the control group was treated at GV20, EX-HN22, BL62 and KI6. Each group underwent 10 sessions administered three times per week. …”
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Application of color Doppler ultrasound in uremia patients with auto angiostomy by Wei Jing-tuan, Chen Su-e, Shao Xiu-hua, Xu Qian-lei, Cen Jie

“…ObjectiveTo analyze influencing factors for the maturation of autogenous radial arterio-cephalic venous fistulas （AVF） in uremia patients by color Doppler ultrasound （CDU）， and to create a CDU-based system to assess the maturation of AVF.MethodsA total of 91 uremia patients treated in the Functional Department of Shanghai Minhang District Hospital of Integrated Traditional Chinese and Western Medicine from June 15， 2023 to August 15， 2024 were selected as the research subjects. …”
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Modification of TIMI Score as a Predictive Model for 30-Day Mortality in Young STEMI Patients by M. Tasrif Mansur, Muhammad Yamin, Lusiani Rusdi, Murdani Abdullah, Birry Karim, C. Martin Rumende, Maruhum Bonar H. Marbun, Hamzah Shatri

“…This research is a retrospective cohort study using medical record data from the Dr. Cipto Mangunkusumo National General Hospital (RSCM) on patients aged ≤50 years who were treated for ST-elevation myocardial infarction (STEMI) from 2018 to 2022. …”
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Acaricidal and Insecticidal Activity of Plant Extracts of Ferola Pseudalliacea, Smyrnopsis Aucheri, Satureja Sahendica and Prangos Ferulacea for the Control of Varroa Mite in Honey... by Ataollah Rahimi, Hami dreza Bahmani, Vahid Mahdavi

“…The experimental colonies were treated with 15 ml of 20, 35, and 50% concentrations of the extracts of the mentioned plants at sunset when all the bees were present in the hive. …”
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Skin mastocytoma in dogs, complex treatment and survival of animals by B. B. Ivashkiv, A. R. Mysak

“…The diagnosis of mastocytoma was set up on the basis of the data of the physical examination of animals and cytological verification of the biopsy material got during targeted, ultrasound-guided, fine-needle biopsy of neoplasias and regional lymph nodes. …”
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Prediction of methylphenidate treatment response for ADHD using conventional and radiomics T1 and DTI features: Secondary analysis of a randomized clinical trial by Mingshi Chen, Zarah van der Pal, Maarten G. Poirot, Anouk Schrantee, Marco Bottelier, Sandra J.J. Kooij, Henk A. Marquering, Liesbeth Reneman, Matthan W.A. Caan

“…Background: Attention-Deficit/Hyperactivity Disorder (ADHD) is commonly treated with methylphenidate (MPH). Although highly effective, MPH treatment still has a relatively high non-response rate of around 30%, highlighting the need for a better understanding of treatment response. …”
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Switching to besifovir in patients with chronic hepatitis B receiving tenofovir disoproxil fumarate: A randomized trial by Hyung Joon Yim, Yeon Seok Seo, Ji Hoon Kim, Won Kim, Young Kul Jung, Jae Young Jang, Sae Hwan Lee, Yun Soo Kim, Chang Wook Kim, Hyoung Su Kim, Jae-Jun Shim, Eun-Young Cho, In Hee Kim, Byung Seok Lee, Jeong-Hoon Lee, Byung Seok Kim, Jeong Won Jang, Hyun Woong Lee, Jung Hyun Kwon, Moon Young Kim, Do Seon Song, Jung Gil Park, Yoon Seok Lee, Eileen L. Yoon, Han Ah Lee, Seong Hee Kang, Jin Mo Yang

“…Background/Aims Besifovir (BSV) showed comparable antiviral activity and superior safety profiles to tenofovir disoproxil fumarate (TDF) in treatment-naïve chronic hepatitis B (CHB). However, no data are available regarding the antiviral efficacy and safety of BSV in patients with CHB who switched from long-term TDF to BSV. …”
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Potency of Lacticaseibacillus paracasei as an alternative to antibiotic growth promoter in broiler chicken challenged with avian pathogenic Escherichia coli by Widya Paramita Lokapirnasari, Lilik Maslachah, Amung Logam Saputro, Efi Rokana, Andreas Berny Yulianto, Zulfi Nur Amrina Rosyada, Muhammad Aviv Firdaus, Himatul Ilma Silfia, Ertika Fitri Lisnanti, Zein Ahmad Baihaqi, Tabita Dameria Marbun, Aswin Rafif Khairullah, Muhammad Shakeel

“…SOD activity was markedly higher, and MDA levels were reduced in probiotic-treated birds compared with the AGP and infected groups. …”
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A Randomized Controlled Trial of a Biodegradable Polymer, Microcrystalline Sirolimus-Eluting Stent (MiStent) versus Another Biodegradable Polymer Sirolimus-Eluting Stent (TIVOLI):... by Bin Wang, Sicong Ma, Zhiyong Wang, Li Zhang, Hanjun Pei, Yang Zheng, Yuejin Yang, Zheng Zhang, Xinqun Hu, Ziwen Ren, Feng Zhang, Changqian Wang, Renqiang Yang, Zhiming Yang, Yuexi Wang, Guosheng Fu, Yu Cao, Zuyi Yuan, Kai Xu, Xin Zhao, Bo Xu, Miaohan Qiu, Quanmin Jing

“…Objective:. Data comparing the outcomes of MiStent (Micell Technologies, Durham, North Carolina, USA) microcrystalline biodegradable polymer (BP) drug-eluting stent (DES) and those of another post-marketing BP-DES, TIVOLI (EssenTech, Beijing, China) are rare. …”
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Geriatric Nutritional Risk Index Assessment in Patients Undergoing Transcatheter Edge-to-Edge Repair by Kenichi Shibata, PT, Masanori Yamamoto, MD, Ai Kagase, MD, Takahiro Tokuda, MD, Hiroshi Tsunamoto, MD, Testuro Shimura, MD, Azusa Kurita, MD, Ryo Yamaguchi, MD, Mike Saji, MD, Masahiko Asami, MD, Yusuke Enta, MD, Masaki Nakashima, MD, Shinichi Shirai, MD, Masaki Izumo, MD, Shingo Mizuno, MD, Yusuke Watanabe, MD, Makoto Amaki, MD, Kazuhisa Kodama, MD, Junichi Yamaguchi, MD, Toru Naganuma, MD, Hiroki Bota, MD, Yohei Ohno, MD, Masahiro Yamawaki, MD, Daisuke Hachinohe, MD, Hiroshi Ueno, MD, Kazuki Mizutani, MD, Toshiaki Otsuka, MD, Shunsuke Kubo, MD, Kentaro Hayashida, MD

“…Background: Transcatheter edge-to-edge repair (TEER) is used to treat patients with mitral regurgitation (MR). The Geriatric Nutritional Risk Index (GNRI) is a well-known nutritional marker that predicts mortality risk. …”
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Durability of benralizumab effectiveness in severe eosinophilic asthma patients with and without chronic rhinosinusitis with nasal polyps: a post hoc analysis from the ANANKE study by Luisa Brussino, Maria Aliani, Elena Altieri, Pietro Bracciale, Maria Filomena Caiaffa, Paolo Cameli, Giorgio Walter Canonica, Giorgio Walter Canonica, Cristiano Caruso, Cristiano Caruso, Stefano Centanni, Fausto De Michele, Stefano Del Giacco, Fabiano Di Marco, Laura Malerba, Francesco Menzella, Girolamo Pelaia, Paola Rogliani, Paola Rogliani, Micaela Romagnoli, Pietro Schino, Jan Walter Schroeder, Gianenrico Senna, Alessandra Vultaggio, Maria D’Amato

“…Earlier studies have shown that benralizumab improves asthma outcomes with greater efficacy if patients present CRSwNP.MethodsThis post hoc analysis of the ANANKE study (NCT04272463) reports data on the long-term effectiveness of benralizumab between SEA patients with and without CRSwNP (N = 86 and N = 75, respectively) treated for up to 96 weeks.ResultsBefore benralizumab initiation, CRSwNP patients displayed longer SEA duration, greater oral corticosteroid (OCS) use and blood eosinophil count. …”
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Effects of Simplified Antihypertensive Treatment Algorithm on Hypertension Management and Hypertension-Related Death in Resource-Constricted Primary Care Setting between 1997 and 2... by Mulalibieke Heizhati, Nanfang Li, Qiaoyan Shi, Xiaoguang Yao, Delian Zhang, Keming Zhou, Menghui Wang, Junli Hu, Gulinuer Duiyimuhan, Wen Jiang, Jing Hong, Le Sun

“…Program effects were evaluated using the data collected in various ways including cross-sectional screenings to population ≥30 years between 1998 and 2015 by comparing treatment and control rates of hypertension, changes in blood pressure (BP) levels and distribution, and proportion of case/total and NCD death for CVD and stroke. …”
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Validation of POD24 as a robust early clinical indicator of poor survival in mantle cell lymphoma from 1280 patients on clinical trials, a LYSA study by Clémentine Sarkozy, Loïc Chartier, Vincent Ribrag, Remy Gressin, Christian H. Geisler, Hanneke C. Kluin-Nelemans, Catherine Thieblemont, Franck Morschhauser, François Lemonnier, Violaine Safar, Benoît Tessoulin, Lucie Oberic, Ghandi Damaj, Hervé Ghesquières, Krimo Bouabdallah, René Olivier Casasnovas, Roch Houot, Wolfram Klapper, Barbara Burroni, Christiane Pott, Marie-Hélène Delfau-Larue, Elizabeth Macintyre, Mary Callanan, Mats Jerkeman, Michael Unterhalt, Eva Hoster, Martin Dreyling, Steven Le Gouill, Olivier Hermine, Morgane Cheminant

“…We performed a pooled analysis of patients recruited in France from six randomized first-line MCL trials. Among 1386 treated MCL patients, 1280 were evaluable for POD24 status: 299 (23.4%) with a POD24 event and 981 (76.6%) without. …”
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A first-in-human Phase I trial of the oral p-STAT3 inhibitor WP1066 in patients with recurrent malignant glioma by John de Groot, Martina Ott, Jun Wei, Cynthia Kassab, Dexing Fang, Hinda Najem, Barbara O'Brien, Shiao-Pei Weathers, Carlos Kamiya Matsouka, Nazanin K Majd, Rebecca A Harrison, Gregory N Fuller, Jason T Huse, James P Long, Raymond Sawaya, Ganesh Rao, Tobey J MacDonald, Waldemar Priebe, Michael DeCuypere, Amy B Heimberger

“…Patients & methods: In a first-in-human open-label, single-center, single-arm 3 + 3 design Phase I clinical trial, eight patients were treated with WP1066 until disease progression or unacceptable toxicities. …”
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Circadian rhythm disruption by PARP inhibitors correlates with treatment toxicity in patients with ovarian cancer and is a predictor of side effectsResearch in context by Deeksha Malhan, Janina Hesse, Nina Nelson, Kay Stankov, Jessica Nguyen, Ouda Aboumanify, Josefin Garmshausen, Gunther Rogmans, Bastian Czogalla, Jens Gerber, Martin Koch, Tomáš Kupec, Oliver Tomé, Ralf Witteler, Mustafa Deryal, Michael Eichbaum, Jalid Sehouli, Elena Ioana Braicu, Angela Relógio

“…These disruptions strongly correlated with the severity and frequency of side effects, including nausea and fatigue, displaying opposite trends between the placebo and rucaparib-treated groups. K-means clustering successfully distinguished rucaparib-treated patients from those receiving placebo based on BMAL1 phase and gene expression profiles. …”
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Palynostratigraphy of the Shemshak and Dalichai formations boundary, north of Semnan and its paleogeographic significance by Fereshteh Sajjadi, Firoozeh Hashemi Yazdi, Mohaddeseh Maleki

“…The available paleontological data (ammonites and dinoflagellate cysts) apparently support this interpretation.Keywords: Palynostratigraphy, Paleogeography, Middle Jurassic, Shemshak and Dalichai formations.  …”
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Multicenter validation of an RNA-based assay to predict anti-PD-1 disease control in patients with recurrent or metastatic head and neck squamous cell carcinoma: the PREDAPT study by Howard L McLeod, A Dimitrios Colevas, Georges Azzi, Kevin C Flanagan, Douglas Adkins, Jessica Ley, Ezra E W Cohen, James Wade, Jon Earls, Jeffrey Hiken, Rachel L Wellinghoff, Michelle M Ponder, William H Westra, Vera Vavinskaya, Leisa Sutton, Ida Deichaite, Orlan K Macdonald, Karim Welaya, Andrew W Pippas, Jennifer Slim, Bruce Bank, Xingwei Sui, Steven E Kossman, Todd D Shenkenberg, Warren L Alexander, Katharine A Price, David N Messina, Jarret I Glasscock, Eric J Duncavage

“…The test used RNA-sequencing data and machine learning models to score each patient and place them into groups of low, medium, or high.Results The OncoPrism-HNSCC prediction significantly correlated with disease control in both the monotherapy cohort (n=62, p=0.004) and the chemo-immunotherapy cohort (n=50, p=0.01). …”
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Transarterial chemoembolization combined with apatinib in the treatment of advanced hepatocellular carcinoma: a prospective, multi-center, real-world study (Ahend-HAP02) by Hang Yuan, Zhen Li, Guang-Shao Cao, Fei Xu, Gang Wu, Peng-Xu Ding, Qiu-Liang Wei, Zu-Kuan Chang, Cheng Xing, Huan-Zhang Niu, Jun Yin, Quan-Jun Yao, Lin Zheng, Jin-Cheng Xiao, Cheng-Shi Chen, Hong-Tao Cheng, Deng-Wei Zong, Wei-Li Xia, Xiang Geng, Xiao-Hui Zhao, Hai-Liang Li, Hong-Tao Hu

“…PurposeTo analyze the efficacy and safety of transarterial chemoembolization (TACE) with apatinib (TACE-A) for the treatment of advanced hepatocellular carcinoma (HCC).MethodsData from advanced HCC patients treated with TACE-A between January 2019 and June 2022 were evaluated. …”
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