Home Respiratory Therapies in Patients With Obstructive Sleep Apnea: A Value-based Care Model in Spain by Irene Cano-Pumarega, Candela Caballero-Eraso, Valentín Cabriada, Mar Mosteiro, Juan Fernando Masa, Ferran Barbé

“…This document proposes a value-based care model to improve adherence and health outcomes in patients with obstructive sleep apnea (OSA) treated with CPAP. The current care model for OSA management adopts a uniform, volume-based approach for all patients, limiting personalized care and reducing service quality without providing objective outcome data. …”
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Malformaciones pulmonares congénitas: ¿Qué impacto tiene la presencia de síntomas preoperatorios en el resultado quirúrgico? by María López-Díaz, Ester Fernández Díaz, Indalecio Cano Novillo, Elena Bergón, Rocío Morante Valverde, Alberto Galindo Izquierdo, Juan L. Antón-Pacheco

“…Patients and methods: Retrospective study of patients with CLM treated with MIS in our hospital between 2003 and 2023. …”
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Efficacy and safety of Tongxinluo capsules combined with conventional therapy for acute myocardial infarction: a systematic review and meta-analysis by Dan Ouyang, Dan Ouyang, Xiao Jiang, Hui Wang, Hui Wang, Ma Li Xu, Ma Li Xu, Hang Qi, Xin Hui Li, Xin Hui Li, Jian Zhong Cao

“…BackgroundTongxinluo capsule, a formally classical commercial Chinese polyherbal preparation, has been utilized to treat patients with acute myocardial infarction for decades.Purpose:This meta-analysis aimed to comprehensively evaluate the clinical outcomes of tongxinluo capsule treated acute myocardial infarction.MethodsRandomized controlled trials evaluating the effectiveness of tongxinluo capsule alone or in combination with conventional therapy in patients with acute myocardial infarction were identified from eight major databases: Chinese Biomedical Medicine, China National Knowledge Infrastructure, Wanfang Med Database, China Science and Technology Journal Database, PubMed, and Cochrane Central Register of Controlled Trials. …”
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Congenital lung malformations: Do preoperative symptoms have an impact in surgical outcomes? by María López-Díaz, Ester Fernández Díez, Indalecio Cano Novillo, Elena Bergón, Rocío Morante Valverde, Alberto Galindo Izquierdo, Juan L. Antón-Pacheco

“…Patients and methods: Retrospective study of patients with CLM treated with MIS in our hospital between 2003 and 2023. …”
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Epidemiological characteristics of medial tibial plateau fractures and effects of two surgical methods for Wahlquist type C fractures by Xu Yunqin, Tang Yong, Deng Pan, Yao Yourong, Wei Qiangqiang, Wang Jianmin

“…Objective: To explore the epidemiological characteristics of medial tibial plateau fractures and compare the clinical outcomes of two surgical methods for Wahlquist type C fractures. Methods: Data of 132 patients with medial tibial plateau fractures who were treated in our hospital from August 1, 2013, to August 1, 2023, were retrospectively collected and analyzed epidemiologically. …”
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Effectiveness of secukinumab in radiographic and non-radiographic axial spondyloarthritis: a European routine-care observational study by Bente Glintborg, Merete Lund Hetland, Tore K Kvien, Brigitte Michelsen, Florenzo Iannone, Karel Pavelka, Ziga Rotar, Maria Jose Santos, Catalin Codreanu, Anne Gitte Loft, Maria Sole Chimenti, Gary J Macfarlane, Gareth T Jones, Mikkel Østergaard, Jakub Zavada, Bjorn Gudbjornsson, Gerður Gröndal, Lykke Midtbøll Ørnbjerg, Adrian Ciurea, Daniela Di Giuseppe, Michael J Nissen, Anabela Barcelos, Irene van der Horst-Bruinsma, Sara Nysom Christiansen, Isabel Castrejón, Sella Aarrestad Provan, Heikki Relas, Simon Horskjær Rasmussen, Ismail Sari, Anna-Mari Hokkanen, Johan K Wallman, Sigrid Vorobjov, Marion Pons, Marleen van de Sande, Corina Mogosan, Lucia Otero-Varela, Karin Laas, Yesim Erez, Katja Perdan Pirkmajer

“…Objectives To compare the treatment effectiveness of secukinumab in radiographic (r) versus non-radiographic (nr) axial spondyloarthritis (axSpA) patients treated in routine care across Europe.Methods Prospectively collected data on secukinumab-treated axSpA patients with known radiographic status were pooled from nine countries.Remission rates based on patient-reported outcomes (PROs; Numeric Rating Scale (0–10), for example, pain ≤2/Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) ≤2 and Ankylosing Spondylitis Disease Activity Score (ASDAS) inactive disease (ID) <1.3 after 6/12/24 months of secukinumab treatment were calculated.Remission and drug retention rates in r-axSpA versus nr-axSpA patients were compared by logistic and Cox regression models (unadjusted/adjusted for age+sex/adjusted for multiple confounders).Results Overall, 1161 secukinumab-treated patients were included (r-axSpA/nr-axSpA: 922/239). …”
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Dynamics of neutralizing antibodies against COVID-19 Omicron subvariants following breakthrough infection in southwest China between December 2022 and April 2024 by Yongquan He, Yi Yin, Yi Zhang, Huiping Yang, Zhiling Jiang, Fang Hao, Taiqiang Zhao, Xiaobin Liu, Yusong Liu, Yong Zeng, Xi Li, Xuemei Chen, Kaiju Xu, Chang Tan, Jie Yang, Li Jiang, Bo Gong, Zhenglin Yang

“…While most COVID-19 patients experienced mild symptoms and were treated as outpatients or at home, some cases progressed to severe illness, necessitating hospitalization or even resulting in death. …”
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Comprehensive molecular portrait reveals genetic diversity and distinct molecular subtypes of small intestinal neuroendocrine tumors by Céline Patte, Roxane M. Pommier, Anthony Ferrari, Felicia Fei-Lei Chung, Maria Ouzounova, Pauline Moullé, Mathieu Richaud, Rita Khoueiry, Maëva Hervieu, Silvia Breusa, Marion Allio, Nicolas Rama, Laura Gérard, Valérie Hervieu, Gilles Poncet, Tanguy Fenouil, Vincent Cahais, Anne-Sophie Sertier, Anne Boland, Delphine Bacq-Daian, Benjamin Ducarouge, Julien C. Marie, Jean-François Deleuze, Alain Viari, Jean-Yves Scoazec, Colette Roche, Patrick Mehlen, Thomas Walter, Benjamin Gibert

“…This latter subtype displays the worst prognosis and resistance to treatments in line with infiltration of cancer-associated fibroblasts. These data provide insights into the origin and diversity of these rare diseases, in the hope of improving clinical research into their management.…”
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Potential Hematopoietic Effects of SGLT2 Inhibitors in Patients with Cardiac Amyloidosis by Nikita Ermolaev, Robin Willixhofer, Christoph Krall, Christina Kronberger, René Rettl, Christina Binder, Franz Duca, Christian Nitsche, Andreas Kammerlander, Michael Poledniczek, Bernhard Gregshammer, Diana Ahmadi-Fazel, Mahshid Eslami, Luciana Camuz Ligios, Johannes Kastner, Jutta Bergler-Klein, Roza Badr Eslam

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Potency and Safety of G12C Inhibitors in Solid Tumors: A Systematic Review by Sara El Zaitouni, Abdelilah Laraqui, Youssra Boustany, Soukaina Benmokhtar, Hicham El Annaz, Rachid Abi, Mohamed Rida Tagajdid, Safae El Kochri, El Arbi Bouaiti, Idriss Lahlou Amine, Rabii Ameziane El Hassani, Khalid Ennibi

“…We review the available clinical trials data on KRAS G12C inhibitors in KRAS G12C-mutated solid tumors. …”
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Results of a non-interventional multicenter observational study on the diagnosis and treatment of patients with axial psoriatic arthritis in rea-world clinical practice in the Russ... by T. V. Korotaeva, E. E. Gubar, E. Yu. Loginova, Yu. L. Korsakova, E. A. Vasilenko, I.-D. Yu. Ilyevsky, L. V. Ivanova, E. Yu. Akulinushkina, P. А. Shesternya, O. V. Matveychuk, Yu. Yu. Grabovetskaya, A. A. Barakat, M. A. Korolev, E. V. Zonova, O. A. Georginova, I. V. Kolotilina, I. M. Marusenko, I. B. Vinogradova, O. B. Nesmeyanova, N. E. Grigoriadi, A. V. Petrov, D. G. Krechikova, T. V. Kropotina, S. P. Yakupova, V. I. Mazurov

“…In 40.5% of patients, axial skeletal involvement in PsA was over-diagnosed due to misinterpretation of clinical and imaging data. The vast majority of patients (77%) were treated with synthetic disease-modifying antirheumatic drugs, mainly methotrexate, which do not affect the activity of spondylitis. …”
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Digital education and exercise therapy versus minimal intervention for young people at high risk of early onset knee osteoarthritis after ACL reconstruction: a study protocol for t... by Jackie L. Whittaker, Amanda Cammalleri, Candice Archibald, Alexandra Brooks-Hill, Patrick Chin, Sarah Clark, Jennifer C. Davis, Alison M. Hoens, Michael A. Hunt, Karin Kausky, Angelina Ko, Lise Leveille, Linda C. Li, Parth Lodhia, Justin M. Losciale, Maxi Miciak, Amber D. Mosewich, Adnan Sheikh, Trish Silvester-Lee, Linda K. Truong, Dominic Wade, David R. Wilson, Hui Xie, Xian He Yan, Ewa M. Roos

“…We will also assess secondary implementation (perceived barriers and facilitators of SOAR delivery), secondary efficiency (incremental cost-utility ratio), and exploratory outcomes. Missing data will be imputed and blinded intention-to-treat analyses performed. …”
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The role of irregular eating behaviors in metabolic dysfunction-associated steatotic liver disease: evidence from a multicenter cross-sectional study in China by Xingxing Ren, Miao Zhang, Xiaoyang Sun, Lili Zheng, Yufang Bi, Qiang Li, Lirong Sun, Fusheng Di, Yushan Xu, Dalong Zhu, Yanyan Gao, Yuqian Bao, Yao Wang, Lanjie He, Xin Gao, Jian Gao, Mingfeng Xia, Hua Bian

“…Methods In this multicenter cross-sectional study, we analyzed data from 1965 adults recruited from diabetes, obesity, and metabolic disease clinics in six municipalities/provinces in China. …”
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Clinical manifestations and prognosis of giant cell arteritis: A retrospective cohort study by E. E. Filatova, N. M. Bulanov, A. D. Meshkov, O. O. Borodin, I. O. Smitienko, E. V. Chachilo, A. A. Nartov, A. L. Filatova, A. V. Naumov, P. I. Novikov, S. V. Moiseev

“…GCs therapy was performed in all patients who agreed to be treated (n=158), methotrexate was used in 49 out of 158 patients, leflunomide – in 9 patients. …”
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CRISPR/Cas9-mediated knockout of SLC15A4 gene involved in the immune response in bovine rumen epithelial cells by Mao-cheng JIANG, Zi-xuan HU, Ke-xin WANG, Tian-yu YANG, Miao LIN, Kang ZHAN, Guo-qi ZHAO

“…In order to gain further insight into the potential function of SLC15A4, we utilized transcriptome data, which revealed a change in the genes between WT-BRECs and SLC15A4-KO. …”
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The Efficacy and Safety of Tolvaptan in Heart Failure Patients with Congestive Signs: A Systematic Review and Meta-Analysis of Randomized Controlled Trials by Mei Zeng, Na Li, Tongshuai Chen, Yun Ti, Chunmei Zhang, Peili Bu

“…The PubMed, Embase, Cochrane Library, and ClinicalTrials.gov databases were searched to collect data from all randomized controlled trials (RCT) examining the efficacy and safety of tolvaptan in heart failure patients with congestive signs compared with placebo or blank control until March 4, 2021. …”
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S1PR4-dependent effects of Etrasimod on primary human myeloid immune cell activation by Fiona K. Sailer, Megan A. Palmer, Blerina Aliraj, Jan Heering, Jan Heering, Andreas Brockmann, Mohammed A. F. Elewa, Mohammed A. F. Elewa, Aissa Röhrig, Aissa Röhrig, Ewgenij Proschak, Ewgenij Proschak, Ewgenij Proschak, Dariusz T. Stepniak, Simeon Ramsey, Bernhard Brüne, Bernhard Brüne, Andreas Weigert

“…Regarding receptor dynamics, we show that Etrasimod induces internalization of S1PR4.ConclusionTaken together, our data show that S1PR4 takes on an essential role in the regulation of various immunological functions, and that Etrasimod can act as a superagonist/functional antagonist of S1PR4.…”
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Infrapyloric lymph node dissection for colon cancer of hepatic flexure in laparoscopic extended right hemicolectomy with D3 lymph node dissection of right colon cancer by Yi Xiaojiang, Feng Xiaochuang, Li Hongming, Liao Weilin, Lu Xinquan, Wang Jiahao, Lin Jiaxin, Diao Dechang

“…[Objectives] To summerize the clinical data of patients with colon cancer of hepatic flexure underwent infrapyloric lymph node dissection in laparoscopic extended right hemicolectomy with D3 lymph node dissection of right colon cancer, aiming to provide reference for clinical diagnosis and treatment. …”
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Comparison of axicabtagene ciloleucel and tisagenlecleucel patient CAR-T cell products by single-cell RNA sequencing by Xuefeng Wang, Paulo C Rodriguez, Frederick L Locke, Xiaoqing Yu, Marco L Davila, Salvatore Corallo, Bijal Shah, Kayla Reid, Michael D Jain, Sean J Yoder, Chaomei Zhang, Reginald Atkins, Meghan A Menges, Ling Cen, Jerald D Noble, Turab J Mohammad, Christina A Bachmeier, Samira Naderinezhad, Lanmin Zhang, Julieta Abraham Miranda, Julio C Chavez, Rebecca S Hesterberg, Luis Cuadrado Delgado, Constanza Savid-Frontera, John L Cleveland

“…Prolonged time in expansion culture, as used during tisa-cel manufacturing, greatly decreased naïve and central memory T-cell subsets.Conclusions Following manufacture, axi-cel is less differentiated and has greater immune activation compared with tisa-cel, potentially accounting for its greater efficacy and toxicity in patients. Our data support the conclusion that tisa-cel is adversely affected by its manufacturing rather than by the CAR construct.…”
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Moving Beyond G‐CSF Mobilization—Learning From a 15‐Year Experience of Different Stem Cell Mobilization Regimens in Multiple Myeloma by Sumeet Mirgh, Bhausaheb Bagal, Sachin Punatar, Anant Gokarn, Nishant Jindal, Akanksha Chichra, Lingaraj Nayak, Sumathi Hiregoudar, Minal Poojary, Suryatapa Saha, Sarika Parab, Shashank Ojha, Prashant Tembhare, Nikhil Patkar, Sweta Rajpal, Gaurav Chatterjee, Libin Mathew, Papagudi Subramanian, Navin Khattry

“…ABSTRACT Background Stem‐cell mobilization in multiple myeloma is usually done with G‐CSF with or without Cyclophosphamide (Cy) based chemotherapy/Plerixafor. Pre‐clinical data suggest the role of proteasome inhibitors in mobilization. …”
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