OCT predictors of retinal atrophy in neovascular age-related macular degeneration treated with aflibercept by Oscar M. Gagliardi, Ludovico Alisi, Giacomo Visioli, Federica Dini, Giuseppe M. Albanese, Stefano Scordari, Marco Marenco, Alessandro Lambiase, Rosalia Giustolisi

“…AIM: To identify optical coherence tomography (OCT) features present at the diagnosis of neovascular age-related macular degeneration (nAMD) that could predict retinal atrophy (RA) and visual performance in patients treated with intravitreal aflibercept. METHODS: OCT data collected at the time of nAMD diagnosis (T0), after the first (T1) and third (T2) intravitreal aflibercept injection, and 5y post-diagnosis (T3) were analyzed. …”
Get full text

Methylation-based biological age and cardiotoxicity risk in breast cancer patients treated with trastuzumab by Jamila Mammadova, Alicia Richards, Adriana Gonzalez-Torriente, Evan R. Adler, Rachel J. Cruz, Stefanie Palfi, Dae Hyun Lee, Christine Sam, Mohammed Al-Jumayli, Anders Berglund, Jong Y Park, Mohammed Alomar, Jacob K. Kresovich

“…Epigenetic clocks and circulating leukocyte subsets were derived from MethylationEPIC BeadChip data, and candidate SNPs were measured using the Global Screening Array. …”
Get full text

Primary prevention of cardiotoxicity in cancer patients treated with fluoropyrimidines: a randomized controlled trial by Johanne D. Lyhne, Vibeke B. Hansen, Lone D. Vestergaard, Susanne E. Hosbond, Martin Busk, Mayooran Gnanaganesh, Else Maae, Birgitte M. Havelund, Torben F. Hansen, Signe Timm, Lars H. Jensen, Mads D. Lyhne

“…Follow-up was 6 months. Data were analyzed using Kaplan–Meier survival function with log-rank test and ROC-analyses. …”
Get full text

Cytokine Pattern of T Lymphocytes in Acute Schistosomiasis mansoni Patients following Treated Praziquantel Therapy by Denise Silveira-Lemos, Matheus Fernandes Costa-Silva, Amanda Cardoso de Oliveira Silveira, Mauricio Azevedo Batista, Lúcia Alves Oliveira-Fraga, Alda Maria Soares Silveira, Maria Carolina Barbosa Alvarez, Olindo Assis Martins-Filho, Giovanni Gazzinelli, Rodrigo Corrêa-Oliveira, Andréa Teixeira-Carvalho

“…Interestingly, we have observed that patients treated with praziquantel showed increased values of lymphocytes as compared with noninfected group (NI) or ACT groups. …”
Get full text

Impact of HLA alloimmunization on clinical outcomes of severe aplastic anemia treated with immunosuppressive therapy by Jibran Durrani, Leonard N. Chen, Ruba N. Shalhoub, Valentina Baez, Joshua Glass, Nu Ri Cha, Xiaoyang Ma, Zhijie Wu, Shouguo Gao, Jennifer Lotter, Olga Rios, Colin O. Wu, Willy A. Flegel, Neal S. Young, Emma M. Groarke, Bhavisha A. Patel

“…Of 444 patients with severe AA treated with immunosuppressive therapy (IST), 99 (22%) had HLA alloimmunization. …”
Get full text

Durvalumab activity in previously treated patients who stopped durvalumab without disease progression by Jean-Charles Soria, Ashok Gupta, Siddharth Sheth, Chen Gao, Nancy Mueller, Natasha Angra, Caroline Germa, Pablo Martinez

“…Background Limited data exist on potential clinical benefit with anti-programmed cell death ligand-1 (PD-L1) retreatment in patients who stop initial therapy for reasons other than disease progression or toxicity and develop disease progression while off treatment.Patients and methods NCT01693562 was a phase I/II study evaluating durvalumab monotherapy in advanced solid tumors. …”
Get full text

Cytokine profile of COVID-19 convalescent plasma and its relationship to outcome of treated patients by Michael P. Potapnev, A. V. Maximovich, I. A. Dunayeu, L. M. Hushchina, F. N. Karpenko

“…Materials and methods. The study included data from 111 patients with COVID-19 who received CCP. …”
Get full text

CYP2D6 genotype and outcome in tamoxifen treated early breast cancer by Linda Thorén, Jonatan D. Lindh, Espen Molden, Marianne Kristiansen Kringen, Jonas Bergh, Erik Eliasson, Sara Margolin

“…Clinical information was collected from medical records. Data on endocrine treatment, use of CYP2D6 inhibitors was retrieved from the Swedish Prescribed Drug Register. …”
Get full text

High-resolution analysis of the treated coeliac disease microbiome reveals strain-level variation by Jelle Slager, Hanna L. Simpson, Ranko Gacesa, Lianmin Chen, Ineke L. Tan, Jody Gelderloos, Astrid Maatman, Cisca Wijmenga, Alexandra Zhernakova, Jingyuan Fu, Rinse K. Weersma, Gieneke Gonera, Iris H. Jonkers, Sebo Withoff

“…CeD onset results from a multifaceted interplay of genetic and environmental factors. While recent data show that alterations in gut microbiome composition could play an important role, many current studies are constrained by small sample sizes and limited resolution.Methods To address these limitations, we analyzed fecal gut microbiota from two Dutch cohorts, CeDNN (128 treated CeD patients (tCeD), 106 controls) and the Lifelines Dutch Microbiome Project (24 self-reported tCeD, 654 controls), using shotgun metagenomic sequencing. …”
Get full text

Evaluation of grip strength in hook of hamate fractures treated with osteosynthesis. Is this surgical treatment necessary? by Claudia Lamas-Gómez, Laura Velasco-González, Aranzazu González-Osuna, Marta Almenara-Fernández, Luis Trigo-Lahoz, Xavier Aguilera-Roig

“…Results: The mean follow-up was 36 months (range, 12–144 months). All 13 cases were treated with ORIF of the hook of the hamate. Mean VAS pain score was 5 preoperatively (4–9) and 1 (0–2) postoperatively. …”
Get full text

ART to prevent vertical transmission in Latin America: where are we in the “Treat‐All” era? by Gabriel Castillo‐Rozas M.D. Ph.D., Fernanda F. Fonseca M.D., Jessica Castilho M.D. M.P.H., Peter F. Rebeiro Ph.D, Daisy M. Machado M.D. Ph.D., Marco Tulio Luque M.D., Emilia M. Jalil M.D. Ph.D., Fernando Mejia M.D., Ahra Kim M.P.H., Bryan E. Shepherd Ph.D, Claudia P. Cortes M.D.

“…In the pre‐treat‐all era, 4.3% (21/485) of infants were born HIV positive, compared to 0.8% (1/128) in the treat‐all era (p = 0.055). …”
Get full text

Splenic volume as a predictor of survival in cancer patients treated with immune checkpoint inhibitors by Yunhua Zhang, Yunhua Zhang, Yunhua Zhang, Xin Fu, Lilong Zhang, Lilong Zhang, Lilong Zhang, Qing Zhou, Qing Zhou, Qing Zhou, Weixing Wang, Weixing Wang, Weixing Wang

“…The meta-analysis results revealed that subjects with higher spleen volumes had a significantly reduced OS (HR: 1.74, 95% CI: 1.12–2.72, p = 0.014) and PFS (HR: 1.35, 95% CI: 1.15–1.58, p < 0.001) compared to counterparts with lower volumes. Furthermore, the data clearly highlighted that patients with increases in splenic volume faced significantly poorer clinical outcomes, as indicated by reduced OS (HR: 1.83, 95% CI: 1.36–2.46, p < 0.001) and PFS (HR: 1.70, 95% CI: 1.28–2.25, p < 0.001) relative to those with decreases in splenic size.ConclusionA higher baseline spleen volume and an increase in spleen volume during ICI therapy were predictors of a poor prognosis in cancer patients treated with ICI.…”
Get full text

Impact of vein-to-vein time in patients with R/R LBCL treated with axicabtagene ciloleucel by Frederick L. Locke, Tanya Siddiqi, Caron A. Jacobson, Sarah Nikiforow, Sairah Ahmed, David B. Miklos, Yi Lin, Matthew A. Lunning, Brian T. Hill, Armin Ghobadi, Zhen-Huan Hu, Michael T. Hemmer, Michael J. Zoratti, Suresh Vunnum, Jonathan Tsang, Clare Spooner, Harry Smith, Christine Fu, Anik Patel, Harry Miao, Shilpa A. Shahani, Debbie L. Mirjah, Hairong Xu, Marcelo C. Pasquini

“…We conducted a systematic literature review (SLR) and meta-analysis to identify differences in V2Vt in patients with R/R LBCL treated with axi-cel, tisa-cel, or liso-cel. The impact of V2Vt (<28 days vs ≥28 to <40 days vs ≥40 days) on effectiveness and safety outcomes was evaluated in patients treated with axi-cel enrolled in a post-authorization safety study using the Center for International Blood and Marrow Transplant Research data. …”
Get full text

Real-world analysis of strategies to prevent thrombosis and bleeding in adults with ALL treated with asparaginase by Joseph F. Mort, David Brighton, Benjamin Mautner, Eric Pierce, Farid Ghamsari, Cecily Allen, Darren D’Souza, Imari Patel, Justin Lawson, Clayton Jackson, Karin Abernathy, Bradley Yelvington, Ryan Miller, Bhagirathbhai Dholaria, Heather Wolfe, Jordan Infield, Susan C. Locke, Rory M. Shallis, Vu H. Duong, Daniel R. Reed, Katherine Walsh, Thomas W. LeBlanc, Michael Keng, Bethany Horton, Firas El Chaer

Get full text

Association of BMI with adherence and outcome in heart failure patients treated with wearable cardioverter defibrillator by Mohammad Abumayyaleh, Katharina Koepsel, Julia W. Erath, Thomas Kuntz, Norbert Klein, Boldizsar Kovacs, Firat Duru, Ardan M. Saguner, Christian Blockhaus, Dong‐In Shin, Fabienne Kreimer, Michael Gotzmann, Hendrik Lapp, Thomas Beiert, Assem Aweimer, Andreas Mügge, Christel Weiß, Ibrahim El‐Battrawy, Ibrahim Akin

“…Methods In a multicentre international registry, we retrospectively collected data from a consecutive series of 1003 patients. …”
Get full text

Characterizations of multi-kingdom gut microbiota in immune checkpoint inhibitor-treated hepatocellular carcinoma by Longhao Zhang, Shanshan Wang, Yajun Liang, Xiaobo Yang, Haitao Zhao, Xinting Sang, Dongya Zhang, Zhou Lan, Hanping Wang, Ziyu Xun, Chenchen Zhang, Chengpei Zhu, Jiashuo Chao, Zilun Pu, Cong Ning, Xianzhi Jiang

“…Herein, we investigated the multi-kingdom microbiota characterization of the gut microbiome, mycobiome, and metabolome using metagenomic, ITS2, and metabolomic data sets of 80 patients with ICI-treated HCC.Results Our findings demonstrated that bacteria and metabolites differed significantly between the durable clinical benefit (DCB) and non-durable clinical benefit (NDB) groups, whereas the differences were smaller for fungi. …”
Get full text

[Translated article] Musculoskeletal injuries treated following the flood in October 2024 in Valencia, Spain by J.F. Garrido Ferrer, J. Diranzo García, X. Bertó Martí, L. Marco Díaz, L. Hernández Ferrando

“…Introduction: The aim of this study was to describe and analyze the musculoskeletal injuries treated at a tertiary hospital, resulting from the sudden flooding and landslides that occurred on October 29, 2024, in the province of Valencia, Spain. …”
Get full text

Different features of acute myeloid leukemia stem cell quantification in intensively treated patients by Lok Lam Ngai, Tom Reuvekamp, Diana Hanekamp, Fleur Janssen, Laura Oudshoorn-van Marsbergen, Jannemieke Carbaat-Ham, Maaike A.M. Hofland, Mona M.H.E. Fayed, Angèle Kelder, Willemijn J. Scholten, Alexander N. Snel, Costa Bachas, Jesse M. Tettero, Dimitri A. Breems, Thomas Fischer, Bjørn T. Gjertsen, Laimonas Griškevičius, Gunnar Juliusson, Arjan A. van de Loosdrecht, Johan A. Maertens, Markus G. Manz, Thomas Pabst, Jakob R. Passweg, Kimmo Porkka, Peter J.M. Valk, Patrycja Gradowska, Bob Löwenberg, Gert J. Ossenkoppele, David C. de Leeuw, Jacqueline Cloos

Get full text

Effect of DNA methylation on inhibitor development in people with hemophilia A treated with FVIII concentrates by Himani Chand, Shermarke Hassan, Andrea Cairo, Roberta Palla, Flora Peyvandi, Flora Peyvandi, Pier M. Mannucci, Isabella Garagiola, Amal El-Beshlawy, Mohsen Elalfy, Vijay Ramanan, Peyman Eshghi, Suresh Hanagavadi, Ramabadran Varadarajan, Mehran Karimi, Mamta V. Manglani, Cecil Ross, Guy Young, Tulika Seth, Shashikant Apte, Dinesh M. Nayak, Elena Santagostino, Maria Elisa Mancuso, Adriana C. Sandoval Gonzalez, Johnny N. Mahlangu, Santiago Bonanad Boix, Monica Cerqueira, Nadia P. Ewing, Christoph Male, Tarek Owaidah, Veronica Soto Arellano, Nathan L. Kobrinsky, Suvankar Majumdar, Rosario Perez Garrido, Anupam Sachdeva, Mindy Simpson, Mathew Thomas, Ezio Zanon, Bulent Antmen, Kaan Kavakli, Marilyn J. Manco-Johnson, Monica Martinez, Esperanza Marzouka, Maria G. Mazzucconi, Daniela Neme, Angeles Palomo Bravo, Rogelio Paredes Aguilera, Alessandra Prezotti, Klaus Schmitt, Brian M. Wicklund, Bulent Zulfikar, Frits R. Rosendaal

Get full text

Mechanical treated natural kapok fiber with Ep through oil-milling process for bio-based modified asphalt: Analysis of ageing resistance and Ep releasing by Shun Chen, Wentian Wang, Xingyang He, Ying Su, Hui Xu, Yingjie Wang, Yiming Cao, Bo Jiang, Sang-keun Oh

Get full text