Age-Specific Clinical and Laboratory Features and Renal Involvement in Children with MIS-C: A Single Tertiary Centre Experience from Vojvodina by Borko Milanović, Vesna Stojanović, Gordana Vijatov-Ðurić, Marijana Savin, Andrea Ðuretić, Jelena Kesić, Nenad Barišić, Ognjen Ležakov, Ivana Vorgučin, Gordana Vilotijević-Dautović, Katarina Koprivšek

“…<i>Conclusions</i>: There are pronounced age-related differences in the clinical presentation of MIS-C, with distinct immune and clinical patterns suggesting developmental influences on disease expression and outcomes. …”
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Organ-system-based subclassification of preeclampsia using machine learning predicts pregnancy outcomes by Yanhong Xu, Yizheng Zu, Xiaosi Lu, Yiping Wang, Jiaying Zheng, Xia Xu, Jianying Yan

“…Conclusions Machine learning identified distinct PE subclasses based on organ system dysfunction patterns, each demonstrating unique pregnancy outcomes. …”
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Global frequency, diagnosis, and treatment of hereditary angioedema with normal C1 inhibitor by Markus Magerl, MD, Marc A. Riedl, MD, MS, Luisa Karla Arruda, MD, PhD, Andrea Bauer, MD, MPH, Alejandro Berardi, MD, Jonathan A. Bernstein, MD, Laurence Bouillet, MD, PhD, Matthew Buckland, PhD, Thomas Buttgereit, MD, Danny M. Cohn, MD, PhD, Timothy Craig, DO, Roberta F. Criado, MD, PhD, Aurélie Du-Thanh, MD, PhD, Olivier Fain, MD, Margarida Gonçalo, MD, PhD, Jens Greve, MD, Anete Sevciovic Grumach, MD, PhD, Mar Guilarte, MD, PhD, Constance Katelaris, MD, PhD, Tamar Kinaciyan, MD, Elena A. Latysheva, MD, Ramon Lleonart, MD, Oscar Calderón Llosa, MD, Eli Mansour, MD, PhD, Vesna Grivcheva-Panovska, MD, PhD, Claudio Parisi, MD, Nelson Augusto Rosario Filho, MD, PhD, Amélia Spínola Santos, MD, Petra Staubach, MD, Anna Valerieva, MD, PhD, Solange Oliveira Rodrigues Valle, MD, PhD, Sherry Danese, MBA, Julie Ulloa, Paul K. Audhya, MD, MBA, Marcus Maurer, MD

“…Objective: This study sought to describe the global frequency, diagnostic pathway, and current treatment patterns of HAE-nC1INH. Methods: Board-certified HAE-treating physicians from accredited Angioedema Centers of Reference and Excellence (ACAREs) were invited to complete a 27-item online survey between December 2022 and April 2023. …”
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Effects of ADMA upon gene expression: an insight into the pathophysiological significance of raised plasma ADMA. by Caroline L Smith, Shelagh Anthony, Mike Hubank, James M Leiper, Patrick Vallance

“…We detected specific patterns of changes that identify pathways involved in processes relevant to cardiovascular risk and pulmonary hypertension. …”
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Upper Crossed Syndrome and Scapulae Upper-Trapping: A Mesotherapy Protocol in Cervicoscapulobrachial Pain—The 8:1 Block by Luyddy Pires, Napoliane Santos, João Vitor Lana, Alex Pontes de Macedo, Fábio Ramos Costa, Gabriel Ohana Marques Azzini, Tomas Mosaner, Daniel de Moraes Ferreira Jorge, Gabriel Silva Santos, Arthur Medeiros, José Alexandre Reale Pereira, José Fábio Lana

“…Patients reported significant improvements in pain relief and functional outcomes, underscoring the clinical utility of the 8:1 block in treating cervicoscapulobrachialgia. This protocol offers a feasible, cost-effective intervention that enhances the efficacy of traditional therapeutic exercises by addressing underlying muscular and biomechanical dysfunctions. …”
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Autoimmune Pulmonary Alveolar Proteinosis: A Rare Diagnosis in Pediatric Age by Inês Pais-Cunha, Augusta Gonçalves, Sara Paulino, José Fontoura Matias, Silva Sónia, Catarina Ferraz, Inês Azevedo

“…Spirometry indicated a mild restrictive pattern (forced vital capacity [FVC] = 77%) and diffusing capacity of the lungs for carbon monoxide (DLCO) showed a moderate decrease at 48.6%. …”
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Synergistic Effects of Low-Frequency Ultrasound and Therapeutic Agents on Endothelial and Renal Cells: Emphasis on Cell Functionality, Oxidative Stress, and Inflammatory Markers by Ieva Čiapienė, Joris Vėžys, Vaiva Lesauskaitė, Indrė Matulevičiūtė, Ugnė Meškauskaitė, Vilius Skipskis, Arvydas Strazdauskas, Sonata Trumbeckaitė, Algimantas Bubulis, Vytautas Jūrėnas, Vytautas Ostaševičius, Vytenis Tamakauskas, Vacis Tatarūnas

“…Endothelial dysfunction contributes to CMD, impairing vascular tone and increasing inflammation. …”
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Appropriateness of Antiplatelet Therapy and Proton Pump Inhibitor Prescribing in End-Stage Kidney Disease: A Retrospective Quality Investigation Study by Michael Che, Sumaiya Ahmed, Ryan Chan, Ayub Akbari, Deborah Zimmerman

“…Overall, it appears that prescribing patterns of DAPT and PPI at our center are unlikely to be a major contributor to the known increased risk of gastrointestinal bleeding in patients treated with hemodialysis. …”
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Clinical features of non-compaction cardiomyopathy across age groups: a retrospective study of 415 patients by Ying Li, Jimei Chen, Min Qiu, Miao Tian, Ziqin Zhou, Ruyue Zhang, Jiazichao Tu, Linjiang Han, Shuheng Zhou, Xinming Li, Jian Zhuang, Shusheng Wen

“…A significant correlation was observed between both LVESD and LVEDD measurements and MR area in patients with NCM (p&lt;0.05).Conclusion Patients with NCM with concomitant MR consistently exhibited left ventricular dilatation and systolic dysfunction across all age groups. Significant age-related variations were observed in clinical presentations, arrhythmia patterns and the prevalence of congenital and valvular heart disease. …”
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Gradient changes in bioprosthetic valve thrombosis: duration of anticoagulation and strategies to improve detection by Vuyisile T Nkomo, Alexander C Egbe, Heidi M Connolly, Patricia A Pellikka, Sorin V Pislaru, Filip Ionescu, Hartzell V Schaff, Ioana Petrescu, Jwan A Naser, Cristina Pislaru

“…We set forth to (1) evaluate patterns of increase in gradients prior to BPVT diagnosis and (2) characterise time-course of response to anticoagulation.Methods Patients treated with warfarin for BPVT (1999–2019) with clinically significant reduction of mean gradients (≥25%) were identified retrospectively. …”
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Temporal changes of spinal microglia in murine models of neuropathic pain: a scoping review by Simran Dhir, Simran Dhir, Hannah Derue, Hannah Derue, Alfredo Ribeiro-da-Silva, Alfredo Ribeiro-da-Silva

“…However, given the number of different NP models and the resource limitations that come with tracking longitudinal changes in NP animals, many studies fail to truly recapitulate the patterns that exist between pain conditions and temporal microglial changes. …”
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Reliability of Scapula Clinical Assessment and Effectiveness of Scapular-Focused Exercises in a Non-Athletic Population with Shoulder Pain – a Literature Review by Maciej Olszewski, Sara Gamrot, Joanna Golec, Elżbieta Szczygieł

“…Scapular movement abnormalities have been defined as scapular dyskinesis. It is treated as a dysfunction that increases the risk of shoulder pain. …”
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Significance of host antimicrobial peptides in the pathogenesis and treatment of acne vulgaris by Agata Lesiak, Paulina Paprocka, Urszula Wnorowska, Angelika Mańkowska, Grzegorz Król, Katarzyna Głuszek, Ewelina Piktel, Jakub Spałek, Jakub Spałek, Sławomir Okła, Sławomir Okła, Krzysztof Fiedoruk, Bonita Durnaś, Bonita Durnaś, Robert Bucki

“…We hypothesized that the increased expression of AMPs and their patterns in AV act as a compensatory mechanism to protect the skin with an impaired permeability barrier. …”
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Comparative effect of dietary fortification of raw and roasted seeds of pumpkin (Cucurbita pepo L) on fertility biomolecules in cisplatin-induced spermatotoxic rats by Seun Funmilola Akomolafe, Mary Aderonke Bola Ogundare, Ibikunle Akinlua, Oluwadamilare Oluwaseun Ajayi, Elijah Olalekan Odesanmi, Olusola Bolaji Adewale

“…However, studies have shown that dietary pattern plays a pivotal role in the protection of chemotherapy-induced testicular damage, and till date no report on the comparative effect of raw and roasted pumpkin seeds against chemotherapy-induced male infertility and reproductive dysfunction. …”
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Clinical Features of Liver Injury Induced by Immune Checkpoint Inhibitors in Japanese Patients by Koji Imoto, Motoyuki Kohjima, Tomonobu Hioki, Tomoyuki Kurashige, Miho Kurokawa, Shigeki Tashiro, Hideo Suzuki, Akifumi Kuwano, Masatake Tanaka, Seiji Okada, Masaki Kato, Yoshihiro Ogawa

“…Four patients in the case series showed diverse clinical features in terms of hepatotoxic pattern, symptoms, and the interval time between the initiation of immunotherapy and the onset of the hepatic irAE. …”
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Identification of a multiple DAMP scavenger mimicking the DAMP-binding site of TLR4 to ameliorate lethal sepsis by Takuya Murao, Gaifeng Ma, Atsushi Murao, Alok Jha, Jingsong Li, Yongchan Lee, Mian Zhou, Ping Wang, Ping Wang, Monowar Aziz, Monowar Aziz

“…Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. …”
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How to Apply the Sequential Correction Technique to Treatment of Congenital Cervicothoracic Scoliosis: A Technical Note and Case Series by Saihu Mao, Kai Sun, Song Li, Jie Zhou, Hongda Bao, Benlong Shi, Xu Sun, Zhen Liu, Yong Qiu, Zezhang Zhu

“…ABSTRACT Objective Hemivertebrae in the cervicothoracic junction in the pediatric population are treated conventionally with a two‐rod instrumentation pattern. …”
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Voluntary Activity Wheel Running Improves Hyperammonaemia‐Induced Skeletal Muscle Molecular and Metabolic Perturbations in Mice by Annette Bellar, Avinash Kumar, Khaviyaa Chandramohan, Saurabh Mishra, Muaz Alsabbagh‐Alchirazi, Artem Astafev, Pugazhendhi Kannan, Amy Attaway, Roman Kondratov, Thomas Jaramillo, Lopa Mishra, Takhar Kasumov, Nicole Welch, Srinivasan Dasarathy

“…Wheel runs were measured, and weekly average rotations, distance, and circadian patterns were analysed. Indirect calorimetry was performed pre‐ and post‐intervention. …”
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Mucormycosis in COVID-19 patients: A cross-sectional study at IGIMS, Patna by Tajwar Yasmeen, Nidhi Prasad, Vikash Kumar, Setu Sinha, Shishir Kumar, Sanjay Kumar

“…Objective: To determine the sociodemographic and associated risk factors, pattern of disease, treatment of mucormycosis and outcome of individual at time of discharge and after three months and six months of follow-up. …”
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Hepatocyte necroptosis is associated with liver damage in dairy cows with ketosis by Menglin Liu, Jingmin Gu, Chenchen Zhao, Jinxia Li, Fanrong Kong, Xinyu Du, Dandan Qi, Enzhu Li, Jie Gao, Xiliang Du, Yuxiang Song, Guowen Liu, Wenwen Gao, Xinwei Li, Lin Lei

“…Necroptosis, a form of programmed cell death associated with cellular lysis, releases damage-associated molecular patterns (DAMP) into injured tissues, thereby amplifying inflammatory responses and tissue damage. …”
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