Heart Failure with Preserved Left Ventricular Ejection Fraction: A Complex Conundrum Simply Not Limited to Diastolic Dysfunction by Angel Lopez-Candales, Talal Asif, Khalid Sawalha, Nicholas B. Norgard

“…Over the last two decades, the changing paradigm of heart failure with preserved ejection fraction (HFpEF) has transformed our understanding not only of the pathophysiology of this clinical entity but also the diagnostic and therapeutic approaches aimed at treating this complex patient population. No longer HFpEF should be seen as simply left ventricular diastolic dysfunction but as a group of that in addition of having small and thick left ventricles with abnormal diastolic filling patterns as their main pathophysiologic abnormality; they also have whole host of different abnormalities. …”
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Persistence of Olfactory Dysfunction in Post CoVid-19 Patients Using Sniffin Sticks-A Prospective Study by Priyanka Thangaraj, Sowmya Gajapathy, Jayita Das Poduval

“…CONCLUSION Knowledge about time pattern on the recovery of OD in Post CoVid patients will be essential in counselling and treating them. …”
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Enantioselective toxicity of (S)-amlodipine towards zebrafish embryos: Abnormal ocular development, cardiac dysfunction, and malformed intersegmental vessels by Chaeeun Kim, Donghyeon Kim, Sung-Eun Lee

“…Enantioselective toxicity was evident in cardiac function, as (S)-AM-induced heart dysfunction, despite both enantiomers displaying similar patterns of heart development-related gene expression. …”
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Edaravone Improves Streptozotocin-Induced Memory Impairment via Alleviation of Behavioral Dysfunction, Oxidative Stress, Inflammation, and Histopathological Parameters by Mahdieh Anoush, Soroush Bijani, Fatemeh Moslemifar, Fatemeh Jahanpour, Ali Kalantari-Hesari, Mir-Jamal Hosseini

“…It was supposed that EDV managed to ameliorate memory dysfunction, discriminatory behavior, oxidative stress, and cellular antioxidant power in a dose-independent pattern in mice.…”
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Functioning in patients with major depression treated with duloxetine or a selective serotonin reuptake inhibitor in East Asia by Novick D, Montgomery W, Haro JM, Moneta MV, Zhu G, Yue L, Hong J, Duenas H, Brugnoli R

“…This treatment difference was more apparent in the subgroup of patients with PPS at baseline. Similar patterns were also observed for SDS subscores (work, social life, and family life).Conclusion: Depressed patients treated with duloxetine achieved better functioning compared to those treated with SSRIs. …”
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Prioritizing FDA approved therapeutics for treating sepsis phenotypes: A network modeling approach based on neutrophil proteomics by Jordan C. Langston, Dan Liu, Qingliang Yang, Salim Merali, Carmen Merali, Narender Singh, Jennifer L. Fisher, Balabhaskar Prabhakarpandian, Laurie E. Kilpatrick, Mohammad F. Kiani, Mohammad F. Kiani

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National Trends in Medication Prescriptions for Male Lower Urinary Tract Symptoms and Erectile Dysfunction: Findings from the Norwegian Prescription Database by Patrick Juliebø-Jones, Ingunn Roth, Christian Arvei Moen, Peder Gjengstø, Christian Beisland

“…Patient summary: In Norway, there were increasing trends in the use of medications to treat benign prostate enlargement (BPE), erectile dysfunction, and urinary incontinence between 2004 and 2020. …”
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Expression of matrix metalloproteinases 1, 2, 9, 12 in xenogenic tissues of epoxy-crosslinked bioprosthetic heart valves explanted due to dysfunction by A. E. Kostyunin, T. V. Glushkova

“…To study the expression patterns of matrix metalloproteinases (MMPs) -1, -2, -9, -12 in the leaflets of the epoxy-treated bioprostheses explanted due to dysfunction and to identify the pathways for the accumulation of these enzymes in the xenogenic tissues.Methods. 19 leaflets from seven epoxy-treated bioprostheses (Kemcor (n = 2), PeriCor (n = 2), UniLine (n = 2) and TiAra (n = 1)) explanted from the mitral or aortic positions during repeat heart valve replacements were included in a study. …”
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The role of irregular eating behaviors in metabolic dysfunction-associated steatotic liver disease: evidence from a multicenter cross-sectional study in China by Xingxing Ren, Miao Zhang, Xiaoyang Sun, Lili Zheng, Yufang Bi, Qiang Li, Lirong Sun, Fusheng Di, Yushan Xu, Dalong Zhu, Yanyan Gao, Yuqian Bao, Yao Wang, Lanjie He, Xin Gao, Jian Gao, Mingfeng Xia, Hua Bian

“…Abstract Background Irregular eating patterns, such as skipping breakfast and late dinner consumption, have been linked to adverse metabolic profiles. …”
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Interactions between Endoplasmic Reticulum Stress and Autophagy: Implications for Apoptosis and Neuroplasticity-Related Proteins in Palmitic Acid-Treated Prefrontal Cells by Xiangli Xue, Feng Li, Ming Cai, Jingyun Hu, Qian Wang, Shujie Lou

“…The present study illustrated that both ER stress and autophagy could be involved in apoptosis and decreased neuroplasticity-related proteins, and the interaction between ER stress and autophagy may play a critical role in apoptosis in PA-treated prefrontal cells. Our results provide new insights into the molecular mechanisms in vitro of lipotoxicity in obesity-related cognitive dysfunction.…”
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Inflammatory signaling pathways in pancreatic β-cell: New insights into type 2 diabetes pathogenesis by Jie Chen, Shinuan Fei, Lawrence W.C. Chan, Xueting Gan, Bibo Shao, Hong Jiang, Sheng Li, Peng Kuang, Xin Liu, Sijun Yang

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The adverse effects of metabolic disorder on left ventricular myocardial mechano-energetic efficiency and dysfunction in ischemic cardiomyopathy: insight from a cardiac MRI study by Li Jiang, Yuan Li, Xue-Ming Li, Ke Shi, Han Fang, Wei‑Feng Yan, Ying‑Kun Guo, Hua‑Yan Xu, Zhi-Gang Yang

“…Conclusions Our results revealed whether coexisting any MetF, rather than coexisting a greater number of MetF, is associated with the reduction of LV myocardial mechano-energetic efficiency and dysfunction in patients with ICM, suggesting that clinicians should promptly identify and treat any coexisting MetF in the management of ICM patients. …”
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Histological profiling of the extracellular matrix of streptozotocin-induced diabetic nephropathy in experimental mice and rats, an analytical study by Anas K. Al Makhzoomi

“…Diabetic nephropathy (DN) is characterized by dysfunction and a complication of the extracellular matrix (ECM) with an abnormal pattern of Glycosaminoglycan (GAG) synthesis. …”
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Morbid Jealousy in Alcohol Dependence: A Cross-sectional Study in Hospital-admitted Patients at a Rural Tertiary Health Center by Harshal Shriram Sathe, Akanksha Nagnath Tamshete, Nitisha Pramod Shirbhate, Gaurav Pawar

“…This study aims to explore the determinants of MJ in patients with alcohol dependence syndrome (ADS), focusing on its correlation with sociodemographic variables, drinking patterns and severity, sexual dysfunction, and couple satisfaction. …”
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Pulmonary hypertension associated with neurofibromatosis type 2 by Hirohisa Taniguchi, Tomoya Takashima, Ly Tu, Raphaël Thuillet, Asuka Furukawa, Yoshiko Furukawa, Akio Kawamura, Marc Humbert, Christophe Guignabert, Yuichi Tamura

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Four secondary malignancies, coronary artery disease, aortic atherosclerosis and severe constrictive pericarditis in a survivor of hodgkin lymphoma treated with radiation therapy:... by A. Jeri-Yabar, J. Garazatua-Gonzalez, W. Montoya-Rivera, V. Ortuzar-Seminario, C. Lozada Zingoni, V. Massuco

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Purinergic receptor antagonism reduces interictal discharges and rescues cognitive function in a mouse model of temporal lobe epilepsy by Nelson Espinosa, Soraya Martín-Suárez, Ariel Lara-Vasquez, Trinidad Montero, Teresa Muro-García, German Fernandez, Juan Manuel Encinas-Pérez, Juan Manuel Encinas-Pérez, Juan Manuel Encinas-Pérez, Pablo Fuentealba

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Oral administration of butylated hydroxytoluene induces neuroprotection in a streptozotocin-induced rat Alzheimer’s disease model via inhibition of neuronal ferroptosis by Parisa Faraji, Elham Parandavar, Hartmut Kuhn, Mehran Habibi-Rezaei, Astrid Borchert, Elham Zahedi, Shahin Ahmadian

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Effects of intravenous immunoglobulin on the negatively transformed subpopulations of neutrophilic granulocytes in newborns with congenital pneumonia and neonatal sepsis by I. V. Nesterova, S. V. Kovaleva, G. A. Chudilova, L. V. Lomtatidze, T. V. Smerchinskaya, V. N. Chapurina

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Interstitial fluid transport in linea alba is involved in acupuncture-induced attenuation of ovarian hypofunction in aged rats by Yaoyao Zhu, Ge Lu, Weixin Li, Chenchen Su, Pengfei Du, Shuyou Wang, Li Yang, Huanfang Xu, Yigong Fang, Xiaojing Song

“…Our study not only provides a mechanistic basis for the clinical efficacy of acupuncture in treating ovarian disorders but also identifies ISF dynamics as a novel therapeutic target in age-related ovarian dysfunction.…”
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