Identification of predictors for bacterial meningitis diagnosis based on transcriptomics and genetic analysis by Hexiang Jiang, Xibing Yu, Jingyan Fan, Houhui Song, Yang Yang

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Transcriptomic Regulatory Mechanisms of Isoflavone Biosynthesis in <i>Trifolium pratense</i> by Kefan Cao, Sijing Wang, Huimin Zhang, Yiming Ma, Qian Wu, Fan Huang, Mingjiu Wang

“…In this study, we systematically analyzed 500 accessions of <i>T. pratense</i> for isoflavone content and performed RNA-seq-based transcriptomic profiling to investigate the molecular mechanisms underlying isoflavone biosynthesis. …”
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Single−cell transcriptomic landscape of sciatic nerve after transection injury by Yiben Ouyang, Mingqian Yu, Tieyuan Zhang, Haofeng Cheng, Liang Zuo, Haolin Liu, Yanjun Guan, Ao Liu, Jiajie Chen, Ruichao He, Sice Wang, Tianqi Su, Yixiao Tan, Yuhui Cu, Xiaochun Zhang, Xiaoyang Fu, Junli Wang, Jinjuan Zhao, Jiang Peng, Yu Wang

“…Together, this work provides a time−resolved single−cell atlas of peripheral nerve regeneration, defines key regulatory circuits within the immune–NF–Gli axis, and identifies phase−specific therapeutic targets—such as early Mac heterogeneity, NF4−mediated matrix remodeling, and Schwann cell remyelination—for enhancing functional recovery following severe nerve injury.…”
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Machine Learning-Driven Transcriptome Analysis of Keratoconus for Predictive Biomarker Identification by Shao-Hsuan Chang, Lung-Kun Yeh, Kuo-Hsuan Hung, Yen-Jung Chiu, Chia-Hsun Hsieh, Chung-Pei Ma

“…<b>Objective:</b> This study employed multiple machine learning algorithms to analyze the transcriptomes of keratoconus patients, identifying feature gene combinations and their functional associations, with the aim of enhancing the understanding of keratoconus pathogenesis. …”
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Sexual dimorphism in lung transcriptomic adaptations in fetal alcohol spectrum disorders by Vishal D. Naik, Dylan J. Millikin, Daniel Moussa, Hong Jiang, Alexander L. Carabulea, Joseph D. Janeski, Jiahui Ding, Kang Chen, Marta Rodriguez-Garcia, Sunil Jaiman, Stephen A. Krawetz, Gil Mor, Jayanth Ramadoss

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The BeeBiome data portal provides easy access to bee microbiome information by Valentine Rech de Laval, Benjamin Dainat, Philippe Engel, Marc Robinson-Rechavi

“…While each of these datasets by itself has provided important insights, the integration of such datasets provides an unprecedented opportunity to obtain a global picture of the microbes associated with bees and their link to bee health. …”
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Courtship Is a Major Factor of Mating‐Shortened Male Lifespan in an Egg Parasitoid by Zi‐Yin Wang, Jing Li, Jia‐Min Tang, Lan‐Feng Qiu, Hao‐Yuan Hu, Peng‐Cheng Liu

“…In summary, our study provides comprehensive insights into post‐mating changes in male longevity and provides a basis for future mechanistic studies.…”
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Integration of transcriptomic and metabolomic analysis reveals light-regulated anthocyanin accumulation in the peel of ‘Yinhongli’ plum by Bo Xiong, Yisong Li, Junfei Yao, Jialu Wang, Linlyu Han, Qingqing Ma, Taimei Deng, Ling Liao, Lijun Deng, Guochao Sun, Mingfei Zhang, Xun Wan, Siya He, Jiaxian He, Zhihui Wang

“…Transcriptomic profiling revealed 6,900 differentially expressed genes (DEGs) between YD and YL, demonstrating significant correlations between the phenylpropanoid and flavonoid biosynthetic pathways. …”
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Arsenic sulfide alleviates the progression of liver cancer malignancy by inhibiting the expression of TLCD1 in mice by Xianglu Li, Xuehua Xing, Lin Wang, Shizong Li

“…This study provides a molecular basis for arsenic sulfide in the treatment of liver cancer.…”
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Unveiling Salt Tolerance Mechanisms and Hub Genes in Alfalfa (<i>Medicago sativa</i> L.) Through Transcriptomic and WGCNA Analysis by Fengdan Wang, Hanfu Wu, Mei Yang, Wen Xu, Wenjie Zhao, Rui Qiu, Ning Kang, Guowen Cui

“…Mantel test analysis revealed that these genes showed strong correlations with physiological indicators. This study will provide important insights for breeding salt-tolerant alfalfa varieties.…”
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Integrated Metabolomic and Transcriptomic Analysis of Volatile Organic Compound Biosynthesis During Mung Bean (<i>Vigna radiata</i>) Seed Development by Nan Xiang, Yihan Zhao, Bing Zhang, Honglin Chen, Xinbo Guo

“…Transcriptomic analysis revealed four downregulated geranylgeranyl diphosphate synthase genes during seed development, leading to terpenoid accumulation patterns. …”
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Liver transcriptome analysis reveals the molecular response to hibernation challenge in the Chinese soft-shelled turtle (Pelodiscus sinensis) by Muhammad Shahid Iqbal, Xiaoqi Ai, Qingjun Zhu, Ijaz Khan, Zeeshan Ali, Tian Lan, Li Ding, Meiling Hong

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Lethal neonatal acidosis: Multiomic investigation of a novel HIBCH variant as the underlying cause by Sonali Patel, Muhammad Zain-ul-abideen, Genevieve Guyol, Lance H. Rodan, Casie A. Genetti, Amy Z. Ren, Philip Connors, Patricia Davenport, Ruby Bartolome, Inderneel Sahai, Vijay S. Ganesh, Monica H. Wojcik

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Vitamin and zeatin treatments promote colchicine-induced haploid chromosome doubling in maize by Chen Chen, Yuling Zhang, Chenxu Liu, Jinlong Li, Jiuran Zhao, Yuandong Wang, Shaojiang Chen

“…In a parallel experiment, exogenous vitamins including thiamine, nicotinic acid, vitamin B6, or trans-zeatin were added to colchicine treatment; there were synergistic effects between vitamins or zeatin and colchicine in haploid artificial chromosome doubling. These results provide novel insights in exploring the molecular responses to antimitotic reagents at both the transcriptomic and metabolomic levels. …”
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Study on gene expression in stomach at different developmental stages of human embryos by Weiyu Guan, Xinran Lu, Yin Zhang, Hongping Ding, Xinmei Liu, Le Yang, Wenran Wang, Jianwu Shi, Shichun Feng

“…As gastric development, the stomach progressively acquires additional functions. This research provides insights into the intricate regulatory networks among the genes involved in embryonic digestive tract development, digestion and embryonic organ morphogenesis. …”
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Distinct Molecular Profiles Underpin Mild-To-Moderate Equine Asthma Cytological Profiles by Anna E. Karagianni, Eric A. Richard, Marie-Pierre Toquet, Erika S. Hue, Anne Courouce-Malblanc, Bruce McGorum, Dominic Kurian, Judit Aguilar, Stella Mazeri, Thomas M. Wishart, Robert Scott Pirie

“…Our adopted multi-omics approach provided a holistic assessment of the immunological status of the lower airways associated with the different cytological profiles of equine asthma.…”
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Potential antibacterial effects and transcriptomic analysis of a novel reversible photoacid-based crystalline coordination polymer by Chenhua Zheng, Yaying Zheng, Binjie Wu, Yuyan Zheng, Shuye Yu, Rui Qiu, Wanling Chen, Xin Chen, Longze Li, Jianzhen Liao, Fen Hu

“…SEM revealed that the material disrupted cell membrane integrity, leading to cell death. Transcriptomic analysis showed that the material inhibited bacterial protein synthesis, disrupted cell membrane protein synthesis, and downregulated oxidative stress-related genes, causing ROS accumulation and inhibiting cell growth.DiscussionThese findings provide a theoretical basis for the potential clinical application of this material as a new antibacterial agent. …”
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Production, characterization, and potential utility of a newly synthesized allohexaploid wheat Triticum kiharae by Tariq Aslam, Tianying Zhang, Taotao Lian, Jiawen Zhai, Jinning Jia, Han Wang, Ruili Lyu, Bao Liu

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Mendelian randomization and transcriptomic analysis reveal a positive cause-and-effect relationship between Alzheimer's disease and colorectal cancer by Wei Du, Xueming Xia, Qiheng Gou, Yan Qiu

“…Conclusions: This study provides evidence of a causal relationship between AD and CRC, suggesting that shared genetic and inflammatory pathways may underlie both conditions. …”
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Dissection of genetic basis underlying heat stress response of Apis cerana by Ao-Mei Li, Chun-Xiu Pang, Xiao-Lin Cai, Fu-Chang Zhuo, Bo Hu, Xue-Hua Huang, Jia-Xing Huang, Yu-Ming Lu

“…Here, we conducted transcriptomic analysis to identify differentially expressed genes (DEGs) and reveal the associated biological processes in the queen head and ovary of honeybee A. cerana under different temperatures. …”
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