Amniotic fluid-derived mesenchymal stem cells as a therapeutic tool against cytokine storm: a comparison with umbilical cord counterparts by Salvatore Vaiasicca, David W. James, Gianmarco Melone, Omar Saeed, Lewis W. Francis, Bruna Corradetti

“…Methods We applied next-generation sequencing (NGS) analysis to compare the transcriptomic profiles of MSCs isolated from two gestational sources: amniotic fluid (AF) obtained during prenatal diagnosis and their clinically relevant umbilical cord counterparts, for which datasets were publicly available. …”
Get full text

Mitigating Cd stress in alfalfa: the role of melatonin and nano-calcium oxide in enhancing photosynthesis and antioxidant defense by Maqsood Ul Hussan, Umer Mahmood, Saeedeh Zarbakhsh, Sadam Hussain, Muhammad Bilal Hafeez, Noreen Zahra, Munib Ahmed, Quanzhen Wang, Mingke Yan

Get full text

mRNA extracted from frozen buffy coat samples stored long term in tubes with no RNA preservative shows promise for downstream sequencing analyses. by Erik Bovinder Ylitalo, Linda Vidman, Sophia Harlid, Bethany Van Guelpen

Get full text

A novel anoikis related gene prognostic model for colorectal cancer based on single cell sequencing and bulk transcriptome analyses by Lei Yang, Yuan Zhang

“…In conclusion, anoikis related genes could be promising prognostic factors for risk stratification of CRC patients.…”
Get full text

Verification of Seed-Priming-Induced Stress Memory by Genome-Wide Transcriptomic Analysis in Wheat (<i>Triticum aestivum</i> L.) by Kincső Decsi, Mostafa Ahmed, Donia Abdul-Hamid, Roquia Rizk, Zoltán Tóth

“…Green seed-priming fertilizer, which is a commonly used seed fertilizer containing macro- and microelements. Genome-wide transcriptomic analysis was performed to examine the effects of treatments. …”
Get full text

Prp16 enables efficient splicing of introns with diverse exonic consensus elements in the short-intron rich Cryptococcus neoformans transcriptome by Manendra Singh Negi, Vishnu Priya Krishnan, Niharika Saraf, Usha Vijayraghavan

“…The presence of multiple introns per transcript with intronic features that are more similar to those of higher eukaryotes makes it a promising model for studying spliceosomal splicing. …”
Get full text

An integrative and comprehensive analysis of blood transcriptomes combined with machine learning models reveals key signatures for tuberculosis diagnosis and risk stratification by Maryam Omrani, Arash Ghodousi, Arash Ghodousi, Daniela Maria Cirillo

“…In this study, we performed an integrative analysis of 324 previously acquired blood transcriptome samples from TB patients, TB contacts, and controls across diverse geographical regions. …”
Get full text

Integrating single-cell RNA sequencing and spatial transcriptomics reveals the therapeutic effect of nitazoxanide in head and neck squamous cell carcinoma by Xiaohua Jiang, Liqi Chen, Zixia Xu, Hangzhe Sun, Jing Ye, Ziyi Guo, Mang Xiao

“…Nitazoxanide is a broad-spectrum antiviral drug showing promise in treating cancer, but its role in regulating autophagy in HNSCC remains unexplored. …”
Get full text

Effect of Dead-Cell <i>Limosilactobacillus ingluviei</i> on Hematological Parameters and Jejunal Transcriptome Profile in Calves During the Weaning Period by Chao Ban, Supreena Srisaikham, Xingzhou Tian, Pipat Lounglawan

“…This highlights the importance of implementing appropriate nutritional strategies to enhance gut health and support optimal growth. Postbiotics is a promising alternative to traditional probiotics, conferring health benefits without the risks associated with live bacteria. …”
Get full text

Non-invasive liquid biopsy based on transcriptomic profiling for early diagnosis of occult peritoneal metastases in locally advanced gastric cancer by Ping’an Ding, Haotian Wu, Jiaxiang Wu, Tongkun Li, Renjun Gu, Lilong Zhang, Xiaoman Niu, Jinchen He, Jiaxuan Yang, Peigang Yang, Honghai Guo, Yuan Tian, Ning Meng, Xiaolong Li, Zhenjiang Guo, Lingjiao Meng, Qun Zhao

“…Abstract This study proposes a novel non-invasive diagnostic approach utilizing transcriptomic profiling of liquid biopsy samples for the early detection of occult peritoneal metastases in locally advanced gastric cancer (LAGC). …”
Get full text

Targeting CD74 in microglia to modulate experimental cerebral ischemia and reperfusion injury: insights from Single-Cell and bulk transcriptomics by Chang Cao, Ting Liu, Lu Peng, Lianxin Li, Zhongmou Xu, Xiang Li, Gang Chen, Haiying Li, Lei Bai

Get full text

LILRA5+ macrophages drive early oxidative stress surge in sepsis: a single-cell transcriptomic landscape with therapeutic implications by Peng Xu, Haoze Li, Zuo Tao, Zixuan Zhang, Xiaohuan Wang, Cheng Zhang

Get full text

Association of alterations in transcriptomics and intestinal immune responses with Bifidobacterium longum BAA2573 in improving dextran sulfate sodium-induced colitis by Wujuan Hao, Lan Gu, Renmin Zhou, Cuilan Huang, Xuyang Wang, Yanshan Liu, Qiong Lin

Get full text

Transcriptome Analysis Reveals the Mechanism of Y0-C10-HSL on Biofilm Formation and Motility of <i>Pseudomonas aeruginosa</i> by Deping Tang, Yali Liu, Huihui Yao, Yanyan Lin, Yanpeng Xi, Mengjiao Li, Aihong Mao

“…Inhibiting biofilm formation is a promising approach for the treatment of biofilm-related infections. …”
Get full text

Single-cell sequencing unveils the transcriptomic landscape of castration-resistant prostate cancer-associated fibroblasts and their association with prognosis and immunotherapy re... by Yifeng Qiu, Yuhan Wang, Jiahe Liu, Kai Sun, Baohua Liu, Qi Hou

“…Methods We ascertained the differential transcriptomic profiles between CRPC-CAFs and PCa-CAFs through single-cell RNA-sequencing (scRNA-seq). …”
Get full text

Dissecting PTPN7‐driven aggressiveness in IDH‐wildtype astrocytomas: multi‐omics, clinical validation, and spatial transcriptomics for prognostic insights by Tung Liu, Yu-Chieh Lin, Pei-Chi Chang, Dueng-Yuan Hueng, Yao-Feng Li

“…Targeting PTPN7 may disrupt immune evasion and support tumor eradication, indicating a promising therapeutic avenue in immunotherapy‐based strategies.…”
Get full text

Investigating the Mechanisms of 15-PGDH Inhibitor SW033291 in Improving Type 2 Diabetes Mellitus: Insights from Metabolomics and Transcriptomics by Yuanfeng Huang, Mingjie Liang, Yiwen Liao, Zirui Ji, Wanfen Lin, Xiangjin Pu, Lexun Wang, Weixuan Wang

“…Then, serum and liver metabolomics, as well as liver transcriptomic analyses, were performed to provide a systematic perspective of the SW033291-ameliorated T2DM. …”
Get full text

Potential mechanisms and therapeutic effect of dietary resveratrol supplementation on the spleen organ of chicken in chronic unpredictable mild stress transcriptomic analysis by Farooque Laghari, Qingqing Chang, Haoran Zhang, Jiaqi Zhang, Liying Pan, Zhaohong Pu, Jun Bao, Runxiang Zhang

Get full text

Integrated metabolomic, transcriptomic and network analysis elucidates therapeutic mechanisms of Ganoderma lucidum spore oil against granulomatous pulmonary nodules by Ya Liu, Wendong Xu, Kexin Wang, Kexin Wang, Zhiye You, Xiaohong Chen, Xiaohong Chen, Huihui Ti, Xiaoli Liang, Lin Cao, Hongfei Cai, Juyan Liu, Zifeng Yang, Zifeng Yang, Zifeng Yang

“…These results position GLSO as a promising therapeutic candidate for granulomatous pulmonary nodules, acting through multifaceted regulatory mechanisms.…”
Get full text

TRAF3 as a potential diagnostic biomarker for recurrent pregnancy loss: insights from single-cell transcriptomics and machine learning by Yi-bo He, Jun-yu Li, Shi-liang Chen, Rui Ye, Yi-ran Fei, Shi-yuan Tong, Yu-xuan Song, Cong Wang, Li Zhang, Ju Fang, Yue Shang, Zhe-zhong Zhang, Jin Chen, Ai-zhong Yang, Jie Liu, Yong-lin Liu

“…Conclusions This study highlights TRAF3 as a promising diagnostic marker and therapeutic target for RPL. …”
Get full text