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Identification of a deubiquitinating gene-related signature in ovarian cancer using integrated transcriptomic analysis and machine learning framework
Published 2025-04-01“…The established DRS model offers a promising tool for risk stratification and may guide personalized therapeutic strategies. …”
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142
Decoding the impact of MMP1+ malignant subsets on tumor-immune interactions: insights from single-cell and spatial transcriptomics
Published 2025-05-01“…In this study, we utilized large-scale single-cell RNA sequencing and spatial transcriptomics to investigate MMP1 expression, its cellular localization, and its impact on tumor progression and immune modulation. …”
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Bidirectional Transcriptome Analysis of Rat Bone Marrow-Derived Mesenchymal Stem Cells and Activated Microglia in an In Vitro Coculture System
Published 2018-01-01“…We also evaluated the effects of rBM-MSC on LPS-stimulated microglia using a reverse coculture system and the same conditions of the transcriptomic analysis. In the transcriptome of rBM-MSCs, 67 genes were differentially expressed, which were highly related with migration of cells, compared to control. …”
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145
Long term exposure to multiple environmental stressors induces mitochondrial dynamics imbalance in testis: Insights from metabolomics and transcriptomics
Published 2025-04-01“…This study employed integrated phenomics, metabolomics, and transcriptomics to investigate physiological disturbances in the testis of mice exposed to multiple adverse environmental stressors for two months. …”
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148
Transcriptomic Profiles for Elucidating Response of Bladder Intracavitary Hyperthermic Perfusion Chemotherapy in High‐Risk Nonmuscular Invasive Bladder Cancer
Published 2025-02-01“…ABSTRACT Background Bladder intracavitary hyperthermic perfusion chemotherapy (HIPEC) is a promising treatment for non‐muscular invasive bladder cancer (NMIBC). …”
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149
Aging-related alternative splicing drive neoantigen emergence revealed by transcriptome analysis of 1,255 human blood samples
Published 2025-05-01“…This study aimed to identify age-related genes and alternative splicing (AS) events by comprehensive transcriptome analysis of 1,255 healthy blood samples from individuals aged 8–87 years. …”
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150
Revealing the Mechanism of <i>Hemerocallis citrina</i> Baroni in Depression Treatment Through Integrated Network Pharmacology and Transcriptomic Analysis
Published 2024-12-01“…Results from network pharmacology and transcriptomics indicated that the PI3K/Akt/CREB signaling pathway is essential for the therapeutic effects of HCB on depression. …”
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151
Integrative Network Pharmacology and Transcriptomics Reveal the Mechanism of Gui-Qi-Yi-Shen Granules in the Treatment of IgA Nephropathy
Published 2025-07-01“…Network pharmacology and transcriptomic analyses identified genes and pathways that may be associated with the effects of GQYS against IgAN. …”
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152
Substantia nigra and blood gene signatures and biomarkers for Parkinson’s disease from integrated multicenter microarray-based transcriptomic analyses
Published 2025-04-01“…PD diagnosis depends on clinical manifestation of symptoms but is lack of effective biomarker.MethodsAvailable human microarray-based transcriptomic datasets of the substantia nigra and blood were acquired for PD cases and controls. …”
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153
Integrated single-cell and transcriptomic analysis of bone marrow-derived metastatic neuroblastoma reveals molecular mechanisms of metabolic reprogramming
Published 2025-08-01“…This study aimed to systematically elucidate the molecular mechanisms underlying metabolic reprogramming in bone marrow–infiltrating metastatic NB cells by integrating single-cell transcriptomic data, bulk RNA-sequencing profiles, and in vitro functional validation. …”
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154
Single‐Nucleus and Spatial Transcriptome Profiling Delineates the Multicellular Ecosystem in Hepatocellular Carcinoma After Hepatic Arterial Infusion Chemotherapy
Published 2025-02-01“…Abstract Hepatic arterial infusion chemotherapy (HAIC) has emerged as a promising treatment strategy for hepatocellular carcinoma (HCC), but a detailed understanding of the multicellular ecosystem after HAIC treatment is lacking. …”
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155
Transcriptome analysis indicates improved adipose tissue function in growing Iberian pig fed olive by-products based diets
Published 2025-05-01“…Supplementing diets with olive by-products offers promising benefits for alleviating animal stress caused by feed restriction without compromising growth. …”
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156
Mitigation mechanism of silicon and iron co-application to cadmium toxicity in tomato seedlings by integrated transcriptomic and physiological correlation analysis
Published 2025-06-01“…This study focused on the physiological and transcriptomic responses of tomato seedlings to Cd stress. …”
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Interplay between MRI radiomics and immune gene expression signatures in oral squamous cell carcinoma
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159
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Identification of sex-linked markers and genes in Portuguese oyster (Magallana angulata)
Published 2025-06-01“…The Portuguese oyster (Magallana angulata) is a valuable aquaculture species with sexual dimorphism in growth and nutritional traits, making it a promising candidate for sex-controlled breeding. However, the genetic mechanisms underlying its sex determination remain poorly understood. …”
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