Lysionotin promoted apoptosis of hepatocellular carcinoma cells via inducing autophagy by Xiaoxue Wang, Weiwei Zhong, Qin Wang, Peng Song, Xia Lin, Bohan Li, Yancun Yin, Chunyan Yang, Minjing Li

“…Abstract Background Hepatocellular carcinoma is a prevalent malignant tumor with a high mortality rate. Natural plants hold promise for its treatment, however, the mechanism of lysionotin induced apoptosis in liver cancer cells unclearly. …”
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Computer-aided analysis reveals metallothionein-positive cancer-associated fibroblasts promote angiogenesis in gastric adenocarcinoma by Xiaolong Jin, Yu Tian, Haoran Zhu, Yuewen Sun, Zhenxing Zhang

“…Their drug sensitivity profiles may hold promise for guiding clinical intervention. In addition, robust spatial co-localization patterns were observed between CAFs, M2 macrophages, and endothelial cells. …”
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A comparison of the expression patterns and diagnostic capability of the ncRNAs NEAT1 and miR-34a in non-obstructive azoospermia and severe oligospermia by Aya Salman, Abdullah F. Radwan, Olfat G. Shaker, Adel A., Ghadir A. Sayed

“…This study highlights the promise of serum NEAT1 and miR-34a as diagnostic markers for non-obstructive azoospermia and severe oligospermia. …”
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ELABELA promotes the migration and homing of bone marrow mesenchymal stem cells to myocardial injury sites through the ERK1/2/miR-299a-5p/Exo70 pathway by Jing-Yu Hou, Hao Wu, Shuang-Mei Li, Xiao-Jing Li, Shu-Jun Yang, Xu-Xiang Chen, Chang-Qing Zhou, Hui-Bao Long, Hai-Dong Wu, Jia-Ying Fu, Ya-Jie Guo, Tong Wang

“…BackgroundBone marrow mesenchymal stem cells (BMSCs) hold promise for repairing myocardial injury following acute myocardial infarction (AMI), but their clinical application is hindered by poor migration, homing efficiency, and survival rates. …”
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Biocontrol Potential of Entomopathogenic Fungi Against Plant-Parasitic Nematodes: A <i>Caenorhabditis elegans</i>-Based Screening and Mechanistic Study by Cheng Cheng, Renjun Zhang, Yanzhen Wang, Shuo Yang, Wenhao Yu, Yuxian Xia

“…This was accompanied by a transcriptome-wide modulation of genes involved in detoxification and immune defense pathways. …”
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Cancer stem cells: landscape, challenges and emerging therapeutic innovations by Haksoo Lee, Byeongsoo Kim, Junhyeong Park, Sujin Park, Gaeun Yoo, Soomin Yum, Wooseok Kang, Jae-Myung Lee, HyeSook Youn, BuHyun Youn

“…Recent advances in single-cell sequencing, spatial transcriptomics, and multiomics integration have significantly improved our understanding of CSC heterogeneity and metabolic adaptability. …”
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Transforming heart transplantation care with multi-omics insights by Zhengbang Zou, Jianing Han, Zhiyuan Zhu, Shanshan Zheng, Xinhe Xu, Sheng Liu

“…Multi-omics technologies, including genomics(donor-derived cell-free DNA), transcriptomics(microRNAs panels, gene expression profiling), proteomics(cell signaling molecule), and metabolomics(ex situ heart perfusion), have demonstrated significant promise in post-transplant monitoring. …”
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Inter-Relationship Between Melanoma Vemurafenib Tolerance Thresholds and Metabolic Pathway Choice by Pratima Nangia-Makker, Madison Ahrens, Neeraja Purandare, Siddhesh Aras, Jing Li, Katherine Gurdziel, Hyejeong Jang, Seongho Kim, Malathy P Shekhar

“…Although combating vemurafenib resistance (VemR) to counter mitochondrial metabolic shift using mitochondria-targeting therapies has promise, no studies have analyzed the relationship between vemurafenib tolerance levels and metabolic plasticity. …”
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Music therapy as a preventive intervention for postpartum depression: modulation of synaptic plasticity, oxidative stress, and inflammation in a mouse model by Qiang Fu, Rui Qiu, Tongtong Yao, Liming Liu, Yaobo Li, Xiaodong Li, Wen Qi, Yuewen Chen, Yong Cheng

“…This study underscores the need for further clinical research to validate the therapeutic efficacy of music in preventing PPD in humans, highlighting its promise as a non-invasive and accessible treatment modality.…”
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Nebulized inhalation of extracellular vesicles containing SPOCK2 suppresses lung adenocarcinoma progression via MAPK inhibition by Ying Wang, Ningning Liu, Chuanqin Xu, Jing Wang, Liyang Dong, Shuang Yang, Junhong Jiang

“…To explore downstream target signal of SPOCK2 in LUAD, RNA transcriptome sequencing was performed and enrichment analysis showed an association between SPOCK2 expression and the MAPK pathway. …”
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Stimulation of regulatory dendritic cells suppresses cytotoxic T cell function and alleviates DEN-induced liver injury, fibrosis and hepatocellular carcinoma by Junjie Wang, Pixu Gong, Qingqing Liu, Menglei Wang, Dengfang Wu, Mengyu Li, Shujie Zheng, Han Wang, Han Wang, Qiaoming Long

“…LAP-treated mice are protected from DEN-induced liver injury, fibrosis and HCC in a TLR2-dependent manner. Single-cell transcriptome profiling revealed that LAP treatment determines an immunosuppressive hepatic T-cell program that is characterized by a significantly reduced cytotoxic activity. …”
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Integrative analyses of single‐cell and bulk RNA sequencing reveal tumour microenvironment features associated with neoadjuvant immunochemotherapy response in oesophageal squamous... by Xianxian Wu, Xiaoxing Ye, Wei Ji, Xiangyang Yu, Ahuan Xie, Zichang Xiang, Zhilin Sui, Jiquan Tang, Zhentao Yu

“…Abstract Background Neoadjuvant chemotherapy combined with immunotherapy (NACI) has shown promise in oesophageal squamous cell carcinoma (ESCC). …”
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UHRF1-mediated epigenetic reprogramming regulates glycolysis to promote progression of B-cell acute lymphoblastic leukemia by Yan Huang, Luting Luo, Yangqi Xu, Jiazheng Li, Zhengjun Wu, Chenxing Zhao, Jingjing Wen, Peifang Jiang, Haojie Zhu, Lingyan Wang, Yanxin Chen, Ting Yang, Jianda Hu

“…Exploring the molecular mechanisms underlying disease progression holds significant promise for improving clinical outcomes. In this investigation, utilizing single-cell transcriptome sequencing technology, we discerned a correlation between Ubiquitin-like containing PHD and RING finger domain 1 (UHRF1) and the progression of B-cell acute lymphoblastic leukemia. …”
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A Novel Molecular Classification Method for Glioblastoma Based on Tumor Cell Differentiation Trajectories by Guanghao Zhang, Xiaolong Xu, Luojiang Zhu, Sisi Li, Rundong Chen, Nan Lv, Zifu Li, Jing Wang, Qiang Li, Wang Zhou, Pengfei Yang, Jianmin Liu

“…Single-cell transcriptome sequencing data from 10 GBM samples were used to identify molecular classification based on differentiation trajectories. …”
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The impact of aging on achilles tendon ossification in mice by Hanhua Cai, Yujian Lan, Huan Liu, Qi Hao

“…Methods We retrieved the transcriptome profile of GSE126118 from the Gene Expression Omnibus (GEO) database. …”
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Dasatinib demonstrates efficacy in organoid derived paclitaxel-resistant Trp53/Cdh1-deficient mouse gastric adenocarcinoma with peritoneal metastasis by Wenshuai Liu, Lingmeng Li, Leilei Guo, Haojie Li, Zhaoqing Tang, Xuefei Wang, Liyu Huang, Yihong Sun

“…DASA showed promise in ameliorating disease progression and improving overall survival in MTC-R GCPM model in C57BL/6 J mice. …”
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A novel gene signature for predicting outcome in colorectal cancer patients based on tumor cell-endothelial cell interaction via single-cell sequencing and machine learning by Lina Pang, Qingxia Sun, Wenyue Wang, Mingjie Song, Ying Wu, Xin Shi, Xiaonan Shi

“…Methods: We conducted an in silico study integrating single-cell RNA sequencing and bulk transcriptome data to characterize the cellular heterogeneity of CRC. …”
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Multi-omic biomarker panel in pancreatic cyst fluid and serum predicts patients at a high risk of pancreatic cancer development by Laura E. Kane, Gregory S. Mellotte, Eimear Mylod, Paul Dowling, Simone Marcone, Caitriona Scaife, Elaine M. Kenny, Michael Henry, Paula Meleady, Paul F. Ridgway, Finbar MacCarthy, Kevin C. Conlon, Barbara M. Ryan, Stephen G. Maher

“…Here, we extensively profile the proteome and transcriptome of patient pancreatic cyst fluid (PCF) (n = 32) and serum (n = 68), before integrating matched omic and biofluid data, to identify biomarkers of pancreatic cancer risk. …”
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Single-Cell Sequencing and Machine Learning Integration to Identify Candidate Biomarkers in Psoriasis: INSIG1 by Zhou X, Ning J, Cai R, Liu J, Yang H, Bai Y

“…In addition, tetrandrine shows promise as a potential treatment for the condition.Keywords: psoriasis, single-cell RNA sequencing, machine learning, INSIG1, pseudotime analysis…”
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Fibroblast IRF7-mediated chondrocyte apoptosis affects the progression of collapse in steroid-induced osteonecrosis of the femoral head by Han Longfei, Fang Weihua, Han Mingli, Zhuang Zhikun, He Mincong, Wei Qiushi

“…Thus, intervention in IRF7 holds promise as one of the key targets for reversing the collapse process of SIONFH. …”
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