In vitro and in vivo drug screens of tumor cells identify novel therapies for high‐risk child cancer by Loretta M S Lau, Chelsea Mayoh, Jinhan Xie, Paulette Barahona, Karen L MacKenzie, Marie Wong, Alvin Kamili, Maria Tsoli, Tim W Failes, Amit Kumar, Emily V A Mould, Andrew Gifford, Shu‐Oi Chow, Mark Pinese, Jamie I Fletcher, Greg M Arndt, Dong‐Anh Khuong‐Quang, Carol Wadham, Daniel Batey, Georgina Eden, Peter Trebilcock, Swapna Joshi, Stephanie Alfred, Anjana Gopalakrishnan, Aaminah Khan, Dylan Grebert Wade, Patrick A Strong, Elodie Manouvrier, Lisa T Morgan, Miriam Span, Jin Yi Lim, Roxanne Cadiz, Caitlin Ung, David M Thomas, Katherine M Tucker, Meera Warby, Geoffrey B McCowage, Luciano Dalla‐Pozza, Jennifer A Byrne, Federica Saletta, Andrew Fellowes, Stephen B Fox, Murray D Norris, Vanessa Tyrrell, Toby N Trahair, Richard B Lock, Mark J Cowley, Paul G Ekert, Michelle Haber, David S Ziegler, Glenn M Marshall

“…Abstract Biomarkers which better match anticancer drugs with cancer driver genes hold the promise of improved clinical responses and cure rates. …”
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LncRNA-mRNA regulatory network reveals key lncRNAs tightly associated with preterm labor and premature rupture of membranes by Guangqiong Yang, Wenjin Qi

“…In our study, we analyzed fetal membrane samples from Term labor (TL), PROM, PTB, and PPROM groups using transcriptome sequencing to identify differentially expressed genes, including both lncRNAs and mRNAs. …”
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Systems Biology of Human Microbiome for the Prediction of Personal Glycaemic Response by Nikhil Kirtipal, Youngchang Seo, Jangwon Son, Sunjae Lee

“…We explore how the gut microbiota affects glucose metabolism and insulin sensitivity by examining a variety of -omics data, including genomics, transcriptomics, epigenomics, proteomics, metabolomics, and metagenomics. …”
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Anti-inflammatory effects of moxifloxacin and levofloxacin on cadmium-activated human astrocytes: Inhibition of proinflammatory cytokine release, TLR4/STAT3, and ERK/NF-κB signalin... by Suttinee Phuagkhaopong, Jidapha Sukwattanasombat, Kran Suknuntha, Christopher Power, Piyanuch Wonganan, Pornpun Vivithanaporn

“…Fluoroquinolones (FQs), widely used antimicrobials with effective blood-brain barrier penetration, show promise in being repurposed as anti-inflammatory drugs. …”
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Rapid DNA and RNA isolation from few or single cells using low-cost NAxtra magnetic nanoparticles by Eirin Johannessen Starheim, Adeel Manaf, Adnan Hashim, Niklas Nonboe Andersen, Erlend Ravlo, Wei Wang, Vidar Langseth Saasen, Nina-Beate Liabakk, Sten Even Erlandsen, Per Arne Aas, Lars Hagen, Magnar Bjørås

“…Additionally, it enables the extraction of high-quality RNA suitable for transcriptomics analyses from limited cell quantities, including single cells. …”
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Identification of novel markers for neuroblastoma immunoclustering using machine learning by Longguo Zhang, Longguo Zhang, Huixin Li, Huixin Li, Fangyan Sun, Fangyan Sun, Qiuping Wu, Qiuping Wu, Leigang Jin, Leigang Jin, Aimin Xu, Aimin Xu, Jiarui Chen, Ranyao Yang, Ranyao Yang, Ranyao Yang

“…However, the effect of the tumor immune microenvironment on neuroblastoma needs to be investigated, and there is a lack of biomarkers to reflect the condition of the tumor immune microenvironment.MethodsThe GEO Database was used to download transcriptome data (both training dataset and test dataset) on neuroblastoma. …”
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Sperm Membrane: Molecular Implications and Strategies for Cryopreservation in Productive Species by Macarena Castro, Karla Leal, Felipe Pezo, María José Contreras

“…In conclusion, the integration of biotechnological and molecular tools holds significant promise for overcoming the current limitations and advancing the efficacy of sperm cryopreservation.…”
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Large-scale CRISPRi screens link metabolic stress to glioblastoma chemoresistance by Xing Li, Wansong Zhang, Yitong Fang, Tianhu Sun, Jian Chen, Ruilin Tian

“…While targeting cancer metabolism shows promise, the relationship between metabolic perturbation and drug resistance remains poorly understood. …”
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Protective effects of Jing-Si-herbal-tea in inflammatory cytokines-induced cell injury on normal human lung fibroblast via multiomic platform analysis by Chien-Hao Wang, Jai-Sing Yang, Chao-Jung Chen, San-Hua Su, Hsin-Yuan Yu, Yu-Ning Juan, Yu-Jen Chiu, Tsung-Jung Ho

“…Conclusion: The findings from our research indicate that JSHT holds promise as a therapeutic agent, potentially offering advantageous outcomes in treating virus infections through various mechanisms. …”
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Ageless harmony: decoding the microbiome–stem cell nexus in aging by Swarup K. Chakrabarti, Dhrubajyoti Chattopadhyay

“…While therapeutics targeting the microbiome hold promise in keeping stem cell homeostasis and tissue repair capacities, the primary focus remains on deepening our understanding of the interplay between the microbiota and stem cells. …”
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Aged neutrophils form mitochondria-dependent vital NETs to promote breast cancer lung metastasis by Ke Wang, Jian Huang, Zhen Wang, Haijun Wang, Jun Pan, Jun Yan, Zhigang Zhang, Fang Jia, Lili Li, Chenghui Yang, Fuming Qiu, Xiaoyan Jin, Pin Wu, Shanshan Sun, Ke Su, Leyi Zhang, Xiuyan Yu, Xuan Shao

“…Additionally, therapeutic interventions of Naged and its formation-linked pathways could effectively decrease breast cancer lung metastasis.Conclusions Naged exerts a vital role in breast cancer lung metastasis, and strategies targeting SIRT1-Naged-NETs axis show promise for translational application.…”
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Instantaneous dose rate as a crucial factor in reducing mortality and normal tissue toxicities in murine total-body irradiation: a comparative study of dose rate combinations by Hongyu Zhu, Shihua Liu, Jiaqi Qiu, Ankang Hu, Wanyi Zhou, Jian Wang, Weihang Gu, Yinuo Zhu, Hao Zha, Rong Xiang, Junli Li, Rui Qiu, Chong Zhao, Peng Huang, Xiaowu Deng

“…Abstract Purpose The ultra-high dose rate (UHDR) radiation shows promise in eradicating tumors while reducing normal tissue toxicities. …”
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Whole-genome bisulfite sequencing of cell-free DNA unveils age-dependent and ALS-associated methylation alterations by Yulin Jin, Karen N Conneely, Wenjing Ma, Robert K. Naviaux, Teepu Siddique, Emily G. Allen, Sandra Guingrich, Robert M. Pascuzzi, Peng Jin

“…Such epigenetic changes also hold significant promise for the diagnosis of neurodegenerative diseases, which often progresses slowly and has a lengthy asymptomatic period. …”
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Detection, molecular function and mechanisms of m5C in cancer by Linhui Zhang, Yuelong Li, Liqing Li, Fei Yao, Maoping Cai, Dingwei Ye, Yuanyuan Qu

“…Moreover, strides in methodologies for discerning m5C have facilitated intricate transcriptome cartography of RNA methylation at the solitary nucleotide echelon. …”
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Comprehensive analysis of keloid super-enhancer networks reveals FOXP1-mediated anti-senescence mechanisms in fibrosis by Hao Yang, Dongming Lv, Xiaohui Li, Yongfei Chen, Hailin Xu, Honglin Wu, Zhiyong Wang, Xiaoling Cao, Bing Tang, Wuguo Deng, Jiayuan Zhu, Zhicheng Hu

“…Through integrated analyses of transcriptomics and proteomics, 10 hub genes that associated with ECM, immune, and metabolic pathways were found. …”
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Unraveling the genetic basis of resistance traits for fungal diseases in sorghum by Vinoth Kumar Govintharaj, M. Arumugam Pillai, V. Sumithra, Andrew Peter Leon, Ephrem Habyarimana, Jeshima Khan Yasin

“…Genome editing of identified resistance genes holds promise for developing high-performing varieties to achieve food and nutritional security.…”
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The heterogeneous sensitivity of pediatric brain tumors to different oncolytic viruses is predicted by unique gene expression profiles by Konstantinos Vazaios, Εftychia Stavrakaki, Lisette B. Vogelezang, Jie Ju, Piotr Waranecki, Dennis S. Metselaar, Michaël H. Meel, Vera Kemp, Bernadette G. van den Hoogen, Rob C. Hoeben, E. Antonio Chiocca, William F. Goins, Andrew Stubbs, Yunlei Li, Marta M. Alonso, Friso G. Calkoen, Esther Hulleman, Jasper van der Lugt, Martine L.M. Lamfers

“…Subsequently, the observed viral efficacies were correlated to whole transcriptome data and Gene Ontology analysis was performed. …”
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Comparison of CRISPR-Cas13b RNA base editing approaches for USH2A-associated inherited retinal degeneration by Lewis E. Fry, Lauren Major, Ahmed Salman, Lucy A. McDermott, Jun Yang, Andrew J. King, Michelle E. McClements, Robert E. MacLaren

“…Abstract CRISPR-Cas13 systems have therapeutic promise for the precise correction of point mutations in RNA. …”
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Pathways to chronic disease detection and prediction: Mapping the potential of machine learning to the pathophysiological processes while navigating ethical challenges by Ebenezer Afrifa‐Yamoah, Eric Adua, Emmanuel Peprah‐Yamoah, Enoch O. Anto, Victor Opoku‐Yamoah, Emmanuel Acheampong, Michael J. Macartney, Rashid Hashmi

“…Machine learning (ML) techniques offer considerable promise in unlocking new pathways for data‐driven chronic disease risk assessment and prognosis. …”
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Biomarkers and therapeutic strategies targeting microglia in neurodegenerative diseases: current status and future directions by Min-Young Noh, Hyuk Sung  Kwon, Min-Soo Kwon, Minyeop Nahm, Hee Kyung Jin, Jae-sung Bae, Seung Hyun Kim

“…Emerging technologies—including single-cell omics, spatial transcriptomics, and artificial intelligence (AI)-driven integration of multimodal data—offer new opportunities to align biomarker profiles with evolving disease states and improve patient stratification. …”
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