Tricin selectively combats KRAS-mutant non-small cell lung cancer by inhibiting the PDGF-BB-induced SRC/MAPK/AP-1/PD-L1 signaling pathway and potentiating the antitumor effect of a... by Jia-Xin Li, Jia-Xin Li, Shi-Yu Tan, Li-Qi Li, Yu-Hong Zheng, Lin Zhao, Hui-Rong Zhu, Hai-Lang He, Yan-Yu Zhang, Run-Ze Li, Tian-Yu Bao, Yi-Zhong Zhang, Xiao-Man Yang, Hao Zhang, Hui-Hui Chen, Bo-Wen Wu, Xin Lin, Xiao-Sheng Lin, Xiao-Sheng Lin, Yin Cheng Lin, Xin-Bing Sui, Ying Xie, Xian-Mei Zhou, Pei-Yu Yan

“…Next, we integrated network pharmacology, molecular docking with transcriptomics analysis and biological methods to probe the underlying mechanisms of tricin in the treatment of patients with KRAS-mutant NSCLC. …”
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GPX4 deficiency-induced ferroptosis drives endometrial epithelial fibrosis in polycystic ovary syndrome by Zhenhong Ye, Ming Cheng, Weisi Lian, Yueqi Leng, Xunsi Qin, Yue Wang, Ping Zhou, Xiyao Liu, Tianliu Peng, Ruiqi Wang, Yilei He, Heng Pan, Yue Zhao, Rong Li

“…These findings may serve as a promising therapeutic target for PCOS-related endometrial dysfunction, as well as valuable strategies for improving PCOS-related adverse pregnancy outcomes.…”
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The role of multiomics in revealing the mechanism of skin repair and regeneration by Shaoyan Shi, Xuehai Ou, Jafeng Long, Xiqin Lu, Siqi Xu, Gang Li

“…Multiomics, an integrated approach combining genomics, transcriptomics, proteomics, and metabolomics, offers unprecedented insights into the complex molecular and cellular mechanisms involved in skin healing. …”
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Editorial: Contemporary applications of machine learning and artificial intelligence for the management of heart failure by Andre Rodrigues Duraes, Mansueto Gomes-Neto, Edimar Alcides Bocchi

“…These studies address early diagnosis through novel biomarkers, disease stratification based on transcriptomics, mechanistic insight into apoptotic pathways, and predictive telemonitoring using real-time AI models. …”
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Targeting Hepatic Stellate Cells for the Prevention and Treatment of Liver Cirrhosis and Hepatocellular Carcinoma: Strategies and Clinical Translation by Hao Xiong, Jinsheng Guo

“…Recent advances in omics, particularly single-cell sequencing and spatial transcriptomics, hold promise for identifying new HSC targets for diagnosing and treating liver fibrosis/cirrhosis and liver cancer.…”
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PATHOMICS – A NOVEL OMICS APPROACH FOR HISTOPATHOLOGY

“…Pathomics complements molecular omics, like genomics or transcriptomics, or radiomics, which aims at quantifying radiology images at the macroscopic level. …”
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Akkermansia muciniphila helps in the recovery of lipopolysaccharide-fed mice with mild intestinal dysfunction by Yue Hu, Yue Hu, Jun Zhou, Xiaoqi Lin

“…Akkermansia muciniphila has shown promise as a probiotic for gut health due to its roles in mucin degradation and short-chain fatty acid production. …”
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The Exploration of <i>Cordyceps militaris</i> Extract as a Postharvest Preservative for <i>Flammulina filiformis</i> by Wenjing Chen, Yan Li, Youran Shao, Hongyu Chen, Ming Gong, Li Wang, Nanyi Li, Ying Wang, Gen Zou

“…<i>Cordyceps militaris</i>, rich in antioxidant and antibacterial components, shows promise as a natural biological preservative. This study aimed to explore the potential of <i>C. militaris</i> extract (CME) as a preservative for <i>F. filiformis</i>. …”
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Decoding the Genes Orchestrating Egg and Sperm Fusion Reactions and Their Roles in Fertility by Ranjha Khan, Muhammad Azhar, Muhammad Umair

“…These approaches not only deepen our molecular understanding of fertility mechanisms but also hold promise for refining diagnostic tools and therapeutic interventions for infertility. …”
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Rational therapeutic targeting of myeloid cells in glioblastoma: challenges and perspectives by Faruk Akay, Maya Saleh

“…In this review, we elaborate on the heterogeneity and plasticity of myeloid cells in GB and discuss the promise and challenges for rational therapeutic targeting of GAMs in GB.…”
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Therapeutic and continuative effects of human umbilical cord–derived mesenchymal stromal cells in food-allergic mice by Yuan Zhao, Yabing Ding, Zhaoyan Wang, Qian Wang, Dou Ye, Zuo Luan

“…Jejunum tissue was analysed by transcriptome sequencing. Our results demonstrated that in the current FA model, hUC-MSC therapy significantly alleviated allergic responses and diarrhoea. …”
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Role of artificial intelligence in digital pathology for gynecological cancers by Ya-Li Wang, Song Gao, Qian Xiao, Chen Li, Marcin Grzegorzek, Ying-Ying Zhang, Xiao-Han Li, Ye Kang, Fang-Hua Liu, Dong-Hui Huang, Ting-Ting Gong, Qi-Jun Wu

“…Particularly, deep learning models have shown promise in accurately diagnosing, classifying histopathological subtypes, and predicting treatment response and prognosis. …”
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Interpretable Multimodal Fusion Model for Bridged Histology and Genomics Survival Prediction in Pan‐Cancer by Feng Gao, Junxiang Ding, Baowen Gai, Du Cai, Chuling Hu, Feng‐Ao Wang, Ruikun He, Junwei Liu, Yixue Li, Xiao‐Jian Wu

“…The work highlights the promise of developing a clinically applicable medical multimodal fusion model. …”
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The next generation of regenerative dentistry: From tooth development biology to periodontal tissue, dental pulp, and whole tooth reconstruction in the clinical setting by Kazuki Morita, Jiacheng Wang, Keisuke Okamoto, Takanori Iwata

“…These innovative concepts and integrated technologies hold the promise of enabling the regeneration of fully functional teeth and periodontal tissues.…”
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Multiplex imaging analysis of the tumor immune microenvironment for guiding precision immunotherapy by Feng Liu, Feng Liu, Feng Liu, Guiqing Li, Guiqing Li, Yi Zheng, Yi Zheng, Yanxia Liu, Yanxia Liu, Kang Liu, Kang Liu

“…Despite current technical and analytical challenges, ongoing technological advancements and integration with emerging methods like spatial transcriptomics and super-resolution imaging promise broader clinical utility, ultimately improving patient outcomes in precision immunotherapy.…”
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Unveiling genetic signatures of immune response in immune-related diseases through single-cell eQTL analysis across diverse conditions by Zhenhua Zhang, Wenchao Li, Qiuyao Zhan, Michelle Aillaud, Javier Botey-Bataller, Martijn Zoodsma, Rob ter Horst, Leo A. B. Joosten, Christoph Bock, Leon N. Schulte, Cheng-Jian Xu, Mihai G. Netea, Marc Jan Bonder, Yang Li

“…Abstract Deciphering the intricate regulatory mechanisms underlying biological processes holds promise for elucidating how genetic variants contribute to immune-related disorders. …”
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Recent Technological Advancements for Identifying and Exploiting Novel Sources of Pest and Disease Resistance for Peanut Improvement by Akshaya Kumar Biswal, Peggy Ozias-Akins, Carl Corley Holbrook

“…Next-generation sequencing (NGS) technologies, bioinformatics pipelines, comparative genomics, and transcriptomics have helped identify a plethora of candidate genes involved in pest resistance. …”
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Biochemical properties of lactic acid bacteria for efficient silage production: an update by Muhammad Faheem Akhtar, Chai Wenqiong, Muhammad Umar, Wang Changfa

“…Additionally, the review outlines emerging trends and prospective developments in LAB advancement for the enhancement of silage, which holds significant promise for breakthroughs in sustainable agriculture and improved animal feed production.…”
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Activation of three targets by a TAL effector confers susceptibility to bacterial blight of cotton by Brendan W. Mormile, Yan Yan, Taran Bauer, Li Wang, Rachel C. Rivero, Sara C. D. Carpenter, Catherine Danmaigona Clement, Kevin L. Cox, Lin Zhang, Xiyu Ma, Terry A. Wheeler, Jane K. Dever, Ping He, Adam J. Bogdanove, Libo Shan

“…CRISPR-Cas9 gene editing supports the function of GhSWEETs in cotton bacterial blight and the promise of disrupting the TALE-binding site in S genes for disease management. …”
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Exploring omics strategies for drug discovery from Actinomycetota isolated from the marine ecosystem by Manik Prabhu Narsing Rao, Syed Raziuddin Quadri, Manda Sathish, Ngoc Tung Quach, Wen-Jun Li, Wen-Jun Li, Arinthip Thamchaipenet, Arinthip Thamchaipenet

“…Combining these strategies holds great promise for discovering new marine-derived compounds with potential therapeutic applications.…”
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