The Class III Peroxidase Gene Family in <i>Populus simonii</i>: Genome-Wide Identification, Classification, Gene Expression and Functional Analysis by Lu Han, Yishuang Ren, Xinru Bi, Guowei Yao, Jinwang Zhang, Hongtao Yuan, Xiaoyu Xie, Junbo Chen, Yunchang Zhang, Sitong Du, Wanying Chen, Kewei Cai, Xiyang Zhao

“…Notably, <i>PsPOD45</i>, <i>PsPOD69</i>, <i>PsPOD33</i>, and <i>PsPOD64</i> were identified as central hub genes in the protein–protein interaction network, making them promising candidates for further functional characterization. …”
Get full text

Tetramethyl bisphenol F exposure induces human ovarian granulosa cell senescence and mouse ovarian damage by regulating ESRRB signalling by Huiyu Fan, Chunming Li, Yifei Lv, Tongyun Qi, Yizhou Huang, Linjuan Ma, Yibing Lan, Peiqiong Chen, Zheng Lou, Jianhong Zhou

“…Tetramethyl bisphenol F (TMBPF), regarded as a promising alternative to bisphenol A (BPA) across multiple industries, is now incorporated into polymer coatings for metal cans used in food and beverage packaging. …”
Get full text

Preclinical and clinical evaluation of intratumoral injection of an IL-12 expressing SKV-012 oncolytic virus for advanced solid tumors by Jing Jin, Zheng Jiang, Jun Liu, Hui Yang, Long Xu, Weiwei Zhang, Xingchen Peng, Nian Yang, Zongliang Zhang, Liangxue Zhou, Aiping Tong, Huaqing Lu, Yongdong Chen, Liyuan Jin

“…Primary endpoints were safety and tolerability, while secondary endpoints were antitumor response and changes in the tumor microenvironment (TME), assessed by RECIST v1.1 criteria and multiplex immunohistochemistry and single-cell transcriptome analysis.Results SKV-012-infected tumor cells secreted high levels of IL-12 and exhibited increased ICP34.5 expression. …”
Get full text

Molecular mechanism of PANoptosis and programmed cell death in neurological diseases by Ketian Hou, Wenhan Pan, Lianhui Liu, Qianqian Yu, Jiahao Ou, Yueqi Li, Xi Yang, Zhenlang Lin, Jun Hui Yuan, Mingchu Fang

“…This molecular crosstalk highlights PANoptosis as a promising therapeutic target for managing immune-related disorders and malignant transformation. …”
Get full text

Synthesis of biosafe spirulina-derived carbon dots and their fluorescence imaging in zebrafish by Yue Wang, Zhizhi Gu, Jingyi Dong, Cunguang Liu, Jie Zhu, Zixu Wang, Jiaying Li, Meichen Lu, Jian Han, Shengnan Cao, Zhuang Xue, Yan Chen, Liyong Chen, Wei Wang

“…Carbon dots (CDs) have emerged as promising fluorescent nanomaterials owing to their superior optical properties and favorable biocompatibility. …”
Get full text

HIF‐1α‐induced long noncoding RNA LINC02776 promotes drug resistance of ovarian cancer by increasing polyADP‐ribosylation by Yangjun Wu, Yu Zeng, Yong Wu, Xinyu Ha, Zheng Feng, Chaohua Liu, Ziqi Liu, Jiajia Wang, Xingzhu Ju, Shenglin Huang, Linhui Liang, Bin Zheng, Lulu Yang, Jun Wang, Xiaohua Wu, Shengli Li, Hao Wen

“…Methods We performed transcriptome‐wide analysis by RNA sequencing (RNA‐seq) data of platinum‐resistant and ‐sensitive OC tissues. …”
Get full text

Construction of cartilaginous organoids based on cartilage extracellular matrix microcarriers to promote articular cartilage regeneration through immune regulation by Hongyu Jiang, Wei Liu, Jiajie Chen, Yue Tian, Zhibo Jia, Yanbin Wu, Yanjun Guan, Leijia Chen, Wenjing Xu, Haoye Meng, Yingjie Xiong, Jianting Ye, Cheng Huang, Ruichao He, Sice Wang, Yufei Ding, Wei Fan, Yunkang Yang, Jiang Peng, Aiyuan Wang

“…Functionalized CORGs were successfully constructed based on CEMMs. Transcriptomics showed that CORGs had a gene expression pattern similar to mesodermal to chondrogenic development. …”
Get full text

Diversity of Gibberellin 2-oxidase genes in the barley genome offers opportunities for genetic improvement by Jingye Cheng, Yong Jia, Camilla Hill, Tianhua He, Ke Wang, Ganggang Guo, Sergey Shabala, Meixue Zhou, Yong Han, Chengdao Li

“…Conclusion: Our results demonstrate the potential of manipulating GA2ox genes to fine tune GA signalling and biofunctions in desired plant tissues and open a promising avenue for minimising the trade-off effects of Green Revolution semi-dwarfing genes on grain size and weight. …”
Get full text

Predicting patients with septic shock and sepsis through analyzing whole-blood expression of NK cell-related hub genes using an advanced machine learning framework by Chao Du, Chao Du, Chao Du, Stephanie C. Tan, Stephanie C. Tan, Heng-Fu Bu, Heng-Fu Bu, Saravanan Subramanian, Saravanan Subramanian, Hua Geng, Hua Geng, Xiao Wang, Xiao Wang, Hehuang Xie, Xiaowei Wu, Tingfa Zhou, Ruijin Liu, Zhen Xu, Bing Liu, Xiao-Di Tan, Xiao-Di Tan, Xiao-Di Tan

“…The need for biomarkers to predict the progression of sepsis to septic shock remains critical, with rapid, reliable methods still lacking. Transcriptomics data has recently emerged as a valuable resource for disease phenotyping and endotyping, making it a promising tool for predicting disease stages. …”
Get full text

Spatial patterns and MRI-based radiomic prediction of high peritumoral tertiary lymphoid structure density in hepatocellular carcinoma: a multicenter study by Juan Chen, Xiong Chen, Kai Fu, Lan Zhou, Shichao Long, Mengsi Li, Linhui Zhong, Aerzuguli Abudulimu, Wenguang Liu, Deng Pan, Ganmian Dai, Yigang Pei, Wenzheng Li

“…This study aimed to elucidate biological differences related to pTLS density and develop a radiomic classifier for predicting pTLS density in HCC, offering new insights for clinical diagnosis and treatment.Methods Spatial transcriptomics (n=4) and RNA sequencing data (n=952) were used to identify critical regulators of pTLS density and evaluate their prognostic significance in HCC. …”
Get full text

Unraveling resistance mechanisms to the novel nucleoside analog RX-3117 in lung cancer: insights into DNA repair, cell cycle dysregulation and targeting PKMYT1 for improved therapy by Mahrou Vahabi, Geng Xu, Dzjemma Sarkisjan, Btissame El Hassouni, Giulia Mantini, Valentina Donati, Bing Wang, Giulia Lencioni, Richard J. Honeywell, Dongmei Deng, Sabrina Strano, Godefridus J. Peters, Giovanni Blandino, Elisa Giovannetti

“…The cytidine analogue RX-3117 shows promise in gemcitabine-resistant cancers, yet mechanisms underlying acquired resistance to this drug remain unexplored. …”
Get full text

ETMR stem-like state and chemo-resistance are supported by perivascular cells at single-cell resolution by Flavia W. de Faria, Nicole C. Riedel, Daniel Münter, Marta Interlandi, Carolin Göbel, Lea Altendorf, Mathis Richter, Viktoria Melcher, Christian Thomas, Rajanya Roy, Melanie Schoof, Ivan Bedzhov, Natalia Moreno, Monika Graf, Marc Hotfilder, Dörthe Holdhof, Wolfgang Hartmann, Ann-Katrin Bruns, Angela Brentrup, Friederike Liesche-Starnecker, Bruno Maerkl, Sarah Sandmann, Julian Varghese, Martin Dugas, Pedro H. Pinto, Sebastian T. Balbach, I-Na Lu, Claudia Rossig, Oliver Soehnlein, Aysegül Canak, Martin Ebinger, Martin Schuhmann, Jens Schittenhelm, Michael F. Frühwald, Ulrich Schüller, Thomas K. Albert, Carolin Walter, Jan M. Bruder, Kornelius Kerl

“…Targeting ETMR-pericyte interactions in the TME presents a promising therapeutic approach.…”
Get full text

3D-printed manganese dioxide incorporated scaffold promotes osteogenic-angiogenic coupling for refractory bone defect by remodeling osteo-regenerative microenvironment by Yipei Yang, Zhenyu Yao, Yuanyi Sun, Yangyi Nie, Yuanchi Zhang, Ziyue Li, Zhiheng Luo, Wenjing Zhang, Xiao Wang, Yuhan Du, Wei Zhang, Ling Qin, Hongxun Sang, Yuxiao Lai

“…Overall, the PMns exhibit superior immunomodulatory, excellent osteogenic-angiogenic properties and promising candidates as bone graft substitutes for therapy clinical refractory bone defects.…”
Get full text

SSL5-AnxA5 Fusion Protein Constructed Based on Human Atherosclerotic Plaque scRNA-Seq Data Preventing the Binding of Apoptotic Endothelial Cells, Platelets, and Inflammatory Cells by Yifei Zhao, Xingyu He, Teng Hu, Tianli Xia, Fangyang Huang, Changming Li, Yiming Li, Fei Chen, Mao Chen, Jun Ma, Yong Peng

“…<b>Conclusions:</b> The bifunctional protein SSL5-AnxA5 exhibits promising potential as a protective agent against local inflammation in arterial tissues, making it an excellent candidate for PSGL1-related therapeutic interventions.…”
Get full text

S100A8/A9 high-expression macrophages mediate renal tubular epithelial cell damage in acute kidney injury following acute type A aortic dissection surgery by Xiujuan Cai, Xin Li, Jian Shi, Lu Tang, Jie Yang, Ronghuang Yu, Zhigang Wang, Dongjin Wang, Dongjin Wang

“…Finally, recombinant protein S100A8/A9 activated the TNF signaling pathway in renal tubular epithelial cells.ConclusionThese findings suggested that S100A8/A9 were promising predictive biomarkers for AKI after surgery for ATAAD. …”
Get full text

SHP2 inhibition and adjuvant therapy synergistically target KIT‐mutant GISTs via ERK1/2‐regulated GSK3β/cyclin D1 pathway by Chunxiao He, Jiaying Yu, Shuang Mao, Shaohua Yang, Xianming Jiang, Lei Huang, Mingzhe Li, Yulong He, Xinhua Zhang, Xi Xiang

“…Immunoblotting, cell cycle analysis, transcriptome analysis and rescue experiments were performed to investigate the molecular mechanisms underlying SHP2 inhibition. …”
Get full text

Targeting S100A9 attenuates social dysfunction by modulating neuroinflammation and myelination in a mouse model of autism by Hong Gong, Yao Lu, Shi-Long Deng, Ke-Yi Lv, Jing Luo, Yi Luo, Zhu-Lin Du, Ling-Feng Wu, Tian-Yao Liu, Xia-Qing Wang, Jing-Hui Zhao, Lian Wang, Mei-Ling Xia, Dong-Mei Zhu, Li-Wei Wang, Xiao-Tang Fan

“…Targeting S100A9 could, therefore, be a promising therapeutic strategy for neuroinflammation-related neurodevelopmental disorders.…”
Get full text

Phenotype and function of human monocytes remain mainly unaffected by very small superparamagnetic iron oxide particles by Sari Hussein, Sari Hussein, Anja Andrea Kühl, Laura Golusda, Laura Golusda, Christina Plattner, Nadine Heinze, Nadine Heinze, Gregor Sturm, Christian Freise, Heike Traub, Mathias Schannor, Zlatko Trajanoski, Matthias Taupitz, Britta Siegmund, Daniela Paclik, Daniela Paclik

“…In summary, the analysis of peripheral blood mononuclear cells and monocytes suggests that VSOP treatment has no major impact on immune cell phenotype or function indicating VSOP as a promising diagnostic tool in MRI for inflammatory bowel disease.…”
Get full text

Epstein-Barr virus hijacks histone demethylase machinery to drive epithelial malignancy progression through KDM5B upregulation by Ya-Qing Zhou, Jia-Xin Jiang, Shuai He, Yi-Qi Li, Xi-Xi Cheng, Shu-Qiang Liu, Pan-Pan Wei, Xin-Yuan Guan, Choon Kiat Ong, Vivien Ya-Fan Wang, Chun-Ling Luo, Jin-Xin Bei

“…Through integrative analyses of single-cell and bulk transcriptome data from epithelial tumor tissues and EBV-infected cells, we identified KDM5B as a critical histone-modifying factor consistently upregulated following EBV infection. …”
Get full text

Gaylussacin, a stilbene glycoside, inhibits chronic obstructive pulmonary disease in mice by Hye-Young Min, Jeong Yeon Sim, Jee Hwan Ahn, Nae-Won Kang, Hye-Jin Boo, Jina Kim, Na-Young Yu, Marta Bottacin, Jungmoo Huh, Choon-Sik Park, Jong-Sook Park, Suckchang Hong, Sungyong You, Dae-Duk Kim, Ho-Young Lee

“…This study supports gaylussacin as a promising therapeutic candidate for the treatment of environmentally induced COPD.…”
Get full text