Comprehensive analysis of histophysiology, transcriptomics and metabolomics in goslings exposed to gossypol acetate: unraveling hepatotoxic mechanisms by Jun Yu, Jun Yu, Haiming Yang, Jian Wang, Zixin Huang, Shi Chen, Hongchang Zhao, Jun Wang, Zhiyue Wang

“…Cottonseed meal is a promising alternative to soybean meal in poultry feed, but concerns over free gossypol limit its use. …”
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Integrating transcriptomics and hybrid machine learning enables high-accuracy diagnostic modeling for nasopharyngeal carcinoma by Hehe Wang, Junge Zhang, Peng Cheng, Lujie Yu, Chunlin Li, Yaowen Wang

“…This study aimed to develop robust machine learning (ML)-driven diagnostic models and identify key biomarkers through integrated analysis of multi-cohort transcriptomic data. Methods Seven NPC transcriptomic datasets (GSE12452, GSE40290, GSE53819, and GSE64634 were merged to form the training cohort, while GSE13597, GSE34573, and GSE61218 served as independent external validation sets) were integrated and preprocessed using ComBat for batch effect correction. …”
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Identification of the intestinal type gastric adenocarcinoma transcriptomic markers using bioinformatic and gene expression analysis by V. V. Volkomorov, E. S. Grigor’eva, G. S. Krasnov, N. V. Litvyakov, N. A. Lisitsyn, M. I. Voevoda, A. V. Belkovets, S. G. Afanas’ev, N. V. Cherdyntseva

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Feeding the future: A new potential nutritional impact of Lactiplantibacillus plantarum and its promising interventions in future for poultry industry by Muhammad Saeed, Hanan Al-Khalaifah, Afaf Al-Nasser, Tahani Al-Surrayai

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Unveiling Ventilator-Associated Pneumonia: S100A8 as a Promising Biomarker Through Integrated RNA-Seq Analysis by Wang Q, Dong J, Jing X, Long Y, Jia H, Li Y, Wang J

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Time-course transcriptomic information reveals the mechanisms of improved drought tolerance by drought priming in wheat by Qing Li, Zhuangzhuang Sun, Zihan Jing, Xiao Wang, Chuan Zhong, Wenliang Wan, Maguje Masa Malko, Linfeng Xu, Zhaofeng Li, Qin Zhou, Jian Cai, Yingxin Zhong, Mei Huang, Dong Jiang

“…Moderate drought priming during the earlier growth stages is a promising strategy for allowing plants to resist recurrent severe drought stress. …”
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Deciphering the tumor immune microenvironment: single-cell and spatial transcriptomic insights into cervical cancer fibroblasts by Zhiheng Lin, Youwei Zhou, Zhenran Liu, Wenyang Nie, Hengjie Cao, Shengnan Li, Xuanling Li, Lijun Zhu, Guangyao Lin, Yanyu Ding, Yi Jiang, Zuxi Gu, Lianwei Xu, Zhijie Zhao, Huabao Cai

“…This study integrates single-cell RNA sequencing (scRNA-seq), spatial transcriptomics, and deconvolution analysis to identify key genes and immunotherapy targets. …”
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Comparative Transcriptomic Analysis Unveils Divergent Effects of FLASH Versus Conventional Irradiation on Skin Cells by Mengmeng Xu, Qiliang Peng, Jun Zhang, Zhiming Xu, Xinyang Cheng, Zhifei Cao, Yongsheng Zhang

“…Objectives FLASH radiotherapy is garnering attention for its capacity to diminish skin toxicity without compromising tumoricidal efficacy, presenting a stark contrast to conventional (CONV) radiotherapy. Despite its promise, the underlying molecular mechanisms of FLASH irradiation (FLASH-IR) on skin are not yet fully elucidated. …”
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Variational graph autoencoder for reconstructed transcriptomic data associated with NLRP3 mediated pyroptosis in periodontitis by Pradeep K. Yadalam, Prabhu Manickam Natarajan, Carlos M. Ardila

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Cannabinol’s Modulation of Genes Involved in Oxidative Stress Response and Neuronal Plasticity: A Transcriptomic Analysis by Serena Silvestro, Marco Calabrò, Alessandra Trainito, Stefano Salamone, Federica Pollastro, Emanuela Mazzon, Aurelio Minuti

“…Overall, our results suggest that CBN holds promise as an adjuvant agent for neurodegenerative diseases by modulating genes involved in neuronal cell survival and axon guidance.…”
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Plasma-based transcriptomic non-coding signature for predicting relapse in pediatric acute lymphoblastic leukemia by Yaping Wang, Xiaopeng Ma, Huimin Li, Ji'ou Zhao, Meiyun Kang, Liucheng Rong, Yao Xue, Jiali Wang, Junwei Tang, Yongjun Fang

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Integrated Analysis of DNA Methylome and Transcriptome Reveals Regulatory Mechanism in the Longissimus Dorsi of Duroc Pigs by Shiyin Li, Yarui Gao, Lixia Ma, Wei Chen, Zhao Ma, Zhanchi Ren, Yunzhou Wang, Yongqing Zeng

“…DNA methylation plays a pivotal role in the epigenetic regulation of gene expression and holds promise for enhancing livestock meat production. In this study, we analyzed the DNA methylome and transcriptome of the longissimus dorsi muscle (LDM) in Duroc pigs with varying growth rates. …”
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CDK inhibitors promote neuroblastoma cell differentiation and increase sensitivity to retinoic acid—a promising combination strategy for therapeutic intervention by Fatemeh Shokraie, Larissa Lechermeier, Pia Bordihn, Philipp Kaps, Steffen Möller, Anna Sophie Schulz, Björn Schneider, Dirk Koczan, Samira Khanipour Roshan, Holger N. Lode, Carl-Friedrich Classen, Olga Hahn, Sascha Troschke-Meurer, Claudia Maletzki

“…Differentiation therapy is an encouraging prospect, with cyclin-dependent kinase inhibitors (CDKis) representing a promising avenue for promoting NB differentiation. …”
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Identification of hub gene associated with colorectal cancer: Integrating Mendelian randomization, transcriptome analysis and experimental verification. by Yu Zhang, Xu Han, Yichun Yang, Jiayan Ren, Zixi Zhang, Yanmin Zhang, Qi Su, Dake Chu

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Identification of druggable targets in acute kidney injury by proteome- and transcriptome-wide Mendelian randomization and bioinformatics analysis by Jiachen Liu, Dianjie Zeng, Yinhuai Wang, Fei Deng, Shuiqing Wu, Zebin Deng

“…Expression patterns of these targets were examined using bulk transcriptome and single-cell transcriptome data. In addition, drug repurposing analyses were conducted to explore the potential of existing medications. …”
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Silk Fibroin Films with Microscopic Surface Pattern as Promising Cartilage Tissue Engineering Scaffold in Supporting MSCs Amplification and Chondrogenic Differentiation by Xin Wang, Junjun Yang, Rong Wang, Yumengfei Huang, Zu Wan, Zhi Wang, Zhenlan Fu, Cheng Chen, Guangxing Chen, Xiaoyuan Gong

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Transcriptomic Approaches to Investigate the Anti-Aging Effects of Blueberry Anthocyanins in a Caenorhabditis Elegans Aging Model by Jie Ding, Jiahui Liu, Qingqi Guo, Na Zhang

“…These findings highlight the potential of blueberry anthocyanins as promising anti-aging agents through multiple physiological and molecular mechanisms.…”
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Deciphering ovarian cancer heterogeneity through spatial transcriptomics, single-cell profiling, and copy number variations. by Songyun Li, Zhuo Wang, Hsien-Da Huang

“…To elucidate the intricate mechanisms underlying HGSOC heterogeneity, we conducted a comprehensive analysis of five single-cell transcriptomes and eight spatial transcriptomes derived from eight HGSOC patients. …”
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Differential Gene Expression Analysis of Whole Blood Transcriptome Between Young and Old Border Collie Dogs by Dávid Jónás, Kitti Tátrai, Zsófia Rékasi, Balázs Egyed, Eniko Kubinyi

“…In conclusion, while some of our findings are promising, further research is needed to standardize environmental factors affecting blood gene expression levels in dogs. …”
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Deciphering the dose-dependent effects of thymoquinone on cellular proliferation and transcriptomic changes in A172 glioblastoma cells. by Rachana Pandey, Purushothaman Natarajan, Umesh K Reddy, Wei Du, Cristian Sirbu, Moussa Sissoko, Gerald R Hankins

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