RIPK2 promotes colorectal cancer metastasis by protecting YAP degradation from ITCH-mediated ubiquitination by Chen Lu, Hongda Liu, Tianyu Liu, Sizheng Sun, Yanan Zheng, Tao Ling, Xiagang Luo, Yiming E, Yuting Xu, Jie Li, Lei Liu, Lin Miao, Zhengxia Liu, Chunzhao Yu

“…Our findings provide deep insights into RIPK2’s role in CRC progression and present a promising target for future therapeutic strategies.…”
Get full text

Therapeutic effects of PDGF-AB/BB against cellular senescence in human intervertebral disc by Changli Zhang, Martha Elena Diaz-Hernandez, Takanori Fukunaga, Sreekala Shenoy, Sangwook Tim Yoon, Lisbet Haglund, Hicham Drissi

“…Our findings reveal a novel anti-senescence role of PDGF in the IVD, making it a promising potential candidate to delay aging-induced IVD degeneration.…”
Get full text

Targeting Redox Signaling Through Exosomal MicroRNA: Insights into Tumor Microenvironment and Precision Oncology by Moon Nyeo Park, Myoungchan Kim, Soojin Lee, Sojin Kang, Chi-Hoon Ahn, Trina Ekawati Tallei, Woojin Kim, Bonglee Kim

“…Incorporating insights from spatial transcriptomics and single-cell analysis, this review provides a mechanistic foundation for the development of exosome-centered, redox-modulating therapeutics. …”
Get full text

Mangiferin Ameliorates HFD-Induced NAFLD through Regulation of the AMPK and NLRP3 Inflammasome Signal Pathways by Zhang Yong, Wang Ruiqi, Yao Hongji, Ma Ning, Jiang Chenzuo, Zhou Yu, Xia Zhixuan, Liu Qiang, Liu Qibing, Lu Weiying, Zhang Xiaopo

“…Our study indicates that Man is a promising prodrug for the therapy of NAFLD patients.…”
Get full text

PA-Win2: In Silico-Based Discovery of a Novel Peptide with Dual Antibacterial and Anti-Biofilm Activity by Jin Wook Oh, Min Kyoung Shin, Hye-Ran Park, Sejun Kim, Byungjo Lee, Jung Sun Yoo, Won-Jae Chi, Jung-Suk Sung

“…<b>Methods:</b> In this study, we utilized a previously developed deep-learning model to identify AMP candidates from the venom gland transcriptome of the spider <i>Pardosa astrigera</i>, followed by experimental validation. …”
Get full text

Quzhou Aurantii Fructus Flavonoids Ameliorate Inflammatory Responses, Intestinal Barrier Dysfunction in DSS-Induced Colitis by Modulating PI3K/AKT Signaling Pathway and Gut Microbi... by Wang H, Huang W, Pan X, Tian M, Chen J, Liu X, Li Q, Qi J, Ye Y, Gao L

“…Western blotting confirmed key regulatory proteins within the differential signaling pathways, guided by transcriptome analysis. Additionally, the influence of QAFF on the gut microbiome was explored through 16S ribosomal RNA (rRNA) sequencing. …”
Get full text

AMF30a promotes survival and function of human corneal endothelial cells by regulating TGF-β/ROCK/HIPPO pathway by Yunkyoung Ryu, Hye-Jin Son, Jin Sun Hwang, Kyung Bo Noh, Sun-Hee Oh, Eun-Kyoung Choi, Young Joo Shin

“…Thus, AMF30a may be a promising therapeutic strategy for hCEC diseases.…”
Get full text

Periplocin induces necroptosis in papillary thyroid carcinoma through DR4 mediated RIPK3 and MLKL signaling by Li Ding, Fengmei Wen, Liang Zeng, Ziwei Li, Gangyin Xie

“…RNA-seq was conducted to compare the transcriptomes of periplocin-treated and untreated TPC-1 cells. …”
Get full text

Identification of biomarkers associated with energy metabolism in hypertrophic cardiomyopathy and exploration of potential mechanisms of roles by Songyan Cai, Tianying Jin, Mintong Liu, Qingyuan Dai

“…Here, biomarkers related to energy metabolism in HCM were identified through bioinformatics analysis.MethodsHCM transcriptome data were acquired from the GEO (GSE36961) database for comparative analysis in order to identify differentially expressed genes (DEGs). …”
Get full text

Single-cell RNA sequencing reveals a B cell-related immunosuppressive landscape and a potential suppressor in hepatocellular carcinoma by Wenhao Hou, Jiaqi Jiang, Liyuan Zhu, Hongwei Xu, Lihui Zhu

“…Methods To characterize the HCC microenvironment, the single-cell transcriptomes of HCC tissues and corresponding noncancerous tissues were analysed. …”
Get full text

Multiomics Analysis Reveals Therapeutic Targets for Chronic Kidney Disease With Sarcopenia by Meiqiu Wang, Lianghui You, Xu He, Yingchao Peng, Ren Wang, Zhiqiang Zhang, Jiaping Shu, Pei Zhang, Xiaoyi Sun, LiLi Jia, Zhengkun Xia, Chenbo Ji, Chunlin Gao

“…Results In the renal transcriptome and TMT, 503 and 377 proteins/genes respectively were co‐upregulated and co‐downregulated. …”
Get full text

Bioinformatics and experimental approach identify DNMT3A as a diagnostic marker associated with regulated cell death patterns in psoriasis by Linyu Zhu, Zhiyu Ye, Ling Wang, Shaomin Chen, Menger Guo, Lvya Zhang, Yuansheng Wu

“…Then, an RCD.score was conducted, and RCD.score demonstrated promising diagnostic capabilities across 10 datasets. …”
Get full text

The suppressive role of GLS in radiosensitivity and irradiation-induced immune response in LUAD: integrating bioinformatics and experimental insights by Peicheng Jiang, Zhifeng Jiang, Su Li, Su Li, Ye-Xiong Li, Yuqiong Chen, Xinyan Li

“…Single-cell and spatial transcriptomics revealed the immunomodulatory effects of GLS expression in the TME. …”
Get full text

Characterization of Thaumatin-like Gene Family Reveals Group V <i>CaTLPs</i> Drive Anthracnose Resistance in Pepper (<i>Capsicum annuum</i>) by Hao Wu, Jian Zeng, Cui Mao, Weifeng Huang, Chuanhong Li, Liya Yang, Xiaohan Zhang, Jiaxian Lin, Jianjun Lei, Yong Zhou, Zhangsheng Zhu, Jie Zheng

“…Through comparative transcriptome analysis and weighted gene co-expression network analysis (WGCNA), 17 gene modules were identified, among which the salmon module showed a strong association with resistance in variety 225. …”
Get full text

Melatonin Enhances the Low-Calcium Stress Tolerance by Regulating Brassinosteroids and Auxin Signals in Wax Gourd by Jingjing Chang, Xuemei Zhu, Yixuan Lian, Jing Li, Xiao Chen, Zhao Song, Lei Chen, Dasen Xie, Baige Zhang

“…This study provides new insights into the role of melatonin in nutrient stress adaptation, offering a promising and sustainable approach to improve nutrient use efficiency in wax gourd and other crops.…”
Get full text

Platelet-derived extracellular vesicles induced through different activation pathways drive melanoma progression by functional and transcriptional changes by Zeynep Tavukcuoglu, Umar Butt, Alessandra V. S. Faria, Johannes Oesterreicher, Wolfgang Holnthoner, Saara Laitinen, Mari Palviainen, Pia R-M Siljander

“…Inhibiting the platelet receptors that modulate the PEVs’ cancer-promoting properties may open up new strategies for identifying promising treatment targets for cancer therapy.…”
Get full text

Calbindin 2 as a Novel Biomarker and Therapeutic Target for Abdominal Aortic Aneurysm: Integrative Analysis of Human Proteomes and Genetics by Yulin Bao, Jiayi Chen, Xudong Han, Ye He, Tongtong Yang, Xinying Shi, Jiawen Chen, Lingfeng Gu, Sibo Wang, Liping Xie, Hao Wang, Liansheng Wang

“…Lenalidomide and genistein hold promising potential as treatments for patients with AAA.…”
Get full text

Assessment and Monitoring of the Wound Micro-Environment in Chronic Wounds Using Standardized Wound Swabbing for Individualized Diagnostics and Targeted Interventions by Julian-Dario Rembe, Waseem Garabet, Jan-Wilm Lackmann, Sadaf Alizadehrahrouei, Matthias Augustin, Joachim Dissemond, Wiebke Ibing, Karl Köhrer, Klaus Pfeffer, Anna Rommerskirchen, Sebastian Alexander Scharf, Tobias Wienemann, Thorsten Wachtmeister, Hubert Schelzig, Ewa Klara Stuermer

Get full text

Profiling of gastric cancer cell-surface markers to achieve tumour–normal discrimination by Henry Yang, Khek Yu Ho, Judith Toh, Michal Marek Hoppe, Teena Thakur, Kar Tong Tan, Brendan Pang, Sharmaine Ho, Rony Roy, Khay Guan Yeoh, Raghav Sundar, Anand Jeyasekharan

“…Background Differentiating between malignant and normal cells within tissue samples is vital for molecular profiling of cancer using advances in genomics and transcriptomics. Cell-surface markers of tumour–normal discrimination have additional value in terms of translatability to diagnostic and therapeutic strategies. …”
Get full text

Characterization of the landscape of the intratumoral microbiota reveals that Streptococcus anginosus increases the risk of gastric cancer initiation and progression by Li Yuan, Libin Pan, Yunzhe Wang, Jing Zhao, Luo Fang, Ying Zhou, Ruihong Xia, Yubo Ma, Zhengchen Jiang, Zhiyuan Xu, Can Hu, Yanan Wang, Shengjie Zhang, Bo Zhang, Haiying Ding, Mengxuan Chen, Haibo Cheng, Ajay Goel, Zhao Zhang, Xiangdong Cheng

“…Here, we integrated multiple types of omics data, including microbiome, transcriptome, and metabolome data, to investigate the functional role of intratumoral bacteria in gastric cancer (GC). …”
Get full text