Post-genome-wide association study dissects genetic vulnerability and risk gene expression of Sjögren’s disease for cardiovascular disease by Xinglin Yi, Erxiong Liu, Yong Wang

“…Cross-phenotype analyses were employed to identify shared variants and genes, followed by a Transcriptome-Wide Association Study (TWAS) and Multi-marker Analysis of Genomic Annotation (MAGMA) based on Multi-Trait Analysis of GWAS (MTAG) results. …”
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Evidence from a Comprehensive Bioinformatics Analysis Point to Possible Therapeutic Targets for Vitiligo by Wang Y, Yao T, Lin Y, Wu J

“…The PPI network revealed that GZMB, FCRL3, and ULK3 interact with the target proteins of existing vitiligo treatments.Conclusion: Our study has identified three promising drug target proteins for the treatment of vitiligo, which merit prioritization in drug development efforts. …”
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miR-184, a downregulated ovary-elevated miRNA transcriptionally activated by SREBF2, exerts anti-apoptotic properties in ovarian granulosa cells through inducing SMAD3 expression by Baosen Shan, Yangan Huo, Zhennan Guo, Qiqi Li, Zengxiang Pan, Qifa Li, Xing Du

“…Here, 13 downregulated OE miRNAs were systematically identified by integrating tissue expression high-throughput data and comparative transcriptome analyses, among which miR-184 was specifically highly expressed in ovary but dramatically downregulated during follicular atresia. …”
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Bioinformatics and experimental validation identify biomarkers for diagnosing Alzheimer’s disease by Hui Liu, Hui Liu, Chenye Li, Congchen Zhai, Congchen Zhai, Mei Li, Lan Ma

“…Additionally, the experiment suggests that c-Myc could serve as a promising blood biomarker for the diagnosis of AD.…”
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Genome‐wide screening of abberant methylated drivers combined with relative risk loci in bladder cancer by Chuanjie Zhang, Kangjie Shen, Yuxiao Zheng, Feng Qi, Jun Luo

“…Conclusion Our study indicated several hub‐MDGs, calculated novel risk score and explored the prognostic value in BCa, which provided a promising approach to BCA prognosis assessment.…”
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SPI1+CD68+ macrophages as a biomarker for gastric cancer metastasis: a rationale for combined antiangiogenic and immunotherapy strategies by Hong Yu, Yulong He, Changhua Zhang, Zhenzhen Zhao, Guofei Deng, Pengliang Wang, Rishun Su, Xuezeng Sun, Zizhen Wu, Zhangsen Huang, Liang Gu, Mingyu Huo, Songcheng Yin

“…The effect of combined antiangiogenic and immunotherapy was further validated using mouse peritoneal metastasis models.Results Single-cell transcriptome analysis and immunohistochemistry demonstrated that SPI1 was expressed in macrophages, with a higher enrichment in metastatic lesions than in primary tumors. …”
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Injectable and Assembled Calcium Sulfate/Magnesium Silicate 3D Scaffold Promotes Bone Repair by In Situ Osteoinduction by Wei Zhu, Tianhao Zhao, Han Wang, Guangli Liu, Yixin Bian, Qi Wang, Wei Xia, Siyi Cai, Xisheng Weng

“…In vivo results confirmed enhanced trabecular density and bone volume compared to controls, indicating effective bone repair and regeneration. (4) Conclusions: The Mg@Ca scaffold offers a promising therapeutic approach for ONFH, providing a minimally invasive solution for bone defect repair while stimulating natural bone regeneration. …”
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Synthesis of U-theraphotoxin-Pv1a_1, an Aedes aegypti larvicidal disulfide bridged peptide from the Colombian tarantula Pamphobeteus verdolaga (Araneae: Theraphosidae) by Sebastián Estrada-Gómez, Cristian Salinas-Restrepo, Leidy Johana Vargas-Muñoz, Fanny Guzmán, Cesar Segura, Davinia Pla, Libia Sanz, Juan J Calvete

“…Its potent contact activity makes n-Pv1a_1 and its synthetic version, s-Pv1a, promising biopesticides for the control of mosquito populations.…”
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Brevilin A, a novel LRRC15 inhibitor, exerts potent anti-rheumatoid arthritis effects by inhibiting the LRRC15/STAT3 signaling pathway by Zhiping Qiao, Qiqi Meng, Bixia Xiao, Yulei Long, Qi Liang, Tao Su

“…However, the anti-RA effect of BrA and its underlying mechanism of action of BrA have not been fully elucidated. Methods Transcriptome analysis was performed to explore biomarkers of RA. …”
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Genome-wide CRISPR/Cas9 screening identifies PTGR2 as a potential therapeutic target for sunitinib resistance in clear cell renal cell carcinoma by Wei Chang, Biao Zhang, Shujun Yang, Xingxing Zhang, Lili Zhang, Su Zhang, Jianzhong Lu, Wei Wang, Panfeng Shang, Zhongjin Yue

“…Utilizing genome-wide CRISPR/Cas9 screening and resistant transcriptomics, we identified that prostaglandin reductase 2 (PTGR2) is a novel therapeutic target to overcome sunitinib resistance in ccRCC. …”
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Regulation of renal ischemia-reperfusion injury and tubular epithelial cell ferroptosis by pparγ m6a methylation: mechanisms and therapeutic implications by Wei Liu, Ziqing Xiong, Tianmei Fu, Juan Yang, Juan Zou, Yize Wu, Linju Kuang, Qian Wang, Song Li, Aiping Le

“…These insights offer promising avenues for therapeutic strategies targeting acute kidney injury.…”
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Effects of Graphene Quantum Dots on Renal Fibrosis Through Alleviating Oxidative Stress and Restoring Mitochondrial Membrane Potential by Kyu Hong Kim, Jong Bo Park, Jung Nam An, Gaeun Bae, Kyu Hyeon Kim, Seong Joon Park, Youngjin Jung, Yong Chul Kim, Jung Pyo Lee, Jae Wook Lee, Dong Ki Kim, Yon Su Kim, Byung Hee Hong, Seung Hee Yang

“…Most significantly, transcriptomics and electron microscopy analyses reveal that GQD treatment enhances mitochondrial respiration‐related gene profiles and improves mitochondrial cristae morphology. …”
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Chen’s peiyuan tang and premature ovarian failure: unveiling the mechanisms through network pharmacology by Xiao Yang, Yi-Ming Mao, Chong Yao, Chong Yao, Ding-ming Song, Yi-bo He, Wei Shen

“…The application of Chinese herbal medicine offers a promising alternative to traditional hormone replacement therapy (HRT).MethodsThis study explores CSPYT’s therapeutic mechanisms in treating POF, focusing on its modulation of autophagy through network pharmacology and transcriptomics-based analysis, predicting potential interactions and pathways. …”
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Scorpion venom peptides enhance immunity and survival in Litopenaeus vannamei through antibacterial action against Vibrio parahaemolyticus by Ling Zeng, Yulin Sun, Hualin Zhang, Xiangxi Yi, Ran Du, Ziming Chen, Qi Wang

“…IntroductionScorpion venom-derived antimicrobial peptides (AMPs) have emerged as promising candidates for combating bacterial infections owing to their potent activity and unique mechanisms of action. …”
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Decoding ARF4 and EIF5B-Based Prognostic Signatures and Immune Landscape Following Insufficient Radiofrequency Ablation in Hepatocellular Carcinoma: Through Multi-Omics and Experim... by Zhang Y, Lu Y, Zheng S, Luo W, Tan M, Luo B

“…Experimental validations confirmed the protective role of ARF4 and EIF5B in IRFA outcomes, while knockdown experiments suggested their involvement in promoting cell proliferation, migration, invasion, and EMT in IRFA models, potentially through pathways like P53 and Transforming Growth Factor Beta(TGF-β) signaling pathway activation as indicated by transcriptome sequencing.Conclusion: ARF4 and EIF5B have demonstrated promising potential as biomarkers influencing patient prognosis following RFA in HCC. …”
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Sparstolonin B potentiates the antitumor activity of nanovesicle-loaded drugs by suppressing the phagocytosis of macrophages in vivo by Yuefeng Zhang, Zuo Mou, Wei Song, Xiaoqin He, Qin Yi, Zhekai Wang, Xietong Mao, Wei Wang, Yangtao Xu, Yang Shen, Peng Ma, Kaihuan Yu

“…Abstract Background Extracellular vesicles (EVs) and extruded nanovesicles (ENVs) are promising nanovesicles (NVs) for drug delivery. However, the application of these NVs is strongly hindered by their short half-life in the circulation. …”
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The Role of PLIN3 in Prognosis and Tumor-Associated Macrophage Infiltration: A Pan-Cancer Analysis by Yang S, Liu H, Zheng Y, Chu H, Lu Z, Yuan J, Xu S

“…The association between PLIN3 expression and the presence of M2 macrophages was validated through analyses incorporating bulk and single-cell transcriptomics, spatial transcriptomics, and multicolor fluorescence staining techniques. …”
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Cross-Species Multi-Omics Analysis Reveals Myeloid-Driven Endothelial Oxidative Stress in Ischemic Stroke by Ziqi Cheng, Hua Zhu, Shi Feng, Yonggang Zhang, Xiaoxing Xiong

“…The targeting of endothelial oxidative injury and myeloid-endothelial crosstalk may represent a promising strategy to mitigate secondary brain injury in ischemic stroke.…”
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PKMYT1 kinase ameliorates cisplatin sensitivity in osteosarcoma by Binfeng Liu, Wei Li, Wenchao Zhang, Chengyao Feng, Lu Wan, Shasha He, Ruiling Xu, Zheng Fu, Zhongyue Liu, Haodong Xu, Xin Jin, Chao Tu, Zhihong Li

“…Here, we conducted a kinome-wide clustered regularly interspaced short palindromic repeats (CRISPR) screen, coupled with transcriptome sequencing, to identify regulators of DDP sensitivity. …”
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Nanoparticle‐Delivered siRNA Targeting NSUN4 Relieves Systemic Lupus Erythematosus through Declining Mitophagy‐Mediated CD8+T Cell Exhaustion by Bincheng Ren, Kaini He, Ning Wei, Shanshan Liu, Xiaoguang Cui, Xin Yang, Xiaojing Cheng, Tian Tian, Ru Gu, Xueyi Li

“…In this study, we identified a CD7highCD74high CD8+T subgroup that were robustly expanded in SLE patients through single‐cell transcriptome sequencing (scRNA‐seq). CD7highCD74high CD8+T cells displayed exhausted features and exhibited a superior diagnostic value in SLE. …”
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