Identification of ECE2 signaling in promoting non-small lung cancer progression through ET1/YAP1/MAGEA3 axis by Huaiqing Xiao, Jiawei Ni, Qun Yu

“…Inhibiting ET1 signaling markedly enhanced the anticancer effectiveness of paclitaxel (PTX), providing a promising approach for managing NSCLC.…”
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Phenylacetylglutamine produced from injury lung alveolar epithelial cells promotes the function of BMSCs by regulating NONRATT006276.2/Mapt pathway by Tianyun Yang, Juan Peng, Rongrong Ren, Lin Song

“…Abstract Mesenchymal stem cell (MSC)-based therapy regenerates damaged structures of the respiratory system and restores lung function, thus providing a promising therapeutic approach for chronic obstructive pulmonary disease. …”
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Loss of function of MusaPUB genes in banana can provide enhanced resistance to bacterial wilt disease by Leena Tripathi, Valentine Otang Ntui, Samwel Muiruri, Trushar Shah, Jaindra Nath Tripathi

“…The gene targets used in this study, MusaPUB22 and MusaPUB23, were identified through prior comparative transcriptomics analysis, which revealed their upregulation in susceptible versus resistant genotypes during early infection with Xvm. …”
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The antifungal peptide AnAFP from Aspergillus niger promotes nutrient mobilization through autophagic recycling during asexual development by Stephan Starke, Laura Velleman, Birgit Dobbert, Luis Seibert, Jordi Witte, Sascha Jung, Vera Meyer

“…Antifungal peptides are promising drug candidates to fight fungal infections in the clinics and agriculture. …”
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Harnessing Artificial Intelligence and Machine Learning for Identifying Quantitative Trait Loci (QTL) Associated with Seed Quality Traits in Crops by My Abdelmajid Kassem

“…I also explored AI-driven integration of multi-omics data—genomics, transcriptomics, metabolomics, and phenomics—to improve resolution in QTL mapping. …”
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Identification of Prognostic Immune-Related Genes by Integrating mRNA Expression and Methylation in Lung Adenocarcinoma by Jie Zhu, Min Wang, Daixing Hu

“…Collectively, INHA, S100A16, the CpG site cg23851011, and the CpG site cg06552037 are promising biomarkers for monitoring the outcomes of LUAD.…”
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Serum CXCL13 as a Novel Biomarker in Oral Squamous Cell Carcinoma by Shin Tojo, Koh‐ichi Nakashiro, Nobuyuki Kuribayashi, Daisuke Uchida

“…Conclusion These findings imply that serum CXCL13 holds diagnostic and prognostic value, showing promise as a novel biomarker for OSCC.…”
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Integrating Agronomic and Molecular Advancements to Enhance Nitrogen Use Efficiency (NUE) and Promote Sustainable Rice Production by Uttam Bahadur Kunwar, Nazer Manzoor, Jiancheng Wen, Naba Raj Pandit

“…Moreover, we examine promising rice genotypes and cultivars with improved NUE and grain yield. …”
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An Attention‐Aware Multi‐Task Learning Framework Identifies Candidate Targets for Drug Repurposing in Sarcopenia by Md Selim Reza, Chuan Qiu, Xu Lin, Kuan‐Jui Su, Anqi Liu, Xiao Zhang, Yun Gong, Zhe Luo, Qing Tian, Martin Nwadiugwu, Shaung Liang, Hui Shen, Hong‐Wen Deng

“…The findings suggest that canagliflozin could be a promising therapeutic candidate for sarcopenia.…”
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The integrative genomic and functional immunological analyses of colorectal cancer initiating cells to modulate stemness properties and the susceptibility to immune responses by Issam Tout, Salim Bougarn, Mohammed Toufiq, Neha Gopinath, Ola Hussein, Abbirami Sathappan, Evonne Chin-Smith, Fazulur Rehaman, Rebecca Mathew, Lisa Mathew, Kun Wang, Li Liu, Abdulrahman Salhab, Oleksandr Soloviov, Sara Tomei, Waseem Hasan, Sahar Da’as, Yosra Bejaoui, Nady El Hajj, Karama Makni Maalej, Said Dermime, Kakil Rasul, Paolo Dellabona, Giulia Casorati, Alice Turdo, Matilde Todaro, Giorgio Stassi, Soldano Ferrone, Xinhui Wang, Cristina Maccalli

“…Results CICs exhibited distinct methylation patterns, transcriptomic profiles, and miRNA expressions compared to differentiated tumor cells (p < 0.05 or 0.01). …”
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Multiple highly methylated CpG sites as potential epigenetic markers for the diagnosis of prostate cancer by Jean-Pierre Roperch, Guillaume Charbonnier, Sandy Figiel, Alastair Lamb, Ian Mills, Claude Hennion, Géraldine Cancel-Tassin, Olivier Cussenot

“…Lower expression level was found, using RNA arrays, in tumor compared to non-tumor tissues for six of the eight genes (p ≤ 0.0001) and in tumor glands with high aggressiveness compared to non-tumor glands (p <  0.0001) for the eight genes using in situ transcriptomics. Conclusions Our study identifies promising DNA methylation markers for the diagnosis of prostate cancer.…”
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Engineering exosomes from fibroblast growth factor 1 pre-conditioned adipose-derived stem cells promote ischemic skin flaps survival by activating autophagy by Xuanlong Zhang, Xiaoqiong Jiang, Huiming Deng, Gaoxiang Yu, Ningning Yang, Abdullah Al Mamun, Feifei Lian, Tianling Chen, Haijuan Zhang, Yingying Lai, Jiayi Huang, Shi Xu, Fuman Cai, Xiaokun Li, Kailiang Zhou, Jian Xiao

“…It was also notabale that FGF1 increased the number of exosomes by upregulating VAMP3, which may be a promising strategy for clinical translation. Conclusion: FEXO markedly improved the survivial rate of ischemic skin flaps through miR-183-5p/GPR137/Pi3k/Akt/mTOR axis, which would be a promising strategy to rescue ischemic skin flaps.…”
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Effects of an acute negative and positive stimulus on immune-related gene expression in the pituitary and head kidney of carp (Cyprinus carpio L.) by Paulina Pawlak, Jonathan Konrad, Andreas Seitz, Constanze Pietsch

“…Both, the head kidney and the pituitary transcriptome analysis, revealed distinct gene expression patterns in fish subjected to the different treatments. …”
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Nanostructured organic sheets sequestering small extracellular vesicles and reactive species to protect against radiation-induced mucositis by Yuefei Zhu, Changyi Xu, Zhixin Li, Xiaomin Bao, Ming Liu, Yangyang She, Renqiang Ma, Xiangzhen Liu, Jian Li, Weiping Wen, Kam W. Leong, Zhaoxu Tu

“…Flow cytometry and transcriptome analyses in irradiated animal models confirm significant mucositis mitigation. …”
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Single-cell multi-omics reveals that FABP1 + renal cell carcinoma drive tumor angiogenesis through the PLG-PLAT axis under fatty acid reprogramming by Yiqiu Wang, Yingchun Liang, Min Li, Jiayi Lu, Sian Zhou, Yaoyu Yu, Changwei Yang, Xinhuang Hou

“…FABP1 + tumors exhibit a unique pattern in spatial transcriptomics, enriched in Extracellular Matrix and angiogenesis-related pathways. …”
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Nrf2 controls homeostatic transcriptional signatures and inflammatory responses in a cell-type specific manner in the adult mouse brain by Xin He, Owen Dando, Jing Qiu

“…Summary: Nrf2 is a promising therapeutic target for neurological disorders, but its mechanisms of action remain unclear. …”
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IL1RAP is an immunotherapeutic target for normal karyotype triple-mutated acute myeloid leukemia by Arnaud Métois, Marie-Eve Bordeleau, Louis Theret, Azadeh Hajmirza, Ossama Moujaber, Jean-François Spinella, Jalila Chagraoui, Nadine Mayotte, Isabel Boivin, Éric Audemard, Léo Aubert, Véronique Lisi, Banafsheh Khakipoor, Azer Farah, Éric Bonneil, Alma Robert, Julie Lippens, Anna Moraitis, François Béliveau, Albert Feghaly, Geneviève Boucher, Richard Marcotte, Patrick Gendron, Pierre Thibault, Sébastien Lemieux, Guillaume Richard-Carpentier, Vincent-Philippe Lavallée, Josée Hébert, Philippe P. Roux, Guy Sauvageau

“…Moreover, internalization of IL1RAP presents a promising avenue for immunotherapeutic intervention.…”
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Fungal Coculture: Unlocking the Potential for Efficient Bioconversion of Lignocellulosic Biomass by Rafael Icaro Matos Vieira, Alencar da Silva Peixoto, Antonielle Vieira Monclaro, Carlos André Ornelas Ricart, Edivaldo Ximenes Ferreira Filho, Robert Neil Gerard Miller, Taísa Godoy Gomes

“…Recent advancements in -omics technologies, including genomics, transcriptomics, and proteomics, have facilitated detailed analysis of fungal metabolism, uncovering novel secondary metabolites and enzymatic pathways activated under specific growth conditions. …”
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Integrated analysis of MIOX gene in prognosis of clear-cell renal cell carcinoma by Yiqiu Wang, Jiayi Lu, Bohan Lin, Jiayin Chen, Fei Lin, Qingshui Zheng, Xueyi Xue, Yong Wei, Shaohao Chen, Ning Xu

“…Based on scRNA-seq and spatial transcriptome analysis, we identified specificity of MIOX in ccRCC. …”
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Identification of WNT16 as a Predictable Biomarker for Accelerated Osteogenic Differentiation of Tonsil-Derived Mesenchymal Stem Cells In Vitro by Yu-Hee Kim, Kyung-Ah Cho, Hyun-Ji Lee, Minhwa Park, Han Su Kim, Joo-Won Park, So-Youn Woo, Kyung-Ha Ryu

“…The application of mesenchymal stem cells (MSCs) for treating bone-related diseases shows promising outcomes in preclinical studies. However, cells that are isolated and defined as MSCs comprise a heterogeneous population of progenitors. …”
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