BRAFV600E‐PROTAC versus inhibitors in melanoma cells: Deep transcriptomic characterization by Solomon O. Alhassan, Zakaria Y. Abd Elmageed, Youssef Errami, Guangdi Wang, Joe A. Abi‐Rached, Emad Kandil, Mourad Zerfaoui

“…Although PROTAC and inhibitor treatments caused overlapping transcriptomic changes, key differences were observed. …”
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Integration of Transcriptomic and Single-Cell Data to Uncover Senescence- and Ferroptosis-Associated Biomarkers in Sepsis by Xiangqian Zhang, Yiran Zhou, Hang Li, Mengru Chen, Fang Peng, Ning Li

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Transcriptome analysis of mesenteric arterioles changes and its mechanisms in cirrhotic rats with portal hypertension by Guangbo Wu, Min Chen, Qiang Fan, Hongjie Li, Zhifeng Zhao, Chihao Zhang, Meng Luo

“…Taken together, our study highlighted remarkable changes in the mesenteric arterioles of cirrhotic rats with PHT. Transcriptome analyses revealed the potential molecular mechanisms of vascular changes in splanchnic hyperdynamic circulation.…”
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Long-read transcriptomics of caviid gammaherpesvirus 1: compiling a comprehensive RNA atlas by Gábor Torma, Ákos Dörmő, Ádám Fülöp, Dóra Tombácz, Máté Mizik, Amanda M. Pretory, See-Chi Lee, Zsolt Toth, Zsolt Boldogkői

“…ABSTRACT Caviid gammaherpesvirus 1 (CaGHV-1), formerly known as the guinea pig herpes-like virus, is an oncogenic gammaherpesvirus with a sequenced genome but an as-yet uncharacterized transcriptome. Using nanopore long-read RNA sequencing, we annotated the CaGHV-1 genome and constructed a detailed transcriptomic atlas. …”
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Transcriptomic profiling of skeletal muscle in the DMD mdx rat model of Duchenne muscular dystrophy by Abdolvahab Ebrahimpour Gorji, Katarzyna Kliczkowska, Marcin Ollik, Caroline Le Guiner, Jacek Wilczak, Wojciech Bielecki, Piotr Ostaszewski, Masoud Shirali, Zahra Roudbari, Tomasz Sadkowski

“…The methods used included histopathological, biochemical, and transcriptomic analyses of dystrophic skeletal muscle from DMD mdx and wild-type (WT) individuals. …”
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MSC-EVs and UCB-EVs promote skin wound healing and spatial transcriptome analysis by Ruonan Li, Haotian Wang, Xiaolong Wang, Yanbin Yang, Kai Zhong, Xuemei Zhang, Heping Li

“…They can be considered promising new agents for promoting skin wound healing.…”
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Single-Cell Transcriptomics Unveils the Mechanistic Role of FOSL1 in Cutaneous Wound Healing by Jingbi Meng, Ge Zheng, Yinli Luo, Ling Ge, Zhiqing Liu, Wenhua Huang, Meitong Jin, Yanli Kong, Shanhua Xu, Zhehu Jin, Longquan Pi

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Single-cell transcriptomics identifies PDGFRA+ progenitors orchestrating angiogenesis and periodontal tissue regeneration by Jianing Liu, Junxi He, Ziqi Zhang, Lu Liu, Yuan Cao, Xiaohui Zhang, Xinyue Cai, Xinyan Luo, Xiao Lei, Nan Zhang, Hao Wang, Ji Chen, Peisheng Liu, Jiongyi Tian, Jiexi Liu, Yuru Gao, Haokun Xu, Chao Ma, Shengfeng Bai, Yubohan Zhang, Yan Jin, Chenxi Zheng, Bingdong Sui, Fang Jin

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Targeting the STAT3/IL-36G signaling pathway can be a promising approach to treat rosacea by Xin Meng, Yun Zhong, Xuyuan Kuang, Yiya Zhang, Li Yang, Yisheng Cai, Fan Wang, Fanping He, Hongfu Xie, Ben Wang, Ji Li

“…Objectives: To investigate the pathogenesis of rosacea and explore new therapeutic strategies. Methods: Transcriptome data from rosacea patients combined with immunohistochemical staining were used to investigate the activation of STAT3 in rosacea. …”
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Boolean modeling of transcriptome data reveals novel modes of heterotrimeric G‐protein action by Sona Pandey, Rui‐Sheng Wang, Liza Wilson, Song Li, Zhixin Zhao, Timothy E Gookin, Sarah M Assmann, Réka Albert

“…Although G‐protein control of the transcriptome has received little attention to date in any system, transcriptome analysis allows us to search for potentially uncommon yet significant signaling mechanisms. …”
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Modified Methylation Following Electrostimulation in a Standardized Setting—Complementing a Transcriptomic Analysis by Biagio Di Pietro, Simona Villata, Anna Plaksienko, Tiziana Guarnieri, Simeone Dal Monego, Margherita Degasperi, Pietro Di Lena, Danilo Licastro, Claudia Angelini, Francesca Frascella, Lucia Napione, Christine Nardini

“…Electrical stimulation (ES) is widely employed in both clinical therapies and research settings where it has shown promise in promoting tissue regeneration, wound healing, and inflammation control. …”
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Baicalin attenuates LPS-induced periodontal inflammation response by inhibiting autophagy by Yifan Cheng, Ming Jiang, Xu Qin, Jing Mao, Yan Liu, Guangxun Zhu

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Integrated transcriptomics of multiple sclerosis peripheral blood mononuclear cells explored potential biomarkers for the disease by Arman Mokaram Doust Delkhah

“…Conclusions: This study could not unveil promising blood biomarkers for MS, possibly due to a small sample size and unaccounted confounding factors. …”
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Therapeutic target prediction for orphan diseases integrating genome-wide and transcriptome-wide association studies by Satoko Namba, Michio Iwata, Shin-Ichi Nureki, Noriko Yuyama Otani, Yoshihiro Yamanishi

“…We make comprehensive predictions for 284 diseases with 4345 inhibitory target candidates and 151 diseases with 4040 activatory target candidates, and elaborate the promising targets using several independent cohorts. …”
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De novo transcriptome assembly and analysis during agarwood induction in Gyrinops versteegii Gilg. seedling by Dina Hermawaty, Titis Setyobudi, Husna Nugrahapraja, Maman Turjaman, Ahmad Faizal

“…Future high-resolution transcriptome data could further elucidate this promising avenue.…”
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Integrative transcriptomic and metabolomic analysis explores the mechanisms by which ACT001 treats MAFLD in mice by Jing Liu, Yibing Zhou, Yinglun Li, Ze Chen, Xue Jiao, Jingqin Hu, Qian Wei, Yuqiang Mi, Ping Li

“…It has the potential to be a promising treatment for MAFLD.…”
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Transcriptomic signatures of severe acute mountain sickness during rapid ascent to 4,300 m by Ruoting Yang, Aarti Gautam, Rasha Hammamieh, Robert C. Roach, Beth A. Beidleman

“…The proposed biomarker panels offer promising avenues for the early diagnosis and prediction of AMS risk, which could enhance preventive and therapeutic strategies.…”
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Identification of candidate genes for leaf size by QTL mapping and transcriptome sequencing in Brassica napus L by Fengjie Cheng, Yuwen Wang, Aoyi Peng, Shuyu Li, Jun Chen, Xiaoxiao Zheng, Jie Xiong, Ge Ding, Bingchao Zhang, Wen Zhai, Laiqiang Song, Wenliang Wei, Lunlin Chen

“…Combining QTL mapping and RNA sequencing, four promising candidate genes, including BnaA10G0085600ZS, BnaA10G0156900ZS, BnaC03G0441700ZS, and BnaC08G0410600ZS, were proposed to control leaf size by regulating cell division. …”
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Integrated analysis of transcriptome, small RNA, and degradome sequencing provides insights into mango anthracnose resistance by Zongling Liu, Qiufei Ouyang, Sangui Yi, Yuting Zhou, Xiaona Xie, Zhengjie Zhu

“…The combined analysis of transcriptome and sRNA sequencing identified 257 miRNA-mRNA interaction pairs. …”
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Single-cell transcriptomics analysis reveals dynamic changes and prognostic signature in tumor microenvironment of PDAC by Yongsheng Li, Zhilong Ding, Tingxin Cheng, Yihuai Hu, Fei Zhong, Shiying Ren, Shiyan Wang

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