Biomaterial-mediated Cell Atlas: an insight from single-cell and spatial transcriptomics by Xiaokun Yang, Mingshu Huang, Huan Chen, Jingtao Dai, Jiahao Chen, Kai Chen, Jiannan Zhou, An Li, Ping Li

“…To address these challenges, single-cell transcriptomics and spatial technologies have emerged as promising tools. …”
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Hepatoprotective drug screening identifies daclatasvir, a promising therapeutic candidate for MASLD by targeting PLIN2 by Rui Shu, Song Tian, Weiyi Qu, Jinjie Yang, Wei Shi, Xinyan Li, Toujun Zou, Changjin Jiang, Yuxuan Zhang, Zifeng Yang, Han Tian, Hailong Yang, Jiajun Fu, Zhi-Gang She, Hongliang Li, Xiao-Jing Zhang

“…Here, this study aims to identify promising drug candidates for MASH and clarify its pharmacological mechanism. …”
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Mechanisms of Microctis Folium in Hyperlipidemia: Integrating Serum Pharmacochemistry, Network Pharmacology, and Transcriptomics by Xiao G, Wu G, Liu Y, Chen W, Zeng Z, Li S, Li Y, Bi X

“…Merr, hyperlipidemia, network pharmacology, serum pharmacochemistry, transcriptomics…”
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Metabolomic and transcriptomic analyses unveil the accumulation of shikimic acid in the leaves of Ginkgo biloba by Wanwen Yu, Minyue Cai, Chenxi You, Wenxuan Wei, Huimin Liu

“…Concurrently, we analyzed downstream metabolites including flavonoids, phenylalanine, tryptophan and tyrosine, along with transcriptomic and metabolomic profiles in HS and LS.ResultsThe concentrations of flavonoids, phenylalanine, tryptophan and tyrosine in HS were markedly lower than those in LS. …”
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Comparative transcriptomic and proteomic analyses of hypoxia response in wild and cultivated tomato roots by Zhihan Zhang, Yabing Hou, Hao Yin, Song Lu, Daliang Liu, Lin Cheng, Houlin Yu, Tao Li, Yiyong Zhao

“…The differentially regulated genes identified in this study represent promising targets for future research and breeding efforts aimed at improving hypoxia tolerance in tomatoes.…”
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Integrative Analysis of Plasma Proteomics and Transcriptomics Reveals Potential Therapeutic Targets for Psoriasis by Hesong Wang, Chenguang Wang, Ruihao Qin, Jia He, Xuan Zhang, Chenjing Ma, Shi Li, Lijun Fan, Liuying Wang, Lei Cao

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An optimized workflow of full-length transcriptome sequencing for accurate fusion transcript identification by Liang Zong, Yabing Zhu, Yuan Jiang, Ying Xia, Qun Liu, Jing Wang, Song Gao, Bei Luo, Yongxian Yuan, Jingjiao Zhou, Sanjie Jiang

“…Continued advancements in long-read sequencing promise deeper insights into fusion gene biology and improved cancer diagnostics.…”
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Deep Learning-Enabled Integration of Histology and Transcriptomics for Tissue Spatial Profile Analysis by Yongxin Ge, Jiake Leng, Ziyang Tang, Kanran Wang, Kaicheng U, Sophia Meixuan Zhang, Sen Han, Yiyan Zhang, Jinxi Xiang, Sen Yang, Xiang Liu, Yi Song, Xiyue Wang, Yuchen Li, Junhan Zhao

“…Spatially resolved transcriptomics enable comprehensive measurement of gene expression at subcellular resolution while preserving the spatial context of the tissue microenvironment. …”
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A bioinformatics analysis and experimental validation of PDGFD as a promising diagnostic biomarker for acute myeloid leukemia by Lulu Yang, Shuangshuang Ren, Lijiang Lou, Jiasu He, Qianlei Huang, Xiaojin Wu, Ranran Zhao

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Garlic Extracts Nanoliposome as an Enhancer of Bioavailability of ABA and Thiamine Content and as an Antifungal Agent Against <i>Fusarium oxysporum</i> f. sp. <i>pisi</i> Infecting... by Barbara Kutasy, Géza Hegedűs, Márta Kiniczky, József Péter Pallos, Ágnes Nagy, István Pócsi, Klaudia Pákozdi, Máté Kállai, Csaba Weingart, Katalin Andor, Bettina Kovács, Eszter Virág

“…However, effective disease management strategies, particularly the implementation of biological control methods, offer promising approaches for mitigating infection severity and limiting pathogen spread. …”
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Genome-wide scanning for candidate lethal genes associated with early embryonic mortality in Holstein dairy cattle by Somaye Rezaei, Abdol Ahad Shadparvar, Hasan Baneh, Shahrokh Ghovvati

“…The availability of large-scale genomic SNP data has proven to be a promising tool for identifying recessive genetic defects. …”
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Assessing the Tolerance of Spotted Longbarbel Catfish as a Candidate Species for Aquaculture to Ammonia Nitrogen Exposure by Song Guo, Linwei Yang, Xiaopeng Xu

“…Recently, the spotted longbarbel catfish has gained attention as a promising aquaculture species, not only for its premium flesh quality but also for its potential role in conservation through sustainable captive breeding programs. …”
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Topical transdermal administration of lenalidomide nanosuspensions-based hydrogels against melanoma: In vitro and in vivo studies by Mengdi Zhang, Haiying Qiu, Zheyi Han, Yazhong Ma, Jingjing Hou, Jingwei Yuan, Haiyan Jia, Menglu Zhou, Hongjie Lu, Yan Wu

“…Network pharmacology and transcriptomic analyses identified key targets and signaling pathways. …”
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Exploring and analyzing two aging related genes FPR1 and UCHL1 and their potential molecular mechanisms in aggravating lumbar disc herniation by Di Zhao, Bang-xin Sha, Ling-feng Zeng, Gui-hong Liang, He-tao Huang, Jian-ke Pan, Jun Liu, Shuai Zhao

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Integrated transcriptomic and functional modeling reveals AKT and mTOR synergy in colorectal cancer by Marcin Duleba, Eliza Zimoląg, Joanna Szuszkiewicz, Marcin Serocki, Joanna Szklarczyk, Olga Dracz, Alexander Kurzejamski, Izabella Więckowska, Marcelina Chmiel, Barbara Lipert, Katarzyna Sarad, Joanna Krawczyk, Oleksii Bryzghalov, Agata Stachowicz-Wałaszek, Karolina Pyziak, Joanna Drozdowska, Krzysztof Baczyński, Konrad Wojtowicz, Maurycy Chronowski, Krzysztof Rataj, Magdalena Otrocka, Michał Mikula, Paula Feliksiak, Rafał Dziadziuszko, Tomasz Rzymski, Andrew Thomason, Krzysztof Brzózka, Andrzej Mazan

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High resolution tissue and cell type identification via single cell transcriptomic profiling. by Muyi Liu, Suilan Zheng, Hongmin Li, Bruce Budowle, Le Wang, Zhaohuan Lou, Jianye Ge

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Elucidating cardiomyocyte heterogeneity and maturation dynamics through integrated single-cell and spatial transcriptomics by Xiaoying Wang, Lizhi Cao, Rui Chang, Junwei Shen, Linlin Ma, Yanfei Li

“…In this study, single-cell and spatial transcriptomics were utilized to analyze cells from neonatal mouse hearts, resulting in a comprehensive atlas delineating the transcriptional profiles of distinct CM subsets. …”
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Integrated transcriptomic and metabolomic analysis reveals stage-associated molecular profiles in Ophiocordyceps sinensis by Tao Wang, Chuyu Tang, Kejia De, Jianzhao Qi, Yuling Li, Xiuzhang Li

“…The upregulation of these DEGs in amino acid-related pathways presents a promising target for studying O. sinensis quality. …”
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Transcriptomic Characterization Reveals Mitochondrial Involvement in Nrf2/Keap1-Mediated Osteoclastogenesis by Eiko Sakai, Takayuki Tsukuba

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Comprehensive sex- and tissue-specific transcriptome of the destructive invasive pest Tuta absoluta adults by Zhiwei Kang, Aoli Lin, Mengqi Ji, Shizhao Jing, Zichao Song, Zhenxaing Li, Limei Song, Jianghua Sun, Cheng Qu

“…Semiochemical-based management is a promising method for controlling this pest. However, there is little known about how T. absoluta recognizes the semiochemical compounds. …”
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