The promising role of nanopore sequencing in cancer diagnostics and treatment by Xinming Su, Qingyuan Lin, Bin Liu, Chuntao Zhou, Liuyi Lu, Zihao Lin, Jiahua Si, Yuemin Ding, Shiwei Duan

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Integrative transcriptomic analysis identifies emetine as a promising candidate for overcoming acquired resistance to ALK inhibitors in lung cancer by Sang‐Min Park, Keeok Haam, Haejeong Heo, Doyeong Kim, Min‐Ju Kim, Hyo‐Jung Jung, Seongwon Cha, Mirang Kim, Haeseung Lee

“…We identified emetine as a promising candidate compound to inhibit the growth of ALKi‐resistant cells. …”
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Unveiling SSR4: a promising biomarker in esophageal squamous cell carcinoma by Jiaqi Zhang, Fang Jia, Chuqiao Li, Shunzhe Song, Aixia Gong

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Gold Nanoparticles Functionalized With 5-Amino-2-Mercaptobenzimidazole: A Promising Antimicrobial Strategy Against Carbapenem-Resistant Gram-Negative Bacteria by Zhang J, Zhang X, Yao Z, Pan J, Ye J, Xia P, Zhou T, Cao J

“…This highlights their potential as a promising antibacterial agent to combat multidrug-resistant GNB. …”
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Age-linked DNA methylation and gene expression patterns in parameningeal head and neck alveolar rhabdomyosarcoma reveal CDK9 as a promising therapeutic target by Sara Patrizi, Silvia Vallese, Sabina Barresi, Matteo Cassandri, Isabella Giovannoni, Lucia Pedace, Luana Abballe, Flavia Vinciarelli, Celeste Antonacci, Alessandra Stracuzzi, Barbara Mancini, Ida Russo, Angela Di Giannatale, Rossella Rota, Rita Alaggio, Franco Locatelli, Giuseppe Maria Milano, Evelina Miele

“…Notably, we identified CDK9 as a promising target, warranting further exploration in the context of ARMS treatment.…”
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Integrative multiomics analysis reveals the subtypes and key mechanisms of platinum resistance in gastric cancer: identification of KLF9 as a promising therapeutic target by Pengcheng Zhang, Lexin Wang, Haonan Lin, Yihui Han, Jingfang Zhou, Hang Song, Peng Wang, Huanhuan Tan, Yajuan Fu

“…Localization and functional evaluation were conducted at the single-cell and spatial transcriptomics levels, and predictive models were developed using machine learning techniques. …”
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The impact of anesthetics on the transcriptome by Anna Pilarz, Joanna Brzoza, Marcin Tomsia

“…The aim of the study is to review the latest literature on the impact of anesthetics on the transcriptome and the human body. A wide range of variations arising from the use of anesthetics has been presented, along with their effects that may extend beyond the perioperative period. …”
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Key Neuropeptides Regulating Molting in Pacific White Shrimp (<i>Penaeus vannamei</i>): Insights from Transcriptomic Analysis by Xianliang Li, Yunjiao Li, Zecheng Li, Hu Chen

“…Additionally, their synthetic products hold promise for improving molting consistency in shrimp aquaculture.…”
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Dissection of transcriptome and metabolome insights into the polyphyllin biosynthesis in Paris by Ping Xu, Qi Mi, Xiaoye Zhang, Xuan Zhang, Mengwen Yu, Yingsi Gao, Xiheng Wan, Yichun Chen, Qiaoyuan Li, Jia Chen, Guowei Zheng

“…Results In this study, we investigate the global metabolic and transcriptomic profiles of three types of Paris polyphylla var. yunnanensis (Franch.) …”
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Metabonomic, transcriptomic, and genomic variation of a population cohort by Michael Inouye, Johannes Kettunen, Pasi Soininen, Kaisa Silander, Samuli Ripatti, Linda S Kumpula, Eija Hämäläinen, Pekka Jousilahti, Antti J Kangas, Satu Männistö, Markku J Savolainen, Antti Jula, Jaana Leiviskä, Aarno Palotie, Veikko Salomaa, Markus Perola, Mika Ala‐Korpela, Leena Peltonen

“…Abstract Comprehensive characterization of human tissues promises novel insights into the biological architecture of human diseases and traits. …”
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IL-19 as a promising theranostic target to reprogram the glioblastoma immunosuppressive microenvironment by Gilbert Aaron Lee, Justin Bo-Kai Hsu, Yu-Wei Chang, Li-Chun Hsieh, Yi-Tien Li, Ying Chieh Wu, Cheng-Ying Chu, Yung-Hsiao Chiang, Wan-Yuo Guo, Chih-Chun Wu, Liang-Wei Chen, Hung-Wen Kao, Wan-Li Lin, Li‑Wen Tseng, Ting-Wei Weng, Duen-Pang Kuo, Sho-Jen Cheng, Yung-Chieh Chen, Shiu-Wen Huang, Hsing-Jien Kung, Cheng-Yu Chen

“…Conclusion IL-19 is a promising theranostic target for reversing immunosuppression and restricting the invasive activity of chemoresistant GBM cells. …”
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Unveiling Wolbachia transcriptomic signature in the arboviral vector Aedes aegypti by Sebastián Mejías, Sebastián Mejías, Natalia E. Jiménez, Natalia E. Jiménez, Natalia E. Jiménez, Carlos Conca, Carlos Conca, J. Cristian Salgado, J. Cristian Salgado, Ziomara P. Gerdtzen, Ziomara P. Gerdtzen, Ziomara P. Gerdtzen, Ziomara P. Gerdtzen

“…IntroductionThe mosquito Aedes aegypti is the main vector of arboviral diseases such as dengue and imposes a global health burden. A promising control strategy is to infect A. aegypti populations with Wolbachia, a genus of intracellular bacteria capable of blocking arboviral infections. …”
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A spatial transcriptomic atlas of the host response to oropharyngeal candidiasis by Sunna Nabeela, Hayden McSwiggin, Rubens Daniel Miserani Magalhaes, Eliciane Cevolani Mattos, Mohammad Mannan, John T. Dillon, Ashley Barbarino, Eman G. Youssef, Shakti Singh, Wei Yan, Ashraf S. Ibrahim, Heather R. Conti, Priya Uppuluri

“…Our study used spatial transcriptomics, a cutting-edge technology that preserves tissue architecture while mapping immune interactions at high resolution. …”
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Advances in Microfluidic Single-Cell RNA Sequencing and Spatial Transcriptomics by Yueqiu Sun, Nianzuo Yu, Junhu Zhang, Bai Yang

“…As omics technologies improve, microfluidic chips can now integrate promising transcriptomics technologies, providing new insights from molecular characterization for tissue gene expression profiles and further revealing the static and even dynamic processes of tissues in homeostasis and disease. …”
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BioGAN: Enhancing Transcriptomic Data Generation with Biological Knowledge by Francesca Pia Panaccione, Sofia Mongardi, Marco Masseroli, Pietro Pinoli

“…In this work, we present BioGAN, a novel generative framework that, for the first time, incorporates graph neural networks into a generative adversarial network architecture for transcriptomic data generation. By leveraging gene regulatory and co-expression networks, our model preserves biological properties in the generated transcriptomic profiles. …”
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Dissection of tumoral niches using spatial transcriptomics and deep learning by Karla Paniagua, Yu-Fang Jin, Yidong Chen, Shou-Jiang Gao, Yufei Huang, Mario Flores

“…Summary: This study introduces TG-ME, an innovative computational framework that integrates transformer with graph variational autoencoder (GraphVAE) models for dissection of tumoral niches using spatial transcriptomics data and morphological images. TG-ME effectively identifies and characterizes niches in bench datasets and a high resolution NSCLC dataset. …”
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Evaluation of transcriptomic changes after photobiomodulation in spinal cord injury by Andrew R. Stevens, Mohammed Hadis, Hannah Alldrit, Michael R. Milward, Valentina Di Pietro, Deena M. A. Gendoo, Antonio Belli, William Palin, David J. Davies, Zubair Ahmed

“…Photobiomodulation (PBM) is a promising therapy which has proven effective at restoring lost function after SCI in pre-clinical models. …”
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Transcriptomic and untargeted metabolomic studies on the anticoccidial activity of eugenol in broilers by Tiantian Geng, Hongjun Yang, Jing Liu, Junlong Zhao, Yanqin Zhou

“…Eugenol demonstrated a lower oocyst output compared to eucalyptus oil, leading us to focus on the mechanism of eugenol's anticoccidial activity using transcriptomic and untargeted metabolomic analyses. Transcriptomic analysis of cecal tissue revealed 749 upregulated and 1057 downregulated differentially expressed genes (DEGs). …”
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ZNF503-AS2 is a promising therapeutic target and is associated with the immune microenvironment in glioma. by Yibo Wu, Guangjing Mu, Fang Li, Yanfei Sun, Xiaoying Lin, Xuemeng Liu, Zhimin Zhao, Mingzhi Han, Donghai Wang, Bin Huang, Xingang Li

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Transcriptomic Profiling of Fruit Development in Black Raspberry Rubus coreanus by Qing Chen, Xunju Liu, Yueyang Hu, Bo Sun, Yaodong Hu, Xiaorong Wang, Haoru Tang, Yan Wang

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