Maternal concentrations of vitamin D metabolites in response to high-dose oral vitamin D during first trimester pregnancy: a randomized controlled trial by Inayah Syafitri, Rima Irwinda, Yudianto Budi Saroyo, Yuditiya Purwosunu, Noroyono Wibowo

“…Both groups showed an increasing trend in the total levels of 25(OH)D, 1,25(OH)2D, VDBP, and 24,25(OH)2D. …”
Get full text

Optimisation of controlled reproduction protocol in broadhead catfish (Clarias macrocephalus Günther, 1864) using Ovopel™: Effect of different hormonal treatment methods on reprodu... by Nguyễn Ngọc Quyến, Nguyễn Thanh Tâm, Thạch Anh Pha, Lý Anh Thuật, Nguyễn Ngọc Lợi, Nguyễn Thị Trúc Quyên, László Horváth, Tamás Müller

“…This study aims to establish novel protocols for hormonal delivery methods and dosages of Ovopel™ (D-Ala6, Pro9 NEt-mGnRH plus metoclopramide) for spawning induction of female broadhead catfish (Clarias macrocephalus) in control conditions. A total of 84 female breeders (238.63 ± 46.98 g) were placed equally into 12 treatments, 7 fish per treatment. …”
Get full text

Study protocol of a randomised controlled trial of prostate radiotherapy in high-risk and node-positive disease comparing moderate and extreme hypofractionation (PRIME TRIAL) by Vedang Murthy, Indranil Mallick, Abhilash Gavarraju, Shwetabh Sinha, Rahul Krishnatry, Tejshri Telkhade, Arunsingh Moses, Sadhna Kannan, Gagan Prakash, Mahendra Pal, Santosh Menon, Palak Popat, Venkatesh Rangarajan, Archi Agarwal, Sheetal Kulkarni, Ganesh Bakshi

“…With a 5% one-sided significance and 80% power, a total of 434 patients will be randomised to both arms equally (217 in each arm). …”
Get full text

The effectiveness and risks of Treating people with Idiopathic Pulmonary fibrosis with the Addition of Lansoprazole (TIPAL): study protocol for a randomised placebo-controlled mult... by Toby M Maher, A John Simpson, Anthony Cahn, David Thickett, Luke Vale, Allan B Clark, Nazia Chaudhuri, Ian Forrest, Lisa G Spencer, Christopher Ward, Stephen Jones, Ganesh Raghu, Andrew M Wilson, Helen Parfrey, Megan Jones, Matthew Hammond, Jaclyn Ann Smith, Shajahan Wahed

“…We aim to undertake an adequately powered double-blind placebo-controlled randomised multicentre clinical trial to assess the change in forced vital capacity (FVC), cough and other important patient-reported outcomes, following 12-month therapy with PPIs in people with IPF.Methods and analysis A total of 298 patients with IPF diagnosed by a multidisciplinary team according to international guidelines who are not receiving PPIs will be enrolled. …”
Get full text

Efficacy and Safety of Bushen Jiedu Tongluo Decoction in Active Rheumatoid Arthritis: Study Protocol for a Multi-Center, Randomized, Double-Blind, Controlled Trial by He Y, Shen J, Wu H, Chen L, Zhou Q, Wang Q, Guo Y, Wu F, Pan X

“…A total of 120 adult participants with active RA will be enrolled, with a balanced treatment allocation (1:1). …”
Get full text

Effects of health education based on self-determination theory on hemodialysis knowledge and self-management in maintenance hemodialysis patients by Jiquan Zhang, Fan Xu, Peimin Zhuang, Xingying Xu, Zhaohua Zou, Wei Qing

“…The study is a quasi-randomized control trial, a total of 86 maintenance hemodialysis patients who met the inclusion criteria were included equally in the intervention and control groups. …”
Get full text

Applying the theory of planned behavior to examine breastfeeding determinants in countries of the Gulf Cooperation Council: a systematic review by Ayoub Al-Jawaldeh, Dana Matbouli, Dima Itani, Sara Diab, Mandy Taktouk, Sally Naalbandian, Lara Nasreddine

“…There was a negative attitude towards the suitability of BF for working mothers and it was common for women to consider that formula feeding and BF provide equal benefits. Perceived behavior control towards exclusive BF and the sufficiency of breast milk supply was identified as low in several studies, particularly amongst primigravida women and mothers of twins. …”
Get full text

A case-control study of the protective effect of alcohol, coffee, and cigarette consumption on Parkinson disease risk: time-since-cessation modifies the effect of tobacco smoking. by Marianne van der Mark, Peter C G Nijssen, Jelle Vlaanderen, Anke Huss, Wim M Mulleners, Antonetta M G Sas, Teus van Laar, Hans Kromhout, Roel Vermeulen

“…In addition, we explored the potential effect modification by intensity, duration and time-since-cessation of smoking on the association between cumulative pack-years of cigarette smoking (total smoking) and PD risk. Data of a hospital based case-control study was used including 444 PD patients, diagnosed between 2006 and 2011, and 876 matched controls from 5 hospitals in the Netherlands. …”
Get full text

Comparison of myopia-related behaviors among Chinese school-aged children and associations with parental awareness of myopia control: a population-based, cross-sectional study by Chaoying Ye, Chaoying Ye, Chaoying Ye, Yujie Wang, Yujia Liu, Yujia Liu, Yujia Liu, Xingxue Zhu, Xingxue Zhu, Xingxue Zhu, Jianmin Shang, Jianmin Shang, Jianmin Shang, Xiaomei Qu, Xiaomei Qu, Xiaomei Qu

“…Questionnaires were designed to investigate children’s behaviors, including responses to sitting position, time of eye use (single continuous near work time and breaks in between, total near work time after school each day), eye rest (break time and style during near work and outdoor time per week), light conditions in the learning environment at home, and parents’ knowledge about myopia prevention and control. …”
Get full text

Risks and Benefits of Nalmefene in the Treatment of Adult Alcohol Dependence: A Systematic Literature Review and Meta-Analysis of Published and Unpublished Double-Blind Randomized... by Clément Palpacuer, Bruno Laviolle, Rémy Boussageon, Jean Michel Reymann, Eric Bellissant, Florian Naudet

“…Five randomized controlled trials (RCTs) versus placebo, with a total of 2,567 randomized participants, were included in the main analysis. …”
Get full text

Short-term outcomes of mini-sling <i>versus</i> transobturator tape in the surgical management of women with stress urinary incontinence. A randomized controlled trial by Ahmed Emam, Khaled Teama, Tarek Salem

Get full text

A parallel arm randomised controlled trial to achieve remission in patients with type 2 diabetes mellitus through dietary and behavioural interventions: a study protocol by A. Singh, J. S. Thakur

“…Participants will be equally allocated into two arms: intervention (n = 145) and control (n = 145). …”
Get full text

Non-immunogenic staphylokinase in patients with massive intermediate-high risk pulmonary embolism: protocol of the FORPE-2 multicenter, double-blind, randomized, placebo-controlled... by S. N. Tereshchenko, E. B. Yarovaya, S. G. Leontiev, I. S. Yavelov, R. M. Shakhnovich, A. D. Erlikh, T. M. Uskach, D. V. Duplyakov, V. A. Kutsenko, O. E. Ivlev, A. G. Soplenkova, A. M. Semenov, M. P. Semenov, S. V. Ivanov, S. S. Markin

“…The FORPE-2 clinical trial has a multicenter, doubleblind, randomized, placebo-controlled design. In clinical sites, patients (486 in total, with a possible 10% dropout rate) with confirmed PE and evidence of right ventricular dysfunction based on computed tomography pulmonary angiography and an increased risk of hemodynamic instability (intermediate-high-risk PE) will be equally randomized into two groups to receive non-immunogenic staphylokinase or placebo. …”
Get full text

Comparative study between the roles of intrauterine misoprostol versus the sublingual route for prevention of postpartum blood loss in elective cesarean sections: a randomized cont... by Adel Atef, Hadeer Salah Eldin Abdelrahman Mohamed Shehata, Yasmin Ahmed Bassiouny, Hesham Gaber Al-Inany

Get full text

Therapeutic effect of focused-extracorporeal shockwave therapy on muscular and adjacent tissue stiffness and pain changes in myofascial pain syndrome: A randomized controlled trial... by Pijakkana Vasvit, Kultida Klarod, Oranat Sukkho, Sirirat Kiatkulanusorn, Phurichaya Werasirirat, Xue-Qiang Wang, Yong-Hui Zhang, Juntip Namsawang, Pornpimol Muanjai, Nongnuch Luangpon

Get full text

Effect of Uncertainty-Aware AI Models on Pharmacists’ Reaction Time and Decision-Making in a Web-Based Mock Medication Verification Task: Randomized Controlled Trial by Corey Lester, Brigid Rowell, Yifan Zheng, Zoe Co, Vincent Marshall, Jin Yong Kim, Qiyuan Chen, Raed Kontar, X Jessie Yang

“…An equal number of participants were in each AI condition. …”
Get full text

THE SOCIOLOGIC APPROACH OF FEMININE CRIMINALITY by MIRELA CRISTIANA NILA STRATONE, BOGDAN GEORGESCU

Get full text

The effects of esketamine on postoperative delirium in older patients with fragile brain function during the non-acute phase following lung cancer surgery: a randomized controlled... by Honglin Fu, Jingna Hu, Xuewei Zhang, Kaiyun Xie, Lihong Hu

“…Esketamine group received esketamine 0.25 mg/kg during anesthesia induction and esketamine 0.1 mg/kg/h during anesthesia maintenance for 30 min. Control group received an equal volume of normal saline during both induction and maintenance of anesthesia. …”
Get full text

Effects of body weight-supported Tai Chi Yunshou training on upper limb motor function in stroke patients: A three-arm parallel randomized controlled trial. by Liying Zhang, Xiaoming Yu, Wangsheng Liao, Jiening Wang, Yan Lu, Naizhen Wang, Zhou Huanxia

Get full text

Effectiveness and Safety of Shenxiong Huanglian Detoxification Granule Combined with Donepezil for the Treatment of Alzheimer&rsquo;s Disease: Study Protocol for a Multicenter, Pra... by Lin J, Liu X, Lin X, Liu N, Pei H, Zhao Y, Yu G, Wang W, Chen C, Hou T, Li X, Lin X, Li H

“…The main purpose of this trial is to assess the effectiveness and safety of Shenxiong Huanglian Detoxification Granule combined with donepezil in individuals diagnosed with mild-to-moderate Alzheimer’s disease.Methods: This is a multicenter, pragmatic, randomized controlled trial. A total of 386 eligible individuals with mild to moderate Alzheimer’s disease will receive random assignment and equal access to the test or control group. …”
Get full text