STUDY OF THE EFFICIENCY AND SAFETY OF MYCOPHENOLATE MOFETIL THERAPY IN PATIENTSWITH SYSTEMIC SCLERODERMA by O A Koneva, L P Ananyeva, O B Ovsyannikova, L V Teplova, M N Starovoitova, O V Desinova, T A Nevskaya, R T Alekperov, E G Lyubimova, L N Denisov

“…The mean MPM therapy duration was 11.4+1.3 months. The Rodnan total skin thickness score, flexion index, forced vital capacity (FVC), diffusing capacity of the lung for carbon monoxide (DLCO), and European Scleroderma Study Group (EScSG) activity index were estimated and a 6-minute walk test (6MWT) was carried out before and after MPM therapy. …”
Get full text

FORMS OF ECONOMIC PROXIMITY AND THEIR IMPACT ON INNOVATION PERFORMANCE: A STUDY OF MULTIDISCIPLINARY COMMERCIAL ORGANISATIONS IN INDUSTRY by A. V. Trachuk, A. V. Kolobov

“…This article analyses the influence of different types of economic proximity (geographical, organisational, technological and social) of business units of multidisciplinary organisations on the effectiveness of their innovative activities. The conducted research is based on a survey of a sample of 83 holdings belonging to 27 MCOs (a total of 189 respondents). …”
Get full text

Efficient conversion of tea residue nutrients: Screening and proliferation of edible fungi by Yufei Zhang, Yanyin Lu, Dandan Pan, Yanyan Zhang, Chen Zhang, Zexin Lin

“…After a 9-days liquid fermentation, M. kaoliang B6 achieved the highest conversion efficiency at 27.8%, attributed to its high cellulase (191 U∙mL−1) and lignin peroxidase (36.9 U∙L−1) activities. …”
Get full text

Quasi-Resonant Flyback Converter as Auxiliary Power-Supply of an 800 V Inductive-Charging System for Electric Vehicles by Darko D. Vracar

“…The maximum efficiency of 87.1% was reached at 620V and rated load. …”
Get full text

PROBLEMS OF EFFICIENCY OF BUDGET SPENDING ON GENERAL EDUCATION DURING ITS REFORMING by E. B. Krylova, M. A. Simakina, A. V. Frigin

“…The authors highlighted that reduced the total number of educational institutions of higher education, compared with 2014. by 5.7% and significantly reduced the number of students and school pupils in particular on specific professional areas, and there was a decrease in the overall number of educational institutions.The authors identified factors that influenced this process, including the demographic collapse in the birth rate in the last decade of the 20th century and marks them active reform activities of the Government of the Russian Federation in the field of general education. …”
Get full text

An agent-based model of patient flow to improve operating room efficiency by Seyedeh Raahil Mousavi, Mohammad Mehdi Sepehri, Esmaeil Najafi

“…Purpose: High efficiency in the operating room may significantly improve the overall performance of the hospital and the service quality provided to patients. …”
Get full text

Transmit Power-Efficient Beamforming Design for Integrated Sensing and Backscatter Communication by Shayan Zargari, Diluka Galappaththige, Chintha Tellambura

Get full text

Assessment of green investment impact on the energy efficiency gap of the national economy by Vladyslav Pavlyk

“…If the increase of energy efficiency leads to decreasing of energy efficiency gap the following could be concluded: increasing of green investment lead to reducing of energy efficiency gap; increasing of renewable energy in the total energy consumption allowed declining the energy efficiency gap. …”
Get full text

BANKING IN DIGITAL AGE: EFFICIENCY OF АNTI-MONEY LAUNDERING SYSTEM by S. Lieonov, T. Vasilyeva, S. Mynenko, T. Dotsenko

Get full text

Sourceless efficiency calibration method for γ spectrum based on numerical analysis by YE Erlei, SHEN Chunxia, NAN Hongjie, LAI Yongfang

“…The γ-ray path trajectory inside the detector, relative position of the source and detector, and peak-to-total ratio were comprehensively analyzed. Efficiency formulas for radioactive point, surface, and volume radioactive sources were formulated. …”
Get full text

A Comparative Study on the Active Constituents, Antioxidant Capacity and Anti-Cancer Activity of Cruciferous Vegetable Residues by Alaa A. Gaafar, Zeinab A. Salama, Farouk K. El-Baz

“…This study is pointed out to estimate the effectiveness of two solvents in the extraction and evaluating the active ingredients and their antioxidant activity as well as anti-cancer efficiency. …”
Get full text

Motor Imagery during Action Observation of Locomotor Tasks Improves Rehabilitation Outcome in Older Adults after Total Hip Arthroplasty by Uros Marusic, Sidney Grosprêtre, Armin Paravlic, Simon Kovač, Rado Pišot, Wolfgang Taube

Get full text

Effect of different types of activated carbon on the adsorption- reduction of Cr(Ⅵ) by mZVI/activated carbon by WANG Wenhao, CHENG Yexing, WANG Yuyin, HOU Tingting, WU Xiaofeng, LI Yucai

“…Based on the excellent adsorption performance of activated carbon(AC) and its characteristic of forming a microelectrolysis system with micro zero-valent iron(mZVI), various mZVI/ACs composite materials were synthesized by ball milling(BM) method, and the removal efficiencies of Cr(Ⅵ) by these materials were explored. …”
Get full text

Influence of mutations at different distances from the active center on the activity and stability of laccase 13B22 by Ruohan Zhang, Yuchen Wang, Xiaolu Wang, Huiying Luo, Yuan Wang, Bin Yao, Huoqing Huang, Jian Tian, Feifei Guan

“…Both mutants showed enhanced degradation efficiency for benzo[a]pyrene and zearalenone. These findings highlight the importance of the residues located far from the active center in the function of laccase (second shell and third shell), suggesting broader implications for enzyme optimization and biotechnological applications.…”
Get full text

Rehabilitation with removable dentures in adults and older people with partial or total edentulism: Chilean Public Health System Experience, 2017–2019 by Karen Danke, DDS, MSc, Ingeborg Bevensee, DDS, Ana Beatriz Silva, DDS, MSc, Alicia Morales, DDS, MSc, Gisela Jara, DDs, MSc, Fabiola Werlinger, MSc, PhD, Mauricio Baeza, DDS, MSc, PhD, María Ignacia Muñoz, DDS, Viviana García Ubillo, MSc, Jorge Gamonal, DDS, MSc, PhD

Get full text

Model-based prediction of nanoparticle and dissolved form ratios using total concentration data: a case study of SNB-101 by Jinha Park, Jinha Park, Soo Hyeon Bae, Sangil Jeon, Young Hwan Park, Dong Cheol Lee, Seunghoon Han, Seunghoon Han

“…Nanoparticle-based formulations, such as SNB-101, offer a promising solution by encapsulating irinotecan and SN-38, enhancing solubility, improving drug delivery efficiency, and reducing systemic toxicity through tumor-specific accumulation via the enhanced permeability and retention (EPR) effect.MethodsThis study aimed to develop a pharmacokinetic (PK) model to differentiate between nanoparticle (NP) and dissolved (S) forms of irinotecan and SN-38 using total plasma concentration data from a Phase I clinical trial of SNB-101 (NCT04640480). …”
Get full text

Deubiquitinase USP2a Sustains Interferons Antiviral Activity by Restricting Ubiquitination of Activated STAT1 in the Nucleus. by Ying Ren, Peng Zhao, Jin Liu, Yukang Yuan, Qiao Cheng, Yibo Zuo, Liping Qian, Chang Liu, Tingting Guo, Liting Zhang, Xiaofang Wang, Guanghui Qian, Lemin Li, Jun Ge, Jianfeng Dai, Sidong Xiong, Hui Zheng

“…STAT1 is a critical transcription factor for regulating host antiviral defenses. STAT1 activation is largely dependent on phosphorylation at tyrosine 701 site of STAT1 (pY701-STAT1). …”
Get full text

Determination of Russian innovative activity tendencies by Marina A. Motova

“…There is an attempt to group main types of economic activity depending on intensity and efficiency of innovative activities on the basis of the available statistical information on dynamics of innovative activities in various industries of economy and with the use of the mathematic and statistical tool, in particular, cluster analysis tool. …”
Get full text

Innovative activity of teachers - myth or reality? by A. P. Usol’tsev, E. P. Antipova

“…Design activity corresponds to the type II; type III - activity of performers with the total development of innovation becoming the accepted norm. …”
Get full text

The Effect of Acute Sleep Extension on Blood Pressure Is Dependent on the Change in Sleep Efficiency by Joaquin U. Gonzales, Cayla Clark, Jacob R. Dellinger

“…The reduction in MAP was significantly different between sleep efficiency groups (<i>p</i> = 0.005, Hedges’ <i>g</i> = 1.21) after adjustment for sex and moderate-to-vigorous physical activity. …”
Get full text