From digitized whole‐slide histology images to biomarker discovery: A protocol for handcrafted feature analysis in brain cancer pathology by Xuanjun Lu, Yawen Ying, Jing Chen, Zhiyang Chen, Yuxin Wu, Prateek Prasanna, Xin Chen, Mingli Jing, Zaiyi Liu, Cheng Lu

“…Abstract Hematoxylin and eosin (H&E)‐stained histopathological slides contain abundant information about cellular and tissue morphology and have been the cornerstone of tumor diagnosis for decades. …”
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Tumor-immune partitioning and clustering algorithm for identifying tumor-immune cell spatial interaction signatures within the tumor microenvironment. by Mai Chan Lau, Jennifer Borowsky, Juha P Väyrynen, Koichiro Haruki, Melissa Zhao, Andressa Dias Costa, Simeng Gu, Annacarolina da Silva, Tomotaka Ugai, Kota Arima, Minh N Nguyen, Yasutoshi Takashima, Joe Yeong, David Tai, Tsuyoshi Hamada, Jochen K Lennerz, Charles S Fuchs, Catherine J Wu, Jeffrey A Meyerhardt, Shuji Ogino, Jonathan A Nowak

“…<h4>Conclusions</h4>Unsupervised discoveries of microgeometric tissue organizational patterns and novel tumor subtypes using the TIPC algorithm can deepen our understanding of the tumor immune microenvironment and likely inform precision cancer immunotherapy.…”
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Novel Insights into Non-Invasive Diagnostic Techniques for Cardiac Amyloidosis: A Critical Review by Marco Maria Dicorato, Paolo Basile, Giuseppe Muscogiuri, Maria Cristina Carella, Maria Ludovica Naccarati, Ilaria Dentamaro, Marco Guglielmo, Andrea Baggiano, Saima Mushtaq, Laura Fusini, Gianluca Pontone, Cinzia Forleo, Marco Matteo Ciccone, Andrea Igoren Guaricci

“…Cardiac magnetic resonance provides high-resolution images associated with tissue characterization. The use of contrast and non-contrast sequences enhances the diagnostic power of this imaging modality. …”
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Deep molecular profiling of synovial biopsies in the STRAP trial identifies signatures predictive of treatment response to biologic therapies in rheumatoid arthritis by Myles J. Lewis, Cankut Çubuk, Anna E. A. Surace, Elisabetta Sciacca, Rachel Lau, Katriona Goldmann, Giovanni Giorli, Liliane Fossati-Jimack, Alessandra Nerviani, Felice Rivellese, Costantino Pitzalis, the STRAP collaborative group

“…Here we analyse RNA-sequencing (RNA-Seq) of pre-treatment synovial tissue from the biopsy-based, precision-medicine STRAP trial (n = 208), to identify gene response signatures to the randomised therapies: etanercept (TNF-inhibitor), tocilizumab (interleukin-6 receptor inhibitor) and rituximab (anti-CD20 B-cell depleting antibody). …”
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Structural brain network organization in children with prenatal alcohol exposure by Xiaoyun Liang, Claire E. Kelly, Chun-Hung Yeh, Thijs Dhollander, Stephen Hearps, Peter J. Anderson, Deanne K. Thompson

“…Structural networks were constructed using the multi-shell multi-tissue constrained spherical deconvolution tractography technique. …”
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Exercise preconditioning alleviates photothrombotic ischemic stroke in mice by orchestrating neutrophils by Tae Yeon Kim, Yun Seo Cho, Jae Yeon Park, Songwon Woo, Kihoon Yuk, Dong Heon Yi, In cheol Jeong, In cheol Jeong, Jin Pyeong Jeon, Yoe-Sik Bae, Min-Chul Lee, Hyo Youl Moon, Hyo Youl Moon, Hyo Youl Moon

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The interplay between homeostatic synaptic scaling and homeostatic structural plasticity maintains the robust firing rate of neural networks by Han Lu, Sandra Diaz-Pier, Maximilian Lenz, Andreas Vlachos

“…Critical network states and neural plasticity enable adaptive behavior in dynamic environments, supporting efficient information processing and experience-dependent learning. Synaptic-weight-based Hebbian plasticity and homeostatic synaptic scaling are key mechanisms that enable memory while stabilizing network dynamics. …”
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Identification and evaluation of metabolic mRNAs and key miRNAs in colorectal cancer liver metastasis by Guanxuan Chen, Shiwen Wang, Meng Zhang, Wenna Shi, Ruoyu Wang, Wanqi Zhu

“…PCR validation in 40 paired tissue samples showed downregulation of CAV1 and upregulation of miRNA-1290 in CRC tissues of patients with liver metastasis. …”
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Host‐Microbial Cometabolite Ursodeoxycholic Acid Protects Against Poststroke Cognitive Impairment by Xuxuan Gao, Feng Zhang, Jiafeng Zhang, Yu Ma, Yiting Deng, Jiaying Chen, Yueran Ren, Huidi Wang, Boxin Zhao, Yan He, Jia Yin

“…Animal studies in mice also showed reduced UDCA levels in plasma and brain tissue following stroke. UDCA administration improved cognitive function in stroke mice by reducing hippocampal microglial activation and neuronal apoptosis. …”
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Advancing Veterinary Oncology: Next-Generation Diagnostics for Early Cancer Detection and Clinical Implementation by Aya Hasan Alshammari, Takuya Oshiro, Umbhorn Ungkulpasvich, Junichi Yamaguchi, Masayo Morishita, Sura Abbas Khdair, Hideyuki Hatakeyama, Takaaki Hirotsu, Eric di Luccio

“…Technological advances in genomics, bioinformatics, and machine learning are driving a shift toward precision medicine, enabling earlier detection, personalized treatments, and monitoring of disease progression. …”
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Use of 3D printed head and neck models for simulating 10 common ENT emergency procedures: a prospective validation study by Kate Stephenson, James Howard, Ananth Vijendren, Andrew Lau, Sanjeev Gupta, Praneta Kulloo, Matt Lechner, James Rudd, Yogesh Bajaj, Umar Rehman, Saleh Okhovat, Dermot Colton, Purnima Sangwan, Cameron Davies-Husband, Max Whittaker, Claudia Taylor, Phoebe Roche, Nicholas Eynon-Lewis, Matt Rollin

“…All faculty were consultant ENT surgeons (n=11).Intervention The 3D models, produced using proprietary 3D printing technology (Fuesetec), were used in a 1-day ENT emergencies course for validating training and confidence of delegates in performing 10 common ENT emergencies.Results A total of 86% (n=77) of delegates found the models extremely or very helpful in learning ENT emergencies. Delegates rated the resemblance to real patients as excellent or very good in both haptic feedback (n=58, 64%) and tissue texture (n=67, 74%). …”
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A novel structural modeling magnitude and orientation radiomic descriptor for evaluating response to neoadjuvant therapy in rectal cancers via MRI by Charlems Alvarez-Jimenez, Jacob T. Antunes, Thomas DeSilvio, Zhouping Wei, Marwa Ismail, Joseph E. Willis, Emily Steinhagen, Andrei Purysko, David Liska, Smitha Krishnamurthi, Marka Crittenden, Michael Gough, Kristina Young, Anant Madabhushi, Eduardo Romero, Pallavi Tiwari, Satish E. Viswanath

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Genetic architecture of bone marrow fat fraction implies its involvement in osteoporosis risk by Zuyou Wu, Yang Yang, Caibo Ning, Jiali Li, Yimin Cai, Yanmin Li, Zilong Cao, Shuangshuang Tian, Jingyi Peng, Qianying Ma, Chunyi He, Shuting Xia, Jun Chen, Xiaoping Miao, Zhen Li, Ying Zhu, Qian Chu, Jianbo Tian

“…Abstract Bone marrow adipose tissue, as a distinct adipose subtype, has been implicated in the pathophysiology of skeletal, metabolic, and hematopoietic disorders. …”
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Role of inflammation-related genes as prognostic biomarkers and mechanistic implications in idiopathic pulmonary fibrosis by Bing Bai, Bing Bai, Bing Bai, Wenfei Zhao, Fazhan Li, Yang Mi, Pengyuan Zheng

“…IntroductionIdiopathic Pulmonary Fibrosis (IPF) is a chronic, progressive lung disorder characterized by excessive fibrosis and structural remodeling of lung tissue. The role of inflammation in developing and progressing IPF is increasingly recognized as critical. …”
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Genetically encoded sensors illuminate in vivo detection for neurotransmission: Development, application, and optimization strategies by Xiaoyu Zhong, Hengyu Gu, Juyao Lim, Peng Zhang, Guangfu Wang, Kun Zhang, Xiaowan Li

“…These include broad applicability, tissue specificity, and non-invasive operation. When combined with advanced microscopic techniques, optogenetics, and machine learning approaches, these sensors have become versatile tools for studying neuronal circuits in intact living systems, providing millisecond-scale temporal resolution and spatial resolution ranging from nanometers to micrometers. …”
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Efficient spheroid morphology assessment with a ChatGPT data analyst: implications for cell therapy by Takuya Sakamoto, Hiroto Koma, Ayane Kuwano, Tetsuhiro Horie, Atsushi Fuku, Hironori Kitajima, Yuka Nakamura, Ikuhiro Tanida, Yujiro Nakade, Hiroaki Hirata, Yoshiyuki Tachi, Hiroshi Sunami, Daisuke Sakamoto, Sohsuke Yamada, Naoki Yamamoto, Yusuke Shimizu, Yasuhito Ishigaki, Toru Ichiseki, Ayumi Kaneuji, Satoshi Osawa, Norio Kawahara

“…Spheroids derived from ADSCs are a viable treatment option with enhanced anti-inflammatory effects and tissue repair capabilities.Objective SphereRing® is a rotating donut-shaped tube that efficiently produces large quantities of spheroids. …”
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Pharmacological inhibition of Kv1.3 channel reduces sevoflurane-induced cognitive impairment through NLRP3-dependent microglial modulation by Bowen Li, Ying Gao, Huiyue Han, Zhu Wang, Yang Zhang, Li Yu, Yunzhi Ling

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Lipid-Metabolism-Related Gene Signature Predicts Prognosis and Immune Microenvironment Alterations in Endometrial Cancer by Zhangxin Wu, Yufei Nie, Deshui Kong, Lixiang Xue, Tianhui He, Kuaile Zhang, Jie Zhang, Chunliang Shang, Hongyan Guo

“…<b>Methods</b>: A total of 552 UCEC and 35 normal tissue samples from The Cancer Genome Atlas (TCGA) database were analyzed to identify differentially expressed lipid-metabolism-related genes (DE-LMRGs). …”
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Exploring the Potential Regulatory Mechanisms of Mitophagy in Ischemic Cardiomyopathy by Li Z, Kong J, Xi S, Jin Z, Yang F, Zhu Z, Liu L

“…Then, biomarkers were identified through machine learning algorithms and Receiver Operating Characteristic curve (ROC) analysis. …”
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Effects and mechanisms of Tieguanyin on the behavior of Alzheimer’s disease APP/PS1 mice by KANG Hyunuk, ZHOU Hui, YE Yushan, LIU Zhonghua, WEI Yuede, YANG Jiangfan, KIM Eunhye, HE Puming, LI Bo, WU Yuanyuan, TU Youying

“…At the end of the behavioral study, they were executed, and their plasma and brain tissue were collected, and then the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) and malondialdehyde (MDA) content in plasma of mice were determined, and the morphological changes of glial cells were observed by immunohistochemical assay. …”
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