HAL-2 promotes homologous pairing during Caenorhabditis elegans meiosis by antagonizing inhibitory effects of synaptonemal complex precursors. by Weibin Zhang, Natasha Miley, Michael S Zastrow, Amy J MacQueen, Aya Sato, Kentaro Nabeshima, Enrique Martinez-Perez, Susanna Mlynarczyk-Evans, Peter M Carlton, Anne M Villeneuve

“…During meiosis, chromosomes align with their homologous pairing partners and stabilize this alignment through assembly of the synaptonemal complex (SC). Since the SC assembles cooperatively yet is indifferent to homology, pairing and SC assembly must be tightly coordinated. …”
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Arecoline regulates glycolipid and endoplasmic reticulum metabolisms in adult grass carp (Ctenopharyngodon idella) by Liangqin Wu, Na Yao, Weidan Jiang, Pei Wu, Yang Liu, Yaobin Ma, Hongmei Ren, Xiaowan Jin, Hequn Shi, Xiaoqiu Zhou, Lin Feng

“…Secondly, arecoline protected mitochondrial function by promoting the mitochondrial respiratory chain complex I–V-related protein expression and triggering the mitochondrial unfolded protein response (UPRmt) (P < 0.05). …”
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Two Functional TP53 Genetic Variants and Predisposition to Keloid Scarring in Caucasians by Andrzej Dmytrzak, Agnieszka Boroń, Beata Łoniewska, Klaudyna Lewandowska, Iwona Gorący, Mariusz Kaczmarczyk, Andrzej Ciechanowicz

“…The pathogenesis of keloid is complex, and many evidences suggest the influence of genetic factors, among them the polymorphisms of the TP53 gene encoding tumor protein p53. …”
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Simulating Marine Ecosystem Dynamics and Biogeochemical Cycling With Multiple Plankton Functional Types by Jun Yu, Kristen M. Krumhardt, J. Keith Moore, Robert T. Letscher, Shanlin Wang, Nicola A. Wiseman, Matthew C. Long, Keith Lindsay, Michael Levy, Colleen M. Petrik, Adam C. Martiny

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Integration of Quality Function Deployment and TRIZ Methodologies to Design a Sanitary Part by Dino Caesaron, Farell Ardani, Vidhea Nurhadi, Yusuf Yekti

“…The main objective of this study was to create the design of specific machining sanitary Spare Parts production due to complexity of the design. In the proposed methodology, Quality Function Deployment is used to convert the subjective requirements from users into an objective technical response. …”
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Chronic Syndesmotic Instability Associated with a Complex Lesion of the Posterior Inferior Tibiofibular Ligament: Review, Case Report, and Surgical Report by Virginie Perez, Nermine Habib, Angela Seidel

“…The combination of osteotomy, TightRope® syndesmosis fixation, and InternalBrace™ PITFL repair provides a reliable option for managing complex PITFL injuries.…”
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Probiotics improve intestinal oxidative stress to protect intestinal barrier function in uremic rats by WEI Meng, JIANG Hong-li, SHI Ke-hui, WANG Meng, SUN Ling-shuang, HE Quan

“…Objective To investigate whether oral probiotic Bifidobacterium animalis subsp.Lactis Bi-07 protects the intestinal barrier function of uremic rats,and explore whether it plays its biological effects by improving oxidative stress in tissues.Methods Thirty SD rats were randomly divided into 3 groups(n=10),sham operation group,uremic group,uremia + probiotic group.For the sham operation group only the renal capsule was opened,and for the uremic group 5/6 nephrectomy was conducted.For the uremia + probiotic group 5/6 nephrectomy was performed and then the animals were administered with Bi-07 every day for 4 weeks.The rats were anesthetized and the jejunum,ileum and colon segments were taken out.The ultrastructure of the intestinal epithelial tight junction complex was observed by scanning electron microscopy combined with lanthanum nitrate staining.The intestinal homogenate was prepared,and malondialdehyde(MDA) content was determined by thiobarbituric acid condensation method;and superoxide dismutase(SOD) activity was determined by xanthine oxidase method.Results Compared with the uremic group,supplement of probiotics could restore the tight junction ultrastructure between epithelial cells,with neat microvilli and intact structure.Compared with the uremic group,the intestinal permeability in the uremia + probiotic group was significantly decreased(P<0.05);serum inflammatory factors hs-CRP,IL-6,TNF-α levels were significantly lower(P<0.05);the intestinal SOD level was significantly increased(P<0.05);and the intestinal MDA showed a decreasing trend,but the difference was not statistically significant(P>0.05).Conclusions Bi-07 can improve intestinal barrier function in uremic rats.The mechanism may be realized by inhibiting intestinal oxidative stress so as to reduce intestinal barrier damage in uremic rats.…”
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Proximity Proteomics Reveals USP44 Forms a Complex with BRCA2 in Neuroblastoma Cells and Is Required to Prevent Chromosome Breakage by Asma Ali, Sajjad Hussain, Tibor Bedekovics, Raymond H. Jeon, Danielle G. May, Kyle J. Roux, Paul J. Galardy

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The influence of the choroid plexus on brain function: beyond its role in cerebrospinal fluid production by Sayako Katada, Kelren S. Rodrigues, Kinichi Nakashima

“…The ChP is composed of tight-junction-bound epithelial cells and the underlying stroma-rich fenestrated capillaries of blood vessels. …”
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Loose binding of the DF axis with the A3B3 complex stimulates the initial activity of Enterococcus hirae V1-ATPase. by Md Jahangir Alam, Satoshi Arai, Shinya Saijo, Kano Suzuki, Kenji Mizutani, Yoshiko Ishizuka-Katsura, Noboru Ohsawa, Takaho Terada, Mikako Shirouzu, Shigeyuki Yokoyama, So Iwata, Yoshimi Kakinuma, Ichiro Yamato, Takeshi Murata

“…These findings suggest that strong interaction between the DF complex and A3B3 complex lowers ATPase activity, but also that the tight binding is responsible for the stable ATPase activity of the complex.…”
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Who needs microtubules? Myogenic reorganization of MTOC, Golgi complex and ER exit sites persists despite lack of normal microtubule tracks. by Kristien J M Zaal, Ericka Reid, Kambiz Mousavi, Tan Zhang, Amisha Mehta, Elisabeth Bugnard, Vittorio Sartorelli, Evelyn Ralston

“…Redistributions of Golgi complex and ER exit sites were incomplete but remained tightly linked under all circumstances, and conditional on centrosomal reorganization. …”
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The Ideal City by Federico M. Butera

“…The cause lies in human activities, which are the product of the current economic and cultural model. The complex environmental system, with its tight interconnections between various planetary boundaries, is closely linked to another complex system: human society. …”
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Skp1 Independent Function of Cdc53/Cul1 in F-box Protein Homeostasis. by Radhika Mathur, James L Yen, Peter Kaiser

“…More importantly, our results assign important biological functions to a sub-complex of cullin-RING ligases that comprises Cdc53/Rbx1/Cdc34, but is independent of Skp1.…”
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Neural Mechanisms and Alterations of Sweet Sensing: Insights from Functional Magnetic Resonance Imaging Studies by Tobias Long, Colette C. Milbourn, Alison Smith, Kyaw Linn Su Khin, Amanda J. Page, Iskandar Idris, Qian Yang, Richard L. Young, Sally Eldeghaidy

“…Both internal and external factors tightly regulate their signalling pathways, and dysfunction within these systems may contribute to the development of metabolic disorders such as obesity and type 2 diabetes (T2D). …”
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Interactions between the Nse3 and Nse4 components of the SMC5-6 complex identify evolutionarily conserved interactions between MAGE and EID Families. by Jessica J R Hudson, Katerina Bednarova, Lucie Kozakova, Chunyan Liao, Marc Guerineau, Rita Colnaghi, Susanne Vidot, Jaromir Marek, Sreenivas R Bathula, Alan R Lehmann, Jan Palecek

“…It is composed of 6-8 polypeptides, of which Nse1, Nse3 and Nse4 form a tight sub-complex. MAGEG1, the mammalian ortholog of Nse3, is the founding member of the MAGE (melanoma-associated antigen) protein family and Nse4 is related to the EID (E1A-like inhibitor of differentiation) family of transcriptional repressors.…”
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Development of nanofiber facial mask inspired by the multi-function of dried ginger (Zingiberis Rhizoma) essential oil by Yiwen Hao, Xia Lin, Wenwen Liu, Tinghongyang Jiang, Xing Zhang, Shasha Yang, You Huang, Wenjing Lai, Chaomei Fu, Zhen Zhang

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A stress-induced paralog of Lhcb4 controls the photosystem II functional architecture in Arabidopsis thaliana by Roberto Caferri, Qian Zhou, Luca Dall’Osto, Antonello Amelii, Jianyu Shan, Zhenfeng Liu, Roberto Bassi

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A ZO-1/α5β1-integrin complex regulates cytokinesis downstream of PKCε in NCI-H460 cells plated on fibronectin. by Saara Hämälistö, Jeroen Pouwels, Nicola de Franceschi, Markku Saari, Ylva Ivarsson, Pascale Zimmermann, Andreas Brech, Harald Stenmark, Johanna Ivaska

“…In the absence of ZO-1, or a functional ZO-1/α5β1-integrin complex, proper actin-dependent constriction between daughter cells is impaired and cells fail cytokinesis. …”
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Nuclear Structure, Size Regulation, and Role in Cell Migration by Yuhao Li, Shanghao Ge, Jiayi Liu, Deseng Sun, Yang Xi, Pan Chen

“…In this review, we provide an updated perspective on the structure and function of nuclear components, focusing on the linker of nucleoskeleton and cytoskeleton complex, the nuclear envelope, the nuclear lamina, and chromatin. …”
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Mammalian Base Excision Repair: Functional Partnership between PARP-1 and APE1 in AP-Site Repair. by Rajendra Prasad, Nadezhda Dyrkheeva, Jason Williams, Samuel H Wilson

“…The BER pathway is mediated by a specialized group of proteins, some of which can be found in multiprotein complexes in cultured mouse fibroblasts. Using a DNA polymerase (pol) β immunoaffinity-capture technique to isolate such a complex, we identified five tightly associated and abundant BER factors in the complex: PARP-1, XRCC1, DNA ligase III, PNKP, and Tdp1. …”
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