BIOLOGICAL RESPONSE OF TREATMENT WITH SAFFRON PETAL EXTRACT ON CYTOKYNE-INDUCED OXIDATIVE STRESS AND INFLAMMATION IN THE CACO-2/THP1 COCOLTURE MODEL

“…Furthermore, the results of our model suggest that SPE treatment restores the functionality of the intestinal barrier by reducing the destruction of tight junctions induced by the inflammatory stimulus. …”
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A new methodology to associate SNPs with human diseases according to their pathway related context. by Burcu Bakir-Gungor, Osman Ugur Sezerman

“…Genome-wide association studies (GWAS) with hundreds of żthousands of single nucleotide polymorphisms (SNPs) are popular strategies to reveal the genetic basis of human complex diseases. Despite many successes of GWAS, it is well recognized that new analytical approaches have to be integrated to achieve their full potential. …”
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Depletion reveals role of bicarbonate in the photosynthetic electron transport chain of Limnospira maxima by Leslie Castillo, Stavroula Nicolaou, Colin Gates, Colin Gates

“…Using chlorophyll fast repetition rate fluorometry, it was observed under bicarbonate depletion that oscillations were still present in a fraction of PSIIs, confirming the functionality of the water oxidizing complex remains in this fraction of centers. …”
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Microbial metabolites and immune modulation by Hassan Ghasemi

“…Even lipopolysaccharides (LPS), traditionally regarded as pro-inflammatory, can have nuanced roles; at low doses, they may condition immune cells to adopt a tolerogenic state, highlighting the complexity of microbial metabolite interactions.9 Microbial metabolites significantly influence innate immunity by enhancing the pathogen-clearing abilities of macrophages, as SCFAs optimize their phagocytic functions. …”
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VPS4B orchestrates response to nuclear envelope stress by regulating ESCRT-III dynamics in glioblastoma by Zuqian Wu, Issei Omura, Atsushi Saito, Kazunori Imaizumi, Yasunao Kamikawa

“…The Nuclear envelope (NE) is frequently challenged by mechanical stimuli involving cells passing through a tight space and such stress is known as “NE stress.” …”
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Large system study of chalcopyrite and pyrite flotation surfaces based on SCC-DFTB parameterization method by Jianhua Chen, Yibing Zhang

“…In this study, we employed the self-consistent charge density functional tight-binding (SCC-DFTB) parameterization method to develop a parameter set, CuFeOrg, which includes the interactions between Cu-Fe-C-H-O-N-S-P-Zn elements, to investigate the surface interactions in large-scale flotation systems of chalcopyrite and pyrite. …”
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Optimisation of the performance and structure of soluble ball seat metal sealing rings based on response surface by CHEN Zhen, RAN Qingjie, CHEN Nengpeng, WANG Qiaomu

“…Horizontal well fracturing technology, as a core tool for efficient development of tight oil and gas reservoirs, is of strategic significance for enhancing the recovery rate of unconventional oil and gas resources. …”
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Ste12/Fab1 phosphatidylinositol-3-phosphate 5-kinase is required for nitrogen-regulated mitotic commitment and cell size control. by David Cobley, Lenka Hálová, Marie Schauries, Adrian Kaczmarek, Mirita Franz-Wachtel, Wei Du, Karsten Krug, Boris Maček, Janni Petersen

“…Tight coupling of cell growth and cell cycle progression enable cells to adjust their rate of division, and therefore size, to the demands of proliferation in varying nutritional environments. …”
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Barriers and Strategies for Oral Peptide and Protein Therapeutics Delivery: Update on Clinical Advances by Kshitis Chandra Baral, Ki Young Choi

“…Peptide and protein (PP) therapeutics are highly specific and potent biomolecules that treat chronic and complex diseases. However, their oral delivery is significantly hindered by enzymatic degradation, instability, and poor permeability through the gastrointestinal (GI) epithelium, resulting in low bioavailability. …”
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The Drosophila hematopoietic niche assembles through collective cell migration controlled by neighbor tissues and Slit-Robo signaling by Kara A Nelson, Kari F Lenhart, Lauren Anllo, Stephen DiNardo

“…Consistency of niche position suggests that placement is important for niche function. However, the complexity of most niches has precluded a thorough understanding of how their proper placement is established. …”
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Defining the Protein Phosphatase 2A (PP2A) Subcomplexes That Regulate FoxO Transcription Factor Localization by Adeline M. Luperchio, Daniel J. Salamango

“…FoxO transactivation activity is tightly regulated by a complex network of signaling pathways and post-translational modifications. …”
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Duplex γ/α-phase evolution of biocompatible high-nitrogen stainless steel in additive manufacturing by Yufeng Tao, Liansheng Lin, Xudong Ren, Xuejiao Wang, Xia Cao, Yunxia Ye, Erjin Zhang, Heng Gu, Zijie Dai

“…Artificial tunability of microstructured high-nitrogen γ/α duplex-phase at tight topological control promises transformative opportunities not possessed by individual ferrite or austenitic phase, allowing pre-programming mechanics (density, strength, hardness, and tensile properties) for next-generation industrial or implantable biomedical uses requiring complex geometries and multi-functions.…”
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Well Performance from Numerical Methods to Machine Learning Approach: Applications in Multiple Fractured Shale Reservoirs by Kailei Liu, Boyue Xu, Changjea Kim, Jing Fu

“…The complexities of hydraulic fracture properties and multiphase flow make it difficult and time-consuming to understand the well performance (i.e., well production) in fractured shale reservoirs, especially when using conventional numerical methods. …”
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Thick-panel origami structures forming seamless surfaces by Rui Peng, Gregory S. Chirikjian

“…Existing methods often introduce structural complexities or fail to ensure seamless surfaces, limiting their practicality. …”
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Rtf1 HMD domain facilitates global histone H2B monoubiquitination and regulates morphogenesis and virulence in the meningitis-causing pathogen Cryptococcus neoformans by Yixuan Jiang, Ying Liang, Fujie Zhao, Zhenguo Lu, Siyu Wang, Yao Meng, Zhanxiang Liu, Jing Zhang, Youbao Zhao

“…Rtf1 is generally considered to be a subunit of the Paf1 complex (Paf1C), which is a multifunctional protein complex involved in histone modification and RNA biosynthesis at multiple stages. …”
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Surface enzyme-polymerization endows Janus hydrogel tough adhesion and regenerative repair in penetrating orocutaneous fistulas by Ye Ju, Chunyue Ma, Ling Ding, Mingyue Shi, Xia Wang, Dongbei Wu, Qing Wu, Xingjun Qin, Qigang Wang

“…Abstract Penetrating orocutaneous or oropharyngeal fistulas (POFs), severe complications following unsuccessful oral or oropharyngeal reconstruction, remain complex clinical challenges due to lack of supportive tissue, contamination with saliva and chewed food, and dynamic oral environment. …”
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Integrated biomimetic bioprinting of perichondrium with cartilage for auricle reconstruction by Litao Jia, Siyu Liu, Luosha Gu, Xiaomin Liu, Kexin Sun, Feiyang Chu, Jinshi Zeng, Wenshuai Liu, Haiyue Jiang, Xia Liu

“…Simulating the anatomical structure of the native auricle designs a sandwich construction model containing bilateral perichondrium and intermediate cartilage, employing a photocrosslinkable acellular cartilage matrix and gelatin bionics matrix microenvironment, applying co-cultured auricular chondrocytes and adipose-derived stem cells creates functional cell populations, designing hatch patterns imitates microscopic arrangement structures, utilizing sacrificial materials forms interlaminar network traffic to enhance the tight connection between layers, and finally, assessing the regenerative quality of the constructs explores their feasibility and stability. …”
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Optimal estimates of trace distance between bosonic Gaussian states and applications to learning by Lennart Bittel, Francesco Anna Mele, Antonio Anna Mele, Salvatore Tirone, Ludovico Lami

“…In this work, we fully resolve this question by demonstrating that if the first and second moments are known up to an error $\varepsilon$, the trace distance error on the state also scales as $\varepsilon$, and this functional dependence is optimal. To prove this, we establish tight bounds on the trace distance between two Gaussian states in terms of the norm distance of their first and second moments. …”
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Profiling of rhizosphere-associated microbial communities in North Alabama soils infested with varied levels of reniform nematodes by Sowndarya Karapareddy, Varsha C. Anche, Sowjanya R. Tamatamu, Madhusudhana R. Janga, Kathy Lawrence, Leopold M. Nyochembeng, Antonette Todd, Lloyd T. Walker, Venkateswara R. Sripathi

“…IntroductionPlant roots, nematodes, and soil microorganisms have a complex interaction in the rhizosphere by exchanging or communicating through biomolecules or chemicals or signals. …”
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Exploring the role of mitochondrial uncoupling protein 4 in brain metabolism: implications for Alzheimer’s disease by Simone M. Crivelli, Aisylu Gaifullina, Jean-Yves Chatton

“…The brain’s high demand for energy necessitates tightly regulated metabolic pathways to sustain physiological activity. …”
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