The Sec1/Munc18 protein Vps45 regulates cellular levels of its SNARE binding partners Tlg2 and Snc2 in Saccharomyces cerevisiae. by Scott G Shanks, Lindsay N Carpp, Marion S Struthers, Rebecca K McCann, Nia J Bryant

“…Intracellular membrane trafficking pathways must be tightly regulated to ensure proper functioning of all eukaryotic cells. …”
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A mechanistic systems biology model of brain microvascular endothelial cell signaling reveals dynamic pathway-based therapeutic targets for brain ischemia by Geli Li, Yuchen Ma, Sujie Zhang, Wen Lin, Xinyi Yao, Yating Zhou, Yanyong Zhao, Qi Rao, Yuchen Qu, Yuan Gao, Lianmin Chen, Yu Zhang, Feng Han, Meiling Sun, Chen Zhao

“…To better understand the complex multifaceted roles of BMECs in the regulation of ischemic stroke pathophysiology and facilitate BMEC-based drug target discovery, we utilized a transcriptomics-informed systems biology modeling approach and constructed a mechanism-based computational multipathway model to systematically investigate BMEC function and its modulatory potential. …”
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Toll-Like Receptor-Mediated Cardiac Injury during Experimental Sepsis by Ina Lackner, Birte Weber, Shinjini Chakraborty, Sonja Braumüller, Markus Huber-Lang, Florian Gebhard, Miriam Kalbitz

“…The development of septic cardiomyopathy is due to complex interactions of damage-associated molecular patters, cytokines, and complement activation products. …”
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Thermo-Hydro-Mechanical Coupling Numerical Simulation on Mechanical Heterogeneity of Coal Rock by Shuiqing Hu, Daobing Wang, Yipeng Li, Xiongfei Liu, Fujian Zhou, Meng Wang, Chunming He, Bo Yu

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The Intestinal Thread of Fate: How the Microbiota Shapes the Story of Liver Disease by Carlo Acierno, Riccardo Nevola, Luca Rinaldi, Ferdinando Carlo Sasso, Luigi Elio Adinolfi, Alfredo Caturano

“…The gut–liver axis plays a critical role, with factors like altered bile acid metabolism and toxic metabolites such as hydrogen sulfide worsening intestinal barrier function and fueling chronic inflammation. This review aims to explore the complex role of the gut–liver axis in MASLD progression, highlighting the mechanisms of intestinal barrier dysfunction, dysbiosis, and microbial contributions to liver injury. …”
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Production, purification and characterization of recombinant, full-length human claudin-1. by Nicklas Bonander, Mohammed Jamshad, Dominik Oberthür, Michelle Clare, James Barwell, Ke Hu, Michelle J Farquhar, Zania Stamataki, Helen J Harris, Karsten Dierks, Timothy R Dafforn, Christian Betzel, Jane A McKeating, Roslyn M Bill

“…The transmembrane domain proteins of the claudin superfamily are the major structural components of cellular tight junctions. One family member, claudin-1, also associates with tetraspanin CD81 as part of a receptor complex that is essential for hepatitis C virus (HCV) infection of the liver. …”
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Porcine intestinal organoids cultured in an organ-on-a-chip microphysiological system by James Bacon, Halie Kitchel, John Stutz, Jack Jia Hua Chen, Aaron Smith, Robert D. Van Horn, Christopher Moreland, Trent Abraham, Thomas Baker, Eitaro Aihara, Kathleen Hillgren

“…These cultures formed villi-like structures and established a tight barrier replete with F-actin and tight junctions. …”
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JMY powers dendritogenesis and is regulated by CaM revealing a general, critical principle in neuromorphogenesis by Maja Kühne, Anna-Lena Zepernick, Britta Qualmann, Michael Manfred Kessels, Maryam Izadi-Seitz

“…Here, we identify the WH2 domain-based actin nucleator JMY as target of the calcium sensor calmodulin, reveal that JMY is critical for dendritic arbor formation and unravel that JMY’s molecular mechanisms employed in dendritic arborization are depended on Arp2/3 complex interaction, Arp2/3 complex activity and functionality of JMY’s WH2 domains, i.e. on JMY’s abilities to promote actin filament formation. …”
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Differences in the effects and action modes of gut commensals against dextran sulfate sodium-induced intestinal inflammation by Dingwu Qu, Zhennan Gu, Saisai Feng, Leilei Yu, Fengwei Tian, Hao Zhang, Wei Chen, Qixiao Zhai

“…The probiotic strains differed in regulating the intestinal microbiota, cytokines (IL-10, IL-1β and interferon (IFN)-γ), and tight junction function (Zonulin-1 and Occludin). …”
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Rhinovirus C replication is associated with the endoplasmic reticulum and triggers cytopathic effects in an in vitro model of human airway epithelium. by Talita B Gagliardi, Monty E Goldstein, Daniel Song, Kelsey M Gray, Jae W Jung, Maxinne A Ignacio, Kimberly M Stroka, Gregg A Duncan, Margaret A Scull

“…Finally, RV-C15 infection resulted in a temporary loss in epithelial barrier integrity and the translocation of tight junction proteins while a reduction in mucociliary clearance indicated cytopathic effects on epithelial function. …”
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Mechanistic insights into the recognition of Fe2+ and solvent-driven selectivity of chalcone-based receptors by Ajay Shankar

“…Spectrosc. 287 (2023) 122107; 303 (2023) 123129], this study offers novel insight into the supramolecular recognition of Fe2+ by receptor R1, wherein the conventional chalcone binding strategy is extended. Density Functional Theory (DFT) is used to differentiate the complexation behavior of chalcone-based receptors (R1, R2, R3), revealing key nucleophilic centres, particularly the carbonyl and phenolic oxygen atoms, as primary coordination sites. …”
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PREDICTION ENDOMETRIAL CANCER IN WOMEN WITH ENDOMETRIAL HYPERPLASTIC PROCESSES IN PREMENOPAUSAL by A. L. Unanyan, I. S. Sidorova, E. A. Kogan, D. V. Baburin

“…We have identified risk factors and determined their significance and relative risk in endometrial oncotransformation based on mathematical analysis of clinical and anamnestic data and molecular-biological indicators. The structural, functional and molecular mechanisms of hyperplastic processes of endometrium in premenopausal women were investigated based on a complex immunohistochemical studies. …”
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An Experimental Dynamic Investigation of the Influence of Melatonin, Serotonin and Tryptophan on the Stability of the DNA Structure by Cristina Manuela Drăgoi, Anca Zanfirescu, Ion-Bogdan Dumitrescu, Anca Ungurianu, Denisa Marilena Margină, Alina-Crenguţa Nicolae

“…Additionally, the influence of calcium and magnesium ions on the resulting complexes of these indole derivatives with ct-DNA has been evaluated. …”
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Stability and Finite-Time Synchronization Analysis for Recurrent Neural Networks with Improved Integral-Type Time-Varying Delays by Meng Li, Gulijiamali Maimaitiaili

“…Firstly, a sufficient criterion for universal asymptotic stability of RNNs with integral time-varying delays is obtained by estimating a tight upper bound of augmented Lyapunov-Krasovskii functional (LKF) derivative with inequality scaling technique and mutually convex combined inequality. …”
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Structure and assembly of the MmpL5/MmpS5 efflux transporter from Mycobacterium tuberculosis by Zhiqi Xiong, Xiaolin Yang, Shule Wang, Caitlan J. Smart, Hazel M. Sisson, Zhenli Lin, Tianyu Hu, Yuting Ran, Chuyao Xu, Xiuna Yang, Yao Zhao, William J. Jowsey, Gregory M. Cook, Matthew B. McNeil, Luke W. Guddat, Zihe Rao, Bing Zhang

“…The stalk secures the tight association of the three MmpL5 subunits and exhibits intrinsic structural flexibility. …”
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Integrative analysis identifies IL-6/JUN/MMP-9 pathway destroyed blood-brain-barrier in autism mice via machine learning and bioinformatic analysis by Cong Hu, Heli Li, Jinru Cui, Yunjie Li, Feiyan Zhang, Hao Li, Xiaoping Luo, Yan Hao

“…Abstract Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition characterized by social communication deficits and restricted, repetitive behaviors. …”
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How (Ultra‐)Rare Gene Variants Improve Our Understanding of More Common Autoimmune and Inflammatory Diseases by Alexandre Belot, Maud Tusseau, Jade Cognard, Sophie Georgin‐Lavialle, Guilaine Boursier, Christian M. Hedrich

“…Additional monogenic diseases such as ELF4, WDR1 mutations and trisomy 8 further illustrate the genetic complexity of this condition. Observations from genetic studies in SLE and Behçet syndrome highlight the complexity of systemic inflammatory diseases in which distinct molecular defects caused by single‐gene mutations can promote lupus or Behçet syndromes, often unrecognizable from their genetically complex “classical” forms. …”
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Evaluasi Kualitas Layanan terhadap Operator Telekomunikasi: Tinjauan Perspektif Pelanggan by Suryat Handoko, Nilda Tri Putri, Jonrinaldi Jonrinaldi

“…PT Semen Padang is now actively promoting synergies and pursuing the company's performance growth to be able to cope with competition in an increasingly tight and complex cement industry. In order to face this, it is necessary to have adequate human resource management from the company. …”
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A Novel Multi-Agent-Based Approach for Train Rescheduling in Large-Scale Railway Networks by Jin Liu, Lei Chen, Zhongbei Tian, Ning Zhao, Clive Roberts

“…While recent research has introduced intelligent solutions to railway traffic management, the tight interdependence of train timetables and the intrinsic complexity of railway networks have hindered the scalability of these approaches to large-scale systems. …”
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THE OPTIMIZATION METHOD OF FUZZY AUTOMATIC CLASSIFICATION IN THE PROBLEM OF COMBINING THE ASSESSMENTS OF TRAJECTOR MEASUREMENTS IN THE RADAR SYSTEM by A. V. Khizhniak

“…By a radiolocation system the author mean an automated hierarchical technical complex that combines, using communication tools, a set of asynchronously functioning radiolocation tools, as well as central and intermediate points that collect, process and issue trajectory radiolocation information. …”
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