A stress-induced paralog of Lhcb4 controls the photosystem II functional architecture in Arabidopsis thaliana by Roberto Caferri, Qian Zhou, Luca Dall’Osto, Antonello Amelii, Jianyu Shan, Zhenfeng Liu, Roberto Bassi

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Mammalian Base Excision Repair: Functional Partnership between PARP-1 and APE1 in AP-Site Repair. by Rajendra Prasad, Nadezhda Dyrkheeva, Jason Williams, Samuel H Wilson

“…The BER pathway is mediated by a specialized group of proteins, some of which can be found in multiprotein complexes in cultured mouse fibroblasts. Using a DNA polymerase (pol) β immunoaffinity-capture technique to isolate such a complex, we identified five tightly associated and abundant BER factors in the complex: PARP-1, XRCC1, DNA ligase III, PNKP, and Tdp1. …”
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Nuclear Structure, Size Regulation, and Role in Cell Migration by Yuhao Li, Shanghao Ge, Jiayi Liu, Deseng Sun, Yang Xi, Pan Chen

“…In this review, we provide an updated perspective on the structure and function of nuclear components, focusing on the linker of nucleoskeleton and cytoskeleton complex, the nuclear envelope, the nuclear lamina, and chromatin. …”
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A Key Role for NF-κB Transcription Factor c-Rel in T-Lymphocyte-Differentiation and Effector Functions by Alexander Visekruna, Anton Volkov, Ulrich Steinhoff

“…The transcription factors of the Rel/NF-κB family function as key regulators of innate and adoptive immunity. …”
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p47phox: A Central Regulator of NADPH Oxidase Function and a Promising Therapeutic Target in Redox-Related Diseases by Madison E. Gamble, Sruthi Sureshkumar, Maria Janina Carrera Espinoza, Natalie L. Hakim, Claudia M. Espitia, Fangchao Bi, Kevin R. Kelly, Wei Wang, Steffan T. Nawrocki, Jennifer S. Carew

“…Within NOX2, the essential scaffold protein p47phox plays a pivotal role in orchestrating enzyme activation and facilitating the assembly and membrane translocation of cytosolic components of the complex. Tight regulation of p47phox activity is crucial, and its disruption is linked to a number of pathological conditions. …”
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Chemical genetic inhibition of Mps1 in stable human cell lines reveals novel aspects of Mps1 function in mitosis. by Tale Sliedrecht, Chao Zhang, Kevan M Shokat, Geert J P L Kops

“…<h4>Background</h4>Proper execution of chromosome segregation relies on tight control of attachment of chromosomes to spindle microtubules. …”
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Unique Function of the Bacterial Chromosome Segregation Machinery in Apically Growing Streptomyces - Targeting the Chromosome to New Hyphal Tubes and its Anchorage at the Tips. by Agnieszka Kois-Ostrowska, Agnieszka Strzałka, Natalia Lipietta, Emma Tilley, Jolanta Zakrzewska-Czerwińska, Paul Herron, Dagmara Jakimowicz

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Protein phosphorylation networks in Baylisascaris procyonis revealed by phosphoproteomic analysis by Qin Meng, Zhikang Li, Qiguan Qiu, Shuyu Chen, Haiyan Gong, Xiaoruo Tan, Xiaoheng Liu, Zhaoguo Chen, Wei Liu

“…The annotated phosphoproteins were associated with various biological processes, including cytoskeletal remodeling, supramolecular complex assembly, and developmental regulation. The phosphopeptide functional enrichment revealed that B. procyonis phosphoproteins were mostly involved in the cytoskeleton cellular compartment, protein binding molecular function, and multiple biological processes, including regulating supramolecular fiber and cytoskeleton organization and assembling cellular protein-containing complexes and organelles. …”
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Circ-0000197 derived from porcine milk small extracellular vesicles promotes intestinal barrier function by sponging miR-429 by Yuxuan Wang, Bilan Chen, Tingzhou Xuan, Kun Ouyang, Jingshen Chen, Hailong Wang, Junyi Luo, Jiajie Sun, Qianyun Xi, Yongliang Zhang, Ting Chen

“…We systematically identified the circRNAs involved in this process and analyzed the miRNAs through which PM-sEV deliver circRNAs to regulate intestinal barrier function. Our findings revealed that PM-sEV promote the expression of the intestinal tight junction proteins ZO-1 and Occludin, both in vivo (mice) and in vitro (IPEC-J2). …”
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Comprehensive identification of cotton EPF/EPFL receptors and functional characterization of the GhEPFL1-1-GhER1 module in drought tolerance by Shichang He, Huijian Sun, Qing Chen, Yanlong Yang, Zixin Zhou, Saiwen Chang, Shuaiqi Lu, Zhencai Liang, Julan Yang, Xiao fei

“…These components form co-receptor complexes that activate the MAPK signaling cascade, playing critical roles in stomatal development, stress responses, and signal transduction. …”
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Engeletin Targets Mitochondrial Dysfunction to Attenuate Oxidative Stress and Experimental Colitis in Intestinal Epithelial Cells Through AMPK/SIRT1/PGC-1α Signaling by Jing Li, Zhijun Geng, Lixia Yin, Ju Huang, Minzhu Niu, Keni Zhang, Xue Song, Yueyue Wang, Lugen Zuo, Jianguo Hu

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Advances in ERECTA Family Regulation of Female Gametophyte Development in <i>Arabidopsis thaliana</i> by Han Su, Xiaohu Jiang, Yanfen Liu, Zhuangyuan Cao, Ziqi Liu, Yuan Qin, Qing He, Hanyang Cai

“…The female gametophyte is central to the reproductive success of flowering plants, with its development being tightly controlled by an intricate network of genes and signaling pathways. …”
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Stochastic Block-Coordinate Gradient Projection Algorithms for Submodular Maximization by Zhigang Li, Mingchuan Zhang, Junlong Zhu, Ruijuan Zheng, Qikun Zhang, Qingtao Wu

“…Moreover, we show that the proposed algorithm achieves the tight (pmin/2F⁎-ϵ) approximation guarantee after O(1/ϵ2) iterations for DR-submodular functions by choosing appropriate step sizes. …”
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Evolution Characteristics and Regional Roles’ Influencing Factors of Interprovincial Population Mobility Network in China by Wei Fang, Pengli An, Siyao Liu

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Tad pili with adaptable tips mediate contact-dependent killing during bacterial predation by Julien Herrou, Laetitia My, Caroline L. Monteil, Marine Bergot, Rikesh Jain, Emmanuelle Martinez, Tâm Mignot

“…Abstract The predatory bacterium, Myxococcus xanthus, kills its prey by contact, using a putative Tight Adherence pilus, known as the Kil system, along with a protein complex resembling the basal body a type-III secretion system, named the “needleless” T3SS*. …”
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A combination of activation and repression by a colinear Hox code controls forelimb-restricted expression of Tbx5 and reveals Hox protein specificity. by Satoko Nishimoto, Carolina Minguillon, Sophie Wood, Malcolm P O Logan

“…Forelimb-restricted expression of Tbx5 and ultimately forelimb formation is therefore achieved through co-option of two characteristics of Hox genes; their colinear expression along the body axis and the functional specificity of different paralogs. Active complexes can be formed by Hox PG proteins present throughout the rostral-caudal LPM while restriction of Tbx5 expression is achieved by superimposing a dominant repressive (Hoxc9) complex that determines the caudal boundary of Tbx5 expression. …”
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PcG-mediated higher-order chromatin structures modulate replication programs at the Drosophila BX-C. by Federica Lo Sardo, Chiara Lanzuolo, Federico Comoglio, Marco De Bardi, Renato Paro, Valerio Orlando

“…However, the interconnection between replication timing control and PcG functions remains unknown. Using Drosophila embryonic cell lines, we find that, while presence of specific PcG complexes and underlying transcription state are not the sole determinants of cellular replication timing, PcG-mediated higher-order structures appear to dictate the timing of replication and maintenance of the silenced state. …”
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The epithelial cell adhesion molecule EpCAM is required for epithelial morphogenesis and integrity during zebrafish epiboly and skin development. by Krasimir Slanchev, Thomas J Carney, Marc P Stemmler, Birgit Koschorz, Adam Amsterdam, Heinz Schwarz, Matthias Hammerschmidt

“…On the molecular level, EVL cells of epcam mutant embryos display reduced levels of membranous Ecad, accompanied by an enrichment of tight junction proteins and a basal extension of apical junction complexes (AJCs). …”
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SMG-1 and mTORC1 act antagonistically to regulate response to injury and growth in planarians. by Cristina González-Estévez, Daniel A Felix, Matthew D Smith, Jordi Paps, Simon J Morley, Victoria James, Tyson V Sharp, A Aziz Aboobaker

“…Here we show that the planarian homolog of the phosphoinositide 3-kinase-related kinase (PIKK) family member SMG-1 and mTOR complex 1 components are required for this tight control. …”
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Trans-synaptic molecular context of NMDA receptor nanodomains by Michael C. Anderson, Poorna A. Dharmasri, Martina Damenti, Sarah R. Metzbower, Rozita Laghaei, Thomas A. Blanpied, Aaron D. Levy

“…Abstract Tight coordination of spatial relationships between protein complexes is required for cellular function. …”
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