Adherence to Physical Activity and Incident Mobility Disability in Older Adults With Mobility Limitations by Alejandro Álvarez‐Bustos, Helio José Coelho‐Junior, Riccardo Calvani, Leocadio Rodriguez‐Mañas, Matteo Tosato, Matteo Cesari, Antonio Cherubini, Alfonso J. Cruz‐Jentoft, Pálmi V. Jónsson, Fabrizia Lattanzio, Marcello Maggio, Regina Roller‐Wirnsberger, Ingrid Rýznarová, Annemie M. W. J. Schols, Cornel C. Sieber, Alan J. Sinclair, Anna Skalska, Timo Strandberg, Achille Tchalla, Eva Topinková, Bruno Vellas, Stephan vonHaehling, Francesco Landi, Emanuele Marzetti, for the SPRINTT consortium

“…PF&S was operationalised as having a total score from 3 to 9 on the short physical performance battery (SPPB), low appendicular lean mass and ability to complete the 400‐m walk test in < 15 min. …”
Get full text

Exploring voluntary sector specialist services for victim-survivors of sexual violence in England: the PROSPER co-production study by Caroline Bradbury-Jones, Sarah Damery, Kirsten Fruin, Clare Gunby, Jenny Harlock, Lucy Hebberts, Louise Isham, Anne-Marie Jones, Fay Maxted, Amelia Mighty, Priti Parmar, Laura Patterson, Jason Schaub, Fee Scott, Harriet Smailes, Debs Smith, Julie Taylor

“…Similarly, the study findings suggest that commissioners need to have the ability to operate flexibly as regards movement of funds to respond to local needs. …”
Get full text

The Effect of Serish Root Gum (Eremurus luteus) as Fat Replacer on Rheological, Physical and Sensory Properties of Low Fat Ice Cream by Fatemeh Sabzmeidani, Masoud Taghizadeh, Mohammad Saleh Hemati Hasan Poor

“…In the sensory evaluation section, the characteristics of creaminess, sweetness, viscosity, roughness, coldness and hardness were evaluated by transient dominant sensation test and these changes were significant in most cases. …”
Get full text

Effect of Berberine on the Inflammatory Response of ANA-1 Cells Induced by Angiotensin Ⅱ Based on TLR4 Signaling Pathway by GAO Dexing, JIA Peizhi, PENG Jun, LIN Wei

“…Compared with the control group, the expression of TLR4, p-p65 protein of the model group after intervention for 12 h was significantly increased, the expression of TLR4, p-p65 protein of the model + the high dose BBR group, the model group + the inhibitor group, the model group + the inhibitor group + the high dose BBR goup was significantly decreased. ⑥ Biochemical test results: compared with the control group, the content of MDA of the model group was significantly increased, SOD activity was significantly decreased, the difference was statistically significant (<italic>P</italic>&lt;0.05), the content of MDA in the model group + the low, medium and high dose BBR group was significantly down-regulated, SOD activity was significantly increased, the difference was statistically significant (<italic>P</italic>&lt;0.05).ConclusionBBR can regulate TLR4 signaling pathway and inhibit the abnormal activation of TLR4 signaling pathway induced by Ang Ⅱ and NF-κB, MAPK signal transduction, and reduce the content of proinflammatory factors and regulate inflammatory response; in addition, BBR can also improve the lipid peroxidation and antioxidant ability of ANA-1 cells induced by Ang Ⅱ, reduce the oxidative stress damage caused by Ang Ⅱ, and protect ANA-1 cells.…”
Get full text

Validation of a novel imaging-guided and anatomy-based classification system for anorectal fistulas: a retrospective clinical evaluation study by Antonio Brillantino, Francesca Iacobellis, Luigi Marano, Adolfo Renzi, Pasquale Talento, Luigi Brusciano, Claudio Gambardella, Umberto Favetta, Michele Schiano Di Visconte, Luigi Monaco, Maurizio Grillo, Mauro Natale Maglio, Fabrizio Foroni, Alessio Palumbo, Maria Laura Sandoval Sotelo, Luciano Vicenzo, Elisa Palladino, Giovanna Frezza, Maria Paola Menna, Paolino Mauro, Stefano Picardi, Mario Massimo Mensorio, Vinicio Mosca, Vincenzo Bottino, Giovanna Ioia, Corrado Rispoli, Marco Di Serafino, Martina Caruso, Roberto Ronza, Barbara Frittoli, Daria Schettini, Luca Stoppino, Franco Iafrate, Giulio Lombardi, Carmine Antropoli, Salvatore Cappabianca, Ludovico Docimo, Roberto Grassi, Alfonso Reginelli

“…Results When compared with the new classification, the Garg classification demonstrated a slightly lower ability to predict the feasibility of fistulotomy in simple fistulas (94.2% vs 99.1%; Fisher exact test, P=0.006). …”
Get full text

Individually controlled noise reducing devices to improve IEQ in classrooms of primary schools by Dadi Zhang

“…Then, an ICND was designed and tested to address the main IEQ problem in classrooms, namely noise. …”
Get full text

Accuracy of Established Prognostic Staging Systems for Cardiac Transthyretin Amyloidosis in the Tafamidis Era by Maximilian Leo Müller, MD, Sebastian Spethmann, MD, Daniel Messroghli, MD, Anna Brand, MD, Isabel Mattig, MD, Katrin Hahn, MD, Ulf Landmesser, MD, Bettina Heidecker, MD

“…The staging systems’ ability to identify subgroups with distinct overall survival was assessed using Kaplan-Meier analyses and pairwise log-rank tests. …”
Get full text

T2‐low severe asthma clinical spectrum and impact: The Greek PHOLLOW cross‐sectional study by Konstantinos Porpodis, Nikolaos Zias, Konstantinos Kostikas, Argyris Tzouvelekis, Michael Makris, George N. Konstantinou, Eleftherios Zervas, Stelios Loukides, Paschalis Steiropoulos, Konstantinos Katsoulis, Anastasios Palamidas, Aikaterini Syrigou, Maria Gangadi, Antonios Christopoulos, Dimosthenis Papapetrou, Fotios Psarros, Konstantinos Gourgoulianis, Eleni Tzortzaki, Stylianos K. Vittorakis, Ioannis Paraskevopoulos, Ilias Papanikolaou, Georgios Krommidas, Dimitrios Latsios, Nikolaos Tzanakis, Miltiadis Markatos, Angeliki Damianaki, Argyrios Manikas, Alexia Chatzipetrou, Dimitrios Vourdas, Ioanna Tsiouprou, Christina Papista, Marina Bartsakoulia, Nikolas Mathioudakis, Petros Galanakis, Petros Bakakos

“…These patients frequently have uncontrolled disease and experience impairments in their quality of life, emotions and work ability.…”
Get full text

Microglial CD2AP deficiency exerts protection in an Alzheimer’s disease model of amyloidosis by Lingliang Zhang, Lingling Huang, Yuhang Zhou, Jian Meng, Liang Zhang, Yunqiang Zhou, Naizhen Zheng, Tiantian Guo, Shanshan Zhao, Zijie Wang, Yuanhui Huo, Yingjun Zhao, Xiao-fen Chen, Honghua Zheng, David M. Holtzman, Yun-wu Zhang

“…Microglial CD2AP-deficient mice were crossed with 5xFAD mice and the offspring were subjected to neuropathological assessment, behavioral tests, electrophysiology, RNA-seq, Golgi staining, and biochemistry analysis. …”
Get full text

Conformation-sensitive targeting of CD18 depletes M2-like tumor-associated macrophages resulting in inhibition of solid tumor progression by Deok-Sang Hwang, Hyunsu Bae, Yingying Cao, Se Eun Lim, Ik-Hwan Han, Ilseob Choi, Hongseo Choi, Soyoung Kim, Chanmi Jeong, Juwon Yang, Jeongyoon Choi, Heekyung Lee, Jin Sun Shin, Hye Duck Yeom, Eun-Ji Lee, Nari Cha, Hyemin Go, Songah Chae, Won-Jun Lee, Minjin Kwon, Hongsung Kim, Hyojung Choi, Sehyun Pak, Namgyeong Park, Eunbin Ko, Junho H Lee, Hwan-Suck Chung, Seong Ho Kang

“…The anticancer efficacy of TB511 was tested using colorectal cancer (CRC) and non-small cell lung cancer (NSCLC) mouse model. …”
Get full text

Eigenvector biomarker for prediction of epileptogenic zones and surgical success from interictal data by Sayantika Roy, Armelle Varillas, Armelle Varillas, Emily A. Pereira, Patrick Myers, Patrick Myers, Golnoosh Kamali, Kristin M. Gunnarsdottir, Kristin M. Gunnarsdottir, Nathan E. Crone, Adam G. Rouse, Jennifer J. Cheng, Michael J. Kinsman, Patrick Landazuri, Patrick Landazuri, Utku Uysal, Carol M. Ulloa, Nathaniel Cameron, Sara Inati, Kareem A. Zaghloul, Varina L. Boerwinkle, Sarah Wyckoff, Niravkumar Barot, Jorge González-Martínez, Joon Y. Kang, Sridevi V. Sarma, Sridevi V. Sarma

“…In particular, the steady-state solution of the DNM highlights the sinks and is characterized by the leading eigenvector of the state-transition matrix of the DNM. To test this, we build patient-specific DNMs from interictal iEEG data collected from 65 patients treated across 6 centers. …”
Get full text

Targeting METTL3 as a checkpoint to enhance T cells for tumour immunotherapy by Kaixin Wu, Sa Li, Guangliang Hong, Hongzhi Dong, Tongke Tang, He Liu, Lingmei Jin, Siyuan Lin, Jingyun Ji, Mingli Hu, Shuntian Chen, Haoyuan Wu, Guanzheng Luo, Haoyuan Wu, Xiangqian Kong, Jiekai Chen, Jiangping He, Hongling Wu

“…Finally, the efficacy of METTL3 inhibition was also tested on human melanoma model (A375) and human T cells. …”
Get full text

Functional Performance Decline Outperforms Sarcopenia and Its Components in Predicting New-Onset Chronic Kidney Disease: A Nationwide Multicenter Study by Liangyu Yin, Furong Li, Tangli Xiao, Jun Zhang, Yan Li, Jicong Luo, Jinghong Zhao, Jiachuan Xiong

“…The study shows that monitoring physical performance, especially the ability to perform everyday tasks, could help identify people at higher risk for CKD. …”
Get full text

The effect of ultrasonic waves and seed priming in conjunction with weed management on yield and yield components of cowpea (Vigna sinensis L.) by Abbas Nasiri Dehsorkhi, hassan makarian, Manouchehr Gholipoor, Hamid Abbasdokht

“…Significant differences between means refer to the probability level of 0.05 by LSD test. Results and Discussion The results showed that all treatments decreased significantly biomass and density of weeds in comparison to control (no weeding). …”
Get full text

Surface distributions and vertical profiles of trace gases (CO, O₃, NO, NO₂) in the Arctic wintertime boundary layer using low-cost sensors during ALPACA-2022 by B. Barret, P. Medina, N. Brett, R. Pohorsky, K. S. Law, S. Bekki, G. J. Fochesatto, J. Schmale, S. R. Arnold, A. Baccarini, M. Busetto, M. Cesler-Maloney, B. D'Anna, S. Decesari, J. Mao, G. Pappaccogli, J. Savarino, F. Scoto, W. R. Simpson

“…To calibrate the measurements, a set of machine learning (ML) calibration methods were tested. For each method, learning and prediction were performed with coincident MICROMEGAS and reference analyser measurements at the downtown site. …”
Get full text

Depression detection based on dual path DCGAN data generation and classification-regression network by LU Jingxue, LI Hongyan, ZHENG Ruichao, QIN Ruizhen

“…The combined MFCC-TEO coefficient has a better ability to characterize depression than MFCC coefficient. …”
Get full text

Symbiosis effects of Mycorrhizal and Pseudomonas on morphophysiological traits of mung bean (Vigna radiata (L.) Wilczek) under moisture stressed condition by Mohammad Salehi, Ali Faramarzi, Manochehr Farboodi, Nasser Mohebalipour, Jalil Ajalli

“…Mean comparison was carried out by the Duncan test at 5% probability level using SPSS (Ver.16). …”
Get full text

The impact of technological mega trends on the development of universities in Iran; A case study of the effects of technological developments on the financing of public universitie... by Reza Naghizadeh

“…In the end, it is suggested that the results of the mentioned research should be examined in different public universities with different levels of ability, and the specific characteristics of the universities. …”
Get full text

Accumulation Differences in Perfluorooctanoic Acid and Its Ether Carboxylic Acid Alternatives in the Manila Clam (Ruditapes philippinarum) by Hanlin QIN, Yujie BI, Shuqi JIANG, Chengchen WU, Zhijun TAN, Qianqian GENG, Mengmeng GUO

“…Therefore, Manila clams (Ruditapes philippinarum) were used as the test organism in this study and exposed to two concentrations (2 ng/mL and 200 ng/mL) of PFOA and its alternatives—HFPO-DA, HFPO-TA, HFPO-TeA—within a mariculture setting.The purpose of this study was to analyze the tissue distribution, accumulation, and elimination patterns of these compounds in clams, and to evaluate differences in the accumulation ability of organisms to enrich PFOA and its ether carboxylic acid alternatives in clams by calculating kinetic parameters. …”
Get full text

Influence of socioeconomic status on functional recovery after ARDS caused by SARS-CoV-2: a multicentre, observational study by Pierre-louis Declercq, Vanessa Bironneau, Jean Dellamonica, Christine Binquet, Laura Federici, Gaetan Beduneau, Nicolas Meunier-Beillard, Thierry Vanderlinden, Marjolaine Georges, Paul Abraham, Bertrand Sauneuf, Matthieu Demeyere, Antoine Rivière, Caroline Clarot, Alexandre Ampere, Pierre Kalfon, Élise Redureau, Mehdi Bousta, Laurie Lagache, Béatrice La Combe, Martine Nyunga, Michel Ramakers, Walid Oulehri, Hugues Georges, Nicolas Delberghe, Gurvan Le Bouar, Arnaud-Felix Miailhe, Sami Hraiech, Marie-Anne Hoppe, George-Daniel Calcaianu, Stéphanie Gélinotte, Marie Labruyère

“…The primary outcome is the presence of lung sequelae at 6 months after ICU discharge, defined either by alterations on pulmonary function tests, oxygen desaturation during a standardised 6 min walk test or fibrosis-like pulmonary findings on chest CT. …”
Get full text