Reinfection rate and disease severity of the BA.5 Omicron SARS-CoV-2 lineage compared to previously circulating variants of concern in the Canary Islands (Spain) by Laura Ciuffreda, José M. Lorenzo-Salazar, Diego García-Martínez de Artola, Helena Gil-Campesino, Julia Alcoba-Florez, Héctor Rodríguez-Pérez, Antonio Íñigo-Campos, Josmar Salas-Hernández, Julia Rodríguez-Nuñez, Adrián Muñoz-Barrera, Agustín Valenzuela-Fernández, Oscar Díez-Gil, Rafaela González-Montelongo, Carlos Flores

“…The emergence of the Omicron SARS-CoV-2 variant of concern has changed the COVID-19 scenario as this variant is characterized by high transmissibility and immune evasion ability. To evaluate the impact of this variant on the Canary Islands (Spain) population, we determined the reinfection rates and disease severity associated with the Omicron sublineages and the previously circulating variants of concern. …”
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Comprehensive analysis of the physiological and molecular responses of phosphate-solubilizing bacterium Burkholderia gladioli DJB4–8 in promoting maize growth by Dao-Jun Guo, Dao-Jun Guo, Dao-Jun Guo, Guo-Rong Yang, Pratiksha Singh, Juan-Juan Wang, Juan-Juan Wang, Xue-Mei Lan, Rajesh Kumar Singh, Jing Guo, Yu-Die Dong, Dong-Ping Li, Dong-Ping Li, Dong-Ping Li, Bin Yang, Bin Yang

“…According to an in vitro plant growth-promoting (PGP) feature study and 16S RNA molecular identification, Burkholderia gladioli DJB4-8, among all strains tested, exhibited the highest in vitro PGP activity, with a phosphate-solubilizing ability of 8.99 mg/L. …”
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Antioxidant and <i>In Vitro</i> Hepatoprotective Activities of a Polyphenol-Rich Fraction from the Peel of <i>Citrus lumia</i> Risso (Rutaceae) by Vincenzo Musolino, Antonio Cardamone, Rosario Mare, Anna Rita Coppoletta, Francesca Lorenzo, Francesca Rita Noto, Angelo Galluccio, Luigi Tucci, Carmine Lupia, Cristina Carresi, Mariangela Marrelli, Samantha Maurotti, Micaela Gliozzi, Tiziana Montalcini, Arturo Pujia, Vincenzo Mollace

“…Finally, the water polyphenolic-rich extract (ClumWp), which was the extract with the highest flavonoid content (18.355 ± 1.607 mg/mL) and the strongest antioxidant activity against hydroxyl radical, was tested to evaluate its potential protective effects on lipid accumulation in both 2D hepatocyte cultures and 3D spheroids. …”
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Stabilization of Ficus carica L. Drink by utilizing varying levels of ultrasound-assisted moringa extract as a natural preservative by Faiza Javed, Saima Tehseen, Faiza Ashfaq, Aysha Sameen, Waseem Khalid, Rizwana Batool, Ahmed Bilal, Muhammad Zubair Khalid, Tawfiq Alsulami, Robert Mugabi, Gulzar Ahmad Nayik

“…Further, ultrasound assisted extracts of moringa at varied levels; 5, 10, 15, and 20 % were incorporated in the fig fruit drink as natural preservative to test antioxidant, storage, and sensory quality against control samples. …”
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Influence of the Great Amazon Reef System and Pleistocene sea-level drops on the phylogeography of Haemulon aurolineatum (Haemulidae) by A. Karim Awhida-Robinson, Eloísa Torres-Hernández, Rodolfo Pérez-Rodríguez, Víctor Julio Piñeros, María Gloria Solís-Guzmán, Arturo Angulo, Nuno Simões, Oscar M. Lasso-Alcalá, Mario Monroy, Omar Domínguez-Domínguez

“…Our investigation has found genetic homogeneity among populations in the Central, Southern, and Brazilian provinces, which may be attributed to the ability of H. aurolineatum to migrate along the mesophotic reefs of the Great Amazon Reef System within the Amazonas-Orinoco plume region.…”
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Nanoparticles encapsulating phosphatidylinositol derivatives promote neuroprotection and functional improvement in preclinical models of ALS via a long-lasting activation of TRPML1... by Valentina Tedeschi, Valeria Nele, Valeria Valsecchi, Serenella Anzilotti, Antonio Vinciguerra, Laura Zucaro, Maria Josè Sisalli, Chiara Cassiano, Nunzia De Iesu, Giuseppe Pignataro, Lorella Maria Teresa Canzoniero, Anna Pannaccione, Giuseppe De Rosa, Agnese Secondo

“…To overcome this drawback we developed a lipid-based formulation of PI(3,5)P2 whose putative therapeutic potential has been tested in in vitro and in vivo ALS models.Pharmacodynamic properties of PI(3,5)P2 lipid-based formulations (F1 and F2) on TRPML1 activity have been characterized by means of patch-clamp electrophysiology and Fura-2AM video-imaging in motor neuronal cells. …”
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Psychometric properties and meaningful change thresholds for the QOL-E instrument in patients with myelodysplastic neoplasms by Esther Natalie Oliva, Shien Guo, Jennifer Lord-Bessen, Aylin Yucel, Roberto Latagliata, Massimo Breccia, Giuseppe A. Palumbo, Grazia Sanpaolo, Marta Riva, Valeria Santini, Uwe Platzbecker, Guillermo Garcia-Manero, Pierre Fenaux, Christopher G. Pelligra

“…The QOL-E domains/summary scores, except for QOL-SEX, had an adequate ability to detect change from baseline to Week 24. …”
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Increased antitumor efficacy of PD-1-deficient melanoma-specific human lymphocytes by Nathalie Labarrière, Lucine Marotte, Sylvain Simon, Virginie Vignard, Emilie Dupre, Malika Gantier, Jonathan Cruard, Jean-Baptiste Alberge, Melanie Hussong, Cecile Deleine, Jean-Marie Heslan, Jonathan Shaffer, Tiffany Beauvais, Joelle Gaschet, Emmanuel Scotet, Delphine Fradin, Anne Jarry, Tuan Nguyen

“…So far, PDCD1 editing has been successfully tested mainly in chimeric antigen receptor T (CAR-T) cells and human primary T cells. …”
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Early Cancer Survivorship Distress Trajectories Associated With Socioeconomic Status and Age: Findings From a Multicenter Prospective Study by Anja Mehnert‐Theuerkauf, Ute Goerling, Tanja Zimmermann, Jochen Ernst, Myriel Hermann, Beate Hornemann, Ulrich Keilholz, Florian Lordick, Olaf von dem Knesebeck, David Kissane, Anne‐Kathrin Köditz, Franziska Springer

“…Generalized Linear Mixed Models (GLMM) were used to test for changes in distress over time, with fixed effects of time, SES, and age. …”
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The clinical value of the neutrophil-to-lymphocyte ratio, systemic immune-inflammation index, monocyte-to-lymphocyte ratio and platelet-to-lymphocyte ratio for predicting the sever... by Xin Zhao, Fen Wu, Shunfeng Zhao, Wenna Chen, Wei Si, Yuanrui Li, Dengke Zhang, Jing Wang, Ningning Wang, Lina Sun, Zhiyu Sun, Haoxiao Chang, Ganqin Du

“…NLR and MLR had similar predictive ability (AUC = 0.654; AUC = 0.608) and were superior to PLR. …”
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MET overexpression contributes to STAT4-PD-L1 signaling activation associated with tumor-associated, macrophages-mediated immunosuppression in primary glioblastomas by Ying Zhang, Zheng Wang, Zheng Zhao, Tao Jiang, Shou-Wei Li, Yong-Jian Zhu, Qiang-Wei Wang, Li-Hua Sun, Zhi-Liang Wang, Kuan-Yu Wang, Guan-Zhang Li, Jian-Bao Xu, Chang-Yuan Ren, Wen-Ping Ma, Hong-Jun Wang, Zhao-Shi Bao

“…RNA expression data from a total of 1243 primary glioma samples (WHO grades 2–4) were assembled, incorporating The Cancer Genome Atlas, Chinese Glioma Genome Atlas, and GSE16011 data sets.Results Pearson’s correlation test from the three data sets indicated that MET showed a robust correlation with programmed death-ligand 1 (PD-L1) and STAT pathways. …”
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Peripheral blood biomarkers as differential diagnostic markers of disease severity in neonates with hyperbilirubinemia by Dereje Mengesha Berta, Negesse Cherie, Berhanu Woldu, Aregawi Yalew, Elias Chane, Amare Mekuaninnit, Mebratu Tamir, Zufan Yiheyis, Abiy Ayele Angelo, Zewudu Mulatie, Adamu Kassie, Bisrat Birke Teketelew

“…The summary statistics were used. The Kruskal Wallis H tests were utilized to compare median differences between groups. …”
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Recovering Immunogenic <i>Orthohantavirus puumalaense</i> N Protein from Pellets of Recombinant <i>Escherichia coli</i> by Natalya Andreeva, Ekaterina Martynova, Polina Elboeva, Milana Mansurova, Ilnur Salafutdinov, Aleksandr Aimaletdinov, Rafil Khairullin, Diksha Sharma, Manoj Baranwal, Sara Chandy, Dilbar Dalimova, Alisher Abdullaev, Mirakbar Yakubov, Albert Rizvanov, Svetlana Khaiboullina, Yuriy Davidyuk, Emmanuel Kabwe

“…Immune reactivity of rN protein was tested by employing in house and commercial VektoHanta-IgG kit ELISA methods (both in vitro and in vivo). (4) Results: The best conditions for scaling up the expression of the PUUV rN protein were an incubation temperature of 20 °C during a 20 h incubation period, followed by induction with 0.5 mM IPTG. …”
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COVID outcome prediction in the emergency department (COPE): using retrospective Dutch hospital data to develop simple and valid models for predicting mortality and need for intens... by Annelies Verbon, Jelmer Alsma, Hester Lingsma, David M Kent, David van Klaveren, Rozemarijn L van Bruchem-Visser, Tom Dormans, Stephanie C E Schuit, Alexandros Rekkas, Rob J C G Verdonschot, Dick T J J Koning, Marlijn J A Kamps, Robert Stassen, Sebastiaan Weijer, Klaas-Sierk Arnold, Benjamin Tomlow, Hilde R H de Geus, Jelle R Miedema, Els van Nood

“…Based on prior literature, we considered quickly and objectively obtainable patient characteristics, vital parameters and blood test values as predictors. We assessed model performance by the area under the receiver operating characteristic curve (AUC) and by calibration plots.Results Of 5831 first-wave patients, 629 (10.8%) died within 28 days after admission. …”
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Transcranial direct current stimulation enhances the efficacy of wearable transcutaneous electrical nerve stimulation for mild knee osteoarthritis in the middle-aged person: a rand... by Chun-Ya Xia, Hao-Zhi Niu, Xin-Wen Zhang, Si-Yan Cai, Ying-Jie Fan, Tian-Pei Xie, Peng-Xia Dong, Xiao-Tong Zu, Ze-Lin Su, Xing-Sheng Lu, Yong-Gang Hao, Min Su

“…The secondary outcomes included participants’ Visual Analog Scale (VAS), step length, cadence, 6-minute walking test (6MWT), active knee range of motion (ROM), and quadriceps strength. …”
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MRI-based texture analysis for the evaluation of the response to neoadjuvant chemoimmunotherapy in locally advanced head and neck squamous cell carcinoma by Haoran Wei, Kai Wang, Fan Yang, Xiaolu Li, Xiaoduo Yu, Yanfeng Zhao, Lin Li, Lizhi Xie, Xiaolei Wang, Meng Lin

“…ROC analysis and the Delong test were used to assess the performance of various models. …”
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Awareness and attitudes towards ear health in classical music students—advancing education and care for professional ear users by Moë Fitzlaff, Moë Fitzlaff, Raphaël Jecker, Alexandra Müller, Mareike Riegert, Cosima Riemenschnitter, Cosima Riemenschnitter, Teresa Wenhart, Katrin Bucher, Tobias Kleinjung, Tobias Kleinjung, Dorothe Veraguth, Dorothe Veraguth, Horst Hildebrandt, Horst Hildebrandt, Horst Hildebrandt, Horst Hildebrandt, David Bächinger, David Bächinger

“…Collaborations between (university) music schools, healthcare providers, and policymakers is crucial to protect the ear health of music students, musicians, and other PEUs, ensuring their ability to perform without preventable ear disorders.…”
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Early prediction of sepsis associated encephalopathy in elderly ICU patients using machine learning models: a retrospective study based on the MIMIC-IV database by Yupeng Han, Xiyuan Xie, Jiapeng Qiu, Yijie Tang, Zhiwei Song, Wangyu Li, Xiaodan Wu, Xiaodan Wu

“…In addition, we simplified the model based on the SHAP feature importance ranking, and the results indicated that the simplified XGBoost model retains excellent predictive ability (AUC=0.858).ConclusionsThe XGBoost model effectively predicts SAE in elderly ICU patients and may serve as a reliable tool for clinicians to identify high-risk patients.…”
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Effect of <i>CTLA4</i> gene polymorphism on relapse probability among patients with acute leukemias after allogenic hematopoietic stem cells transplantation by D. S. Romaniuk, A. A. Khmelevskaya, M. Yu. Drokov, N. N. Popova, V. A. Vasilieva, L. A. Kuzmina, G. A. Efimov, E. N. Parovichnikova, V. G. Savchenko

“…The long-term outcome of allo-HSCT depends directly on the ability of cytotoxic T-lymphocytes to recognize and eliminate the residual tumor. …”
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Heterodimeric IL-15 delays tumor growth and promotes intratumoral CTL and dendritic cell accumulation by a cytokine network involving XCL1, IFN-γ, CXCL9 and CXCL10 by Bernard A Fox, Cristina Bergamaschi, George N Pavlakis, Antonio Valentin, Jenifer Bear, Barbara K Felber, Shawn M Jensen, Hrishikesh Pandit, Bethany A Nagy, Dimitris Stellas, Maggie Cam

“…Several preclinical models support the antitumor activity of hetIL-15 promoting its application in clinical trials.Methods The antitumor activity of hetIL-15 produced from mammalian cells was tested in mouse tumor models (MC38 colon carcinoma and TC-1 epithelial carcinoma). …”
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