Genetic and phenotypic associations of frailty with cardiovascular indicators and behavioral characteristics by Yihan Chen, Siying Lin, Shuangyu Yang, Mengling Qi, Yu Ren, Chong Tian, Shitian Wang, Yuedong Yang, Jianzhao Gao, Huiying Zhao

“…Introduction: Frailty Index (FI) is a common measure of frailty, which has been advocated as a routine clinical test by many guidelines. The genetic and phenotypic relationships of FI with cardiovascular indicators (CIs) and behavioral characteristics (BCs) are unclear, which has hampered ability to monitor FI using easily collected data. …”
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Toxic Effects of 3,3′-Iminodipropionitrile on Vestibular System in Adult C57BL/6J Mice In Vivo by Shan Zeng, Wenli Ni, Hui Jiang, Dan You, Jinghan Wang, Xiaoling Lu, Liman Liu, Huiqian Yu, Jingfang Wu, Fangyi Chen, Huawei Li, Yunfeng Wang, Yan Chen, Wenyan Li

“…HC loss and supporting cell (SC) loss after IDPN treatment was dose-dependent and resulted in dysfunction of the vestibular system, as indicated by the swim test and the rotating vestibular ocular reflex (VOR) test. …”
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The moderating effect of self-efficacy on the relationship between parents and children and academic participation, considering the mediating variable of learning adaptation among... by meysam karamipour, samaneh mataji, rezvaneh kazem nezhad, maryam esfandyari

“…It is also defined as a person's judgment about his abilities to organize and implement specific activities in order to obtain various academic performance plans (Kostagiolas et al, 2019).   …”
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Volatile-mediated plant interactions: an innovative approach to cultivar mixture selection for enhanced pest resilience by Dimitrije Markovic, Dimitrije Markovic, Gaëtan Seimandi-Corda, Gaëtan Seimandi-Corda, Vili Harizanova, Atanaska Stoeva, Sari Himanen, Stephanie Saussure, Andja Radonjic, Gordana Đurić, Ivana Lalićević, Sokha Kheam, Sokha Kheam, Merlin Rensing, Jannicke Gallinger, Jannicke Gallinger, Samantha M. Cook, Velemir Ninkovic

“…We propose a trait-based laboratory method to identify complementary pairs of cereal cultivars based on their ability to prime one another’s defense response through volatile organic compounds (VOCs). …”
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Building a machine learning-assisted echocardiography prediction tool for children at risk for cancer therapy-related cardiomyopathy by Lindsay A. Edwards, Christina Yang, Surbhi Sharma, Zih-Hua Chen, Lahari Gorantla, Sanika A. Joshi, Nicolas J. Longhi, Nahom Worku, Jamie S. Yang, Brandy Martinez Di Pietro, Saro Armenian, Aarti Bhat, William Border, Sujatha Buddhe, Nancy Blythe, Kayla Stratton, Kasey J. Leger, Wendy M. Leisenring, Lillian R. Meacham, Paul C. Nathan, Shanti Narasimhan, Ritu Sachdeva, Karim Sadak, Eric J. Chow, Patrick M. Boyle

“…Abstract Background Despite routine echocardiographic surveillance for childhood cancer survivors, the ability to predict cardiomyopathy risk in individual patients is limited. …”
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Geometrical Features of Subbasal Corneal Whorl-like Nerve Patterns in Dry Eye Disease by Ziqing Feng, MD, Kang Yu, MD, Yupei Chen, MS, Gengyuan Wang, MS, Yuqing Deng, MD, Wei Wang, MD, Ruiwen Xu, MD, Yimin Zhang, MD, Peng Xiao, PhD, Jin Yuan, MD, PhD

“…Methods: All subjects underwent comprehensive ophthalmic examinations, dry eye tests, and in vivo confocal microscopy to visualize the whorl-like corneal nerve at the inferior whorl (IW) region and the straight nerve at the central cornea. …”
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A non-invasive nomogram for predicting heart failure with preserved ejection fraction in taiwanese outpatients with unexplained dyspnea and fatigue by Yi-Wei Chung, Jen-Fang Cheng, Yen-Liang Lin, Hung-Jui Chuang, Chia-Chuan Chuang, Cheng-Wei Chen, Wei-Ming Huang, Cho-Kai Wu, Lian-Yu Lin

“…The nomogram showed good discriminatory ability (C-index = 0.842) and calibration performance (p = 0.873) and high net benefit (0.1−0.95). …”
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Evaluation of a novel chemiluminescent immunoassay for autoantibody detection in pemphigus and bullous pemphigoid by Na Zhang, Ming Wang, Lili Hou, Yanyu Zhang, Yan Zhao, Luyang Du, Xiaoqing Li, Xia Liu, Hongwei Zhou, Jiaxuan Hao, Jing Tian, Qiuping Yu, Lixia Li, Fangming Cheng, Hai-Zhou Zhou

“…Its ability to assess disease severity and clinical relevance makes it a valuable tool for managing these conditions.…”
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Deep dive into hydrologic simulations at global scale: harnessing the power of deep learning and physics-informed differentiable models (<i>δ</i>HBV-globe1.0-hydroDL) by D. Feng, D. Feng, D. Feng, H. Beck, J. de Bruijn, J. de Bruijn, R. K. Sahu, Y. Satoh, Y. Wada, J. Liu, M. Pan, K. Lawson, C. Shen

“…Moreover, regionalized differentiable models demonstrated stronger spatial generalization ability (median KGE 0.64) than a traditional parameter regionalization approach (median KGE 0.46) and even LSTM for ungauged region tests across continents. …”
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Hospital-based caregiver intervention for people following hip fracture surgery (HIP HELPER): multicentre randomised controlled feasibility trial with embedded qualitative study in... by Phillipa Logan, Sally Hopewell, Matthew L Costa, Allan B Clark, Susan Dutton, Sarah Lamb, Sarah Hanson, Toby O Smith, Opinder Sahota, Melissa Taylor, Alex Herring, Yan Cunningham, Maninderpal Matharu, Diane Williams, Maria Crotty, K PFEIFFER, Helen Jowett, Polly-Anna Ashford, Reema Khoury, Allie Welsh, Kelly Grant, Rene Gray, Penny Clifford, Lis Freeman, Sarah Langford, Dr Mark Baxter, Jessica Pawson, Anna Mellows, Kate Lacey, Anna Cromie, Gail Menton, Warren Corbett, Vishwanath Joshi, Maria Baggot, Katie Sheehan

“…The COVID-19 pandemic impacting on site’s ability to deliver the research. Modifications are necessary to the design for a viable definitive RCT.Trial registration number ISRCTN13270387.…”
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Antimicrobial peptide Hs02 with rapid bactericidal, anti-biofilm, and anti-inflammatory activity against carbapenem-resistant Klebsiella pneumoniae and Escherichia coli by Deyi Zhao, Miran Tang, Panjie Hu, Xiaowei Hu, Weijun Chen, Zhexiao Ma, Huanchang Chen, Haifeng Liu, Jianming Cao, Tieli Zhou

“…In vitro, hemolysis and cytotoxicity assays confirmed Hs02’s safety at the tested concentrations and proved that Hs02 improved the survival rate of Galleria mellonella larvae. …”
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MARCKSL1 interacted with F‐actin to promote esophageal squamous cell carcinoma mobility by modulating the formation of invadopodia by Yue Zhao, Xiufeng Xie, Lusong Tian, Fang Liu, Yulin Sun, Haizhen Lu, Xiaohang Zhao, Yousheng Mao

“…Methods CCK8, Transwell and wound‐healing assays were employed to test the effect of MARCKSL1 on proliferation, invasion and migration in vitro. …”
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Development and validation of a clinical prediction model for hospitalization after emergency department admission in patients with cancer by Z.L.R. Kaplan, D. van Klaveren, J.G.A. den Duijn, R.J.C.G. Verdonschot, N. Wlazlo, J.G.J.V. Aerts, J. Bromberg, H.F. Lingsma, J. Alsma, M.M.E.M. Bos

“…The model showed good calibration (intercept −0.04, slope 0.86) and discriminative ability [C-statistic 0.71, 95% confidence interval (CI) 0.68-0.74]. …”
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Morphological, Physiological, Biochemical, and Molecular Characterization of Fungal Species Associated with Papaya Rot in Cameroon by Moussango Victor Davy, Voundi Olugu Steve, Tchabong Raymond Sammuel, Marie Ampères Bedine Boat, Ntah Ayong Moise, Anna Cazanevscaia Busuioc, Priscile Ebong Mbondi, Andreea Veronica Dediu Botezatu, Manz Koule Jules, Maria Daniela Ionica Mihaila, Rodica Mihaela Dinica, Sameza Modeste Lambert

“…Isolation and pathogenicity tests were performed according to Koch’s postulate. …”
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A novel multiscale feature enhancement network using learnable density map for red clustered pepper yield estimation by Chenming Cheng, Chenming Cheng, Jin Lei, Jin Lei, Zicui Zhu, Lijian Lu, Lijian Lu, Zhi Wang, Zhi Wang, Jiali Tao, Jiali Tao, Xinyan Qin, Xinyan Qin

“…It also achieved the highest R-squared (R²) value of 0.9802 on the test dataset, beating the best performing DSNet by 0.98%. …”
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Using easy-to-collect indices to develop and validate models for identifying metabolic syndrome and pre-metabolic syndrome by Chao Shi, Chao Shi, Yin Cheng, Ling Ma, Lanqiqi Wu, Hongjuan Shi, Yining Liu, Yining Liu, Jinyu Ma, Jinyu Ma, Huitian Tong, Huitian Tong

“…Area under the receiver operating characteristic curve (AUC), Hosmer and Lemeshow test, bootstrap method, Brier score and Decision Curve Analysis were employed to evaluate the performance of the models.ResultsModel 1 comprised factors such as WC, SBP, DBP and gender. …”
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Prediction of primary biliary cholangitis among health check-up population with anti-mitochondrial M2 antibody positive by Haolong Li, Song Liu, Xu Wang, Xinxin Feng, Siyu Wang, Yanli Zhang, Fengchun Zhang, Li Wang, Tengda Xu, Yongzhe Li

“…Methods A total of 72,173 Chinese health check-up individuals tested AMA-M2, of which non-PBC AMA-M2 positive individuals were performed follow-up. …”
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The wzc mutation mediates virulence changes in K1-type Klebsiella pneumoniae within the same patient by Gaoqin Teng, Gaoqin Teng, Qiuying Qin, Qiuying Qin, Shuo Ding, Shuo Ding, Yanchao Wu, Yanchao Wu, Yingying Fu, Meng Zhang, Xiaoqiang Yang, Ye Jin, Ye Jin, Zhijiang Xu, Zhijiang Xu, Man Huang, Man Huang

“…This mutation was verified using string tests and anti-centrifugal assays. Additionally, in vivo bioassays and animal infection models were conducted to further validate the findings. …”
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Development of a Long-Acting Follicle-Stimulating Hormone Using Serum Albumin Fab-Associated Technology for Female Infertility by Daham Kim, Yoon Hee Cho, Min Jeong Kang, So Jeong Lee, Soohyun Lee, Bo Hyon Yun, Hyunjin Chi, Jeongsuk An, Kyungsun Lee, Jaekyu Han, Susan Chi, Moo Young Song, Sang-Hoon Cha, Eun Jig Lee

“…Its biological efficacy was confirmed through assays measuring its ability to stimulate cyclic adenosine monophosphate (cAMP) production, estradiol synthesis, and the expression of human cytochrome P450 family 19 subfamily A member 1 (hCYP19α1) and human steroidogenic acute regulatory protein (hSTAR) in human ovarian granulosa (KGN) cells. …”
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EFFECTIVENESS AND SAFETY OF FAVIPIRAVIR INFUSION IN PATIENTS HOSPITALIZED WITH COVID-19 by L. A. Balykova, K. Ya. Zaslavskaya, V. F. Pavelkina, N. A. Pyataev, N. M. Selezneva, N. V. Kirichenko, A. Yu. Ivanova, G. V. Rodoman, K. B. Kolontarev, K. S. Skrupsky, E. N. Simakina, O. A. Mubarakshina, A. V. Taganov, D. Yu. Pushkar

“…Research in the development of new therapeutic agents with a wide spectrum of the antiviral activity and a low ability to develop resistance remains the main dimension in combating the global threat to public health. …”
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