Pathway activation model for personalized prediction of drug synergy by Quang Thinh Trac, Yue Huang, Tom Erkers, Päivi Östling, Anna Bohlin, Albin Osterroos, Mattias Vesterlund, Rozbeh Jafari, Ioannis Siavelis, Helena Backvall, Santeri Kiviluoto, Lukas Orre, Mattias Rantalainen, Janne Lehtiö, Soren Lehmann, Olli Kallioniemi, Yudi Pawitan, Trung Nghia Vu

“…We trained and validated DIPx in the AstraZeneca-Sanger (AZS) DREAM Challenge human cell-line dataset using two separate test sets: Test Set 1 comprised the combinations already present in the training set, while Test Set 2 contained combinations absent from the training set, thus indicating the model’s ability to handle novel combinations. …”
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Applying ionic liquids as oil additives for gearboxes: Going beyond the state of the art by bridging the nano-scale and component level by Azhaarudeen Anifa Mohamed Faruck, Philipp G. Grützmacher, Chia-Jui Hsu, Dominik Dworschak, Hsiu-Wei Cheng, Markus Valtiner, Kristof Stagel, Philipp Mikšovsky, Apurba Ranjan Sahoo, Aitor Sainz Martinez, Katharina Bica-Schröder, Michael Weigand, Carsten Gachot

“…Their solid—liquid interface, friction and load-carrying capacity, and wear (scuffing) behavior are studied on the nano-, lab-, and component-scale, respectively, at a different range of temperature and loading conditions by using the atomic force microscopy (AFM), Schwing—Reib—Verschleiß (SRV) friction tests, and Brugger tests, as well as forschungsstelle für zahnräder und getriebebau (FZG) back-to-back gear test rig. …”
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Meta-analyses of the effects of high-intensity interval training in elite athletes—part I: mean effects on various performance measures by Hans-Peter Wiesinger, Hans-Peter Wiesinger, Hans-Peter Wiesinger, Thomas Leonard Stöggl, Thomas Leonard Stöggl, Nils Haller, Nils Haller, Julia Blumkaitis, Tilmann Strepp, Francesca Kilzer, Anna Schmuttermair, Will G. Hopkins

“…The assessment of the moderators indicated good evidence of greater effects as follows: with more aerobic types of HIIT for V˙O2max (+2.6%); with HIIT added to conventional training for most measures (+1.1–2.3%); during the competition phase for V˙O2max (+4.3%); and with tests of longer duration for sprint (+5.5%) and time trial (+4.9%). …”
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Cover crop impacts on soil organic matter dynamics and its quantification using UAV and proximal sensing by Nikolaos-Christos Vavlas, Rima Porre, Liang Meng, Ali Elhakeem, Fenny van Egmond, Lammert Kooistra, Gerlinde B. De Deyn

“…We tested whether cover crop mixtures promote SOM accumulation more than cover crop monocultures in a 6-year field experiment with arable crop rotation on sandy soil. …”
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Exploring the value of hybrid capture-based next-generation sequencing technology in the suspected diagnosis of bloodstream infections by Xinyuan Liu, Zhitao Gan, Zengshun Lin, Xiaojun Lin, Jianying Yuan, Lili Rong, Jiachang Chen, Jun Liu, Yingzhen Li, Chaohui Hu

“…In this study, we investigated the ability of hybrid capture-based next generation sequencing technology to detect pathogens in peripheral blood samples collected from patients with suspected BSI. …”
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Entrainment of neural oscillations during language processing in Early-Stage schizophrenia by Tineke Grent-’t-Jong, Pradeep Dheerendra, Paolo Fusar-Poli, Joachim Gross, Andrew I. Gumley, Rajeev Krishnadas, Lars F. Muckli, Peter J. Uhlhaas

“…In the current study, we tested the hypothesis that neural oscillations are impaired during speech tracking in early-stage ScZ and in participants at clinical high-risk for psychosis (CHR-P). …”
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Physical activity complexity, cognition, and risk of cognitive impairment and dementia in the Baltimore Longitudinal Study of Aging by Yurun Cai, Junhong Zhou, Paul W. Scott, Qu Tian, Amal A. Wanigatunga, Lewis Lipsitz, Eleanor M. Simonsick, Susan M. Resnick, Luigi Ferrucci, Dianxu Ren, Jennifer H. Lingler, Jennifer A. Schrack

“…METHODS A total of 637 older adults (age 73.9 ± 11.3 years) in the BLSA completed a 7‐day wrist‐worn accelerometer assessment and neuropsychological tests from 2015 to 2020. Using logistic regression and structural equation modeling, we examined cross‐sectional associations of PA complexity with MCI/dementia and cognition. …”
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Prediction of solid pseudopapillary tumor invasiveness of the pancreas based on multiphase contrast-enhanced CT radiomics nomogram by Dabin Ren, Liqiu Liu, Aiyun Sun, Yuguo Wei, Tingfan Wu, Yongtao Wang, Xiaxia He, Zishan Liu, Jie Zhu, Guoyu Wang

“…Model performance was assessed through Delong’s test and receiver operating characteristic (ROC) curve analysis. …”
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The effects of small geographical resolution and age on the phyllosphere microbial diversity of Castanopsis eyrei in subtropical forest by Lei Xie, XuXu Bao, Shuifei Chen, Hui Ding, Yanming Fang

“…Furthermore, our observation of a negative correlation between host performance and phyllosphere pathogens underscores the potential self-limiting ability of plants.…”
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A simple scalable extracellular vesicle isolation method using polyethylenimine polymers for use in cellular delivery by Marie Ange Djeungoue Petga, Catherine Taylor, Alexander Macpherson, Surendar Reddy Dhadi, Thomas Rollin, Jeremy W. Roy, Anirban Ghosh, Stephen M. Lewis, Rodney J. Ouellette

“…EVs isolated from CCM collected from SUM159 cells that express CD63 fused to a dual EGFP-Renilla-split tag were tested for their ability to reconstitute functional luciferase by delivering the CD63-EGFP-Renilla-split tag to SUM159 recipient cells loaded with a cytopermeable Renilla luciferase substrate. …”
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Hybrid liquid–PCM thermal management for high–capacity lithium–ion batteries under fast charging: A parametric comparative study by Houssein Ammar, Mahdi Delbani, Farouk Fardoun, Bassem El Zoghbi, Hussein Mouzanar, Jalal Faraj, Mahmoud Khaled

“…Additionally, a cost–performance analysis highlights the hybrid system's ability to provide superior thermal regulation at a modest increase in weight and implementation cost. …”
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Is noxious stimulus-evoked electroencephalography response a reliable, valid, and interpretable outcome measure to assess analgesic efficacy in neonates? A systematic review and in... by Luke Baxter, Marianne van der Vaart, Maria M. Cobo, Patricia Y. Gunawan, Karel Allegaert, Jonathan M. Davis, Mark Turner, Robert M. Ward, Edress Darsey, James P. Sheppard, Aomesh Bhatt, John van den Anker, An N. Massaro, Ramona L. Walls, Laura S. Song, Kanwaljit Singh, INC Pain Working Group, Rebeccah Slater

“…Abstract Background There are several major challenges limiting our ability to test analgesic efficacy for treatment of neonatal pain, and progress in analgesic drug studies in neonates has stalled. …”
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Development of Real-Time and Lateral Flow Dipstick Recombinase Polymerase Amplification Assays for the Rapid Field Diagnosis of MGF-505R Gene-Deleted Mutants of African Swine Fever... by Jizhou Lv, Junhua Deng, Yu Lin, Dongjie Chen, Xiangfen Yuan, Fang Wei, Caixia Wang, Xiaolin Xu, Shaoqiang Wu

“…Deletion of the virulence-related genes MGF-505/360 and EP402R generated from the virulent genotype II virus significantly reduces its virulence, and animal tests using one of the recombinant viruses show great lethality and transmissibility in pigs. …”
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Evaluation of the Effects of Thymoquinone on RAGE/NOX4 Expressions and Brain Tissue Morphometry in Experimental Alzheimer’s Disease Induced by Amyloid Beta 1–42 Peptide by Şükrü Ateş, Harun Ülger, Sümeyye Uçar, Aslı Okan, Mert Ocak, Ecma Güvenilir, Zeynep Yılmaz Şükranlı, Emin Kaymak, Züleyha Doğanyiğit, Serpil Taheri, Seher Yilmaz

“…The results showed that TMQ may have ameliorative effects on memory, spatial learning, learning ability, and anxiety in AD. We showed that TMQ has an antioxidative effect by decreasing MDA levels by the ELSIA method (<i>p</i> < 0.05). …”
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MODERN ONCO DRUG FOR INTERNAL USE by O. L. Orlova, L. L. Nikolaeva, L. A. Korol, M. V. Dmitrieva, A. P. Polozkova, A. V. Lantsova, I. D. Gulyakin, N. A. Oborotova

“…There are about 75% of orally administered drugs that have the ability to be absorbed in the gastrointestinal tract within 1−3 hours after administration. …”
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Link-Level Evaluation of Uplink Cell-Free MIMO in 5G NR Over Frequency-Selective Channels by Mostafa Rahmani Ghourtani, Junbo Zhao, Yi Chu, Hamed Ahmadi, David Grace, Robert G. Maunder, Alister Burr

“…Cell-free (CF) MIMO has emerged as a promising next-generation technology, primarily due to its ability to provide uniformly high-quality service to all user equipment (UEs), regardless of their location. …”
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How trait mindfulness protects late adolescents from stress-induced sleep problems: the unique role of mindfulness facets and gender differences by Huiting Cao, Jing Qian, Fenghua Tang, Yunyan Dong, Haining Ren, Xiaoran Xue, Ningning Mao, Xiaoyu Liu

“…Since the measurement tool for the Observing facet only had 1 question tested on observing inner feelings, and other questions are all about observing bodily sensations and outer environments, this study implies that insomnia therapies focus on enhancing the ability to anchor attention in the present moment, especially towards bodily sensations and the outer environment, may be particularly effective in buffering the long-term impact of daily stressors on sleep for young females. …”
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TMEM115: a promising marker for glioma immunotherapy and prognosis by Hang Yin, Hang Yin, Feng Wang, Feng Wang, Haiyan Xu, Haiyan Xu, Manyu Xu, Manyu Xu, Pengpeng Lu, Pengpeng Lu, Xiaojing Zhang, Lei Yang, Bing Lu, Pingping Sun, Jianfei Huang, Jianfei Huang

“…In addition, χ2 test and Cox regression analyses were performed to investigate whether TMEM115 protein expression is related to clinical characteristics and patient outcomes.ResultsThe results revealed a significant increase in TMEM115 expression in tumors than in non-tumor brain tissues, and knockdown of TMEM115 affects the ability of glioma cell lines to proliferate, migrate, and invade. …”
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The Value of the Systemic Immune-Inflammation Index in Predicting Survival Outcomes in Patients with Brain Metastases of Non-Small-Cell Lung Cancer Treated with Stereotactic Radiot... by Yanan Zhang, Zeyang Chen, Feng Jin, Dong Guo, Qingqing Chen, Zhengcao Liu, Shengjun Ji, Guanqi Gao

“…The optimal cutoff value of the SII for predicting prognosis was assessed by receiver operating characteristic (ROC) curves with the maximum log-rank values. The discriminative ability of predicting prognosis was calculated and compared using the Kaplan–Meier method and log-rank test. …”
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Evaluation of a single-use bioartificial liver (BAL) biocartridge consisting of cryopreservable alginate encapsulated liver cell spheroids as a component of HepatiCan™, a novel bio... by Eloy Erro, Tom Brookshaw, Barry Fuller, Sweta Chandel, Joana Mendonca da Silva, Elizaveta Zotova, Sherri-Ann Chalmers, Alfie Watt, Clare Selden

“…The suitability of designs, and their ability to deliver the required hydrodynamic conditions for AELS, during both spheroid production and treatment phases, was addressed by computational fluid dynamics (CFD). …”
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