Pancreatic β-cell regeneration in situ by the ALK3 agonist THR-123 by Silvia Álvarez-Cubela, Isabella D. Altilio, Mayur Doke, Dagmar Klein, Alejandro Tamayo, Óscar Alcázar, Carlos García Santana, Mirza Muhammad Fahd Qadir, Charles García Alver, Francis Cruz, Olivia Biggs, Jorge David Tovar Castro, Belén Navarro-Rubio, Camillo Ricordi, Alejandro Caicedo, Peter Buchwald, Ashutosh Agarwal, Elisa Oltra, Ricardo Luis Pastori, Juan Domínguez-Bendala

“…Abstract The demonstration that BMP signaling activates progenitor-like populations within pancreatic ducts supports the potential use of BMP receptor agonists to induce islet neogenesis in situ. In this context, we tested the ability of THR-123, a cyclic peptide with BMP-7-like activity, to regenerate β-cell mass in diabetic mice. …”
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Antibacterial and Anti-Influenza Activities of <i>N</i>-Heterocyclic Carbene–Gold Complexes by Michele Pellegrino, Paola Checconi, Jessica Ceramella, Carla Prezioso, Dolores Limongi, Maria Marra, Annaluisa Mariconda, Alessia Catalano, Marta De Angelis, Lucia Nencioni, Maria Stefania Sinicropi, Pasquale Longo, Stefano Aquaro

“…Metal-based complexes, such as <i>N</i>-heterocyclic carbene–gold (NHC–gold) complexes, show promising therapeutic potential due to their ability to inhibit various pathogens. Methods: Eight NHC–gold complexes were synthesized and tested for antibacterial activity against <i>Escherichia coli</i>, <i>Enterococcus faecalis, Staphylococcus aureus</i>, and for anti-influenza activity in lung and bronchial epithelial cells infected with influenza virus A/H1N1. …”
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Multimodal prediction based on ultrasound for response to neoadjuvant chemotherapy in triple negative breast cancer by Maohua Lyu, Shouheng Yi, Chunyan Li, Yu Xie, Yu Liu, Zeyan Xu, Zhitao Wei, Huan Lin, Yunlin Zheng, Chunwang Huang, Xi Lin, Zaiyi Liu, Shufang Pei, Biao Huang, Zhenwei Shi

“…The BCRP model showed a promising ability in predicting response to neoadjuvant chemotherapy in TNBC, and could provide valuable information for survival.…”
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Interpretable multiparametric MRI radiomics-based machine learning model for preoperative differentiation between benign and malignant prostate masses: a diagnostic, multicenter st... by Wenjun Zhou, Wenjun Zhou, Zhangcheng Liu, Zhangcheng Liu, Jindong Zhang, Shuai Su, Yu Luo, Lincen Jiang, Kun Han, Guohua Huang, Jue Wang, Jianhua Lan, Delin Wang

“…Five ML models were established, among which the random forest (RF) model presented the best predictive ability, with AUCs of 0.929 (95% confidential interval [CI]: 0.885–0.963) and 0.852 (95% CI: 0.758–0.934) in the internal and external test sets, respectively. …”
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Total flavonoids of Astragalus membranaceus protect against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in mice by inhibiting ferroptosis through SLC7A11/GPX... by Zitian Gao, Gaorui Wang, Yujie Chen, Wuke Yuan, Jun Cai, Aiping Feng, Jie Fang, Qi Xu, Xiaojun Wu

“…In addition, the neuroprotective effects of TFA were associated with its ability to restore MPTP/MPP+ induced downregulation of SLC7A11 and glutathione peroxidase 4 (GPX-4). …”
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Improving Artificial Intelligence–based Microbial Keratitis Screening Tools Constrained by Limited Data Using Synthetic Generation of Slit-Lamp Photos by Daniel Wang, BA, Bonnie Sklar, MD, James Tian, MD, Rami Gabriel, MD, Matthew Engelhard, MD, PhD, Ryan P. McNabb, PhD, Anthony N. Kuo, MD

“…To assess synthetic image quality, we performed a visual Turing test. Three cornea fellows tested their ability to identify 20 images each of (1) real healthy, (2) real diseased, (3) synthetic healthy, and (4) synthetic diseased. …”
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Responses of maximal fat oxidation and Fatmax to incremental exercise and electrical muscle stimulation in overweight men by Minoo Bassami, Shirin Khaknejad, Rasoul Easlami, Ali Nejatian Hoseinpour

“…In the second session, they repeated the same test, with electrical muscle stimulation applied during the exercise test. …”
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Estudio piloto para la valoración del equilibrio en mujeres adultas con un elemento cinemático (Balance assessment in adult women with a cinematic element: a pilot study) by Raquel Leirós Rodríguez, Mª Elena Arce Fariña, José Luis García Soidán

“…This paper assesses the balance through a wide range of kinematic conditions assessment for later compare them with existing balance tests in clinical practice. The goal was to achieve a holistic measure of balance and more reliably identify what underlying systems are present in each of the tests. …”
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Simple preparation method and selective adsorption performance of novel activated carbon particles by Shu Ling, An Yi, Wang Xiaohan, Qin Weipu, Yang Lin, Liu Xiangdong

“…Similar AC adsorption tests were carried out for 12 hours. These two tests were all repeated five times and the obtained samples were put together respectively. …”
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Perception and Production of French Nasal Vowel Contrasts by English- and Spanish-Speaking L2 Learners by Vincent Chanethom, Patrick-André Mather

“…Les participants à cette étude ont complété une série de tâches expérimentales, dont un test de niveau en langue française, un test de production orale pour lire des mots illustrant les voyelles nasales du français, et un test de perception orale pour distinguer des paires de mots. …”
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Examining Weight Suppression, Leptin Levels, Glucagon-Like Peptide 1 Response, and Reward-Related Constructs in Severity and Maintenance of Bulimic Syndromes: Protocol and Sample C... by Pamela K Keel, Lindsay P Bodell, Sarrah I Ali, Austin Starkey, Jenna Trotta, J Woody Luxama, Chloé Halfhide, Naomi G Hill, Jonathan Appelbaum, Diana L Williams

“…ObjectiveOur funded project aimed to test concurrent associations among WS, physiological factors (leptin concentrations and postprandial glucagon-like peptide 1 [GLP-1] response), behavioral indicators of RVE (breakpoint on progressive ratio tasks) and reward satiation (ad-lib test meal intake), self-report of these core constructs, and binge-eating severity in BN-S (aim 1); test prospective associations to determine whether WS predicts BN-S maintenance in longitudinal models and whether posited mediators also predict BN-S maintenance (aim 2); and determine whether associations between WS and BN-S severity and maintenance are mediated by alterations in leptin levels, GLP-1 response, RVE, and reward satiation (aim 3). …”
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Mapping cross-reactive residues in the G-H loop of foot-and-mouth disease virus: insights for serotype-specific design by Abdelaziz A. Yassin, Abdelaziz A. Yassin, Abdelaziz A. Yassin, Anna B. Ludi, Santina Grazioli, Emiliana Brocchi, Daniel Horton, Daniel Horton, Donald P. King, Amin S. Asfor

“…D9 and B2 Mabs were raised against serotype O and tested against three more sets of peptides: (1) nine overlapping peptides with one amino acid difference, (2) alanine scanning peptide, both for O1K strain and (3) four mutated peptides one for A22 and three for SAT2 strains in the enzyme-linked immunosorbent assay format with correlation to virus neutralisation test.ResultsThe D9 Mab was bound to peptides corresponding to the G-H loops of serotype O, A, and SAT1 strains, but only neutralised serotype O and SAT1 strains in the virus neutralisation test. …”
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Blood group antigens visualisation on leukocytes by Grigorovich Kravchun Pavlo, Solomonivna Leontyeva Frida, Dmytrivna Povelichenko Olena, Yuriivna Dielievska Valentyna

“…Results: Polyclonal sera from O blood group persons without weak blood group antigens in contrast to monoclonal antibodies demonstrated the ability to reveal weak blood group specific antigens on leukocytes by the method of mixed agglutination reaction. …”
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Vital Sign and Biochemical Data Collection Using Non-contact Photoplethysmography and the Comestai Mobile Health App: Protocol for an Observational Study by Gianvincenzo Zuccotti, Paolo Osvaldo Agnelli, Lucia Labati, Erika Cordaro, Davide Braghieri, Simone Balconi, Marco Xodo, Fabrizio Losurdo, Cesare Celeste Federico Berra, Roberto Franco Enrico Pedretti, Paolo Fiorina, Sergio Maria De Pasquale, Valeria Calcaterra

“…Agreement between pairs of measurements (app vs reference devices and standard tests) will be represented using Bland-Altman plots. …”
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Extended spectrum AmpC and metallo-beta-lactamases in Serratia and Citrobacter spp. in a disc approximation assay by Meher Rizvi, Nazish Fatima, Mohd. Rashid, Indu Shukla, Abida Malik, Aayesha Usman, Shireen Siddiqui

“…Methodology: Clinical isolates of Serratia and Citrobacter were tested for ESBL production. Cefoperazone (CP)/cefoperazone sulbactam (CPS), piperacillin (PIP)/piperacillin-tazobactam (TZP) and ceftazidime (CAZ)/ceftazidime-clavulanic acid (CAZ-CLAV) combinations were compared for their ability to detect ESBL producers phenotypically. …”
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Establishing CD19 B-cell reference control materials for comparable and quantitative cytometric expression analysis. by Lili Wang, Rukmini Bhardwaj, Howard Mostowski, Paul N Patrone, Anthony J Kearsley, Jessica Watson, Liang Lim, Jothir Pichaandi, Olga Ornatsky, Daniel Majonis, Steven R Bauer, Heba A Degheidy

“…Flow cytometry has emerged as a critically important platform due to its high-throughput capability and its ability to simultaneously measure multiple parameters in the same sample. …”
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Automatic body condition scoring system for dairy cows in group state based on improved YOLOv5 and video analysis by Jingwen Li, Pengbo Zeng, Shuai Yue, Zhiyang Zheng, Lifeng Qin, Huaibo Song

“…This system enhances feature extraction ability by introducing dual path networks and convolutional block attention modules and improves efficiency by replacing some modules from the standard YOLOv5s with deep separable convolution to reduce parameters. …”
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Maplirpacept: a CD47 decoy receptor with minimal red blood cell binding and robust anti-tumor efficacy by Mithunah Krishnamoorthy, Mithunah Krishnamoorthy, Ruth Seelige, Christopher R. Brown, Nancy Chau, Natasja Nielsen Viller, Lisa D. S. Johnson, Emma Linderoth, Jean C. Y. Wang, Jean C. Y. Wang, Jean C. Y. Wang, Christopher P. Dillon, Keith Abayasiriwardana, Clare Lees, Mark Wong, Megan M. Kaneda, Robert A. Uger, Gloria H. Y. Lin, Gloria H. Y. Lin

“…Maplirpacept (TTI-622, PF-07901801) is a CD47 blocking fusion protein consisting of a human SIRPα fused to an IgG4 Fc region and designed to limit binding to RBCs.MethodsTo determine maplirpacept binding to RBCs and interference with blood tests, human blood samples were used. The ability of maplirpacept to promote macrophage-mediated phagocytosis of human tumor cells was assessed using both confocal microscopy and flow cytometry. …”
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An Investigation of Manifold-Based Direct Control for a Brain-to-Body Neural Bypass by E. Losanno, M. Badi, E. Roussinova, A. Bogaard, M. Delacombaz, S. Shokur, S. Micera

“…<italic>Results:</italic> We identified an intrinsic low-dimensional space (called manifold) capturing the co-variation patterns of the monkey&#x0027;s neural activity associated to reach-to-grasp movements. We then tested the animal&#x0027;s ability to directly control a computer cursor using cortical activation along the manifold axes. …”
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Analysis of Two Bradyrhizobium japonicum Strains with Different Symbiotic Matching for Nodulation by Primary Proteomic by Da-wei GUAN, Ming-chao MA, Zhong-yu MA, Xin JIANG, Li LI, Feng-ming CAO, De-long SHEN, Hui-jun CHEN, Jun LI

“…The results showed that the amount and categories of proteins identified in this test were different when the two strains were treated by symbiotic nodulation. …”
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