Discovery of 15-deoxynaphthomycins activating the antioxidant NRF2-ARE pathway from Streptomyces sp. N50 via genome mining, global regulator introduction, and molecular networking by Min-Seon Kim, Baskar Selvaraj, Hee-Tae Yeo, Jun-Su Park, Jae Wook Lee, Jin-Soo Park

“…Also, the presence of quinone moieties in these compounds, which are known to activate NRF2, they were tested for their ability to activate NRF2. Among the new compounds, three (1, 5, and 6) activated the antioxidant NRF2-ARE signaling pathway. …”
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Viperin and Its Effect on SVCV Replication in Common Carp, <i>Cyprinus carpio</i> by Yan Meng, Xi Hu, Nan Jiang, Yuding Fan, Yiqun Li, Mingyang Xue, Chen Xu, Wenzhi Liu, Yong Zhou

“…In this study, the common carp <i>viperin</i> (<i>cc-viperin</i>) gene is characterized, and we determine whether it has the ability to inhibit spring viremia of carp virus (SVCV) replication in EPC cells. …”
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Heterogeneity and main controlling factors of black shale in first Member of Lower Carboniferous Luzhai Formation in Northern Liucheng Slope, Guizhong Depression by LIN Yifei, QIN Yinglun, LU Yongchao, ZHUO Seqiang, WANG Chuan, LU Wenshi, CUI Qinyu, CEN Wenpan

“…The black shale of the Lower Carboniferous Luzhai Formation in the Northern Liucheng Slope of the Guizhong Depression has strong vertical heterogeneity， which seriously restricts the evaluation and fracturing ability of the shale reservoir in the later stage. …”
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High‐Resolution Simulation of Dense Fog in Tianjin City: Effect of Horizontal Resolutions From Mesoscale to Large Eddy Scale by Meng Tian, Shun Li, Wei Wei, Jianbo Yang, Bingui Wu, Suhong Ma, Yang Guo, Qing Liu, Haohao Nie

“…At a horizontal resolution of 40 m, the WRF‐LES simulation yields the smallest errors in boundary layer temperature and humidity profiles, owing to its ability to capture the fine‐scale structure of buoyancy oscillations at the fog top. …”
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The Cytotoxic Potential of Humanized γδ T Cells Against Human Cancer Cell Lines in <i>In Vitro</i> by Husheem Michael, Abigail T. Lenihan, Mikaela M. Vallas, Gene W. Weng, Jonathan Barber, Wei He, Ellen Chen, Paul Sheiffele, Wei Weng

“…Gamma delta (γδ) T cells are noteworthy due to their potent ability to kill various cancer cells without needing conventional antigen presentation. …”
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The study of the antagonistic and growth-stimulating characteristics of Bacillus subtilis strains, promising for the development of the effective biofungicides by A. M. Asaturova, T. M. Sidorova, N. S. Tomashevich, N. A. Zhevnova, A. I. Khomyak, A. E. Kozitsyn, V. M. Dubyaga, M. D. Pavlova, N. M. Sidorov, V. V. Allakhverdyan

“…In the period from 2012 to 2015 on Kalym winter wheat variety plants there were carried out field tests of the liquid culture of B. subtilis BZR 336g and BZR 517 strains isolated from natural sources that exhibit antifungal activity against phytopathogenic fungi Fusarium graminearum, F. culmorum, Microdochium nivale and Pyrenophora tritici-repentis, and are also able to have a positive effect on the growth and development of plants. …”
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Incorporating genotype information in a precise prediction model for platinum sensitivity in epithelial ovarian cancer by Nai-Yi Du, Yan Li, Hui Zheng, Ya-Kun Liu, Lu-Sha Liu, Jianbang Xie, Shan Kang

“…The correlation between clinical factors and drug sensitivity was evaluated using statistical tests. Approximately 700,000 single-nucleotide polymorphism (SNP) sites were assessed for association with drug sensitivity via the Genome-wide Association Study (GWAS). …”
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A Convolutional Neural Network Model for Classifying Resting Tremor Amplitude in Parkinson&#x2019;s Disease by Augusto Ielo, Serena Dattola, Lilla Bonanno, Paolo De Pasquale, Alberto Cacciola, Angelo Quartarone, Maria Cristina De Cola

“…Our method exploited the ability of CNNs to classify RT amplitude efficiently, aiming at simplify diagnostic processes, enhancing the accuracy of the RT assessment in clinical settings.…”
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Fu’s subcutaneous needling approach versus electroacupuncture for knee osteoarthritis: protocol for comparative effectiveness and safety randomized controlled trial by Linan Liu, Linan Liu, Jian Sun, Hu Li, Hu Li, Zhaojian Zheng, Jin Lu, Qin Lyu, Tianyu Bai

“…Our team has demonstrated through clinical trials that FSN can effectively relieve pain and improve walking ability in patients with KOA. However, studies on the difference in clinical efficacy of FSN in treating KOA still lack clinical validation with large samples. …”
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The efficacy of saffron supplementation on inflammation and oxidative stress in patients with type-2 diabetes mellitus: a meta-analysis by Lulu Qin, Lulu Qin, Nini Hu, Nini Hu, Kejing Wang, Kejing Wang, Lin Chen, Lin Chen

“…The investigation aimed to find studies that tested the efficacy of saffron supplements in reducing inflammation and oxidative stress in people with type 2 diabetes. …”
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Effects of lumbar joint mobilization on trunk control, balance, and gait in patients with stroke: study protocol for a randomized controlled trial by Can Chen, Bo Yan, Shan He, Ruidi Wu, XiaoHua Han, Yong Chen, Hong Chen, Lingfeng Xie

“…These dysfunctions are closely related to the ability to perform activities of daily living. Therefore, restoring these functions has become the primary rehabilitation goal for stroke patients. …”
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Green synthesis, Optimization and Characterization of SiO2 nanoparticles using Aspergillus tubingensis F20 isolated from drinking water by Sohila A. Abd Elmohsen, Samah A. Mohmed, Ghadir E. Daigham, Essam M. Hoballah, Nagwa M. Sidkey

“…This study aimed to demonstrates a positive correlation between silica metal tolerance ability of a drinking water fungi and its potential for the synthesis of silica oxide (SiO2) nanoparticles (NPs). …”
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Lestaurtinib’s antineoplastic activity converges on JAK/STAT signaling to inhibit treatment naïve and therapy resistant forms ovarian cancer by Esther P. B. Rodman, Michael J. Emch, Xiaonan Hou, Archit Bajaj, Nicole A. Pearson, August J. John, Yamillie Ortiz, Adam D. Bass, Saloni Singh, Gustavo Baldassarre, Scott H. Kaufmann, S. John Weroha, John R. Hawse

“…In contrast, the most well-known JAK/STAT inhibitor, ruxolitinib, lacked antineoplastic activity against all ovarian cancer cell lines and PDX models tested. This divergent behavior was reflected in the ability of lestaurtinib to block both Y701/705 and S727 phosphorylation of STAT1 and STAT3, whereas ruxolitinib failed to block S727. …”
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Prevalence of disability in Iranian older adults in Tehran, Iran: A population-based study by Vahid Rashedi, Mohsen Asadi-Lari, Mahshid Foroughan, Ahmad Delbari, Reza Fadayevatan

“…The data were analyzed using descriptive statistics and Chi-square test. Results: Of the total study population, 54.8% (n = 8,264) were males. …”
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MAOA: A Swift and Effective Optimization Algorithm for Linear Antenna Array Design by Anoop Raghuvanshi, Abhinav Sharma, Abhishek Kumar Awasthi, Abhishek Sharma, Rahul Singhal, Kim Soon Chong, Sew Sun Tiang, Wei Hong Lim

“…Its primary advantage is its ability to avoid local minima by striking a balance between global exploration and local exploitation searches. …”
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Introduction of dynamic constitutive model into parallel computing system of strata motion and modeling of impact fracture process of roadway by Xuebin WANG, Qinjie ZHANG, Yishan PAN, Liqiang MA, Xiaoshuai LI, Dong LIU, Xueyuan BAI, Shuangyin CHEN

“…., StrataKing developed by us in the past ten years, the dynamic modeling ability is developed. The present method is validated through modeling the dynamic tests for rock specimens in uniaxial compression. …”
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Derivatives of Amodiaquine as Potent Human Cholinesterases Inhibitors: Implication for Treatment of Alzheimer’s Disease by Ana Matošević, Dejan M. Opsenica, Marija Bartolić, Nikola Maraković, Andriana Stoilković, Katarina Komatović, Antonio Zandona, Suzana Žunec, Anita Bosak

“…All compounds displayed an ability to chelate biometal ions Fe²⁺, Zn²⁺ and Cu²⁺ and an antioxidant power comparable to that of standard antioxidants. …”
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Investigating the Knowledge of General Dental Students and Residents Regarding Practical Self-Assessment Skills by Fatemeh Sadat Sajadi, Zahra Salari, MohadeseSadat TabatabaeiRad, Ali Abedi, Reyhaneh Aftabi

“…Data were analyzed using a T-test, analysis of variance, and multivariate regression in SPSS 21 software. …”
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A spatio-temporal fusion-based approach for multi-dimensional classification of Parkinson’s disease progression using multi-modal dataset by Vinay Kukreja, Vandana Ahuja, Modafar Ati, Hariharan Shanmugasundaram, Murugaperumal Krishnamoorthy, Rishabh Sharma, Abhishek Bhattacherjee

“…The traditional methods demonstrate insufficient ability to detect the complex spatial-temporal connections between various clinical data types which highlights the need for advanced computational approaches. …”
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Study protocol of sustaining home palliative care for patients with Heart Failure (HF) and their family caregivers in rural Appalachia: a mixed methods randomized clinical trial by Ubolrat Piamjariyakul, Stephanie Young, Angel Smothers, Sijin Wen, R. Osvaldo Navia, George Sokos, Ann E. Hendrickson, Peggy Fink, Diana Niland, Matthew Hottle, Angelo C. Giolzetti, Carol E. Smith

“…Methods The aim of this mixed methods randomized controlled trial (RCT) is to test the integrated nurse-led intervention bundle of the HF home EOLPC (HF-FamPALhomeCARE) and to assess its ability to maintain sustainability with rural stakeholders, visiting volunteers, and the WV Faith Community Nurse Network. …”
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