ANV600 is a novel PD-1 targeted IL-2Rβγ agonist that selectively expands tumor antigen-specific T cells and potentiates PD-1 checkpoint inhibitor therapy by Christoph Huber, Christian Stocker, Patrizia Murer, Ulisse Salazar, Nicole Egli, Laetitia Petersen, Pia Neubert, Alexander Rau, Andreas Katopodis, Anais Zurbach, Dario Reichenstein

“…ANV600 is a novel bispecific antibody–cytokine fusion protein that targets a non-blocking epitope on PD-1, enabling cis-targeted IL-2Rβγ agonism while preserving combinability with therapeutic PD-1 inhibitors. …”
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Augmenting Engagement in Decentralized Clinical Trials for Atrial Fibrillation: Development and Implementation of a Programmatic Architecture by Toluwa Daniel Omole, Andrew Mrkva, Danielle Ferry, Erin Shepherd, Jessica Caratelli, Noah Davis, Richmond Akatue, Timothy Bickmore, Michael K Paasche-Orlow, Jared W Magnani

“…ResultsThe trials enrolled 513 participants, surpassing recruitment goals for the rural (n=270; target n=264) and metropolitan (n=243; target n=240) studies. …”
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Research on Evaluation and Improvement Policy of Higher Education Development Based on TOPSIS-Synthetic Control Method by Huan-Ming Zhang, Rui-Qi Ma, Meng-Xiang Deng, Xian-Bei Liu

“…The TOPSIS and the combination weighting method based on goal programming are used to measure the scores of higher education development levels of 19 major countries in the world in the recent 20 years, and the horizontal and vertical comparative analysis is carried out. …”
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The Impact of Human Resource Management Practices on Farms Development and Succession Planning – a PLS-SEM Approach by Marius Ogrezeanu, Alexandru Capatina, Cristina Bianca Pocol

“…The study’s practical implications suggest that policymakers and agricultural stakeholders should develop targeted HR support programs to enhance employee retention and succession planning.…”
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Development of tolerance to bedaquiline by overexpression of trypanosomal acetate: succinate CoA transferase in Mycobacterium smegmatis by Gloria Mavinga Bundutidi, Kota Mochizuki, Yuichi Matsuo, Mizuki Hayashishita, Takaya Sakura, Yuri Ando, Gregory Murray Cook, Acharjee Rajib, Frédéric Bringaud, Michael Boshart, Shinjiro Hamano, Masakazu Sekijima, Kenji Hirayama, Kiyoshi Kita, Daniel Ken Inaoka

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Prdm5 regulates collagen gene transcription by association with RNA polymerase II in developing bone. by Giorgio Giacomo Galli, Kristian Honnens de Lichtenberg, Matteo Carrara, Wolfgang Hans, Manuela Wuelling, Bettina Mentz, Hinke Arnolda Multhaupt, Cathrine Kolster Fog, Klaus Thorleif Jensen, Juri Rappsilber, Andrea Vortkamp, Les Coulton, Helmut Fuchs, Valérie Gailus-Durner, Martin Hrabě de Angelis, Raffaele Adolfo Calogero, John Robert Couchman, Anders Henrik Lund

“…We demonstrate here that Prdm5 is highly expressed in developing bones; and, by genome-wide mapping of Prdm5 occupancy in pre-osteoblastic cells, we uncover a novel and unique role for Prdm5 in targeting all mouse collagen genes as well as several SLRP proteoglycan genes. …”
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Development and validation of the Iranian Minimum Data Set for Epidermolysis Bullosa: A mixed method approach. by Somayeh Paydar, Shahrbanoo Pahlevanynejad, Farkhondeh Asadi, Hamideh Ehtesham, Azam Sabahi

“…The use of this standardized approach can help benchmark clinical practice and target improvements worldwide.…”
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The role of interleukin 1 in the development of human diseases: focus on Anakinra (IL-1 receptor antagonist) by E. L. Nasonov, M. Yu. Samsonov

“…An analysis of the results of the clinical use of Anakinra indicates that treatment with this drug should be considered as a promising direction in the pharmacotherapy of systemic autoinflammatory diseases (SAIDs) and critical conditions in children and adults associated with the development of hyperinflammation. The main directions of the Anakinra clinical research program are presented, including: determining the place of the drug in the implementation of the "Treat to Target" strategy and personalization of therapy, primarily in patients with “resistant” (difficult-to-treat) subtype of rheumatoid arthritis and comorbid pathology, as well as with severe forms of microcrystalline arthritis; the possibility of using Anakinra to improve the early diagnosis of SAIDs in children and adults; creation of the Russian register of patients with SAIDs, who are potentially indicated for treatment with Anakinra.…”
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Design and Development of a Public AI Referee Assistance System Based on Harmony OS Platform by Jingjing Zhao, Chang Zhu, Bo Leng, Jiantao Qi

“…The AI referee assistance system uses the Harmony OS platform to build a frontend mini-program and uses the YOLOV5 algorithm to detect and track corresponding targets, ultimately achieving judgments both inside and outside the bounds as well as serving violations. …”
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NAA10 (N-Alpha-Acetyltransferase 10): A Multifunctional Regulator in Development, Disease, and Cancer by Zeng Quan Yang, Ion John Campeanu, Ivan Lopez, Manaal Syed, Yuanyuan Jiang, Hilda Afisllari

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Mitochondrial dynamics, biogenesis, mitophagy and oxidative stress in gestational obesity: A review by Karenth Milena Rodríguez-Córdoba, Sofia Agreda Soto, Jenniffer Alejandra Castellanos Garzón, Maria Carolina Pustovrh-Ramos

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INVESTIGATING YEMENI EFL LEARNERS’ INVOLVEMENT IN CLASSROOM ORAL ACTIVITIES AND ITS CORRELATION TO THEIR SPEAKING PROFICIENCY DEVELOPMENT by Sabri Thabit Saleh Ahmed

“…This study investigated Yemeni EFL learners’ involvement in classroom oral activities and its correlation to their speaking proficiency development with a reference to three rural faculties of education affiliated to Aden University. …”
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To be fair: Development and illustration of the Comprehensive Appraisal of Fairness Evidence (CAFE) model to advance SEL assessment practices by Christopher J. Anthony, Stephen N. Elliott, James C. DiPerna, Pui-Wa Lei

“…Likewise, the development of social emotional assessments has increased in technical sophistication. …”
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<p><strong>Target-site insensitivity to some acaricides in a field population of <em>Tetranychus urticae</em> Koch (</strong><strong>Acari: Tetranychidae) from Egypt</strong></p> by Haggag Zein, Abdallah M. Afifi, Fatma S. Ali, El-Sayed Shaurub, Mahmoud Ahmed

“…We recommend focusing on the use of integrated pest management programs and pesticide alternatively to manage resistance. …”
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Assessing key soft skills in organizational contexts: development and validation of the multiple soft skills assessment tool by Daiana Colledani, Daiana Colledani, Egidio Robusto, Pasquale Anselmi

“…Notably, interpersonal communication skills and moral integrity emerged as crucial skills.DiscussionThe MSSAT is a valuable tool for organizations to assess the soft skills of their employees, thereby contributing to design targeted development programs.…”
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Pengembangan Sumber Daya Manusia dan Pengaruhnya Terhadap Kualitas Tenaga Kependidikan Universitas Buana Perjuangan Karawang by aji tuhagana, Asep Jamaludin, Wanta Wanta

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Pengembangan Sumber Daya Manusia dan Pengaruhnya Terhadap Kualitas Tenaga Kependidikan Universitas Buana Perjuangan Karawang by aji tuhagana, Asep Jamaludin, Wanta Wanta

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Mechanisms of radioresistance and radiosensitization strategies for Triple Negative Breast Cancer by Yuxuan Wang, Zhiwei Liu, Yulu Lv, Jiayang Long, Yao Lu, Panpan Huang

“…The above pathways mainly include DNA damage repair, programmed cell death, cancer stem cells (CSC), antioxidant function, tumor microenvironment, and epithelial–mesenchymal transition (EMT) pathway. …”
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Urate lowering therapy in primary care: rheum for improvement by Emilie Schurenberg, Edward M. Huddleston, Kenneth G. Saag

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Nested association mapping population in japonica rice: Development, characterization, and application in genome-wide association studies by Bhagwat Nawade, Sang-Ho Chu, Sunhee Kim, Chang-Yong Lee, Jinsong Bao, Yong-Jin Park

“…Further phenotypic performance analysis of haplotypes from these hotspot regions revealed significant differences in the targeted traits. The study validates the potential of KNU_NAM and GWAS for high-resolution genetic mapping in rice breeding programs, highlighting the utility of these populations for enhancing genetic diversity and improving trait selection in rice.…”
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