Advancing the development of TRIP13 inhibitors: A high-throughput screening approach by Rae M. Sammons, Soma Ghosh, Lacin Yapindi, Eun Jeong Cho, Faye M. Johnson, Kevin N. Dalby

Get full text

Analysis of The State of The Tourism Industry in Russia аnd The Direction of Its Development by P. G. Nikolenko, A. M. Terekhov

“…The research of domestic authors is more focused on the implementation of program-targeted methods and the identification of problems of assessment and prospects for the development of the industry in the Russian Federation. …”
Get full text

Prediction of potential drug targets and key inhibitors (ZINC67974679, ZINC67982856, and ZINC05668040) against Rickettsia felis using integrated computational approaches by Sudais Rahman, Hsien Liu, Mohibuallah Shah, Mashal M. Almutairi, Iram Liaqat, Tetsuya Tanaka, Chien-Chin Chen, Chien-Chin Chen, Chien-Chin Chen, Chien-Chin Chen, Abdulaziz Alouffi, Abid Ali

Get full text

EXTERNAL QUALITY ASSESSMENT OF GENERAL EDUCATION AS A FACTOR OF TEACHERS’ PROFESSIONAL DEVELOPMENT by T. V. Potemkinа, T. I. Pudenko, A. A. Rudneva

“…The main reasons for this situation are found out: lack of the target information products for system of professional development prepared by results of certification and monitoring procedures; lack of unified methodological and methodical approaches to development of programs of professional development of teachers; insufficient development of expert and analytical activity at regional institutes of professional development. …”
Get full text

Lung cancer in older patients by D. A. Kharagezov, Yu. N. Lazutin, S. P. Pyltsin, A. G. Milakin, O. N. Stateshny, I. A. Leyman, E. A. Mirzoyan

Get full text

Effect of a patient education program focused on weight stigma on quality of life and self-efficacy in patients living with obesity: study protocol for a randomized controlled tria... by Guillaume Ramsamy, Catherine Esnard, STEREOBES Consortium, Helena Mosbah, David Soussi Berjonval, Jean Pierre Faure, Marion Albouy

“…Methods The study compares two parallel arms following different interventions: Patient Education as Usual (PEU) program and the newly developed Patient Education STEREOBES (PES) program, which integrates additional components to counteract weight stigma. …”
Get full text

The “Lifelong Learning” concept as a factor of competitiveness and sustainable social and economic development by M. Ye. Tsoy, V. Yu. Shchekoldin, N. V. Yakovenko

“…The data for the study was collected by means of an online survey via Google Forms service.Six groups of educational services consumers were identified: 1st – “LLL” consumers who identify their learning experience as ineffective (corresponding to the response “get nothing out of learning”); 2nd – men and women not more than 35 years old, targeting mainly not in the family, but in building a career, quite often participating in various educational activities; 3rd – women who choose the format of training in the form of retraining programs; 4th – women working as freelancers or self‐employed, some of them on maternity leave; 5th – women up to about 35 years old, working as line workers, without children and without higher education; 6th – men under the age of 40, with a good financial situation, who independently choose a certain training programme in order to obtain specific knowledge.The concept of “Lifelong Learning” involves the continuous development and improvement of skills, competences and knowledge throughout life, which helps to enhance competitiveness and sustainability of social and economic development.…”
Get full text

Strengthening Good Village Governance Strategy: Transparency, Accountability, and Inclusive Rural Development by Aji Baskoro

“…This pivotal legislation grants villages autonomy to independently manage their resources and budgets, targeting enhanced rural prosperity through substantial financial allocations. …”
Get full text

Formation of methodological foundations for the analysis of national development in conditions of foreign economic discrimination by O. M. Pisareva

“…An approach to assessing the impact of sanctions is presented based on a conjugate analysis of the dynamics of target groupings of indicators. An example of calculations, visualization and interpretation of the results of assessing sanctions resistance and export-import dependence of the national economy based on a set of technical indicators for significant areas of socio-economic development of the discriminated country is illustrated. …”
Get full text

Development and implementation of a credentialing system for clinicians providing eating disorder care by Gabriella Heruc, Kim Hurst, Sarah Trobe, Beth Shelton, Emma Spiel, Siân A. McLean

“…To engage with clinicians, incentive schemes were used, including a limited evidence sunset period encouraging the existing workforce to apply, and professional development programs targeting the upskilling of clinicians new to eating disorder treatment. …”
Get full text

IMPORT SUBSTITUTION IN RUSSIA AS DEVELOPMENT FACTOR IN GLOBAL CHALLENGES PERIOD OF 2017–2019 by N. I. Komkov, N. N. Bondareva

“…The forecast of achievement of planned targets for import substitution programs in the Russian Federation on condition of further total economy modernization for import substitution is developed.conclusions and relevance: the statistics of large-scale revolutionary transition of the enterprises of the Russian Federation to a full cycle of production instead of the short technological chains which have taken roots in the last 20 years is collected. …”
Get full text

METHODOLOGICAL BASES OF ECOLOGICAL CULTURE FORMATION OF PUPILS ON THE BASIS OF ECO-DEVELOPMENT IDEAS by Natalia F. Vinokurova, Vera V. Nikolina, Olga E. Efimova

“…The methodological basis of constructing of the model formation of pupils’ ecological culture is developed from the standpoint of the idea of eco-development (noosphere, co-evolution, sustainable development) and a set of axiological, cultural, personal-activity, co-evolutionary, cultural and ecological approaches. …”
Get full text

Appropriate Budgetary Policy for a Changing Economy by S. P. Solyannikova

“…The article shows that for improvement of the formation mechanism of state programs and national projects and budget efficiency growth, it is necessary to monitor the compliance of tax expenditures and budget subsidies with the target indicators of state programs.…”
Get full text

Geospatial patterns of progress towards UNAIDS ‘95-95-95’ targets and community vulnerability in Zambia: insights from population-based HIV impact assessments by Suilanji Sivile, Diego F Cuadros, Lloyd Mulenga, Sulani Nyimbili, Natalie Vlahakis, Theodora Savory, Tuhin Chowdhury, Masabho Milali, Daniel T Citron, Khozya Davie Zyambo, Anna Bershteyn

Get full text

Adeno-associated virus-clustered regularly interspaced short palindromic repeats/cas9‑mediated ovarian cancer treatment targeting PD-L1 by Tamaki Yahata, Saori Toujima, Izumi Sasaki, Naoyuki Iwahashi, Megumi Fujino, Kaho Nishioka, Tomoko Noguchi, Yuko Tanizaki-Horiuchi, Tsuneyasu Kaisho, Kazuhiko Ino

“…This study aimed to develop a novel gene immunotherapy model targeting programmed death ligand 1 (PD-L1) in vivo in ovarian cancer using adeno-associated virus (AAV)-clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 and investigate its efficacy. …”
Get full text

Integrative multi-omics identifies AP-1 transcription factor as a targetable mediator of acquired osimertinib resistance in non-small cell lung cancer by Bengisu Dayanc, Sude Eris, Nazife Ege Gulfirat, Gulden Ozden-Yilmaz, Ece Cakiroglu, Ozlem Silan Coskun Deniz, Gökhan Karakülah, Serap Erkek-Ozhan, Serif Senturk

“…These findings provide novel insights into the epigenetic and transcriptional control of osimertinib resistance in EGFR-mutant NSCLC, highlighting AP-1 as a targetable vulnerability of resistance-related hallmarks and offering a promising avenue for developing resistance reversal strategies.…”
Get full text

Overcoming beta-lactam resistance in Pseudomonas aeruginosa by targeting metallo-beta-lactamase VIM-1: a one-microsecond molecular dynamics simulation study by Mohammed Salleh M. Ardawi, Samar A. Badreddine, Muhammad Yasir, Muhammad Yasir, Aiah M. Khateb, Aiah M. Khateb, Safaa A. Turkistani, Ahmed Afandi, Samah O. Noor, Adhari Alselmi, Adhari Alselmi, Vivek Dhar Dwivedi, Vivek Dhar Dwivedi, Esam I. Azhar, Esam I. Azhar

Get full text

Readiness for scale up following effectiveness-implementation trial: results of scalability assessment of the Community Partnership Program for diabetes self-management for older a... by Melissa Northwood, Tracey Chambers, Kathryn Fisher, Rebecca Ganann, Maureen Markle-Reid, Marie-Lee Yous, Ron Beleno, Gary Gaudet, Andrea Gruneir, Helen Leung, Craig Lindsay, Kasia Luebke, Gail Macartney, Ethel Macatangay, Janet MacIntyre, Carolyn MacPhail, William Montelpare, Allan Morrison, Lisa Shaffer, Martha St. Pierre, Frank Tang, Catharine Whiteside

“…The final phase of this program of research was to assess scalability and determine the critical factors and next steps for the development of a scale up plan. …”
Get full text

Development of a flavour wheel for Coffea canephora using rate-all-that-apply by Fabiana M. Carvalho, Enrique A. Alves, Mateus M. Artêncio, Alvaro L. L. Cassago, Lucas L. Pereira

Get full text

Level Characteristics of Foreign Language Communicative Competence Development of Students for Technical Specialties by Anastasiia Ptushka

“…The system of levels of foreign language proficiency is closely related to the system of control, assessment and self-assessment of the level foreign language communicative competence development. Each type of foreign language communicative competence corresponds to its own level of learning, that differs in final target settings. …”
Get full text