SCENARIO FOR THE DEVELOPMENT OF VITICULTURE IN BULGARIA THROUGH THE CONTEXT OF THE GREEN DEAL by Desislava TOTEVA

“…The challenges facing the development of agriculture and rural areas in Bulgaria during the CAP program period 2023-2027 are related to the renewal of production potential and the modernization of activities to improve competitiveness, added value, and well-being in rural areas. …”
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Development of multivalent CAR T cells as dual immunotherapy and conditioning agents by Quenton Rashawn Bubb, Mohammad Balood, Gabe Eduardo Seir, Leah Swartzrock, Ethan Haslett, Katie Ho, Peng Xu, Saida G. Wiltz, Elena Sotillo, Tanja A. Gruber, Rebecca M. Richards, Crystal L. Mackall, Agnieszka Czechowicz

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Transcriptome analysis to identify genes related to programmed cell death resulted from manipulating of BnaFAH ortholog by CRISPR/Cas9 in Brassica napus by Zhou Zhou, Tiantian Zhi, Jie Zou, Gang Chen

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Pemberdayaan Peternak KTT Jaya dan KTT MBS di Desa Purworejo Melalui Pelatihan Pembuatan Complete Feed Pengabdian Program Desa Binaan by Joko Riyanto, Ayu Intan Sari, Aidila Kanaya Putri, Abelita Kusbianto, Aisah Nurul Aulia Rahma, Sesilia Novita Ardelie, Muhammad Fahturrohman Zuhdi, Okid Parama Astirin, Syamsul Hadi, Ari Prasetyo, Zakaria Husein Abdurrahman

“…This Village Development Program is funded by the Ministry of Education, Culture, Research, and Technology. …”
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Regulation of SLC7A11 as an unconventional checkpoint in tumorigenesis through ferroptosis by Zhenyi Su, Yanqing Liu, Lin Wang, Wei Gu

“…Although cell-cycle arrest, senescence, and apoptosis are well accepted as the classic barriers in tumorigenesis, recent studies indicate that metabolic regulation is equally important as a major checkpoint in cancer development. It is well accepted that ferroptosis, an iron-dependent programmed cell death, acts as a new type of tumor suppression mechanism tightly linked with numerous metabolic pathways. …”
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Bintrafusp alfa, a bifunctional fusion protein targeting TGF-β and PD-L1, in patients with human papillomavirus-associated malignancies by Renee N Donahue, Jeffrey Schlom, James L Gulley, Ravi A Madan, Caroline Jochems, Elizabeth Lamping, Julius Strauss, Marijo Bilusic, Fatima Karzai, Christian S Hinrichs, Edward McClay, Jennifer L Marté, Lisa M Cordes, Andrew Hill, Byoung Chul Cho, Sébastien Salas, Laureen S Ojalvo, P Alexander Rolfe, Margaret E Gatti-Mays, Jason M Redman, Houssein A Sater, Andrea Burmeister, Genevieve Jehl

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Halymenia durvillei Extracts Exert Antiobesity Effects by Targeting hosl‐1‐Mediated Lipolysis in a Glucose‐Induced Caenorhabditis elegans Model by Kawita Chumphoochai, Sukrit Promtang, Pawanrat Chalorak, Preeyanuch Manohong, Nakorn Niamnont, Montakan Tamtin, Prasert Sobhon, Simon Tuck, Krai Meemon

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Oncolytic peptide LTX-315 induces anti-pancreatic cancer immunity by targeting the ATP11B-PD-L1 axis by Meng Wang, Xing Huang, Tingbo Liang, Tianyu Tang, Gang Zhang, Minghao Lu, Zhengtao Hong, Junming Huang, Xiao Zhi

“…Therefore, LTX-315, or the development of ATP11B-targeting drugs, might improve the efficacy of cancer immunotherapy.…”
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Bioinformatics and Experimental Insights Into miR‐182, hsa_circ_0070269, and circ‐102,166 as Therapeutic Targets for HCV‐Associated HCC by Yasmeen Ishaq, Bisma Rauff, Badr Alzahrani, Aqsa Ikram, Hasnain Javed, Imran Abdullah, Ghulam Mujtaba

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Health Research in the Developing World: A Gastroenterological View from Bangladesh by J Richard Hamilton

“…University links with the west, private enterprises and specially targeted programs are involved in developing world health research but they have not been able to foster and leave behind sustainable, high quality research programs. …”
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A specific reconditioning training program implemented 12 months after ACL surgery improves lower-limb jump variables in amateur soccer players by Sergio Jiménez-Rubio, Tomás García-Calvo, Luis Manuel Martínez-Aranda, Luis Manuel Martínez-Aranda, Javier Raya-González

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Rebuilding Tigray’s textile and garment industry: the role of vocational skills development by Gebretsadik Gebru Wubet, Alemseged Gerezgiher Hailu, Kinfe Abraha Gebre-Egziabher

“…Theoretically, this study contributes to the body of knowledge by providing a framework for understanding the role of vocational skills development in post-conflict industrial recovery. Practically, it offers actionable insights for policymakers, industry stakeholders, and vocational training institutions to design targeted VSD programs that integrate infrastructure repair, technology adoption, and public-private partnerships. …”
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What Do We Know About <i>Staphylococcus aureus</i> and Oxidative Stress? Resistance, Virulence, New Targets, and Therapeutic Alternatives by Mírian Letícia Carmo Bastos, Gleison Gonçalves Ferreira, Isis de Oliveira Kosmiscky, Ieda Maria Louzada Guedes, José Augusto Pereira Carneiro Muniz, Liliane Almeida Carneiro, Ísis Lins de Carvalho Peralta, Marcia Nazaré Miranda Bahia, Cintya de Oliveira Souza, Maria Fâni Dolabela

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Influence of protein-peptide bioregulator isolated from bovine sclera and incorporated into an albumin-based cryogel on the sclera in a model cultivation of a posterior eye segment by O. V. Yamskova, M. S. Krasnov, E. V. Sidorsky, V. I. Lozinsky

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Targeted genotyping (90K-SPET) facilitates genome-wide association studies and the prediction of yield-related traits in faba bean (Vicia faba L.) by Antonio Lippolis, Salvador A. Gezan, Jorrit Zuidgeest, Valeria Cafaro, Bert-Jan van Dinter, Geert Elzes, Maria-João Paulo, Luisa M. Trindade

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Targeting degradation of IKZF1 and IKZF3 through modulation of the E3 ligase substrates in the context of cellular therapies for multiple myeloma by David Kegyes, Anamaria Bancos, Adrian Bogdan Tigu, Ioana Rus, Delia Dima, Diana Cenariu, Madalina Nistor, Raluca Munteanu, Diana Gulei, Alina Tanase, Anca Colita, Anca Buzoianu, Cristina Iuga, Mihnea Zdrenghea, Evangelos Terpos, Stefan O. Ciurea, Aaron Ciechanover, Hermann Einsele, Ciprian Tomuleasa

“…The treatment landscape of MM has undergone a dramatic transformation in recent decades, shifting from conventional chemotherapy to more targeted approaches. In order to overcome intrinsic and acquired resistance mechanisms that frequently restrict the efficacy of single-agent therapies, drug combination strategies have been developed to simultaneously target multiple pathogenetic pathways. …”
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Multiomics integration analysis identifies tumor cell-derived MIF as a therapeutic target and potentiates anti-PD-1 therapy in osteosarcoma by Yan Liao, Hao Yao, Weidong Chen, Yutong Zou, Ji Fang, Jiongfeng Zhang, Zehao Guo, Jian Tu, Junkai Chen, Zijun Huo, Lili Wen, Xianbiao Xie

“…This study aimed to leverage multiomics integration to develop a new risk model, characterizing the immune features of osteosarcoma to uncover novel therapeutic targets.Methods Metabolomics profiling was conducted to identify key metabolites in osteosarcoma. …”
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Molecular detection of hrHPV-induced high-grade squamous intraepithelial lesions of the cervix through a targeted RNA next generation sequencing assay by Julia Faillace Thiesen, Elise Jacquemet, Pascal Campagne, Denis Chatelain, Etienne Brochot, Yves-Edouard Herpe, Nolwenn M. Dheilly, Fabrice Bouilloux, Bénédicte Rognon, Alexandre Douablin, Guillaume Leboucher, Florent Percher, Marc Eloit, Philippe Pérot

“…Abstract Background Cervical cancer screening programs are increasingly relying on sensitive molecular approaches as primary tests to detect high-risk human papillomaviruses (hrHPV), the causative agents of cervix cancer. …”
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Unravelling the Dynamics of Chlamydia trachomatis and Neisseria gonorrhoeae Co-infections in Men who have Sex with Men: Insights from the Swiss PrEPared Program by Dr Enrique Rayo, Dr. Delia Onorini, Dr. Cory Leonard, Dr. Hanna Marti, MSc. Theresa Pesch, Dr. Benjamin Hampel, Prof. Nicola Low, Prof. Nicole Borel

“…Our goal is to provide the most complete and clinically relevant image possible of MSM risk for STI to ultimately contribute to development of targeted prevention strategies. While both sampling and analysis are ongoing at the time of writing, we decided to include non-PrEP user for further sampling, to rule out the influence of PrEP-use on the results. …”
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The need for professional development in improving teaching practices in primary schools in Kosovo by Voglushe Kurteshi, Mirlinda Bunjaku-Isufi, Jehona Rrustemi

“…Variables analyzed included teaching experience, identified professional development needs, preferred training modalities, and mentoring frameworks.ResultsThe findings indicate a strong demand for updated and differentiated professional development programs, irrespective of teaching experience or training background. …”
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