TARGETING PRC2 ENHANCES THE ANTITUMOR CYTOTOXIC CAPACITY OF ANTI-CD19 CAR-T CELLS AGAINST HEMATOLOGICAL MALIGNANCIES by MLR Carvalho, CO Andrade, MP Cabral-Piccin, GS Kinker, GAF Vitiello, L Abdo, RAG Cambui, MH Bonamino, TS Medina

“…Collectively, our results demonstrated that targeting PRC2 may be a promising approach to enhance a functional effector program in CAR-T cells against hematological malignancies.…”
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CHIRP-Seq: FOXP2 transcriptional targets in zebra finch brain include numerous speech and language-related genes by Gregory L. Gedman, Todd H. Kimball, Lee L. Atkinson, Daniella Factor, Gabriela Vojtova, Madza Farias-Virgens, Timothy F. Wright, Stephanie A. White

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Lanthanide conjugate Pr-MPO elicits anti-cancer activity by targeting lysosomal machinery and inducing zinc-dependent cataplerosis by Gregory Lucien Bellot, Dan Liu, Marc Fivaz, Sanjiv K. Yadav, Charanjit Kaur, Shazib Pervaiz

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miR-34a-5p modulation of polycystic ovary syndrome via targeting the NOTCH signaling pathway by Kexin Zhang, Xiaomeng Wang, Fang Liu, Hong Lin, Yan Wang, Min Zhao, Xiaofei Wang, Yijing Chu, Lin Xu

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Combinatorial targeting of NMDARs and 5-HT4Rs exerts beneficial effects in a mouse model of Alzheimer’s disease by Briana K. Chen, Holly C. Hunsberger, Alicia Whye, Louise C. Matthews, Alyson Yook, Moshe J. Willner, Ryan W. Logan, Stefanie Johns, Eric Weisblum, Christine A. Denny

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Fundamental Movement Skills and Sports Skills: Testing a Path Model by Fernando Garbeloto, Sara Pereira, Eduardo Guimarães, José Maia, Go Tani

“…Based on the premise that FMSs are the basis for sport skills, we implemented a 10-week intervention program targeting two FMSs (running and stationary dribbling) and one SSS (speed dribbling), followed by immediate and long-term assessments. …”
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THE ANALYSIS OF STATE AND DEVELOPMENT OF AVIATION INDUSTRY OF RUSSIAN FEDERATION by M. Bogdanova, M. Prikhodchenko

“…The article analyzes the investment in the development of the Russian aviation industry within the framework of the federal target programs.…”
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The Sixth Mass Extinction and Amphibian Species Sustainability Through Reproduction and Advanced Biotechnologies, Biobanking of Germplasm and Somatic Cells, and Conservation Breedi... by Robert K. Browne, Qinghua Luo, Pei Wang, Nabil Mansour, Svetlana A. Kaurova, Edith N. Gakhova, Natalia V. Shishova, Victor K. Uteshev, Ludmila I. Kramarova, Govindappa Venu, Mikhail F. Bagaturov, Somaye Vaissi, Pouria Heshmatzad, Peter Janzen, Aleona Swegen, Julie Strand, Dale McGinnity

“…Reproduction and advanced biotechnologies, biobanking of germplasm and somatic cells, and conservation breeding programs (RBCs) offer a transformative change in biodiversity management. …”
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De-risking vaccine development: lessons, challenges, and prospects by Vega Masignani, Ricardo Palacios, Marie-Thérèse Martin, Fabian Tibaldi, V. Kumaran Vadivelu

“…Abstract Vaccine development is long and costly. Technical, clinical, regulatory, and manufacturing risks throughout the development cycle hampered manufacturers’ efforts towards more challenging and financially less rewarding targets, with profound implications for public health. …”
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Targeting p62 by sulforaphane promotes autolysosomal degradation of SLC7A11, inducing ferroptosis for osteosarcoma treatment by Qiuming Zou, Xiaofeng Zhou, Jianqin Lai, Haixia Zhou, Jinxuan Su, Zhijing Zhang, Xiaosong Zhuang, Lili Liu, Ruijie Yuan, Sijia Li, Siyu Yang, Xinyi Qu, Jiezhu Feng, Yongqi Liu, Zisheng Li, Shiting Huang, Zhi Shi, Yu Yan, Zhiming Zheng, Wencai Ye, Qi Qi

“…Identification of novel therapeutic targets and development of targeted drugs are one of the most feasible strategies for OS treatment. …”
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MECHANISM OF INNOVATIVE INFRASTRUCTURE OF SUPPORT OF SMALL BUSINESS DEVELOPMENT by L. Rudenko

“…The relevance of the stated theme is determined by the target setting of the Russian state to build a new economy of an innovative type, where small enterprises can become drivers of innovative development. …”
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STATE SUPPORT FOR DEVELOPMENT OF PERSONNEL POTENTIAL IN HOSPITALITY IN CHINA by Yu Yi

“…Further step towards improving thecompetitiveness of Chinese tourism shouldbe to develop a national target program fortraining of hospitality…”
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Digitalization and project management as factors of sustainable development of the organization by I. N. Ivanov, L. V. Orlova, S. I. Ivanov

“…The study formulates the conditions for achieving sustainable development of an individual enterprise, as well as the procedure for setting appropriate target indicators. …”
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Basic approaches to personnel health management in the workplace by J. N. Skulkina

“…Corporate health and well-being programsare becoming more relevant as they allow organizations not only to manage risk factors in the field of personnel health, but also to reduce the costs associated with the loss of ability of employees, and also contribute to the growth of labor productivity and team engagement In fact, more and more evidence indicates that workplace interventions based on a coordinated, planned and integrated approach to improving the health of workers are more effective than traditional individual measures for a healthy lifestyle. Target. The purpose of this article is to describe the main approaches to the development of “healthy jobs”, the features of the implementation of corporate health promotion programs.Materials and methods. …”
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Accelerated vaccine process development by orthogonal protein characterization by D. Andrew James, Lisa Szymkowicz, Lois Yin, Hetvi Shah, Michael Leach, Roman M. Chicz

“…Characterization and release assays for vaccine programs were developed under similar time constraints to support bioprocess development, scaleup and formulation. …”
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Macrophage targeting precision nanomedicine utilizing ROS-responsive metallozyme-loaded nanomicelle for enhanced treatment of gout-induced inflammation by Padmanaban Sathiyamoorthy, Shyam Vasvani, Sree Samanvitha Kuppa, Adityanarayan Mohapatra, Amal Babu, Yong-Yeon Jeong, Hong Yeol Yang, Jong Keun Seon, Chang-Moon Lee, In-Kyu Park

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Cancer cell-derived extracellular vesicles: a potential target for overcoming tumor immunotherapy resistance and immune evasion strategies by Minseo Ahn, Minseo Ahn, Jeong-Geon Mun, Yohan Han, Yohan Han, Yohan Han, Jae Ho Seo, Jae Ho Seo, Jae Ho Seo

“…Therefore, understanding the role of EVs in the immunotherapy resistance is crucial for developing targeted strategies to counteract their effects and ultimately improve therapeutic outcomes. …”
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Moving beyond species: fungal function in house dust provides novel targets for potential indicators of mold growth in homes by Neeraja Balasubrahmaniam, Jon C. King, Bridget Hegarty, Karen C. Dannemiller

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Targeting Death Receptor 5 (DR5) for the imaging and treatment of primary bone and soft tissue tumors: an update of the literature by Zakareya Gamie, Anja Krippner-Heidenreich, Craig Gerrand, Kenneth Samora Rankin

“…Developments have been made to test novel agents, and imaging has been used to detect DR5 in preclinical models and patients. …”
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Targeting CX3CR1 Signaling Dynamics: A Critical Determinant in the Temporal Regulation of Post-Stroke Neurorepair by Quan He, Tong Zhou, Quanwei He

“…Despite challenges like biomarker validation, mechanistic exploration, and cross-species differences, integrating cutting-edge technologies such as spatial metabolomics and AI-driven dynamic modeling promises to shift stroke therapy toward personalized spatiotemporal programming. Temporally targeting CX3CR1 signaling may offer a key basis for developing next-generation precision neural repair strategies for stroke.…”
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