M1 macrophage-membrane-cloaked paclitaxel/β-elemene nanoparticles targeting cervical cancer for enhanced therapy by Yi Wang, Jiakun Wang, Chengbo Huang, Yang Ding, Leyao Lv, Yuhao Zhu, Nuo Chen, Yingyi Zhao, Qing Yao, Shengjie Zhou, Mei Chen, Qibing Zhu, Lifeng Li, Fengyun Chen

“…Therefore, we propose a combination therapy using PTX/β-ELE to improve chemotherapy sensitivity. To enhance targeted drug delivery, we developed M1-macrophage-membrane-coated nanoparticles (M1@PLGA/PTX/β-ELE) for co-delivery of PTX&β-ELE. …”
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In Situ Proliferating Peptide Nanoparticle Augments Multi‐Target Intervention of Secondary Brain Damage Following Subarachnoid Hemorrhage by Yibin Zhang, Peisen Yao, Fuxiang Chen, Shufa Zheng, Xuegang Niu, Haojie Wang, Yuanxiang Lin, Bin Gao, Dezhi Kang

“…Abstract Subarachnoid hemorrhage (SAH), a lethal stroke subtype, involves complex pathological cascades triggered by neuro‐glial units for persistent neuroinflammation, oxidative damage and programmed neuronal cell death. Single‐target and traditional multi‐target therapies, derived from individual drugs, show limited efficacy in addressing these interconnected events, due to spatiotemporal heterogeneity of action in single‐target components. …”
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The role of target 3D-reconstructions when analysyng qualitative characteristics of the surface of circular-shaped growth in the lungs by V. G. Kolmogorov, V. K. Konovalov, S. L. Leonov, M. N. Lobanov

“…Target 3D reconstruction was carried out with the use of 3D Fly Through program (Toshiba Medical Systems, Japan) which removed the tissue surrounding CSG at a distance of 5–10 mm from the outer boundaries.CSG was inscribed into a cube. …”
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First in human dose calculation of a single-chain bispecific antibody targeting glioma using the MABEL approach by John H Sampson, Luis Sanchez-Perez, Teilo H Schaller, David J Snyder, Ivan Spasojevic, Patrick C Gedeon

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The effect of rTMS intervention with different targets on neural remodeling in stroke patients: a randomized controlled trial by Li Zhao, Li Chen, Qiu Wang, Xinyi Li, Sha Li, Chunxiao Wan

“…BackgroundrTMS is widely used to improve motor function in patients with ischemic stroke, but there are few studies on different targets. In order to develop a clinical precision rehabilitation program, this study aims to explore the effects of rTMS at different targets on neural remodeling in patients with subcortical stroke by combining motor function assessment, multimodal MRI and electrophysiological methods.Methods69 stroke patients were randomly assigned to the sham group, M1 group, and SMA group. …”
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Innovative developments in deep brain stimulation devices by Della Torre Attilio, La Torre Domenico, Guzzi Giusy, Volpentesta Giorgio, Lavano Angelo

“…Implementing a multimodal programming strategy and incorporating cutting-edge current fractionation technology and image-guided tools for lead localization and brain sensing reduces reliance on traditional trial-and-error programming methods. …”
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The Potential of Tube Industry Development in Conditions of Instability by A. P. Garnov, O. V. Devyatkin, G. A. Rybina

“…To resolve it a set of measures is necessary, such as starting the mechanism of innovation development in machine-building manufacturing; working-out the program of developing home industry of electronics, software, systems of management and engineering; motivating the growth in production capacities of machine-building enterprises. …”
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France’s Development Assistance Strategy to African Countries by Marina V. Klinova, Olga E. Trofimova

“…Data of ODA budget funds allocation of government structural divisions and the legally established solidarity priorities in development, the fight against poverty, global inequalities, and protecting global public goods (Law-Programming 2021) are analyzed. …”
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Collecting Research Evidence to Inform Programming to Tackle Violence Against Young Women and Girls: The Importance of Diverse Data for Policy Making by Dirk Schubotz, Siobhán McAlister, Gail Neill

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Impact of a specialized care program in the prevention and managing of skin integrity disorder in pediatric patients after open heart surgery by Faramarz Kalhor, Mayam Mlekpour, Ahmadreza Yazdannik, Hamid Bigdelian

“…The intervention group received targeted care program measures, while the control group followed standard care procedures. …”
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THE PLACE AND ROLE OF THE MANAGING AUTHORITY FOR OPERATIONAL PROGRAM FOR FISHERIES AND MARITIME AFFAIRS (AM-POPAM) IN THE ABSORPTION OF EUROPEAN FUNDS FOR THE PERIOD 2014-2020 by Sebastian GUT

“…The methodology used consisted in studying the bibliographic sources, collecting, processing, analyzing and interpreting the data provided by the databases of DGP and MADR, as well as formulating conclusions on the status of projects submitted, amounts allocated, achievement of targets and measures that can be taken further to support fishing and aquaculture activities.…”
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Equity in initial health evaluation utilization among world trade center health program members enrolled during 2012–2022 by Ruiling Liu, Michael O’Reilly, Sarah Rockhill, Lillian Fu, Kendra C. Smith, Emma Butturini, Albeliz Santiago-Colón, Rachael L. Shaw, Kevin Pressley, Geoffrey M. Calvert

“…This study aimed to evaluate equity in IHE utilization among Program members to inform the development of targeted interventions. …”
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Programmed cell death pathways in lung adenocarcinoma: illuminating tumor drug resistance and therapeutic opportunities through single-cell analysis by Long Li, Shancheng He

“…These results contribute to a growing framework for developing precise and adaptable cancer therapies tailored to specific tumor characteristics.…”
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An attachment‐based program for parents of youth with clinically significant mental health problems: Scaling up and drilling down to mechanisms of change by Marlene M. Moretti, Sebastian P. Dys, Stephanie G. Craig, Carlos A. Sierra Hernandez, Natalie Goulter, Katherine O’Donnell, Dave S. Pasalich

“…Abstract Background Given the prevalence and recent increases in youth mental health problems, there is a pressing need for interventions that target transdiagnostic protective factors that could be targeted as mechanisms of change in treatment. …”
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Understanding Effectiveness of International Sanctions by Thomas Biersteker

“…Taking into consideration the difficulty of conflicts and issues over which sanctions are applied – North Korea’s nuclear program, Iran’s potential development of nuclear weapon program, ethnic and religious conflicts in Africa, the Middle East – 20 % should not be considered a small figure. …”
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Identification and characterization of signature genes related to fetoplacental vascular endothelial cell programming in gestational diabetes mellitus using bioinformatics analysis by Chunhong Liu, Chunhong Liu, Chunhong Liu, Caicheng Wei, Caicheng Wei, Caicheng Wei, Yulan Lu, Fu Chai, Fu Chai, Fu Chai, Chunfang Wang, Chunfang Wang, Chunfang Wang, Yonglong Zeng, Yonglong Zeng, Yonglong Zeng, Huatuo Huang, Huatuo Huang, Huatuo Huang

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Immunohistochemical Expression of Programmed Death Ligand-1 in Colorectal Carcinoma and its Association with Clinicopathological Profile: A Cross-sectional Study by Sindhu Radhakrishnan, Shameera Begum, Bhavani Krishnamurthy, Rajan Vaithianathan, Sowmya Srinivasan

“…Checkpoint blockade therapy targeting Programmed Cell Death-1 (PD-1) and its ligand, Programmed Death Ligand-1 (PD-L1), using anti-PD-1 and anti-PD-L1 monoclonal antibodies is under evaluation for treating cancers of the gastrointestinal tract. …”
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Ecological and economic profile of cities: on the way to sustainable development by V. Nazarenko, О. Voytovich

“…Cities seek to balance their economic growth and preserve the state of the environment. One of the programs that more and more cities are implementing at the municipal level is the sustainable development program (based on the Paris Climate Agreement). …”
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Managing programmatic trade-offs for centers of teaching and learning: Applying a segmentation, targeting, and positioning approach to pedagogical offerings by Caitlin P. DeClercq, Christopher V.H.-H. Chen, Ian Althouse, Mark Phillipson

“…This approach has helped us clarify and target our pedagogical priorities, allowing us to make appropriate trade-offs to produce more focused educational development programming that better meets our audience’s needs, constraints, and contexts.…”
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Targeting early diagnosis and treatment of pancreatic cancer among the diabetic population: a comprehensive review of biomarker screening strategies by Jie Yang, Chengming Wen, Hongkai Guo, Yahui Chai, Guodong Sun, Huijuan Cheng

“…A comprehensive understanding of these mechanisms can inform the development of targeted therapeutic strategies, potentially improving patient outcomes by concurrently managing diabetes and pancreatic cancer. …”
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