Image Fusion of High-Resolution DynaCT and T2-Weighted MRI for Image-Guided Programming of dDBS by Fadil Al-Jaberi, Matthias Moeskes, Martin Skalej, Melanie Fachet, Christoph Hoeschen

“…<b>Objectives:</b> This study aimed to develop a semi-automated registration method for aligning preoperative non-contrast T2-weighted MRI with postoperative high-resolution cone-beam CT (DynaCT) in patients undergoing directional deep brain stimulation (dDBS) surgery targeting the subthalamic nucleus (STN). …”
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Exploring community willingness and barriers to digital solutions and training for dengue prevention: a cross-sectional study in major urban areas of Malaysia by Nazri Che Dom, Rahmat Dapari, Husna Ahmad Kamal, Qamarul Nazri Harun, Siti Aekbal Salleh, Ahmad Falah Aljaafre

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Programmed cell death signatures-driven microglial transformation in Alzheimer’s disease: single-cell transcriptomics and functional validation by Mi-Mi Li, Ying-Xia Yang, Ya-Li Huang, Shu-Juan Wu, Wan-Li Huang, Li-Chao Ye, Ying-Ying Xu

“…BackgroundThis study aims to develop and validate a programmed cell death signature (PCDS) for predicting and classifying Alzheimer’s disease (AD) using an integrated machine learning framework. …”
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Spread and Scale of the Integrated Nutrition Pathway for Acute Care Across Canada: Protocol for the Advancing Malnutrition Care Program by Katherine L Ford, Celia Laur, Rupinder Dhaliwal, Roseann Nasser, Leah Gramlich, Johane P Allard, Heather Keller

“…Champions created a site implementation team to target practice change in a specific area related to malnutrition care and use AMC program-specific tools and resources to implement improvements and collect site information through quarterly audits of patient charts to track implementation of nutrition care best practices. …”
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Clinical evaluation of the implementation of the first pilot Russian integrated program for an integrated approach to the management of diabetes mellitus “NORMA” by G. R. Galstyan, A. Y. Mayorov, O. G. Melnikova, N. I. Holmskaya, Z. A. Hamradjanov, V. I. Milyutin, M. V. Shestakova

“…In this regard, the search for new integrated solutions that could strengthen disease control and improve clinical outcomes becomes relevant.AIM: To assess the impact of the developed integrated approach to disease management on the clinical and metabolic outcomes of patients with type 1 (T1DM) and type 2 diabetes mellitus (T2DM) participating in the “NORMA” pilot program for 3 and 6 months.MATERIALS AND METHODS: “NORMA” is the first Russian program designed to implement an integrated approach to DM management combines structured online education, blood glucose monitoring, supervision by endocrinologist, and administrative support. …”
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Digital Horizons in Teacher Education Development by A. N. Makarenko, L. G. Smyshlyaeva, N. N. Minaev, O. M. Zamyatina

“…The paper presents the authors’ vision of the new teacher education formats at the target, organizational, activity and technological levels. …”
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GLOBAL TRENDS IN SUPPORTING EDUCATIONAL AND ACADEMIC WORK AND AIMS OF THEIR INTRODUCTION IN UNIVERSITY by Larisa N. Pavlova

“…The most acute targets of current and strategic nature are discussed. …”
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Targeting neuroinflammation: 3-monothiopomalidomide a new drug candidate to mitigate traumatic brain injury and neurodegeneration by Shih Chang Hsueh, Pathik Parekh, Buyandelger Batsaikhan, Neil Vargesson, David Tweedie, Weiming Luo, Chirag N. Patel, Dong Liu, Ross A. McDevitt, Abdul Mannan Baig, Yu Kyung Kim, Sun Kim, Inho Hwang, Juwan Kim, Mee Youn Lee, Anna R. Carta, Warren R. Selman, Barry J. Hoffer, Dong Seok Kim, Nigel H. Greig

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Molecular Docking Analysis of Flavonoid from Strobilanthes crispus L. as Potential Inhibitors of Mycobacterium tuberculosis Targeted Proteins by Rita Arbianti, Linatri Purwati Latifah, Graciella Sisila, Tania Surya Utami, Ibnu Maulana Hidayatullah, Fatimah Azizah Riyadi, Yuswan Muharam

“…Therefore, this study aimed to conduct a molecular docking analysis of two flavonoid compounds (quercetin and catechin) obtained from Strobilanthes crispus L. as potential inhibitors of Mycobacterium tuberculosis target proteins using the AutoDock Vina program. The results showed that quercetin was a potent inhibitor of the targeted proteins of M. tuberculosis. …”
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Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA): A Targeted Antioxidant Strategy to Counter Oxidative Stress in Retinopathy by Marco Zeppieri, Caterina Gagliano, Fabiana D’Esposito, Mutali Musa, Irene Gattazzo, Maria Sole Zanella, Federico Bernardo Rossi, Alessandro Galan, Silvia Babighian

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Prospects for increasing efficiency of state social assistance to the population based on a social contract by A. S. Abroskin, N. A. Abroskina

“…The program effectiveness problems have been studied in the chronology of its regulatory and methodological framework formation and development stages. …”
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Novel Antischistosomal Drug Targets: Identification of Alkaloid Inhibitors of SmTGR via Integrated In Silico Methods by Valéria V. M. Paixão, Yria J. A. Santos, Adriana O. Fernandes, Elaine S. Conceição, Ricardo P. Rodrigues, Daniela A. Chagas-Paula, Silvio S. Dolabella, Tiago B. Oliveira

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PREMIERE study: reaching target blood pressure level – a success in coronary heart disease treatment by Yu. A. Karpov, S. A. Shalnova, A. D. Deev

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An antibody-drug conjugate targeting soluble and membrane-bound TGFα is effective against pancreatic tumors by Inés Romero-Pérez, Juan Carlos Montero, Mónica Redondo-Puente, María del Carmen Gómez-García, Mireia Morell-Ginestà, Gabriel Capellá, Atanasio Pandiella

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NUMERICAL SIMULATION OF COOLING JET FROM HYDROGEN AND DEUTERIUM AS APPLICABLE TO INSTALLATIONS ON RECEIVING CRYOGENIC MONODISPERSE TARGETS by A. V. Bukharov, A. F. Ginevsky, E. V. Vishnevsky

“…Drops are cooled due to evaporation and become granules. The developed model, the program for determination of parameters of steady monodisperse disintegration of liquid cryogenic streams and results of numerical calculations can be used during creation of units for receiving high-speed cryogenic monodisperse targets.…”
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Research progress on natural plant metabolites targeting apoptosis for endometriosis prevention and treatment: a systematic review by Yang Yu, Yang Yu, Yufei Zhu, Mengyao Gao, Yu Wang, Shiying Li, Ying Gou

“…Accumulating evidence suggests that abnormal apoptosis is intricately linked to the development and progression of EMs and that targeted promotion of cell apoptosis may contribute to the prevention and treatment of EMs. …”
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Targeting the epigenetic regulation of ferroptosis: a potential therapeutic approach for sepsis-associated acute kidney injury by Yuhang Yang, Xinqi Deng, Wenyuan Li, Yan Leng, Yonghong Xiong, Bihan Wang, Siyuan Gong, Yunhao Wang, Baichuan Yang, Wei Li

“…Ferroptosis is an iron-dependent programmed cell death pathway, which is proved to play a critical role in the process of sepsis-associated acute kidney injury through various mechanisms. …”
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Policies and programmes to improve preconception nutrition in South Asia by Avishek Hazra, Tashi Choedon, Monica Shrivastav, Raj Kumar Verma, Cheshta Gulati, Dhammica Rowel, Abner Daniel, Preetu Mishra, Naveen Paudyal, Naureen Arshad, Muhammad Salman, Wisal Khan, Khadija Khalif Osman Warfa, Muhammad Amin, Ahmadwali Aminee, Ireen Akhter Chowdhury, Kinley Dorji, Indrani Chakma, Aishath Shahula Ahmed, Hari Prasad Pokhrel, Danielle Schoenaker, Jane Hirst, Ranadip Chowdhury, Naomi M. Saville, Faith Miller, Zivai Murira, Vani Sethi

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Delayed Transition to 20-Valent Pneumococcal Conjugate Vaccine in Pediatric National Immunization Programs: Forgone Public Health and Economic Benefit by Johnna Perdrizet, An Ta, Liping Huang, Warisa Wannaadisai, Aleksandar Ilic, Kyla Hayford, Ayman Sabra

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Mosaic vaccine design targeting mutational spike protein of SARS- CoV-2: An immunoinformatics approach by Ysrafil Ysrafil, Arlan K. Imran, Prisca Syafriani Wicita, Vyani Kamba, Fihrina Mohamad, Ismail Ismail, Ayyub Harly Nurung, Noviyanty Indjar Gama, Sari Eka Pratiwi, Indwiani Astuti, Firzan Nainu, Talha Bin Emran

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